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| 1 | Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer显示文摘AIM: To analyze predictive factors for lymph node metastasis in early gastric cancer.METHODS: We analyzed 1104 patients with early gastric cancer(EGC) who underwent a gastrectomy with lymph-node dissection from May 2003 through July 2011. The clinicopathologic factors and molecular markers were assessed as predictors for lymph node metastasis. Molecular markers such as microsatellite instability, human mut L homolog 1, p53, epidermal growth factor receptor(EGFR) and human epidermal growth factor receptor 2(HER2) were included. The χ2 test and logistic regression analysis were used to determine clinicopathologic parameters.RESULTS: Lymph node metastasis was observed in 104(9.4%) of 1104 patients. Among 104 cases of lymph node positive patients, 24 patients(3.8%) were mucosal cancers and 80 patients(16.7%) were submucosal. According to histologic evaluation, the number of lymph node metastasis found was 4(1.7%) for well differentiated tubular adenocarcinoma, 45(11.3%) for moderately differentiated tubular adenocarcinoma, 36(14.8%) for poorly differentiated tubular adenocarcinoma, and 19(8.4%) for signet ring cell carcinoma. Of 690 EGC cases, 77 cases(11.2%) showed EGFR overexpression. HER2 overexpression was present in 110 cases(27.1%) of 406 EGC patients. With multivariate analysis, female gender(OR = 2.281, P = 0.009), presence of lymphovascular invasion(OR = 10.950, P < 0.0001), diameter(≥ 20 mm, OR = 3.173, P = 0.01), and EGFR overexpression(OR = 2.185, P = 0.044) were independent risk factors for lymph node involvement.CONCLUSION: Female gender, tumor size, lymphovascular invasion and EGFR overexpression were predictive risk factors for lymph node metastasis in EGC. | Eun Hyo Jin Dong Ho Lee Sung-Ae Jung Ki-Nam Shim Ji Yeon Seo Nayoung Kim Cheol Min Shin Hyuk Yoon Hyun Chae Jung | 2015 | World Journal of Gastroenterology2015，21，2： | 30 |
| 2 | Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials显示文摘Photodynamic therapy(PDT) is an emerging, non-invasive therapeutic strategy that involves photosensitizer(PS) drugs and external light for the treatment of diseases. Despite the great progress in PS-mediated PDT, their clinical applications are still hampered by poor water solubility and tissue/cell specificity of conventional PS drugs. Therefore, great efforts have been made towards the development of nanomaterials that can tackle fundamental challenges in conventional PS drug–mediated PDT for cancer treatment. This review highlights recent advances in the development of nano-platforms, in which various functionalized organic and inorganic nanomaterials are integrated with PS drugs, for significantly enhanced efficacy and tumor-selectivity of PDT. | Eun Ji Hong Dae Gun Choi Min Suk Shim | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 22 |
| 3 | Impact of tumor location on clinical outcomes of gastric endoscopic submucosal dissection显示文摘AIM:To determine whether there is a correlation between the location of the lesion and endoscopic submucosal dissection(ESD)outcome.METHODS:From January 2008 to December 2010,ESD of 1443 gastric tumors was performed.En bloc resection rate,complete resection rate,procedure time and complication rate were analyzed according to the tumor location.RESULTS:The rates of en bloc resection and complete resection were 91%(1318/1443)and 89%(1287/1443),respectively.The post-ESD bleeding rate was 4.3%,and perforation rate was 2.7%.Tumors located in the upper third of the stomach were associated with a longer procedure time and significantly higher rates of incomplete resection,piecemeal resection,and perforation than tumors below the upper third of the stomach.Posterior wall lesions had significantly longer procedure times and higher rates of incomplete resection and piecemeal resection than lesions in other locations.In multivariate analysis,posterior wall lesions and upper third lesions were significantly associated with incomplete resection and perforation,respectively.In post-ESD bleeding analysis,location was not a significant related factor.CONCLUSION:More advanced endoscopic techniques are required during ESD for lesions located in the upper third or posterior wall of the stomach to decrease complications and improve therapeutic outcomes. | Ji Young Yoon Choong Nam Shim Sook Hee Chung Wan Park Hyunsoo Chung Hyuk Lee Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jun Chul Park | 2014 | World Journal of Gastroenterology2014，20，26： | 10 |
| 4 | Detection of Helicobacter pylori DNA in Human Biliary Tree and Its Association with Hepatolithiasis显示文摘 | Seung-Jae Myung Myung-Hwan Kim Ki Nam Shim Yeon-Suk Kim Eun Ok Kim Hong-Ja Kim Eun-Taek Park Kyo-Sang Yoo Byeung-Cheol Lim Dong Wan Seo Sung Koo Lee Young Il Min Ji Yeon Kim | 2000 | Digestive Diseases and Sciences2000，，7： | 2 |
| 5 | Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats显示文摘Objective: To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng(KRG, Panax ginseng) in rats fed with a high-fat diet(HFD). Methods: Twenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks;subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re(10 mg/kg, intraperitoneal injection) for a further 3 weeks(n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide(NO) expression, leptin, neuropeptide Y(NPY), cholecystokinin(CCK) in the brains were measured. Results: In the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats(P<0.05 or P<0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight(P<0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group(P<0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group(P<0.05). Conclusion: PD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals. | Hyun-Jung Park Ji Hyun Kim Insop Shim | 2019 | Chinese Journal of Integrative Medicine2019，25，12： | 2 |
| 6 | Long-term outcome of capsule endoscopy in obscure gastrointestinal bleeding: a nationwide analysis显示文摘 | Yang Min Jin Kim Seong Jeon Yoon Jeen Jong Im Dae Cheung Myung-Gyu Choi Jin-Oh Kim Kwang Lee Byong Ye Ki-Nam Shim Jeong Moon Ji Kim Sung Hong Dong Chang | 2013 | Endoscopy2013，，： | 2 |
| 7 | DJ-1 mediates paraquat-induced dopaminergic neuronal cell death显示文摘 | Hyun Joo Kwon Jun Young Heo Jung Hee Shim Ji Hoon Park Kang Sik Seo Min Jeong Ryu Jeong Su Han Minho Shong Jin H. Son Gi Ryang Kweon | 2011 | Toxicology Letters2011，，： | 2 |
| 8 | Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women显示文摘 | Young Joo Jeon Yi Seul Choi HyungChul Rah Su Yeoun Kim Dong Hee Choi Sun Hee Cha Ji Eun Shin Sung Han Shim Woo Sik Lee Nam Keun Kim | 2011 | Gene2011，，2： | 1 |
| 9 | Fast image segmentation based on multi-resolution analysis and wavelets显示文摘 | Kim BG Shim JI Park DJ | 2003 | Pattern recognition letters2003，24，16： | 1 |
| 10 | Sensitization of the apoptotic effect of gamma-irradiation in genistein-pretreated CaSki cervical cancer ceils 显示文摘 | Shin JI Shim JH Kim KH | 2008 | J Microbiol Bioteclmol2008，18，3： | 1 |
| 11 | Expression of Myeloid Antigen in Neoplastic Plasma Cells Is Related to Adverse Prognosis in Patients with Multiple Myeloma显示文摘 | Hyoeun Shim Joo Hee Ha Hyewon Lee Ji Yeon Sohn Hyun Ju Kim Hyeon-Seok Eom Sun-Young Kong Dong Soon Lee | 2014 | BioMed Research International2014，，： | 1 |
| 12 | Detection of Helicobacter pylori DNA in Human Biliary Tree and Its Association with Hepatolithiasis显示文摘 | Seung-Jae Myung Myung-Hwan Kim Ki Nam Shim Yeon-Suk Kim Eun Ok Kim Hong-Ja Kim Eun-Taek Park Kyo-Sang Yoo Byeung-Cheol Lim Dong Wan Seo Sung Koo Lee Young Il Min Ji Yeon Kim | 2000 | Digestive Diseases and Sciences2000，，7： | 1 |
| 13 | Nonribosomal peptide synthase is responsible for the biosynthesis of siderophore in Vibrio vulnificus MO6-24/O显示文摘 | Kim IH Shim JI Lee KE | 2008 | J Microbiol Bioteehrml2008，18，1： | 1 |
| 14 | Dendritic cell-based immunotherapy for colon cancer using an HLA-A*0201-restricted cytotoxic T-lymphocyte epitope from tumor-associated antigen 90K显示文摘联系肿瘤的抗原 90K 通过它和 galectin-3 的相互作用在房间房间和房间细胞外的矩阵粘附被含有,使它成为为新免疫疗法的发展的一个新奇目标并且 integrin-β 1 并且高度在恶意的纸巾被表示。我们用细胞毒素的 T 淋巴细胞由自体同源的树枝状的房间导致了并且与 90K 肽搏动了的 90K-specific 为结肠癌调查了潜在的免疫疗法治疗。我们选择了三肽(绑在 HLA-A* 的 90K 351, 90K 5 和 90K 523) ; 0201 个分子根据他们的有约束力的亲密关系由 peptide-T2 绑定试金决定了。树枝状的房间与 90K 肽搏动了导致了成熟树枝状的房间的有效产生并且向 Th1 展出了提高的 T 房间刺激和天真的 T 房间的极化。树枝状的房间与 90K 肽搏动了产生有势力 lysed T2 房间与每 90K 肽装载了的细胞毒素的 T 淋巴细胞,和 90K +/HLA-A2+ 结肠癌房间线包括 HCT116 和 SW480,在一个剂量依赖者和 HLA-A* 0201-restricted 举止。没有杀死在 90K +/HLA-A2− DLD1 或 90K −/HLA-A2− K562 房间被观察。因此,我们相信 90K 刺激的那个细胞毒素的 T 淋巴细胞搏动肽树枝状的房间自然地认出结肠癌房间在 HLA-A2 的上下文介绍的 90K 肽,并且杀死 90K-positive 肿瘤房间。树枝状的房间搏动了, 90K 肽导致了 granzyme B 和 perforin 的正式就职对 HCT116 和 SW480 房间的积极 CD8 + T 房间,然而并非 DLD1 房间。在结论, 90K-specific 细胞毒素的 T 淋巴细胞,由与 90K 刺激 T 房间产生了搏动肽的树枝状的房间,能是为结肠癌的免疫疗法治疗的有用受动器房间。 | Ji Hee Lee Myong-Suk Park Jun-Eul Hwang Sang-Hee Cho Woo-Kyun Bae Hyun-Jeong Shim Dae-Eun Kim Ik-Joo Chung | 2013 | Cellular & Molecular Immunology2013，10，3： | 1 |
| 15 | Effects of PWHT on Microstructure and Mechanical Properties of Weld Metals of Ni-Based Superalloy 617 and 263 for Hyper-Supercritical Power Plants显示文摘It is well known that solid solution-strengthened alloy 617 and γ' precipitation-strengthened alloy 263 have excellent mechanical properties and corrosion resistance at high temperatures.Hyper-supercritical power plants work at temperatures above 700 ℃,and these superalloys are considered candidate materials for steam turbines components of these power plants.In this study,gas tungsten arc weldability of these superalloys was evaluated,and the effects of postweld heat treatment(PWHT) on the microstructural characteristics and the mechanical properties of their weld metals were investigated.Scanning transmission electron microscopy,energy-dispersive spectroscopy and electron probe microanalysis were utilized for the investigation.The experimental results confirmed that these weld metals had different characteristics in microstructure and mechanical properties.PWHT resulted in the precipitation of intergranular carbides,γ' particles and an increase in tensile strength of these superalloy weld metals.Furthermore,fine γ' particles,which were not detected in the as-welded metal of alloy 263,were precipitated after PWHT and those particles were the reason for the drastic increase in tensile strength. | Jeong Kil Kim Hae Ji Park Deog Nam Shim | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，12： | 1 |
| 16 | Epigallocatechin gallate suppresses hmg cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein l显示文摘 | Shim JH Su ZY Chae JI | 2010 | Cancer Prey Res (Phila)2010，3，5： | 1 |
| 17 | Factors affecting quality of life in Korean patients with chronic heart failure显示文摘 | Sang Hui CHU Won Hee LEE Ji Soo YOO So Sun KIM Il Sun KO Eui Geum OH JuHee LEE Mona CHOI Joo Young CHEON Chi Young SHIM Seok‐Min KANG | 2014 | Japan Journal of Nursing Science2014，，1： | 1 |
| 18 | Clinical outcomes for patients with perforations during endoscopic submucosal dissection of laterally spreading tumors of the colorectum显示文摘 | Jung Yoon Yoon Jeong Hwan Kim Ji Young Lee Sung Noh Hong Sun-Young Lee In-Kyung Sung Hyung Seok Park Chan Sup Shim Hye Seung Han | 2013 | Surgical Endoscopy2013，，2： | 1 |
| 19 | Embolization effects of chitosan microspheres on rabbit kidney显示文摘 | Lee JI Kwak BK Shim H J | 2003 | Chung-Ang Journal of Medicine2003，28，1： | 1 |
| 20 | Exudative pleural effusionand pleural leu- kocytoelastic vaseulitis in limited seleroderma 显示文摘 | Lee YH Ji JD Shim J J | 1998 | J Rheumatol1998，5，5： | 1 |
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