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| 1 | Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C显示文摘AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to IFN.METHODS:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively determined.RESULTS: Twenty-five patients completed IFN therapy.Eight patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy subjects.In vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C. | Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki | 2004 | World Journal of Gastroenterology2004，10，5： | 12 |
| 2 | Advanced diffusion magnetic resonance imaging in patients with Alzheimer’s and Parkinson’s diseases显示文摘The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective biomarkers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Diffusion magnetic resonance imaging is a robust tool used to evaluate brain microstructural complexity and integrity, axonal order, density, and myelination via the micron-scale displacement of water molecules diffusing in tissues. Diffusion tensor imaging, a type of diffusion magnetic resonance imaging technique is widely utilized in clinical and research settings;however, it has several limitations. To overcome these limitations, cutting-edge diffusion magnetic resonance imaging techniques, such as diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and free water imaging, have been recently proposed and applied to evaluate the pathology of neurodegenerative diseases. This review focused on the main applications, findings, and future directions of advanced diffusion magnetic resonance imaging techniques in patients with Alzheimer's and Parkinson's diseases, the first and second most common neurodegenerative diseases, respectively. | Koji Kamagata Christina Andica Taku Hatano Takashi Ogawa Haruka Takeshige-Amano Kotaro Ogaki Toshiaki Akashi Akifumi Hagiwara Shohei Fujita Shigeki Aoki | 2020 | Neural Regeneration Research2020，15，9： | 11 |
| 3 | Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant显示文摘We report a case of fatal liver failure due to reactivation of lamivudine-resistant HBV. A 53-year-old man was followed since 1998 for HBV-related chronic hepatitis. Serum HBV-DNA was 150 MEq/mL (branched DNA signal amplification assay) and ALT levels fluctuated between 50-200 IU/L with no clinical signs of liver cirrhosis. Lamivudine (100 mg/d) was started in May 2001 and serum HBV-DNA subsequently decreased below undetectable levels. In May 2002, serum HBV-DNA had increased to 410 MEq/mL, along with ALT flare (226 IU/L). The YMDD motif in the DNA polymerase gene had been replaced by YIDD. Lamivudine was continued and ALT spontaneously decreased to the former levels. On Oct 3 the patient presenting with general fatigue, nausea and jaundice was admitted to our hospital. The laboratory data revealed HBV reactivation and liver failure (ALT: 1828 IU/L, total bilirubin: 10 mg/dL, and prothrombin INR: 3.24). For religious reasons, the patient and his family refused blood transfusion, plasma exchange and liver transplantation. The patient died 10 d after admission. The autopsy revealed remarkable liver atrophy. | Tatehiro Kagawa Norihito Watanabe Hisashi Kanouda Ichiro Takayama Tadahiko Shiba Takashi Kanai Kazuya Kawazoe Shinji Takashimizu Nobue Kumaki Kazuo Shimamura Shohei Matsuzaki Tetsuya Mine | 2004 | World Journal of Gastroenterology2004，10，11： | 10 |
| 4 | Gastric xanthoma is a predictive marker for metachronous and synchronous gastric cancer显示文摘AIM To investigate predictive markers for metachronous and synchronous gastric cancer(GC), which can develop after endoscopic submucosal dissection(ESD).METHODS A total of 352 patients underwent ESD for early GC at NTT West Osaka Hospital between June 2006 and February 2016. Exclusion criteria were as follows: Remnant stomach, unknown Helicobacter pylori status, and endoscopic observation of the whole stomach outside our hospital. We analyzed data from 192 patients comprising 109 patients with solitary GC(Group A) and 83 with metachronous and synchronous GC(Group B). We retrospectively investigated the clinicopathological and endoscopic characteristics, and endoscopic risk score as predictive markers for GC.RESULTS The median age of Group B [72 years(interquartile range 63-78)] was significantly higher than that of Group A [66 years(interquartile range 61-74), respectively, P = 0.0009]. The prevalence of intestinal metaplasia in Group B tended to be higher than that in Group A(57.8% vs 45.0%, P = 0.08). The prevalence of gastric xanthoma(GX) in Group B was significantly higher than that in Group A(54.2% vs 32.1%, P = 0.003). The atrophy score in Group B was significantly higher than that in Group A(P = 0.005). Multivariate analysis revealed that higher age and the presence of GX were independently related to metachronous and synchronous GC [OR = 1.04(1.01-1.08), P = 0.02; and OR = 2.11(1.14-3.99), P = 0.02, respectively].CONCLUSION The presence of GX is a useful predictive marker for metachronous and synchronous GC. | Narihiro Shibukawa Shohei Ouchi Shuji Wakamatsu Yuhei Wakahara Akira Kaneko | 2017 | World Journal of Gastrointestinal Oncology2017，9，8： | 8 |
| 5 | Generalized Morrey spaces and trace operator显示文摘The theory of generalized Besov-Morrey spaces and generalized Triebel-Lizorkin-Morrey spaces is developed. Generalized Morrey spaces, which Mizuhara and Nakai proposed, are equipped with a parameter and a function. The trace property is one of the main focuses of the present paper, which will clarify the role of the parameter of generalized Morrey spaces. The quarkonial decomposition is obtained as an application of the atomic decomposition. In the end, the relation between the function spaces dealt in the present paper and the foregoing researches is discussed. | NAKAMURA Shohei NOI Takahiro SAWANO Yoshihiro | 2016 | Science China Mathematics2016，59，2： | 6 |
| 6 | Surgical spacer placement and proton radiotherapy for unresectable hepatocellular carcinoma显示文摘Few potentially curative treatment options exist apart from hepatic resection for patients with huge hepatocellular carcinoma (HCC). Proton radiotherapy is a promising new modality which has an inherent antitumor effect against HCC. However, the application of proton radiotherapy for tumors adjacent to the gastrointestinal tract is restricted because the tolerance dose of the intestine is extremely low. A novel two-step treatment was developed with surgical spacer placement and subsequent proton radiotherapy to administer proton radiotherapy with curative intent. This report presents a case of a patient with a huge unresectable HCC treated by this method who achieved disease-free survival of more than 2 years. This new strategy may potentially be an innovative and standard therapy for unresectable HCC in the near future. | Shohei Komatsu Yuichi Hori Takumi Fukumoto Masao Murakami Yoshio Hishikawa Yonson Ku | 2010 | World Journal of Gastroenterology2010，16，14： | 5 |
| 7 | Real-time color holographic video reconstruction using multiple-graphics processing unit cluster acceleration and three spatial light modulators显示文摘We demonstrate real-time three-dimensional(3D)color video using a color electroholographic system with a cluster of multiple-graphics processing units(multi-GPU)and three spatial light modulators(SLMs)corresponding respectively to red,green,and blue(RGB)-colored reconstructing lights.The multi-GPU cluster has a computer-generated hologram(CGH)display node containing a GPU,for displaying calculated CGHs on SLMs,and four CGH calculation nodes using 12 GPUs.The GPUs in the CGH calculation node generate CGHs corresponding to RGB reconstructing lights in a 3D color video using pipeline processing.Real-time color electroholography was realized for a 3D color object comprising approximately 21,000 points per color. | Shohei Ikawa Naoki Takada Hiromitsu Araki Hiroaki Niwase Hiromi Sannomiya Hirotaka Nakayama Minoru Oikawa Yuichiro Mori Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito | 2020 | Chinese Optics Letters2020，18，1： | 4 |
| 8 | Hepatic osteodystrophy complicated with bone fracture in early infants with biliary atresia显示文摘Biliary atresia(BA) is one of the major hepatobiliary abnormalities in infants and one of the causes of hepatic osteodystrophy.Bone disease may be caused by the malabsorption of calcium and magnesium by vitamin D in hepatobiliary diseases in which bile flow into the intestines is deficient or absent.Bone fracture before Kasai hepatic portoenterostomy or within one month after the procedure in an infant with BA is very rare.We herein report two infants:one infant with BA who initially presented with a bone fracture before Kasai hepatic portoenterostomy,and the other at 4 wk after Kasai hepatic portoenterostomy,and also provide a review of the literature.Moreover,we conclude that clinicians should consider BA in infants with bone fracture during early infancy. | Tadao Okada Shohei Honda Hisayuki Miyagi Masashi Minato Akinobu Taketomi | 2012 | World Journal of Hepatology2012，4，10： | 3 |
| 9 | Bandgap-tunable lateral and vertical heterostructures based on monolayer Mo1-xWxS2 alloys显示文摘有特定的 bandgaps 的二维的半导体的 heterostructures 的制造是认识到这些材料的完整的潜力在的一条重要途径电子并且 optoelectronic 设备。几个组最近基于象 WSe 2, MoSe 2, WS 2, 和瞬间 2 那样的典型半导体的转变金属 dichalcogenides (TMDC ) 的单层报导了侧面、垂直的 heterostructures 的直接生长。这里,我们基于 bandgap 悦耳的瞬间 1-x W x 由 WO 3 和哞 3 的有图案的薄电影的 sulfurization 的 S 2 合金单层。这些有图案的电影能够在水晶生长阶段期间由转变金属的散开产生许多集中坡度。在高温度下面,这导致瞬间 1-x W x 有各种各样的作文和 bandgaps 的 S 2 合金,在底层上取决于晶体的位置。这些合金的 Heterostructures 在低温度的生长期间在一个单个领域以内在 W/Mo 的比率通过逐步的变化被获得。单层瞬间 1-x W x S 2 合金,经常甚至在轻轻的条件下面降级,被涂层完成有另外的单层的合金。现在的调查结果表明学习并且优化基于 TMDC 的 heterostructures 的光、电的性质在未来设备应用允许材料的使用的一个有效工具。 | Yu Kobayashi Shohei Mori Yutaka Maniwa Yasumitsu Miyata | 2015 | Nano Research2015，8，10： | 3 |
| 10 | Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: Case report and literature review显示文摘Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC rearrangements and coinfected with Epstein-Barr virus (EBV) infection presenting with various endoscopic findings. A 38-yearold homosexual man who presented with anemia and was diagnosed with an human immunodeficiency virus infection for the first time. GI endoscopy revealed multiple dish-like lesions, ulcerations, bloody spots, nodular masses with active bleeding in the stomach, erythematous flat lesions in the duodenum, and multiple nodular masses in the colon and rectum. Magnified endoscopy with narrow band imaging showed a honeycomb-like pattern without irregular microvessels in the dish-like lesions of the stomach. Biopsy specimens from the stomach, duodenum, colon, and rectum revealed diffuse large B-cell lymphoma concomitant with EBV infection that was detected by high tissue EBV-polymerase chain reaction levels and Epstein-Barr virus small RNAs in situ hybridization. Fluorescence in situ hybridization analysis revealed a fusion between the immunoglobulin heavy chain (IgH) and c-MYC genes, but not between the IgH and BCL2 loci. After 1-mo of treatment with HAART and R-CHOP, endoscopic appearance improved remarkably, and the histological features of the biopsy specimens revealed no evidence of lymphoma. However, he died from multiple organ failure on the 139 th day after diagnosis. The cause of his poor outcome may be related to MYC rearrangement. The GI tract involvement in ARL is rarely reported, and its endoscopic findings are various and may be different from those in non-AIDS GI lymphoma; thus, we also conducted a literature review of GI-ARL cases. | Shohei Tanaka Naoyoshi Nagata Sohtaro Mine Toru Igari Taiichiro Kobayashi Jun Sugihara Haruhito Honda Katsuji Teruya Yoshimi Kikuchi Shinichi Oka Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，29： | 3 |
| 11 | Two-stage treatment with hepatectomy and carbon-ion radiotherapy for multiple hepatic epithelioid hemangioendotheliomas显示文摘Hepatic epithelioid hemangioendothelioma(HEH)is a rare neoplasm of vascular origin with variable malignant potential.Because most patients with this condition have multiple bilobar lesions,liver transplantation is the standard treatment,and hepatectomy is much less frequently indicated.We describe a case of a 35-yearold woman with unresectable multiple bilobar HEH successfully treated by combination treatment with hepatectomy and carbon-ion radiotherapy.This case is very meaningful since it demonstrated the effectiveness of carbon-ion radiotherapy for HEH and the possibility of expanding the curative treatment options for multiple bilobar hepatic tumors. | Shohei Komatsu Takeshi Iwasaki Yusuke Demizu Kazuki Terashima Osamu Fujii Atsushi Takebe Akihiro Toyokawa Kazuhiro Teramura Takumi Fukumoto Yonson Ku Nobukazu Fuwa | 2014 | World Journal of Gastroenterology2014，20，26： | 2 |
| 12 | Impact of Antithrombin III Concentrates on Portal Vein Thrombosis After Splenectomy in Patients With Liver Cirrhosis and Hypersplenism显示文摘 | Hirofumi Kawanaka Tomohiko Akahoshi Nao Kinjo Kozou Konishi Daisuke Yoshida Go Anegawa Shohei Yamaguchi Hideo Uehara Naotaka Hashimoto Norifumi Tsutsumi Morimasa Tomikawa Yoshihiko Maehara | 2010 | Annals of Surgery2010，，1： | 2 |
| 13 | CO2加氢催化剂Cu/ZrO2/SiO2上Zr(IV)表面位对甲醇生成速率的影响(英文)显示文摘Cu/ZrO2/SiO2是有效的CO2选择加氢制甲醇催化剂.为了理解混合氧化物基催化剂中ZrO2的作用,在Cu和Zr的K边进行了原位X-射线吸收光谱测试.在反应条件下, Cu保持金属态,而Zr以三类配位环境的形式存在:体相ZrO2,配位饱和的、以及不饱和的Zr(Ⅳ)表面位.配位不饱和Zr表面位可通过线性拟合参比的X射线吸收近边结构光谱进行定量,发现其数量与甲醇生成速率有关,因而表明Zr(Ⅳ)Lewis酸表面位在驱动选择生成甲醇反应中的重要性.这与提出的机理是一致的:在裂解H2的Cu纳米颗粒与稳定反应中间体的Zr(Ⅳ)表面位之间的界面上进行CO2加氢. | Erwin Lam Kim Larmier Shohei Tada Patrick Wolf Olga V. Safonova Christophe Copéret | 2019 | Chinese Journal of Catalysis2019，40，11： | 2 |
| 14 | Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma显示文摘 | Shohei Komatsu Takumi Fukumoto Yusuke Demizu Daisuke Miyawaki Kazuki Terashima Ryohei Sasaki Yuichi Hori Yoshio Hishikawa Yonson Ku Masao Murakami | 2011 | Cancer2011，，21： | 2 |
| 15 | An Automobile Exterior Design Approach Model Linking Form and Color显示文摘 | Shohei Takebuchi Hiroki Asami Kakuro Amasaka | 2012 | China-USA Business Review2012，11，8： | 2 |
| 16 | Water-assisted self-sustained burning of metallic single-walled carbon nanotubes for scalable transistor fabrication显示文摘Although aligned arrays of semiconducting single-walled carbon nanotubes(s-SWNTs) are promising for use in next-generation electronics owing to theirultrathin bodies and ideal electrical properties, even a small portion of metallic(m-) counterparts causes excessive leakage in field-effect transistors (FETs).To fully exploit the benefits of s-SWNTs for use in large-scale systems, it isnecessary to completely eliminate m-SWNTs from as-grown SWNT arrays andthereby obtain purely semiconducting large-area arrays, wherein numerousFETs can be flexibly built. In this study, we performed electrical burning ofm-SWNTs assisted by water vapor and polymer coating to eliminate m-SWNTsover a long length for the scalable fabrication of transistors from the remainings-SWNT arrays. During the electrical-breakdown process, the combination ofwater vapor and the polymer coating significantly enhanced the burning ofthe SWNTs, resulting in a self-sustained reaction along the nanotube axis. Wefound that m-SWNT segments partially remaining on the anode side resultedfrom one-way burning from the initial breakdown position, where Joule-heating-induced oxidation first occurred. The s-SWNT-enriched arrays obtained wereused to fabricate multiple FETs with a high on-off current ratio. The resultsindicate the advantages of this approach over conventional electrical breakdownfor the large-scale purification of s-SWNTs. | Keigo Otsuka Taiki Inoue Yuki Shimomura Shohei Chiashi Shigeo Maruyama | 2017 | Nano Research2017，10，9： | 2 |
| 17 | One-step reconstruction of the right inferior hepatic veins using auto-venous grafts in living donor liver transplantation显示文摘 | Toru Ikegami Ken Shirabe Shohei Yoshiya Yuji Soejima Tomoharu Yoshizumi Hideaki Uchiyama Takeo Toshima Takashi Motomura Yoshihiko Maehara | 2013 | Surgery Today2013，，7： | 2 |
| 18 | Tunable Separation of Single-Walled Carbon Nanotubes by Dual-Surfactant Density Gradient Ultracentrifugation显示文摘我们在场在由密度坡度 ultracentrifugation (DGU ) 的围单人赛的碳 nanotubes (SWNT ) 的分离的表面活化剂的效果的系统的研究。通过快活的密度,层位置,和用胆汁盐钠 deoxycholate (文档) 和 anionic 的 SWNT 分离的光吸收度系列的分析腌钠 dodecyl 硫酸盐(SDS ) ,我们在产出不同 DGU 结果澄清这二表面活化剂的角色和相互作用。这里描述的分离机制能也在由预言不同开始的配方的结果的品质上设计新 DGU 实验帮助,改进 DGU 的功效并且简化 post-DGU 分别。 | Pei Zhao Erik Einarsson Georgia Lagoudas Junichiro Shiomi Shohei Chiashi Shigeo Maruyama | 2011 | Nano Research2011，4，7： | 2 |
| 19 | Privacy preservation in permissionless blockchain:A survey显示文摘Permissionless blockchain,as a kind of distributed ledger,has gained considerable attention because of its openness,transparency,decentralization,and immutability.Currently,permissionless blockchain has shown a good application prospect in many fields,from the initial cryptocurrency to the Internet of Things(IoT)and Vehicular Ad-Hoc Networking(VANET),which is considered as the beginning of rewriting our digital infrastructure.However,blockchain confronts some privacy risks that hinder its practical applications.Though numerous surveys reviewed the privacy preservation in blockchain,they failed to reveal the latest advances,nor have they been able to conduct a unified standard comprehensive classification of the privacy protection of permissionless blockchain.Therefore,in this paper,we analyze the specific characteristics of permissionless blockchain,summarize the potential privacy threats,and investigate the unique privacy requirements of blockchain.Existing privacy preservation technologies are carefully surveyed and evaluated based on our proposed evaluation criteria.We finally figure out open research issues as well as future research directions from the perspective of privacy issues. | Li Peng Wei Feng Zheng Yan Yafeng Li Xiaokang Zhou Shohei Shimizu | 2021 | Digital Communications and Networks2021，7，3： | 2 |
| 20 | SJWD14101600000482显示文摘 | Naoyoshi Nagata Ryota Niikura Tomonori Aoki Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Junichi Akiyama Mikio Yanase Masashi Mizokami Naomi Uemura | 2014 | J Gastroenterol Hepatol2014，，10： | 2 |
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