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| 1 | Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues显示文摘MicroRNAs (miRNAs) have been demonstrated to play an important role in regulation of the immuno- inflammatory response; however, the function of miRNAs in periodontal inflammation has not been investigated. The objective of this study was to explore the properties of miRNAs in periodontal inflammation by comparing miRNA profiles of inflamed and healthy gingival tissues. Gingival tissues were obtained from 10 periodontitis patients and 10 healthy subjects. After RNA extraction, miRNA profiles were analyzed by microarray, and expression levels of selected miRNAs were confirmed by real-time quantitative reverse transcription polymerase chain reaction (RT-PCR). Analyses using two computational methods, Targetscan and MicroRNA.org, were combined to identify common targets of these miRNAs. Finally, the individual miRNA expression levels of three toll-like receptor (TLR)-related miRNAs from inflamed and healthy gingival tissues were evaluated by RT-PCR. Ninety-one miRNAs were found to be upregulated and thirty-four downregulated over two-fold in inflamed gingival tissue compared with those in healthy gingival tissue. Twelve selected inflammatory-related miRNAs, hsa-miR-126*, hsa-miR-20a, hsa-miR-142-3p, hsa-miR-19a, hsa-let-7f, hsa-miR-203, hsa-miR-17, hsa-miR-223, hsa-miR-146b, hsa-miR-146a, hsa-miR-155, and hsa-miR-205 showed comparable expression levels by microarray and real-time quantitative RT-PCR analyses. In addition, the putative inflammation targets of these miRNAs were predicted, and three that were tested (hsa-miRNA-146a, hsa-miRNA-146b, and hsa-miRNA-155), showed significant differences between inflamed and healthy gingiva. This remarkable difference in miRNA profiles between periodontal diseased and healthy gingiva implicates a probable close relationship between miRNAs and periodontal inflammation. The data also suggest that the regulation of TLRs in periodontal inflammation may involve miRNA pathways. | Yu-feng Xie Rong Shu Shao-yun Jiang Da-li Liu Xiu-li Zhang | 2011 | International Journal of Oral Science2011，3，3： | 36 |
| 2 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 3 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 4 | Twenty-five years of change in scleractinian coral communities of Daya Bay (northern South China Sea) and its response to the 2008 AD extreme cold climate event显示文摘世界范围的珊瑚礁石逐渐地正在变得并且有害地影响在之上由包括的许多因素,重要气候变化,例如全球温暖和增加的 El Nino 南部的摆动活动。通常,珊瑚礁石的坚持,在特别低纬度,部分地,海运被管理不超过集体死亡能在发生的批评限制(∼30 ° C ) 的表面温度。因此,它被想珊瑚那生活在高纬度(即,当前更凉爽的海表面温度) 将多半比珊瑚生活在对假设未来温度增加更有利作出回应低纬度(即,当前更温暖的海表面温度) 。因而,高纬度的珊瑚社区可以有潜力在面临潜在的未来时为许多珊瑚种类充当 refugia 的区域全球温暖。Daya 海湾(22 ° 3 1 ′22 ° 5 0 ′N ) ,北华南海,包含几个高纬度的 non-reefal 珊瑚社区并且在这个区域以内代表 scleractinian 珊瑚的最在北方的分布之一。显著地, Daya 海湾经历了在整个过去的 50 年的在空和海表面温度中的戏剧的温暖。在这篇论文,我们在 Daya 海湾珊瑚社区分析 25 年变化,把两个基于历史性的调查并且我们的最近 2006 2008 地区性的生态的调查。我们的结果建议与预言相反,在过去的 25 年期间在在 Daya 海湾以内的珊瑚盖子有重要衰落(即,在到在 2008 的 15.3% 仅仅珊瑚盖子的 1983/1984 的 76.6% 珊瑚盖子) 。如此的变化也在最丰富的珊瑚种类反映重要移动,从 Acropora pruinosa 到 Favites abdita。大多数现代珊瑚社区变得以前在 15 和 30 年之间建立了,相应于增加的冬季海表面温度的一个时期。然而,很少的殖民地变得在最后 15 年以内建立了,尽管有温暖的一个更强烈的时期。由考虑另外的因素,我们假设那直接人为的影响,而非气候的事件,限制了发展,并且驾驶了衰落,最后 15 年里的 Daya 海湾珊瑚社区。Daya 海湾也在过去的 50 年期间受到了偶尔的极端冷事件,与最近的发生在 2008 年初(13 年 1 月 13 日 2 月) 。在 2008 冷事件期间,最低空气温度到达仅仅 6.6 ° C,和吝啬的海表面温度 2 月秋天,包括在 12.3 ° C 的六连续的天 < 14 ° C。显著地,海表面温度在通常在 scleractinian 珊瑚社区导致集体死亡的假设批评更低的温度阀值(∼13 ° C ) 下面掉落。令人惊讶地,我们的珊瑚社区调查,以前进行了两个(2007 年 8 月) 并且在以后(2008 年 2 月下旬) 极端 2008 冷事件,证明 Daya 海湾珊瑚生态系统恰好被影响在之上在冷时期期间。那些观察建议 Daya 海湾 scleractinian 珊瑚社区开发了改编到低海表面温度。总的来说,我们的数据支持高纬度的珊瑚社区例如 Daya 海湾,有的假设在潜在的未来的来临为 scleractinian 珊瑚充当 refugia 的区域的潜力全球温暖。 | CHEN TianRan YU KeFu SHI Qi LI Shu Gilbert J. Price WANG Rong ZHAO MeiXia CHEN TeGu ZHAO JianXin | 2009 | Chinese Science Bulletin2009，54，12： | 22 |
| 5 | Lunar topographic model CLTM-s01 from Chang’E-1 laser altimeter显示文摘More than 3 million range measurements from the Chang’E-1 Laser Altimeter have been used to produce a global topographic model of the Moon with improved accuracy. Our topographic model, a 360th degree and order spherical harmonic expansion of the lunar radii, is designated as Chang’E-1 Lunar Topography Model s01 (CLTM-s01). This topographic field, referenced to a mean radius of 1738 km, has an absolute vertical accuracy of approximately 31 m and a spatial resolution of 0.25o (~7.5 km). This new lunar topographic model has greatly improved previous models in spatial coverage, accuracy and spatial resolution, and also shows the polar regions with the altimeter results for the first time. From CLTM-s01, the mean, equatorial, and polar radii of the Moon are 1737103, 1737646, and 1735843 m, respectively. In the lunar-fixed coordinate system, this model shows a COM/COF offset to be (-1.777, -0.730, 0.237) km along the x, y, and z directions, respectively. All the basic lunar shape parameters derived from CLTM-s01 are in agreement with the results of Clementine GLTM2, but CLTM-s01 offers higher accuracy and reliability due to its better global samplings. | PING JinSong HUANG Qian YAN JianGuo CAO JianFeng TANG GeShi SHU Rong | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，7： | 19 |
| 6 | An Integrated Analysis of Risk Factors of Cognitive Impairment in Patients with Severe Carotid Artery Stenosis显示文摘Objective To investigate cognitive dysfunction in patients with carotid artery stenosis(CAS) and potential risk factors related to cognitive-especially memory-dysfunction. Methods Forty-seven patients with carotid artery stenosis were recruited into our study cohort. The Mini-Mental State Examination(MMSE) and the Montreal Cognitive Assessment(MoCA) were adopted to assess cognitive function, the Wechsler Memory Scale(WMS) to assess memory function, high-resolution MRI and enhanced ultrasound to evaluate carotid plaques, and computed tomography perfusion(CTP) imaging to evaluate intracranial blood perfusion. Single-factor analysis and multiple-factor regression analysis were used to analyze potential risk factors of cognitive impairment. Results Mini-Mental State Examination test results showed that 22 patients had cognitive impairment, and MoCA test results showed that 10 patients had cognitive impairment. Analysis of various risk factors indicated that the average memory quotient of female patients was higher than that of males(P = 0.024). The cognitive and memory performance of those with an educational background above high school were significantly better than those of participants with high school or lower(P = 0.045). Patients with abnormal intracranial perfusion performed worse on the MMSE test(P = 0.024), and their WMS scores were significantly lower(P = 0.007). The MMSE scores and the memory quotients were significantly lower in patients with a history of cerebral infarction(MMSE, P = 0.047, memory quotient score, P = 0.018). Conclusion A history of cerebral infarction and abnormal cerebral perfusion are associated with decline in overall cognitive function and memory in patients with carotid stenosis. Being female and having an educational background above high school may be protective factors in the development of cognitive dysfunction. | LUO Ru Tao WANG Pei Jiong DENG Xiao Feng ZHOU Shu Jie ZHAO Meng QIAN Jing ZHANG Dong WANG Rong ZHANG Yan | 2018 | Biomedical and Environmental Sciences2018，31，11： | 17 |
| 7 | Persistence of hepatitis B vaccine immune protection and response to hepatitis B booster immunization显示文摘AbstractAIMToidentifythepersistenceofimmuneprotectionofChinamade,plasmaderivedhepatitisBvaccineafterinfancyimmunizationandt... | LI Hui 1, LI Rong Cheng 2, LIAO Su Su 1, YANG Jin Ye 2, ZENG Xian Jia 1 and WANG Shu Sheng 2 | 1998 | World Journal of Gastroenterology1998，4，6： | 15 |
| 8 | Construction of HBV-specific ribozyme and its recombinant with HDV and their cleavage activity in vitro显示文摘AIM To construct the recombinant of HDVcDNA and HBV-specific ribozyme gene byrecombinant PCR in order to use HDV as atransporting vector carrying HBV-specificribozyme into liver cells for inhibiting thereplication of HBV.METHODS We separately cloned the ribozyme(RZ)gene and recombinant DVRZ(comprisingHDV cDNA and HBV-specific ribozyme gene)intothe downstream of T7 promoter of pTAdv-Tvector and studied the in vitro cleavage activityof their transcripts(rRZ,rDVRZ)on target RNA(rBVCF)from in vitro transcription of HBV Cgene fragment(BVCF).RESULTS Both the simple(rRZ)and therecombinant ribozyme rDVRZ could efficientlycatalyze the cleavage of target RNA(rBVCF)under different temperatures(37℃,42℃ and55℃)and Mg2+concentrations(10 mmol/L,15 mmol/L and 20 mmol/L)and their catalyticactivity tended to increase as the temperaturewas rising.But the activity of rRZ was evidentlyhigher than that of rDVRZ.CONCLUSION The recombinant of HDV cDNAand ribozyme gene had the potential of beingfurther explored and used in gene therapy of HBVinfection. | Shu Juan Wen Kai Jun Xiang Zhen Hua Huang Rong Zhou Xue Zhong Qi | 2000 | World Journal of Gastroenterology2000，6，3： | 10 |
| 9 | Establishment of transgenic mouse harboring hepatitis B virus (adr subtype) genomes显示文摘INTRODUCTIONHepatitis B virus (HBV) belongs to the group ofhepatovirus, a major pathogen of human acute andchronic hepatitis B[1 4], which has a very closeassociation with human hepatocellular carcinoma(HCC)[5-8], For example, a statistical data from ahospital in Shanghai showed that 80% of HCCpatients were positive for HBsAg ( personalcommunication). | Yi Ping Hu1 Wei Jiang Hu1 Wen Chao Zheng2 Jian Xiu Li1 De Shun Dai1 Xin Min Wang1 Shu Zhong Zhang1 Hong Yu Yu3 Wei Sun4 Guang Rong Hao4 1Department of Cell Biology, Second Military Medical University, Shanghai 200433, China2University of Wisconsin, Madison, WI 53705, USA3Department of Pathology, Second Military Medical University, Shanghai 200433, China4Center of laboratory Animals, Second Military Medical University, Shanghai 200433, China | 2001 | World Journal of Gastroenterology2001，7，1： | 9 |
| 10 | Long-term eficacy of plasma-derived hepatitis B vaccine among Chinese children:a 12-year folow-up study显示文摘INTRODUCTIONToevaluatelongtermeficacyofaplasmaderivedhepatitisBvaccineandprovideevidencefordecisionmakingonthevaccineboost... | LIAO Su Su 1, LI Rong Cheng 2, LI Hui 1, YANG Jin Ye 2, ZENG Xian Jia 1, GONG Jian 2, WANG Shu Sheng 2, LI Yan Ping 2 and ZHANG Kong Lai 1 | 1999 | World Journal of Gastroenterology1999，5，2： | 9 |
| 11 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 12 | New features of the Moon revealed and identified by CLTM-s01显示文摘Previous analyses showed a clear asymmetry in the topography,geological material distribution,and crustal thickness between the nearside and farside of the Moon. Lunar detecting data,such as topography and gravity,have made it possible to interpret this hemisphere dichotomy. The high-resolution lunar topographic model CLTM-s01 has revealed that there still exist four unknown features,namely,quasi-impact basin Sternfeld-Lewis (20°S,232°E),confirmed impact basin Fitzgerald-Jackson (25°N,191°E),crater Wugang (13°N,189°E) and volcanic deposited highland Yutu (14°N,308°E). Furthermore,we analyzed and identified about eleven large-scale impact basins that have been proposed since 1994,and classified them according to their circular characteristics. | HUANG Qian PING JinSong SU XiaoLi SHU Rong TANG GeShi | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 7 |
| 13 | Effects of ethanol on the in situ synthesized Cu/SiO_2 catalyst:Texture,structure,and the catalytic performance in hydrogenation dimethyl oxalate to ethylene glycol显示文摘Cu/SiO2 催化剂被 tetraethyl orthosilicate (TEOS ) 的水解作用作为合作溶剂或 TEOS/H2O 用乙醇在一阶段溶液在 situ 综合二阶段溶液,由氨蒸发在 SiO2 上由铜的降水列在后面。在 dimethyl 盐的加氢,一个阶段水解作用准备的催化剂展出了更高的活动和乙烯乙二醇(例如) 在更低的温度的选择由于它的更大的赌注表面区域和多模式的毛孔分发比二的分阶段执行。在 488503 K,催化剂与水 / 乙醇(W/E ) 在一个阶段答案准备了 3:1 的体积比率例如展出了 9095% 选择,当催化剂由二个阶段准备了时,水解作用例如到达了 90% 仅仅在 498503 K 的选择。 | Shu Rong Wang Ling Jun Zhu Ying Ying Zhu Xiao Lan Ge Xin Bao Li | 2011 | Chinese Chemical Letters2011，22，3： | 6 |
| 14 | Securing Parked Vehicle Assisted Fog Computing With Blockchain and Optimal Smart Contract Design显示文摘Vehicular fog computing(VFC)has been envisioned as an important application of fog computing in vehicular networks.Parked vehicles with embedded computation resources could be exploited as a supplement for VFC.They cooperate with fog servers to process offloading requests at the vehicular network edge,leading to a new paradigm called parked vehicle assisted fog computing(PVFC).However,each coin has two sides.There is a follow-up challenging issue in the distributed and trustless computing environment.The centralized computation offloading without tamper-proof audit causes security threats.It could not guard against false-reporting,free-riding behaviors,spoofing attacks and repudiation attacks.Thus,we leverage the blockchain technology to achieve decentralized PVFC.Request posting,workload undertaking,task evaluation and reward assignment are organized and validated automatically through smart contract executions.Network activities in computation offloading become transparent,verifiable and traceable to eliminate security risks.To this end,we introduce network entities and design interactive smart contract operations across them.The optimal smart contract design problem is formulated and solved within the Stackelberg game framework to minimize the total payments for users.Security analysis and extensive numerical results are provided to demonstrate that our scheme has high security and efficiency guarantee. | Xumin Huang Dongdong Ye Rong Yu Lei Shu | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 6 |
| 15 | Stannous-acetylacetonate:A new catalyst for poly(trimethylene terephthalate) synthesis显示文摘Stannous-acetylacetonate was prepared efficiently and characterized by 1H NMR and FT-IR. Its catalytic activity for poly(trimethylene terephthalate) (PTT) synthesis was investigated. By this catalyst, the degree of esterification of pure terephthalic acid was up to 91.7% after reaction at 260°C for 2 h, while the intrinsic viscosity and content of ter- minal carboxyl groups of the corresponding PTT polymerized at 260°C, 60 Pa for 2 h was 0.8816 dL/g and 17 mol/t, respectively. Stannous-acetylacetonate was more active and promising than tetrabutyl titanate and stannous octoate for PTT synthesis. | Shu Yong Jia Yu Rong Ren Liang Ming Liu Dan Zhang Yi Zeng Gong Ying Wang | 2007 | Chinese Chemical Letters2007，18，7： | 5 |
| 16 | Extracting more light for vertical emission:high power continuous wave operation of 1.3-μm quantum-dot photonic-crystal surface-emitting laser based on a flat band显示文摘For long distance optical interconnects,1.3-μm surface-emitting lasers are key devices.However,the low output power of several milliwatts limits their application.In this study,by introducing a two-dimensional photonic-crystal and using InAs quantum dots as active materials,a continuous-wave,13.3-mW output power,1.3-μm wavelength,room-temperature surface-emitting laser is achieved.In addition,such a device can be operated at high temperatures of up to 90℃.The enhanced output power results from the flat band structure of the photonic crystal and an extra feedback mechanism.Surface emission is realized by photonic crystal diffraction and thus the distributed Bragg reflector is eliminated.The proposed device provides a means to overcome the limitations of low-power 1.3-μm surface-emitting lasers and increase the number of applications thereof. | Huan-Yu Lu Si-Cong Tian Cun-Zhu Tong Li-Jie Wang Jia-Min Rong Chong-Yang Liu Hong Wang Shi-Li Shu Li-Jun Wang | 2019 | Light(Science & Applications)2019，8，1： | 5 |
| 17 | Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang,China显示文摘The Crimean-Congo hemorrhagic fever virus(CCHFV),a member of the genus Orthonairovirus and family Nairoviridae,is transmitted by ticks and causes severe hemorrhagic disease in humans.To study the epidemiology of CCHFV in different ecosystems in Xinjiang,China,a total of 58,932 ticks were collected from Tarim Basin,Junggar Basin,Tianshan Mountain,and Altai Mountain from 2014 to 2017.Hyalomma asiaticum asiaticum was the dominant tick species in Tarim and Junggar basins,whereas Dermacentor nuttalli and Hyalomma detritum were found in Tianshan Mountain and Altai Mountain,respectively.Reverse transcription-polymerase chain reaction of the CCHFV small(S)genome segment was used for the molecular detection.The CCHFV-positive percentage was 5.26%,6.85%,1.94%,and 5.56% in Tarim Basin,Junggar Basin,Tianshan Mountain,and Altai Mountain,respectively.Sequences of the S segment were used for phylogenetic analysis and the results showed that the newly identified CCHFV strains belonged to two clades.Our study confirms that H.asiaticum asiaticum is the major vector of CCHFV in desert habitats which is consistent with previous studies,and also suggests that H.detritum and D.nuttalli are emerging vectors for CCHFV in Xinjiang.Moreover,this study reports the presence of CCHFV in the mountain habitat of Xinjiang for the first time,suggesting that future surveillance of CCHFV should also include mountainous areas. | Abulimiti Moming Xihong Yue Shu Shen Chenchen Chang Cheng Wang Tao Luo Yanfang Zhang Rong Guo Zhihong Hu Yujiang Zhang Fei Deng Surong Sun | 2018 | Virologica Sinica2018，33，1： | 5 |
| 18 | Effect of Sheng Xue Ning Tablets on Renal Anemia in Patients Subject to Maintenance Hemodialysis and Safety Evaluation: A Multi-setting Prospective Randomized Study显示文摘This study compared Sheng Xue Ning(SXN)tablets with ferrous succinate(FS)tablets in terms of their efficacy for the treatment of iron-deficient renal anemia and safety in patients subject to maintenance hemodialysis(MHD).A total of 94 patients undergoing MHD were randomly assigned to an experiment group(receiving oral SXN tablcts,SXN group)and a control group(orally given FS tablets,FS group)and followed up for 12 weeks.Erythropoietin(EPO)was used in both groups.The eficacy was assessed by detecting the subsequent changes in hemoglobin(Hb),serum iron(SI),SF and transferrin saturation(TSAT).At the 12th week,Hb and TSAT levels in both groups were significantly increased compared to those in the screening period(P<0.05).However,no significant difference in Hb and TSAT was found between the two groups.The average weekly EPO dosage used was lower in SXN group than in FS group(P<0.05)at the 10th week and the 12th week.Our study showed that SXN tablets can effectively ameliorate renal anemia and keep iron metabolism stable in MHD patients,and its efficacy is virtually close to that of FS tablets.Meanwhile,SXN tablets can reduce the dosage of EPO and have a good safety profile. | Xiao-jing TANG Shu RONG Chang-lin MEI Zhao-hui NI Geng-ru JIANG Wei-jie YUAN Nian-song WANG Zhi-yong GUO Jun MA Hai-dong YAN Li-ming ZHANG | 2020 | Current Medical Science2020，40，2： | 5 |
| 19 | Emissions of parent, nitrated, and oxygenated polycyclic aromatic hydrocarbons from indoor corn straw burning in normal and controlled combustion conditions显示文摘Emission factors(EFs) of parent polycyclic aromatic hydrocarbons(pPAHs), nitrated PAHs(nPAHs), and oxygenated PAHs(oPAHs)were measured for indoor corn straw burned in a brick cooking stove under diferent burning conditions. The EFs of total 28 pPAHs,6 nPAHs and 4 oPAHs were(7.9 ± 3.4),(6.5 ± 1.6)×10 3, and(6.1 ± 1.4)×10 1mg/kg, respectively. Fuel charge size had insignificant influence on the pollutant emissions. Measured EFs increased significantly in a fast burning due to the oxygen deficient atmosphere formed in the stove chamber. In both restricted and enhanced air supply conditions, the EFs of pPAHs, nPAHs and oPAHs were significantly higher than those measured in normal burning conditions. Though EFs varied among diferent burning conditions, the composition profiles and calculated isomer ratios were similar, without significant diferences. The results from the stepwise regression model showed that fuel burning rate, air supply amount, and modified combustion efciency were the three most significant influencing factors, explaining 72%–85% of the total variations. | Guofeng Shen Miao Xue Siye Wei Yuanchen Chen Bin Wang Rong Wang Yan Lv Huizhong Shen Wei Li Yanyan Zhang Ye Huang Han Chen Wen Wei Qiuyue Zhao Bing Li Haisuo Wu Shu Tao | 2013 | Journal of Environmental Sciences2013，25，10： | 5 |
| 20 | A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China显示文摘Crimean-Congo hemorrhagic fever virus(CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world.Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China.Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents. | Rong Guo Shu Shen Yanfang Zhang Junming Shi Zhengyuan Su Dan Liu Jinliang Liu Juan Yang Qiguo Wang Zhihong Hu Yujiang Zhang Fei Deng | 2017 | Virologica Sinica2017，32，1： | 5 |
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