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| 1 | Variable Sets principle and method for flood classification显示文摘Flood classification is an effective way to improve flood forecasting accuracy. According to the opposite unity mathematical theorem in Variable Sets theory, this paper proposes a Variable Sets principle and method for flood classification, which is based on the mathematical theorem of dialectics basic laws. This newly proposed method explores a novel way to analyze and solve engineering problems by utilizing a dialectical thinking. In this paper, the Tuwei River basin, located in the Yellow River tributary, is taken as an example for flood classification. The results obtained in this study reveal the problems in a previous method—Set Pair Analysis classification method. The variable sets method is proven to be theoretically rigorous, computationally simple. The classification results are objective, accurate and consistent with the actual situations. This study demonstrates the significant importance of using a scientifically sound method in solving engineering problems. | CHEN ShouYu XUE ZhiChun LI Min | 2013 | Science China(Technological Sciences)2013，56，9： | 20 |
| 2 | Sox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancer显示文摘Gastric cancer stem-like cells(GCSCs) have been identified to possess the ability of self-renewal and tumor initi-ation.However,the mechanisms involved remain largely unknown.Here,we isolated and characterized the GCSCs by side population(SP) sorting procedure and cultured sphere cells(SC) from human gastric cancer cell lines SGC-7901,BGC-823,MGC-803,HGC-27 and MKN-28.The sorting and culture assay revealed that SP cells proliferated in an asymmetric division manner.In addition,SP cells exhibited a higher potential of spheroid colony formation and greater drug resistance than non-SP cells(NSP).Moreover,the SC were found with enhanced capabilities of drug resistance in vitro and tumorigenicity in vivo.Sox2 mRNA and protein was highly and significantly overex-pressed in the SP cells and SC.Importantly,downregulation of Sox2 with siRNA obviously reduced spheroid colony formation and doxorubicin efflux,as well as increased apoptosis rate in sphere cells in vitro and suppressed tumori-genicity in vivo.These results suggest that both SP cells and cultured SC enrich with GCSCs and that Sox2 plays a pivotal role in sustaining stem cell properties and might be a potential target for gastric cancer therapy. | Tian Tian Yajie Zhang Shouyu Wang Jianwei Zhou Shan Xu | 2012 | The Journal of Biomedical Research2012，26，5： | 11 |
| 3 | Hydrogen peroxide primes heart regeneration with a derepression mechanism显示文摘当成年的人的心很限制了再生潜力时,成年 zebrafish 心能充分在 20% 室的切除术以后再生。尽管以前的报告建议象 FGF 和 PDGF 那样的发展发信号小径在成年的心新生被再使用,内在的细胞内部的机制仍然保持大部分未知。这里,我们显示出那 H 2 O 2 充当新奇 epicardial 和心肌的信号在成年 zebrafish 为新生告知心。未经触动的心的实时成像揭示了高度局部性的 H 2 O 2(~ 30 μ M ) 在在切除术地点的心外膜和邻近的紧缩的心肌层的生产。减少的 H 2有 Duox 禁止者 diphenyleneiodonium (点每英寸)或 apocynin 的 O 2形成,或清除 H 2当时,由过氧化氢酶 overexpression 的 O 2显著地损害了心脏的新生外长的 H 2 O 2在心脏的新生上救了点每英寸的禁止的效果,显示那 H 2 O 2是在这个过程的一个必要、足够的信号。机械学地,提高了 H 2 O 2 使动摇氧化还原作用敏感的磷酸酶 Dusp6 并且因此增加了 Erk1/2 的 phosphorylation。当 dusp6 的转基因的 overexpression 损害了心脏的新生时, Dusp6 禁止者 BCI 完成了类似的支持 regenerative 效果。H 2 O 2 在招募起一个双作用通过二条相对独立的小径的有免疫力的房间和支持的心新生。我们结束那 H 2 潜在地从 Duox/Nox2 产生的 O 2 由解开通过包含 Dusp6 的 derepression 机制发信号的地图 kinase 在 zebrafish 支持心新生。 | Peidong Han Xiao-Hai Zhou Nannan Chang Cheng-Lu Xiao Shouyu Yah He Ren Xin-Zhuang Yang Mei-Ling Zhang Qing Wu Boyang Tang Ju-Peng Diao Xiaojun Zhu Chuanmao Zhang Chuan-Yun Li Heping Cheng Jing-Wei Xiong | 2014 | Cell Research2014，24，9： | 10 |
| 4 | Variable sets method for urban flood vulnerability assessment显示文摘On the basis of dialectics basic laws and mathematical theorems of variable sets,this paper proposes a variable sets method for urban flood vulnerability assessment.In this method,the comprehensive relative membership degree of multi-indices is represented by an index relative difference degree,which follows the characteristics of dialectical philosophy and mathematics.According to the quality-quantity exchange theorem,the relative difference degree of two adjacent levels(h and h+1),whose index standard interval values cross the boundaries,equals 0 in the urban flood vulnerability assessment.On the basis of the opposite unity theorem,the sum of relative membership degrees should be equal to 1 when indices lie in the adjacent degrees h and h+1.The variable sets method is proved to be theoretically rigorous and computationally simple.This paper takes 29 cities of Hunan province as an example to assess the urban flood vulnerability,and then compares the results from this newly developed method with the assessment results obtained from the fuzzy comprehensive evaluation and fuzzy set pair analysis methods. | CHEN ShouYu XUE ZhiChun LI Min ZHU XuePing | 2013 | Science China(Technological Sciences)2013，56，12： | 9 |
| 5 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 6 | Photoelastic Visualization of Ultrasound Generated by Pulsed Laser显示文摘We applied the dynamic photoelastic technique to visualize the ultrasound generated in a glass sample by an Nd:YAG pulsed laser.When a laser pulse was incident on the surface of the glass sample covered,by thin layer of black ink,narrow pulses of JongitudinaJ,shear,and surface acoustic waves were seen in the sample.The photoelastic picture also showed that the directivity patterns of ultrasound generated in the present case qualitatively agree with the theoretical prediction for the case of a normal surface-acting force. | ZHANG Shouyu ZHANG Pengzhi SHEN Jianzhong DENG Jingjun YING Chongfu | 1993 | Chinese Physics Letters1993，10，12： | 5 |
| 7 | Nanosecond photoelectric effects in all-oxide p-n junction of La_(0.9)Sr_(0.1)MnO_(3)/SrNb_(0.01)Ti_(0.99)O_(3)显示文摘Nanosecond (ns) photoelectric effects have been observed in all-oxide p-n junctions of La0.9Sr0.1MnO3/SrNb0.01Ti0.99O3 for the first time. The rise time was about 23 ns and the full width at half maximum was about 125 ns for the open-circuit photovoltaic pulse when the La0.9Sr0.1MnO3 thin film in the p-n junction was irradiated by a laser of ~20 ns pulse duration and 308 nm wavelength. The photovoltaic sensitivity was 80 mV/mJ for a 308 nm laser pulse. | HUANG Yanhong L(U) Huibin HE Meng ZHAO Kun CHEN Zhenghao CHENG Bolin ZHOU Yueliang JIN Kuijuan DAI Shouyu YANG Guozhen | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 4 |
| 8 | Metallic Mineral Resources Assessment and Analysis System Design显示文摘This paper presents the aim and the design structure of the metallic mineral resources assessment and analysis system. This system adopts an integrated technique of data warehouse composed of affairs processing layer and analysis application layer. The affairs processing layer includes multiform databases (such as geological database, geophysical database, geochemical database), while the analysis application layer includes data warehouse, online analysis processing and data mining. This paper also presents in detail the data warehouse of the present system and the appropriate spatial analysis methods and models. Finally, this paper presents the prospect of the system. | Hu Guangdao Chen Jianguo Chen Shouyu Institute of Mathematical Geology and Remote Sensing, China University of Geosciences, Wuhan 430074, China | 2000 | Journal of Earth Science2000，19，3： | 3 |
| 9 | Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma显示文摘Autophagy is a critical cellular homeostatic mechanism,and its dysfunction is linked to invasive breast carcinoma(BRCA).Recently,several omics methods have been applied to explore autophagic regulators in BRCA;however,more reliable and robust approaches for identifying crucial regulators and druggable targets remain to be discovered.Thus,we report here the results of multi-omics approaches to identify potential autophagic regulators in BRCA,including gene expression(EXP),DNA methylation(MET)and copy number alterations(CNAs)from The Cancer Genome Atlas(TCGA).Newly identified candidate genes,such as SF3 B3,TRAPPC10,SIRT3,MTERFD1,and FBXO5,were confirmed to be involved in the positive or negative regulation of autophagy in BRCA.SF3 B3 was identified firstly as a negative autophagic regulator,and siRNA/shRNA-SF3 B3 were shown to induce autophagyassociated cell death in in vitro and in vivo breast cancer models.Moreover,a novel small-molecule activator of SIRT3,1-methylbenzylamino amiodarone,was discovered to induce autophagy in vitro and in vivo.Together,these results provide multi-omics approaches to identify some key candidate autophagic regulators,such as the negative regulator SF3 B3 and positive regulator SIRT3 in BRCA,and highlight SF3 B3 and SIRT3 as new druggable targets that could be used to fill the gap between autophagy and cancer drug development. | Shouyue Zhang Jin Zhang Yang An Xiaoxi Zeng Ziyi Qin Yuqian Zhao Heng Xu Bo Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 3 |
| 10 | A Comparative Study of Fish Assemblages Near Aquaculture, Artificial and Natural Habitats显示文摘Habitat plays a critical role in regulating fish community structure. Using the data collected from a monthly trammel net survey in Ma'an archipelago off the east coast of China, we evaluated impacts of five different habitats(artificial reefs, mussel farms, cage aquaculture, rocky reefs and soft bottom) on fish assemblages. This study suggests that artificial reefs(AR) have significantly higher species richness, abundance and diversity than mussel farms(MF) or soft bottom(SB) habitats during most seasons, and that fish taxa in the AR habitats are similar to those in the rocky reef(RR) habitats. Two different fish assemblage patterns were revealed in the study area using non-metric multidimensional scaling ordination: an assemblage dominated by reef fishes(especially by Scorpaenidae species) in AR, RR and cage aquaculture(CA) habitats and an assemblage dominated by Sciaenidae species in MF and SB habitats. We suggest that reef fishes play a key role in differentiating fish community structures in the study area. Although few differences in fish abundance and diversity were found between the CA and SB habitats, a more diverse age structure was observed in the CA habitats. A much more complex fish assemblage and enhanced population of local species were established as a result of the presence of both floating and fixed artificial structures, probably through improved survival rates. | WANG Zhenhua CHEN Yong ZHANG Shouyu WANG Kai ZHAO Jing XU Qiang | 2015 | Journal of Ocean University of China2015，14，1： | 3 |
| 11 | Novel optical properties and induced magnetic moments in Ru-doped hybrid improper ferroelectric Ca3Ti2O7显示文摘Hybrid improper ferroelectric Ca3Ti2O7 and Ca3Tii 9RuO.iO7 ceramics were successfully synthesized by conventional solid-state reaction method.Two strongest diffraction peaks located around 2θ=33°shifted towards the lower angle region with Ru substitution,reflecting structure variation.Grain growth and higher oxygen vacancy concentration after doping resulted in a reduction in the coercive field about 20 kV/cm.Optical bandgap estimated by UV-vis diffuse reflectance(DR)spectrum and X-ray photoelectron spectroscopy(XPS)valence band spectra showed a decreasing trend due to the existence of impurity energy level upon Ru doping,which was consistent with the results of first-principles calculations.The origin of the unexpected induced magnetic moments in Ru-dope Ca3Ti2O7 is also discussed. | Xingxing WU Shouyu WANG Winnie WONG-NG Qiang GU Yao JIANG Chao WANG Shuang MA Weifang LIU | 2021 | Journal of Advanced Ceramics2021，10，1： | 2 |
| 12 | Effectiveness of stocking Sparus macrocephalus fry in situ in the East China Sea显示文摘The sea area surrounding Baishishan Island has abundant fishery resources because of its plentiful food and rocky reefs that provide refuge from predators.However,overfishing has occurred in many areas and some species’local populations need to be replenished through stocking programs.This case study,using Sparus microcephalus as the test species,designed and analyzed detailed stocking strategies to improve the survival ratio and control the active range of the released fishes.Controlled variables included release location,release time,and tidal level.Two stocking strategies were designed,executed,and evaluated for comparison.A traditional stocking method was applied to the high flow area of Baishishan Island in Xiangshan Bay,East China Sea.The released fry were transported by boat and released to the sea using buckets.Released fish were traced using plastic tags.The average distance of the 19 recaptured fry from the release point was 7.6 km with 52.9%mortality rate.The distance at recapture and mortality rate among recaptured individuals showed that the traditional releasing method was not successful.An in situ stocking method was used in a low tide area and natural process was imitated to decrease the stress response and promote physiological adaptation.The purpose of this method was to prolong the release process applying temporary net cages at the release location,which resulted in a regional distribution of the released fish and possibly improving the food availability.A new Sr+tagging technique was adopted to evaluate the release effect and quantify comparative release data.Only 1 fish among the 354 caught was found farther than 1 km from the release point in the following 6 months.The results validated the promotion of the new stocking technique. | Qingsong Hu Ning Bao Hafiz Abdur Rahman Yazhou Jiang Shouyu Zhang Jun Li Jikang Shentu | 2019 | Aquaculture and Fisheries2019，4，2： | 2 |
| 13 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 14 | Fuzzy set theories and methods for municipal environmental quality assessment显示文摘 | | 1995 | The Journal of Fuzzy Mathematics (USA)1995，3，1： | 1 |
| 15 | Fuzzy Approach to Preaulifying Construction Contractors 显示文摘 | Yawei Li Xiangtian Nie Shouyu Chen | 2007 | Construction Engineering and Management2007，，7： | 1 |
| 16 | Fuzzy recognition theoretic model显示文摘 | Chen Shouyu | 1993 | Journal of Fuzzy Mathematics1993，，2： | 1 |
| 17 | Effect of calcium oxide on pyrolysis of coal in a fluidized bed显示文摘 | ZHU Tingyu ZHANG Shouyu HUANG Jiejie | | 0，，03： | 1 |
| 18 | Spectrum Characteristics and Transfer Function of the Hydrograph of the Deep Aqueous System显示文摘The fluctuation of most of the hydrograph in the deep aqueous system records the fluid pulsation in lithosphere and variation of the earth’s crust. Many observations have verified that groundwater is an ideal information carrier of the crust. In this paper, the series of input (precipitation, air pressure, Earth tide etc.) and output (water level, artesian flow) of the deep aqueous system are studied by using the spectrum analysis and system theory. The application concepts of transfer function and the spectral structure of the hydrograph enrich the knowledge of the deep aqueous system. Two typical spectral structures of the hydrograph of the deep aqueous system are obtained by comparing with many water-bearing systems of the Jizhong depression. One is from well Ma-17 and the other is from the well Xinze-5. Finally, the physical models of forming the spectrum of the hydrograph are constructed on the basis of the spectrum research on the deep aqueous system. | Chen Baoren, Liu Shuyun, Earth Sciences Dept., Nanjing University, Nanjing, Jiangsu, China Jin Peikang Geological Dept., Tulane University, New Orleans, LA 70118, U.S.A. and Dong Shouyu Hebei Province Seismological Bureau, Shijiazhuang, Hebei, China | 1993 | Acta Geologica Sinica(English Edition)1993，67，4： | 1 |
| 19 | Colossal magnetoresistance and spin-glass properties of La(1-x)TexMnO3(x=0.04,0.1)显示文摘For the first time, a novel material of La1-x- TexMnO3 (x = 0.04, 0.1), in which the La ions are replaced by the nonmetal element Te in the Chalcogen, has been synthesized. The material has a rhombohedral lattice with the space group of R3c, and Te ions have a tetravalence state. The curves of the resistivity vs. temperature indicate that this material has the property of a metal-semiconductor transition and the colossal magnetoresistance (CMR) effect. The maximum magnetoreistance ratio MR=[(0)()]/(0)H? is about 51% at 4 T for x = 0.1. Besides, a spin-glass behavior at low magnetic fields is observed in this compound. | TAN Guotai, DUAN Peng, DAI Shouyu, CHEN Zhenghao, LU Huibin & ZHOU Yueliang Laboratory of Optical Physics, Institute of Physics & Center for Condensed Matter Physics, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Chen Zhenghao (e-mail: zhchen @aphy.iphy.ac.cn) | 2003 | Chinese Science Bulletin2003，48，13： | 1 |
| 20 | Trace elements of pyrite and S,H,O isotopes from the Laowan gold deposit in Tongbai,Henan Province,China:implications for ore genesis显示文摘The Laowan deposit is a large gold deposit in the Qinling-Dabie orogenic belt where pyrite is the main Au-bearing mineral phase.We present results from the occurrences of gold,trace elements and sulfur isotopes of pyrite,and hydrogen and oxygen isotopes of quartz and calcite to elucidate the sources of ore-forming fluid;the genesis of pyrite and the ore-forming process.From field observations,five generations of pyrite are identified;one formed in a metamorphic-diagenetic epoch(PyI),and the others during four mineralization stages:1)the coarse-grained pyrite-quartz stage(PyII),2)the quartz and medium-to fine-grained pyrite stage(PyIII),3)the polymetallic sulfide stage(PyIV),and 4)the carbonate-quartz stage(PyV).Gold mainly occurs in PyIII and PyIV.We find that Au,Ag,Pb,and Cu are incorporated into pyrite as micro-/nano-inclusions and that Co,Ni,As,and Se enter the pyrite lattice via isomorphous replacement.The Co/Ni values and Se concentrations indicate that PyI formed from metamorphic hydrothermal fluids and that pyrites(PyII,PyIII,and PyIV)from the ore-forming stages typically reflect a hydrothermal genesis involving magmatic fluid.Theδ^34S values of PyI(1.45‰-2.09‰)are similar to that of plagioclase amphibole schist,indicating that S was primarily derived from wall rock,while those of PyII,PyIII,and PyIV(3.10‰-5.55‰)suggest that S was derived from the Guishanyan Formation and the Laowan granite.The four mineralization stages show a systematic decrease inδD(from−77.1‰to−82.8‰,−84.7‰,and−102.7‰),while theδ^18OH2O values showed a gradual decrease from 5.7 to 2.7‰,1.0‰,and−1.3‰.These data show that the ore-forming fluid was similar to a mixture of magmatic and meteoric waters.Thus,we conclude that the Laowan gold deposit is related to magmatic-hydrothermal fluid. | Yuehua Zhao Shouyu Chen Jianli Chen Shuaiji Wu | 2020 | Frontiers of Earth Science2020，14，3： | 1 |
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