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| 1 | Features and Formation Mechanism of Faults and Potash-forming Effect in the Lop Nur Salt Lake,Xinjiang,China显示文摘The Lop Nur Salt Lake, located in the eastern part of the Tarim Basin, Xinjiang, China, has become a playa in the Quaternary. Rhombic in shape, the Lop Nur depression is mainly controlled by the NE-striking and nearly N-S-striking sets of faults. Since 1995, a superlarge brine potash deposit with potash resources of 2.50×108 t has been found in the Luobei subbasin in the northeastern part of the Lop Nur. We intensively studied the features and formation mechanism of faults inside the Lop Nur through satellite images, geomorphologic survey and continuous conductivity imaging and found seven subparallel graben faults formed under the action of nearly N 10o E principal compressional stress during deposition of the Lop Nur Salt Lake. These faults are up to >60 km long and 1–4 km wide and may extend downward for 1000 m or more. It is just under the action of these tensional faults that potash subbasins formed. The largest subbasin is the Luobei subbasin and the smaller ones are the Luoxi hollow, Erbei hollow and Tienan hollow. Investigation also indicates that the graben faults in the Lop Nur not only control the origin of the potash subbasins, but they themselves are also good brine reservoir structures, in which abundant potash-rich brines are stored. Therefore, The faults had played an important role in the potash formation of the Lop Nur. | LIU Chenglin WANG Mili JIAO Pengcheng LI Shude CHEN Yongzhi | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 33 |
| 2 | The effect of a secretion-enhanced heavy chain on improving intein-based dual-vector co-delivery of a full-length factor Ⅷ gene显示文摘Treatment of hemophilia A by gene therapy is adversely affected by inefficient FVIII secretion and the large FVIII gene,which is difficult to package in the promising adeno-associated virus (AAV) vectors.Inhibited secretion of FVIII is caused mainly by inefficient secretion of its heavy chain.Previously,we have employed a protein splicing-based dual-vector to co-transfer a B-domain-deleted FVIII (BDD-FVIII) gene,suggesting that the light chain,covalently ligated to a co-expressed heavy chain can improve the secretion of spliced BDD-FVIII.However,its level of secretion was affected by inefficient secretion the heavy chain.Here,we studied the effect of a mutant heavy chain with L303E/F309S substitutions,which enhance FVIII secretion on the heavy chain itself and spliced FVIII when using a protein splicing-based split-delivery of a full-length FVIII gene.Eukaryotic vectors expressing Ssp DnaB intein-fused mutant heavy and light chains were transiently co-transfected into cultured COS-7 cells.A spliced FVIII protein was seen in co-transfected cells by Western blot analysis.The heavy chain was secreted by cells transfected with the mutant heavy chain gene alone at (39±11) ng/mL and this secretion increased to (123±13) ng/mL when cells were co-transfected with the light chain gene,which was greater than the secretion of wild-type heavy chain.The amount of spliced FVIII in the culture supernatant of co-transfected cells was (86±14) ng/mL,with an activity of (0.61±0.08) IU/mL,which was greater than that of wild-type FVIII co-transfected cells.Spliced FVIII and bioactivity were also detected in the combined culture supernatant of cells individually transfected with mutant heavy and light chain gene at a higher level than that of combined wild-type heavy and light chain transfections.This suggested that the heavy chain with improved secretion markedly increased the efficacy of protein splicing-based split delivery of the full-length FVIII gene using a dual-vector.These results encourage the transfer of this technology to an animal model using a dual-AAV vector. | ZHU FuXiang YANG ShuDe LIU ZeLong MIAO Jing QU HuiGe CHI XiaoYan | 2011 | Chinese Science Bulletin2011，56，2： | 8 |
| 3 | Improving Joint Features and Mechanical Properties of Pinless Fiction Stir Welding of Alcald 2A12-T4 Aluminum Alloy显示文摘As a new solid state welding,pinless friction stir welding(PFSW) can be used to join thin-wall structures.In this study,four new pinless tools with different groove distributions were designed and manufactured in order to enrich technological storage of PFSW and obtain sound joint with high quality of alclad 2A12-T4 alloy.The results show that the small-obliquity tool is detrimental to the transfer of plasticized materials,resulting in the formation of kissing bond defect.For the through-groove tool or the large-curvature tool,bigger flashes form on the joint surface and alclad layer is observed in the nugget zone(NZ),deteriorating mechanical properties.Compared with the above-mentioned three tools,using the six-groove tool with rational curvature and obliquity can not only yield sound joint with small flashes and thickness reduction,but also prevent alclad from flowing into NZ,which has potential to weld thin alclad aluminum alloys.Meanwhile,the tensile strength and elongation of joint using the six-groove tool reach the maximum values of 362 MPa and 8.3%,up to 85.1% and 64% of BM. | Zhenlei Liu Hutao Cui Shude Ji Minqiang Xu Xiangchen Meng | 2016 | Journal of Materials Science & Technology2016，32，12： | 7 |
| 4 | Dissimilar Al/Mg alloys friction stir lap welding with Zn foil assisted by ultrasonic显示文摘The Zn-added ultrasonic assisted friction stir lap welding(UaFSLW) was carried out to improve the quality of dissimilar Al/Mg alloys joint. The effects of ultrasonic power on the joint quality were also investigated.The results indicated that the larger effective lap width and mixing region between Mg and Al(Mg/Al MR) were attained by Zn foil addition and external ultrasonic assistance. Compared with the conventional joint, the finer and better-distributed Mg-Zn IMCs placing the continuous Al-Mg IMCs were formed in the Mg/Al MR of the Zn-added UaFSLW joint. The Zn foil addition and external ultrasonic assistance significantly improved the tensile shear load of the joint, and the load was increased with the increase of the ultrasonic power. The maximum tensile shear load of 7.95 kN was attained, which was 52.6% larger than that of the conventional joint. | Shude Ji Shiyu Niu Jianguang Liu | 2019 | Journal of Materials Science & Technology2019，35，8： | 6 |
| 5 | THE INITIAL-BOUNDARY VALUE PROBLEMS OF NONLINEAR AND NONLOCAL SINGULARLY PERTURBED REACTION DIFFUSION SYSTEM显示文摘In this paper the initial-boundary value problem for nonlocal singularly perturbed reaction diffusion system are considered.Using the iterative method and the compa- rison theorem,the existence and asymptotic behavior of the solution for the problem are studied. | Liu Shude~1 Chen Lihua~2 Mo Jiaqi~(1,3) (1.Dept.of Math.,Anhui Normal University,Wuhu 241000,Anhui 2.Dept.of Math.,Fuqing Branch of Fujian Normal University,Fuqing 350300,Fujian 3.Division of Computational Science,E-Institutes of Shanghai Universities,at SJTU,Shanghai 200240) | 2008 | Annals of Differential Equations2008，24，1： | 5 |
| 6 | Improving Joint Morphologies and Tensile Strength of Al/Mg Dissimilar Alloys Friction Stir Lap Welding by Changing Zn Interlayer Thickness显示文摘The pure Zn foils with different thicknesses(0.02, 0.05, 0.1, 0.2 and 0.3 mm) were selected as interlayers to improve the quality of friction stir lap welding joint of 7075-T6 Al and AZ31 B Mg dissimilar alloys. The effects of the interlayer thickness on joint formation, microstructure and tensile strength were analyzed. The results displayed that the maximum length of the boundary between stir zone(SZ) and thermo-mechanically affected zone in lower plate was obtained by the addition of the Zn interlayer with 0.05 mm thickness. The Mg–Zn intermetallic compounds(IMCs) were discontinuously distributed in the SZ, replacing the continuous Al–Mg IMCs. The size of Mg–Zn IMCs increased with the increase in the thickness of the Zn interlayer. The maximum tensile shear strength of 276 N mm-1 was obtained by the addition of 0.05 mm Zn foil, which increased by 45.6% of that of the joint without the Zn foil addition. | Jinglin Liu Shiyu Niu Rong Ren Shude Ji Lei Wang Zan Lv | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，11： | 5 |
| 7 | Prediction of Large Structure Welding Residual Stress by Similitude Principles显示文摘On basis of the similitude principles, the conception of virtual simulative component and the auxiliary value of welding residual stress, which is deduced by the welding conduction theory, the relation of the welding residual stress between the simulative component and the practical component was attained. In order to verify the correctness of the relation, the investigation was done from the view of the welding experiment and the numerical simulation about the simulative component and the practical component. The results show that the distribution of welding residual stress of the simulative component is the same as that of the practical component. The ratio of welding residual stress attained by the experiment or the simulation method between the practical runner and the simulative component was compared with the ratio obtained by the similitude principles. Moreover, the error is less than 10%. This provides a new idea to predict the welding stress distribution of large practical structure by the contractible physical model, which is important for the welding experiment and the numerical simulation. | Shude Ji Liguo Zhang Xuesong Liu Jianguo Yang | 2009 | Journal of Materials Science & Technology2009，25，6： | 4 |
| 8 | Effect of Welding Technologies on Decreasing Welding Residual Stress of Francis Turbine Runner显示文摘On basis of the subsection welding and the local heating s reasonable technological parameters obtained by plane experiment,the welding residual stress field of some Francis turbine runner is regulated and controlled.For the experimental plane with a thickness of 16 mm,the effect of subsection welding on decreasing welding residual stress of the prior welding section is obvious when the distance is less than 50 mm away from the end of latter welding section.For the local heating,the best position,where the effect on decreasing the welding residual stress of plane is best,is 60 mm or so away from the edge of heating area.The experimental results of runner show that the subsection welding can make the residual compressive stress engender in the blade dangerous area while the stress value is greatly influenced by the length of the welding section of blade outlet.The local heating can further decrease the value of residual stress near blade outlet,while the local heating processed after heat treatment is better than that processed before heat treatment. | Shude Ji Liguo Zhang Xuesong Liu Jianguo Yang | 2010 | Journal of Materials Science & Technology2010，26，10： | 3 |
| 9 | A functionalized separator enables dendrite-free Zn anode via metal-polydopamine coordination chemistry显示文摘Designing a multifunctional separator with abundant ion migration paths is crucial for tuning the ion transport in rocking-chair-type batteries.Herein,a polydopamine-functionalized PVDF(PVDF@PDA)nanofibrous membrane is designed to serve as a separator for aqueous zinc-ion batteries(AZIBs).The functional groups(OH and NH)in PDA facilitate the formation of Zn O and Zn N coordination bonds with Zn ions,homogenizing the Zn-ion flux and thus enabling dendrite-free Zn deposition.Moreover,the PVDF@PDA separator effectively inhibits the shuttling of V-species through the formation of V-O coordination bonds.As a result,the Zn/NH_(4)V_(4)O_(10) battery with the PVDF@PDA separator exhibits enhanced cycling stability(92.3%after 1000 cycles at 5 A g^(-1))and rate capability compared to that using a glass fiber separator.This work provides a new avenue to design functionalized separators for high-performance AZIBs. | Yanfen Liu Shude Liu Xuesong Xie Zhicheng Li Pinji Wang Bingan Lu Shuquan Liang Yan Tang Jiang Zhou | 2023 | InfoMat2023，5，3： | 2 |
| 10 | Prediction ofLarge Structure Welding Residual Stress by Similitude Principles显示文摘 | Shude Ji Liguo Zhang Xuesong Liu Jianguo Yang | | Journal of Materials Sc0，，： | 1 |
| 11 | Achieving High‑Quality Aluminum to Copper Dissimilar Metals Joint via Friction Stir Double‑Riveting Welding显示文摘In order to achieve a high-quality joining of aluminum(Al)and copper(Cu)dissimilar metals,a new friction stir doubleriveting welding(FSDRW)with a Cu rod as the rivet was proposed,and the rotating tool with a large concave angle shoulder was specially designed.The results showed that under the thermal–mechanical effect of rotating tool,the Cu rod was deformed to be a double riveting heads structure with a Cu anchor at the upper surface of Al plate and an Al anchor above the lap interface of joint,and these two anchors greatly enhanced the mechanical interlocking of Al/Cu joint.The effective bonding interfaces were formed among the double riveting heads structure,the upper Al plate and the lower Cu plate,which contained the Cu/Cu interface and the Al/Cu interface.The Cu/Cu interface without the kissing bond and the Al/Cu interface with the rationally thin AlCu and Al_(2)Cu intermetallic compounds(IMCs)layers were beneficial to heightening the joint tensile shear strength.The maximum tensile shear load of the FSDRW joint achieved 5.52 kN,and the joint under different plunging depths of rotating tool presented a mixed mode of ductile fracture and brittle fracture.This novel FSDRW technique owns the advantages of strong mechanical interlocking and superb metallurgical bonding,and provides a new approach to acquiring a high-quality Al/Cu dissimilar metals joint. | Shude Ji Xiao Cui Lin Ma Hua Liu Yingying Zuo Zhiqing Zhang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，4： | 1 |
| 12 | Active-passive radial-additive friction stir repairing of mechanical hole out of dimension tolerance of AZ31 magnesium alloy显示文摘In order to avoid the depth increasing of repaired hole and eliminate the super-fine grain band in stir zone by radial-additive friction stir repairing(R-AFSR), a solid-state repairing technique of active-passive radial-additive friction stir repairing(AP-RAFSR) assisted by the truncated cone-shaped filling material was proposed in this study. The mechanical hole out of dimension tolerance of AZ31 magnesium alloy was chosen as the repaired object. The results indicated that the AP-RAFSR process rather than the R-AFSR process avoided the kissing bond in the bottom of the repairing interface under the condition of the tool pin length equal to the height of the standard mechanical hole.The continuously-distributed and large-length super-fine grain bands were eliminated in the stir zone by AP-RAFSR. The maximum tensile and compressive-shear strengths of repaired hole by AP-RAFSR reached 190.6 MPa and 138.9 MPa at 1200 rpm respectively, which were equivalent to 97.7% and 89.6% of those of the standard mechanical hole. This AP-RAFSR process assisted by the truncated cone-shaped filling material provides a new technique to obtain a no-depth-increasing, defect-free and high-strength repaired mechanical hole. | Hua Liu Zhenlei Liu Shude Ji Yumei Yue Zhibo Dong Changlong Chen | 2023 | Journal of Magnesium and Alloys2023，11，9： | 0 |
| 13 | Microstructural formation and mechanical performance of friction stir double-riveting welded Al-Cu joints显示文摘A novel friction stir double-riveting welding(FSDRW) technology was proposed in order to realize the high-quality joining of upper aluminum(Al) and lower copper(Cu) plates,and this technology employed a Cu column as a rivet and a specially designed welding tool with a large concave-angle shoulder. The formations, interfacial characteristics, mechanical properties and fracture features of Al/Cu FSDRW joints under different rotational velocities and dwell times were investigated. The results showed that the well-formed FSDRW joint was successfully obtained.The cylindrical Cu column was transformed into a double riveting heads structure with a Cu anchor at the top and an Al anchor at the bottom, thereby providing an excellent mechanical interlocking.The defect-free Cu/Cu interface was formed at the lap interface due to the sufficient metallurgical bonding between the Cu column and the Cu plate, thereby effectively inhibiting the propagation of crack from the intermetallic compound layer at the lap interface between the Al and Cu plates. The tensile shear load of joint was increased first and then decreased when the rotational velocity and dwell time of welding tool increased, and the maximum value was 5.52 k N. The FSDRW joint presented a mixed mode of ductile and brittle fractures. | Shude JI Zhiqing ZHANG Peng GONG Hua LIU Xiao CUI Yewei ZHANG | 2023 | Chinese Journal of Aeronautics2023，36，8： | 0 |
| 14 | A Novel Friction Stir Spot Riveting of Al/Cu Dissimilar Materials显示文摘In order to eliminate the disadvantages of the keyhole in conventional friction stir spot welding joint and attain the highstrength lap joint of Al/Cu dissimilar metals,a novel welding technique,named as friction stir spot riveting(FSSR),was proposed.A pinless tool and an extra filling stud were employed.The Al/Cu spot joints without keyhole defect were achieved by the FSSR.A Cu anchor-like structure was formed,which greatly increased the mechanical interlocking between the upper Al sheet and lower Cu sheet.The thin intermetallic compounds containing CuAl2 and CuAl at the Al/Cu interface strengthened the joining interface between the Al sheet and the Cu stud.Increasing rotating velocity increased frictional heat and plastic deformation and then eliminated the interfacial joining defects.The FSSR joint with the maximum tensile shear load of 3.50 kN was achieved at a rotating velocity of 1800 rpm and a dwell time of 20 s,whose fracture path passed through the softened region of upper Al sheet.In summary,the novel FSSR technique has the advantages of strong mechanical interlocking and metallurgical bonding between dissimilar materials,thereby attaining the high-strength spot joint. | Jinglin Liu Qi Song Lihui Song Shude Ji Mingshen Li Zhen Jia Kang Yang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，1： | 0 |
| 15 | Stabilizing zinc anode using zeolite imidazole framework functionalized separator for durable aqueous zinc-ion batteries显示文摘Aqueous zinc-ion batteries(AZIBs) hold great promise as a viable alternative to lithium-ion batteries owing to their high energy density and environmental friendliness.However,AZIBs are consistently plagued by the formation of zinc dendrites and concurrent side reactions,which significantly diminish their overall service life,In this study,the glass fiber separator(GF) is modified using zeolite imidazole salt framework-8(ZIF-8),enabling the development of efficient AZIBs.ZIF-8,which is abundant in nitrogen content,efficiently regulates the desolvation of [Zn(H_(2)O)_(6)]^(2+) to inhibit hydrogen production.Moreover,it possesses abundant nanochannels that facilitate the uniform deposition of Zn~(2+) via a localized action,thereby hindering the formation of dendrites.The insulating properties of ZIF-8 help prevent Zn^(2+) and water from trapping electron reduction at the layer surface,which reduces corrosion of the zinc anode.Consequently,ZIF-8-GF achieves the even transport of Zn^(2+) and regulates the homogeneous deposition along the Zn(002) crystal surface,thus significantly enhancing the electrochemical performance of the AZIBs,In particular,the Zn|Zn symmetric cell with the ZIF-8-GF separator delivers a stable cycle life at0.5 mA cm^(-2) of 2300 h.The Zn|ZIF-8-GF|MnO_(2) cell exhibits reduced voltage polarization while maintaining a capacity retention rate(93.4%) after 1200 cycles at 1.2 A g^(-1) The unique design of the modified diaphragm provides a new approach to realizing high-performance AZIBs. | Weisong Zhang Xinyan Zhu Ling Kang Ziyu Peng Jing Zhu Liang Pan Lei Dai Shude Liu Ling Wang Yongguang Liu Zhangxing He | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 16 | Control of Titanium Alloy Thin Plate Welding Distortion by Trailing Peening显示文摘The technology of trailing peening is a kind of promisingly bran-new technology which can be used to control weldingstress and distortion of Ti alloy thin plate. Control of TC4 Ti alloy thn plate welding stress and distortion underthe condition of conventional welding and trailing peening is performed, respectively. The results show that thetechnology of trailing peening effectively reduces deflection and transverse shrinkage of thin plate weldment. Themaximum deflection is decreased from 15 mm under the conditior of conventional welding to 5 mm, while the weldtransverse shrinkage is decreased from 0.5 mm to about 0.1 mm. | Xuesong LIU Hongyuan FANG Shude JI Zhibo DONG | 2003 | Journal of Materials Science & Technology2003，19，z1： | 0 |
| 17 | Photovoltaic-powered supercapacitors for driving overall water splitting:A dual-modulated 3D architecture显示文摘Due to the growing demand for clean and renewable hydrogen fuel,there has been a surge of interest in electrocatalytic water-splitting devices driven by renewable energy sources.However,the feasibility of self-driven water splitting is limited by inefficient connections between functional modules,lack of highly active and stable electrocatalysts,and intermittent and unpredictable renewable energy supply.Herein,we construct a dualmodulated three-dimensional(3D)NiCo_(2)O_(4)@NiCo_(2)S_(4)(denoted as NCONCS)heterostructure deposited on nickel foam as a multifunctional electrode for electrocatalytic water splitting driven by photovoltaic-powered supercapacitors.Due to a stable 3D architecture configuration,abundant active sites,efficient charge transfer,and tuned interface properties,the NCONCS delivers a high specific capacity and rate performance for supercapacitors.A twoelectrode electrolyzer assembled with the NCONCS as both the anode and the cathode only requires a low cell voltage of 1.47 V to achieve a current density of 10 mA cm^(−2) in alkaline electrolyte,which outperforms the state-of-the-art bifunctional electrocatalysts.Theoretical calculations suggest that the generated heterointerfaces in NCONCS improve the surface binding capability of reaction intermediates while regulating the local electronic structures,which thus accelerates the reaction kinetics of water electrolysis.As a proof of concept,an integrated configuration comprising a two-electrode electrolyzer driven by two series-connected supercapacitors charged by a solar cell delivers a high product yield with superior durability. | Zixu Sun Lijuan Sun See Wee Koh Junyu Ge Jipeng Fei Mengqi Yao Wei Hong Shude Liu Yusuke Yamauchi Hong Li | 2022 | Carbon Energy2022，4，6： | 0 |
| 18 | DNA barcoding of fishes from Zhoushan coastal waters using mitochondrial COI and 12S rRNA genes显示文摘Accurate species identification is a key component of biodiversity research.DNA barcoding is an effective molecular method used for fish species identification.We aimed to study the DNA barcoding of fish in Zhoushan coastal waters,explore the differences and applicability of two gene fragments(12S rRNA and COI)of DNA barcoding in fish species identification,and established a comprehensive fish barcoding reference database.Two hundred and eighty-seven captured fish samples from Zhoushan coastal waters were identified using morphological characteristics and DNA barcoding.A total of 26412S rRNA sequences(belonging to eight orders,31 families,55 genera,and 66 species)and 188 COI sequences(belonging to seven orders,30 families,48 genera,and 58 species)were obtained.The lengths of the 12S rRNA sequences ranged from 165 to 178 bp,and the guanine-cytosine(GC)content was 45.37%.The average 12S rRNA interspecific and intraspecific genetic distances(K2P)were 0.10%and 26.66%,respectively.The length of the COI sequence ranged 574–655 bp,and the content of GC was 45.97%.The average 12S rRNA interspecific and intraspecific genetic distances(K2P)were 0.16%and 27.45%,respectively.The minimum interspecific genetic distances of 12S rRNA and COI(1.23%and 1.86%)were both greater than their maximum intraspecific genetic distances(2.42%and 8.66%).Three molecular analyses(NJ tree,ABGD,and GMYC)were performed to accurately identify and delineate species.Clustering errors occurred when the 12S rRNA sequences were delimited using the NJ tree method,and the delimitation results of ABGD and GMYC are consistent with the final species identification results.Our results demonstrate that DNA barcoding based on 12S rRNA and COI can be used as an effective tool for fish species identification,and 12S rRNA has good application prospects in the environmental DNA(eDNA)metabarcoding of marine fish. | Yehui WANG Na SONG Shude LIU Zhi CHEN Anle XU Tianxiang GAO | 2023 | Journal of Oceanology and Limnology2023，41，5： | 0 |
| 19 | SOLVABILITY OF SOME SINGULARLY PERTURBED SEMI-LINEAR DIFFERENTIAL SYSTEM显示文摘In this paper, we consider the solvability for a singularly perturbed Robin problem of semi-linear differential system. Using the boundary layer corrective method, the formal asymptotic solution is constructed. Finally, the uniform validity of such asymptotic expansions solution is proved. | Liu Shude, Mo Jiaqi (Dept. of Math., Anhui Normal University, Wuhu 241000, Anhui Division of Computational Science, E-Institutes of Shanghai Universities, at SJTU, Shanghai 200240) Chen Xiu Dept. of Math. and Physics, Hefei University, Hefei 230601) | 2008 | Annals of Differential Equations2008，24，4： | 0 |
| 20 | Adjuvant tamoxifen switched to exemestane treatment in postmenopausal women with estrogen receptor-positive early breast cancer:A pragmatic,multicenter,and prospective clinical trial in China显示文摘Objective:This post-approval safety study assessed the efficacy and safety of exemestane after 2-3 years of tamoxifen treatment among postmenopausal women with estrogen receptor-positive(ER+)early breast cancer in China.Methods:Enrolled patients had received 2-3 years of tamoxifen and were then switched to exemestane for completion of 5 consecutive years of adjuvant endocrine therapy.The primary endpoint was the time from enrollment to the first occurrence of locoregional/distant recurrence of the primary breast cancer,appearance of a second primary or contralateral breast cancer,or death due to any cause.Other endpoints included the proportion of patients experiencing each event,incidence rate per annum,relationships between human epidermal growth factor receptor 2 status and time to event,and relationship between disease history variables and time to event.Results:Overall,558 patients were included in the full analysis set:397(71.1%)completed the study,20experienced an event,and 141 discontinued[47 owing to an adverse event(AE);37 no longer willing to participate].Median duration of treatment was 29.5(range,0.1-57.7)months.Median time to event was not reached.Eventfree survival probability at 36 months was 91.4%(95%CI,87.7%-95.1%).The event incidence over the total exposure time of exemestane therapy was 3.5 events/100 person-years(20/565).Multivariate analysis showed an association between tumor,lymph node,and metastasis stage at initial diagnosis and time to event[hazard ratio:1.532(95%CI,1.129-2.080);P=0.006].Most AEs were grade 1 or 2 in severity,with arthralgia(7.7%)being the most common treatment-related AE.Conclusions:This study supports the efficacy and safety of exemestane in postmenopausal Chinese women with ER+breast cancer previously treated with adjuvant tamoxifen for 2-3 years.No new safety signals were identified in the Chinese population. | Binghe Xu Huiping Li Zefei Jiang Lin Gu Jinhai Tang Hui Xie Yueyin Pan Yunjiang Liu Shude Cui Xiaojia Wang Li Cai Yiqiong Zhang Huadong Zhao Zhimin Shao | 2022 | Chinese Journal of Cancer Research2022，34，6： | 0 |
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