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| 1 | Nomogram to predict overall survival after gallbladder cancer resection in China显示文摘AIM To integrate clinically significant variables related to prognosis after curative resection for gallbladder carcinoma(GBC) into a predictive nomogram.METHODS One hundred and forty-two GBC patients who underwent curative intent surgical resection at Peking Union Medical College Hospital(PUMCH) were included. This retrospective case study was conducted at PUMCH of the Chinese Academy of Medical Sciences and Peking Union Medical College(CAMS & PUMC) in China from January 1, 2003 to January 1, 2018. The continuous variable carbohydrate antigen 19-9(CA19-9) was converted into a categorical variable(cCA19-9) based on the normal reference range. Stages 0 to IIIA were merged into one category, while the remaining stages were grouped into another category. Pathological grade X(GX) was treated as a missing value. A multivariate Cox proportional hazards model was used to select variables to construct a nomogram. Discrimination and calibration of the nomogram were performed via the concordance index(C-index) and calibration plots. The performance of the nomogram was estimated using the calibration curve. Receiver operating characteristic(ROC) curve analysis and decision curve analysis(DCA) were performed to evaluate the predictive accuracy and net benefit of the nomogram, respectively.RESULTS Of these 142 GBC patients, 55(38.7%) were male, and the median and mean age were 64 and 63.9 years, respectively. Forty-eight(33.8%) patients in this cohort were censored in the survival analysis. The median survival time was 20 months. A series of methods, including the likelihood ratio test and Akaike information criterion(AIC) as well as stepwise, forward, and backward analyses, were used to select the model, and all yielded identical results. Jaundice [hazard ratio(HR) = 2.9; 95% confidence interval(CI): 1.60-5.27], cCA19-9(HR = 3.2; 95%CI: 1.91-5.39), stage(HR = 1.89; 95%CI: 1.16-3.09), and resection(R)(HR = 2.82; 95%CI: 1.54-5.16) were selected as significant predictors and combined into a survival time predictive nomogram(C-index = 0.803; 95%CI: 0.766-0.839). High prediction accuracy(adjusted C-index = 0.797) was further verified via bootstrap validation. The calibration plot demonstrated good performance of the nomogram. ROC curve analysis revealed a high sensitivity and specificity. A high net benefit was proven by DCA.CONCLUSION A nomogram has been constructed to predict the overall survival of GBC patients who underwent radical surgery from a clinical database of GBC at PUMCH. | Yi Bai Zhi-Song Liu Jian-Ping Xiong Wei-Yu Xu Jian-Zhen Lin Jun-Yu Long Fei Miao Han-Chun Huang Xue-Shuai Wan Hai-Tao Zhao | 2018 | World Journal of Gastroenterology2018，24，45： | 25 |
| 2 | Analysis of observations on the urban surface energy balance in Beijing显示文摘1 年(20092010 ) 大小从在一个 325-m 塔的三垂直的层位于闹市区北京的传感器获得的城市的表面精力平衡(SEB ) 被分析。结果显示出那:(1 ) 从 325-m 塔的大小代表位于半潮湿的温暖适度的大陆人季风气候地区的城市的 SEB 特征。在典型热、多雨的夏天,感冒和干燥冬季,测量鲍恩比率在冬季在夏天和最大值是最小的。在 140 m 测量春天,夏天,秋天,和冬季的鲍恩比率分别地是 2.86, 0.82, 1.17,和 4.16。(2 ) 在 140-m 的高度(在经常的流动层) ,中午反照率是 0.10 夏天, 0.12 为春天和秋天,并且 0.14 为冬季。白天的比率理智的热流动,潜伏的热流动,和捕捞放射的存储热流动是 0.25, 0.16,和 0.59 清楚天空的天,并且 0.33, 0.19,和 0.48 为多云的天分别地。(3 ) 在清楚天空的天下面,夜间理智的热流动是几乎零,但是潜伏的热流动比零大。为多云的天,夜间理智的热流动比在冬季的潜伏的热流动稍微大。向上的热流动是的夜间大概由于人为的版本(为夏天的主要潜伏的热,当时为冬季的潜伏、理智的热) 。 | MIAO ShiGuang DOU JunXia CHEN Fei LI Ju LI AiGuo | 2012 | Science China Earth Sciences2012，55，11： | 23 |
| 3 | Endoscopic transpancreatic septotomy as a precutting technique for difficult bile duct cannulation显示文摘AIM: To evaluate the technique of transpancreatic septotomy(TS) for cannulating inaccessible common bile ducts in endoscopic retrograde cholangiopancreatography(ERCP).METHODS: Between May 2012 and April 2013, 1074 patients were referred to our department for ERCP. We excluded 15 patients with previous Billroth Ⅱ gastrectomy, Roux-en-Y anastomosis, duodenal stenosis, or duodenal papilla tumor. Among 1059 patients who underwent ERCP, there were 163 patients with difficult bile duct cannulation. Pancreatic guidewire or pancreatic duct plastic stent assistance allowed for successful ERCP completion in 94 patients. We retrospectively analyzed clinical data from 69 failed patients(36 transpancreatic septotomies and 33 needle-knife sphincterotomies). RESULTS: Of the 69 patients who underwent precut papillotomy, common bile duct cannulation was successfully achieved in 67. The success rates in the TS and needle knife sphincterotomy(NKS) groups were 97.2%(35/36) and 96.9%(32/33), respectively, which were not significantly different(P > 0.05). Complications occurred in 11 cases, including acute pancreatitis(n = 6), bleeding(n = 2), and cholangitis(n = 3). The total frequency of complications in the TS group was lower than that in the NKS group(8.3% vs 24.2%, P < 0.05).CONCLUSION: Pancreatic guidewire or pancreatic duct plastic stent assistance improves the success rate of selective bile duct cannulation in ERCP. TS and NKS markedly improve the success rate of selective bile duct cannulation in ERCP. TS precut is safer as compared with NKS. | Lin Miao Quan-Peng Li Ming-Hui Zhu Xian-Xiu Ge Hong Yu Fei Wang Guo-Zhong Ji | 2015 | World Journal of Gastroenterology2015，21，13： | 13 |
| 4 | Plasma neutrophil-gelatinase-associated lipocalin and cystatin C could early diagnose contrast-induced acute kidney injury in patients with renal insufficiency undergoing an elective percutaneous coronary intervention显示文摘 | LIU Xiao-li WANG Zhi-jian YANG Qing YU Miao SHEN Hua NIE Bin HAN Hong-ya GAO Fei ZHOU Yu-jie | 2012 | Chinese Medical Journal2012，，6： | 12 |
| 5 | Temporal echocardiography findings in patients with fulminant myocarditis: beyond ejection fraction decline显示文摘The features of myocardial strains from speckle-tracking echocardiography (STE) have not been well defined in fulminant myocarditis (FM) patients.In this study,changes in the left ventricular ejection fraction (LVEF) and global and layer-specific myocardial strains over time were monitored.We aimed to determine the echocardiographic patterns of FM and ascertain their significance in FM treatment.Twenty patients who were clinically diagnosed with FM and received mechanical life support were prospectively enrolled.Conventional echocardiographic measurements were obtained,and serial strain echocardiography was performed from admission to hospital discharge until LVEF recovery (> 50%).Global/regional peak systolic longitudinal strains (GLS/RLS) and layer-specific longitudinal strains were quantified,and their changes with time were monitored in 14 FM patients.All patients had severely impaired cardiac function.Steep improvement in LVEF and GLS were observed within 6 days.Layer-specific strain analysis showed that reduction at admission or recovery at discharge in the endocardium and epicardium strains were equal.In conclusion,FM patients who received mechanical circulatory supports exhibited steep improvement in ventricular function within 6 days.The patchy and diffused distribution pattern of reduced RLS and equally and severely impaired strain in the endocardium and epicardium are valuable features in the diagnosis of FM. | Houjuan Zuo Rui Li Fei Ma Jiangang Jiang Kun Miao Haojie Li Eike Nagel Marijana Tadic Hong Wang Dao Wen Wang | 2020 | Frontiers of Medicine2020，14，3： | 10 |
| 6 | Synthesis of a benzoxazine monomer containing maleimide and allyloxy groups显示文摘新奇 benzoxazine 单体 3-(4-allyloxy )phenyl-3,4-dihydro-2H-6-(N-maleimido )-1,3-benzoxazine (AMB ) 被综合,结构被英尺红外证实,(1 ) H NMR。AMB 的热分析(DSC ) 证明烯丙氧基组的介绍减少了熔点并且展出了一扇狭窄、对称的治好的发热的窗户。 | Yan Tang Qing Lai Zhao Ke Zeng Pei Kai Miao Ke Zhou Wen Rui Tang Hong Fei Zhou Tao Liu Yi Peng Wang Gang Yang | 2007 | Chinese Chemical Letters2007，18，8： | 10 |
| 7 | Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage显示文摘Objective To investigate the effect of simulated microgravity and carbon ion irradiation(CIR) on spermatogenic cell apoptosis and sperm DNA damage to the testis of male Swiss Webster mice,and assess the risk associated with space environment.Methods Sperm DNA damage indicated by DNA fragmentation index(DFI) and high DNA stainability(HDS) was measured by sperm chromatin structure assay(SCSA).Apoptosis of spermatogenic cells was detected by annexin V-propidium iodide assay.Bax(the expression levels of p53) and proliferating cell nuclear antigen(PCNA) were measured by immunoblotting;p53 and PCNA were located by immunohistology.Results HDS,DFI,apoptosis index,and the expression levels of p53 and Bax were detected to be significantly higher in the experimental groups(P<0.05) compared with those in the control group;however,the PCNA expression varied to a certain degree.p53-and PCNA-positive expression were detected in each group,mainly in relation to the spermatogonic cells and spermatocytes.Conclusion The findings of the present study demonstrated that simulated microgravity and CIR can induce spermatogenic cell apoptosis and sperm DNA damage.Sperm DNA damage may be one of the underlying mechanisms behind male fertility decline under space environment.These findings may provide a scientific basis for protecting astronauts and space traveler's health and safety. | LI Hong Yan ZHANG Hong MIAO Guo Ying XIE Yi SUN Chao DI Cui Xia LIU Yang LIU Yuan Yuan ZHANG Xin MA Xiao Fei XU Shuai GAN Lu ZHOU Xin | 2013 | Biomedical and Environmental Sciences2013，26，9： | 10 |
| 8 | New progress in CT and MRI examination and diagnosis of small intestinal tumors显示文摘Precise examination and diagnosis of small intestinal tumors is difficult because of the curved course and overlapping canal of the small intestine. Traditional technology for intestinal canal examination and endoscopy cannot exhibit the intestinal wall and extra-luminal structure well. With the development and advancement of multi-slice spiral computed tomography and magnetic resonance imaging (MRI), computed tomography enteroclysis (CTE) and magnetic resonance enteroclysis (MRE) are widely used in the examination and diagnosis of small intestinal tumors. CTE and MRE, with three-dimensional imaging capabilities and excellent soft-tissue contrast, can analyze the abnormalities of peripheral intestinal structure as well as the tunica mucosa. In addition, these two technologies can clearly reveal the localization, appearance, degree of mesenteric infiltration and remote tumor metastasis, which increases our cognition of the imaging diagnosis for intestinal tumors. Here we review recent progress in imaging (CT and MRI) examination and diagnosis of small intestinal tumors. | Fei Miao Ming-Liang Wang Yong-Hua Tang | 2010 | World Journal of Gastrointestinal Oncology2010，2，5： | 8 |
| 9 | Effect of Heat Treatment on Silica Aerogels Prepared via Ambient Drying显示文摘硅石 aerogels 在由 usingethanol/trimethylchlorosilane ( TMCS )的周围的弄干被准备作为毛孔水交换和表面 modificationof ,在 drying.The 前的湿胶化获得了的 /heptane 答案像海绵的结构 withuniform 毛孔尺寸 distribution.The 在 hydrophobicity 上热处理完成的硅石 aerogels 展览,特定的 surfacearea 和另外的性质是显示的 investigated.The 结果 silicaaerogels 的 hydrophobicity 能被维持直到增加 heati 的 350 °C . | Fei SHI Lijiu WANG Jingxiao LIU Miao ZENG | 2007 | Journal of Materials Science & Technology2007，23，3： | 7 |
| 10 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 11 | Assessment of early radial injury after transradial coronary intervention by high-resolution ultrasound biomicroscopy: innovative technology application显示文摘 | SHEN Hua ZHOU Yu-jie LIU Yu-yang DU Jie LIU Xiao-li YAN Zhen-xian WANG Zhi-jian GAO Fei YANG Shi-wei JIA De-an HAN Hong-ya YU Miao MA Qian XU Xiao-han | 2012 | Chinese Medical Journal2012，，19： | 6 |
| 12 | A rare case of hypokalemia-induced rhabdomyolysis显示文摘 | Rong HE Wen-Jia GUO Fei SHE Guo-Bin MIAO Fang LIU Ya-Jun XUE Yuan-Wei LIU Hao-Tian WANG Ping ZHANG | 2018 | Journal of Geriatric Cardiology2018，15，4： | 6 |
| 13 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 14 | Clinical practice guidelines for diagnosis and treatment of invasive breast cancer:Chinese Society of Breast Surgery(CSBrS)practice guidelines 2021显示文摘The survival of patients with breast cancer has been greatly improved by comprehensive treatment including surgery,radiotherapy,and systemic treatment,among which surgical treatment remains the mainstay.Breast surgeons must not only master surgical skills but also develop the ability to treat disease comprehensively.To improve the ability of breast surgeons in China to diagnose breast cancer early,perform reasonable surgical treatment,and provide comprehensive treatment orientation,the Chinese Society of Breast Surgery(CSBrS)has reported the key issues in the diagnosis and treatment of invasive breast cancer through opinion collection and expert discussion. | Miao Liu Chao-Bin Wang Fei Xie Yuan Peng Shu Wang Chinese Society of Breast Surgery | 2021 | Chinese Medical Journal2021，，9： | 6 |
| 15 | CT manifestations and features of solid cystic tumors of the pancreas显示文摘Objective: To study retrospectively the manifestationsand characteristics of solid cystic tumor of the pan-creas(SCTP) on CT.Methods: Nine patients with solid cystic tumor of thepancreas underwent resection with pathological andimmunohistochemical confirmation. All the patientswere female, aged 27.7 years on average at onset ofthe disease. CT scan was performed in patients withor without intravenous injection of contrast medium;it was also performed in the arterial phase in 4 pa-tients.Results: Solid and cystic structures were observed intumors of the pancreas. Solid structure demonstratedlow or iso-density on unenhanced CT, poor enhance-ment in the arterial phase and marked enhancementin the portal venous phase on contrast material-en-hanced CT. Cystic structure showed low density onboth pre- and pro-contrast views. The CT findings oftumors with predominantly cystic or equal propor-tion of solid and cystic structure: mural nodules forsolid structure, 'floating cloud' signs, or solid andcystic crossing distributions. Cystic structure oftumors predominately solid presenting as a beadingappearance under capsule. In round, oval and com-pletely encapsulated tumors in the pancreas, thegreater vessel enhanced with well-defined margins onpro-contrast images. No dilatation was observed ofthe common bile and pancreatic ducts.Conclusion: The characteristics of solid cystic tumorof the pancreas revealed by CT could confirm the di-agnosis of the disease in combination with onset ageand sex of patients. | Fei Miao Ying Zhan Xiao-Ying Wang Deng-Bin Wang Ke-Ming Chen Ao-Rong Tang Hao Jiang the Department of Radiology, Ruijin Hospital, Shanghai 200025, China Department of Pathology, Ruijin Hospital. Shanghai 200025. China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，3： | 5 |
| 16 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 17 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 18 | Numerical method of static aeroelastic correction and jig-shape design for large airliners显示文摘In this paper,a coupled CFD-CSD method based on N-S equations is described for static aeroelastic correction and jig-shape design of large airliners.The wing structural flexibility matrix is analyzed by a finite element method with a double-beam model.The viscous multi-block structured grid is used in aerodynamic calculations.Flexibility matrix interpolation is fulfilled by use of a surface spline method.The load distributions on wing surface are evaluated by solving N-S equations with a parallel algorithm.A flexibility approach is employed to calculate the structural deformations.By successive iterations between steady aerodynamic forces and structural deformations,a coupled CFD-CSD method is achieved for the static aeroelastic correction and jig-shape design of a large airliner.The present method is applied to the static aeroelastic analysis and jig-shape design for a typical large airliner with engine nacelle and winglet.The numerical results indicate that calculations of static aeroelastic correction should employ tightly coupled CFD-CSD iterations,and that on a given cruise shape only one round of iterative design is needed to obtain the jig-shape meeting design requirements. | HUANG Wei LU ZhiLiang GUO TongQing XUE Fei ZHANG Miao | 2012 | Science China(Technological Sciences)2012，55，9： | 4 |
| 19 | Enhanced modeling of latent heat flux from urban surfaces in the Noah/single-layer urban canopy coupled model显示文摘The numerical modeling of the impacts of urban buildings in mesoscale meteorological models has gradually improved in recent years. Correctly representing the latent heat flux from urban surfaces is a key issue in urban land-atmosphere coupling studies but is a common weakness in current urban canopy models. Using the surface energy balance data at a height of 140 m from a 325 m meteorological tower in Beijing, we conducted a 1-year continuous off-line simulation by using a coupled land surface model and a single-layer urban canopy model and found that this model has a relatively large systematic error for simulated latent heat flux. To improve the numerical method for modeling latent heat flux from urban surfaces, we combined observational analysis and urban land surface model to derive an oasis effect coefficient for urban green areas; to develop a temporal variation formula for water availability in urban impervious surfaces; and to specify a diurnal profile and the maximum values of anthropogenic latent heat release for four seasons. These results are directly incorporated into the urban land surface model to improve model performance. In addition, this method serves as a reference for studies in other urban areas. | MIAO ShiGuang CHEN Fei | 2014 | Science China Earth Sciences2014，57，10： | 4 |
| 20 | A NEW DAMAGE MECHANICS BASED APPROACH TO FATIGUE LIFE PREDICTION AND ITS ENGINEERING APPLICATION显示文摘An approach based on continuum damage mechanics to fatigue life prediction for structures is proposed. A new fatigue damage evolution equation is developed, in which the parameters are obtained in a simple way with reference to the experimental results of fatigue tests on standard specimens. With the utilization of APDL language on the ANSYS platform, a finite element implementation is presented to perform coupling operation on damage evolution of material and stress redistribution. The fatigue lives of some notched specimens and a Pitch-change-link are predicted by using the above approach. The calculated results are validated with experimental data. | Fei Shen Weiping Hu Qingchun Meng Miao Zhang | 2015 | Acta Mechanica Solida Sinica2015，28，5： | 4 |
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