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| 1 | Anelasticity of twinned CuO nanowires显示文摘CuO nanowires (NW ) 的机械行为被调查由在 situ 传播电子显微镜学。在压缩期间, NW 展出了与高机械的应力联系的高弯曲的能力。有趣地,滞弹性一致地在压力版本以后被观察。进一步的调查显示滞弹性对 CuO NW 内在,尽管 electronbeam 照耀加速形状恢复被证明有能力。机制基于联系双胞胎的原子的合作运动被建议说明这现象。结果提供卓见进 CuO NW 的机械性质,它是为抑制系统的 nanoscale 的有希望的材料。 | Huaping Sheng He Zheng Fan Cao Shujing Wu Lei Li Chun Liu Dongshan Zhao Jianbo Wang | 2015 | Nano Research2015，8，11： | 9 |
| 2 | Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies显示文摘大多数病原体在人的 mucosal 表面开始他们的感染。因此, mucosal 种痘,通过特别口头或 intranasal 管理线路,高度为传染疾病被需要。同时,基于蛋白质的抗原提供一种更安全的选择给基于的整个病原体或 DNA 在疫苗的开发的。然而,在他们到达指向,相对低的 immunogenicity ,以及蛋白质抗原的低稳定性的地点以前, intranasally 或口头上地交付了蛋白质疫苗的唯一的 biopharmaceutical 障碍需要克服,要求有头脑、调整的 mucosal 疫苗明确的表达包括 immunostimulants 的选择,合适的疫苗的交货系统的鉴定,和准确作文和生产条件的决心。这评论试图提供蛋白质的新调查基于抗原的疫苗的明确的表达开发,包括 immunostimulants 和为 intranasal 和口头的政府的疫苗的交货系统的优化的用法。 | Shujing Wang Huiqin Liu Xinyi Zhang Feng Qian | 2015 | Protein & Cell2015，6，7： | 6 |
| 3 | Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors显示文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. | Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 5 |
| 4 | SLIDE, the Protein Interacting Domain of Imitation Switch Remodelers, Binds DDT-Domain Proteins of Different Subfamilies in Chromatin Remodeling Complexes显示文摘The Imitation Switch(ISWI)type adenosine triphosphate(ATP)-dependent chromatin remodeling factors are conserved proteins in eukaryotes,and some of them are known to form stable remodeling complexes with members from a family of proteins,termed DDT domain proteins.Although it is well documented that ISWIs play important roles in different biological processes in many eukaryotic species,the molecular basis for protein interactions in ISWI complexes has not been fully addressed.Here,we report the identi cation of interaction domains for both ISWI and DDT domain proteins.By analyzing CHROMATIN REMODELING11(CHR11)and RINGLET1(RLT1),an Arabidopsis thaliana ISWI(AtISWI)and AtDDT domain protein,respectively,we show that the SLIDE domain of CHR11 and the DDT domain together with an adjacent sequence of RLT1 are responsible for their binding.The Arabidopsis genome contains at least 12genes that encode DDT domain proteins,which could be grouped into ve subfamilies based on the sequence similarity.The SLIDE domain of AtISWI is able to bind members from different AtDDT subfamilies.Moreover,a human ISWI protein SNF2H is capable of binding AtDDT domain proteins through its SLIDE domain,suggesting that binding to DDT domain proteins is a conserved biochemical function for the SLIDE domain of ISWIs in eukaryotes. | Jiaqiang Dong Zheng Gao Shujing Liu Guang Li Zhongnan Yang Hai Huang Lin Xu | 2013 | Journal of Integrative Plant Biology2013，55，10： | 4 |
| 5 | Activation of disease resistance against Botryosphaeria dothidea by downregulating the expression of MdSYP121 in apple显示文摘In plants,the vesicle fusion process plays a vital role in pathogen defence.However,the importance of the vesicle fusion process in apple ring rot has not been studied.Here,we isolated and characterised the apple syntaxin gene MdSYP121.Silencing the MdSYP121 gene in transgenic apple calli increased tolerance to Botryosphaeria dothidea infection;this increased tolerance was correlated with salicylic acid(SA)synthesis-related and signalling-related gene transcription.In contrast,overexpressing MdSYP121 in apple calli resulted in the opposite phenotypes.In addition,the results of RNA sequencing(RNA-Seq)and quantitative real-time PCR(qRT-PCR)assays suggested that MdSYP121 plays an important role in responses to oxidation–reduction reactions.Silencing MdSYP121 in apple calli enhanced the expression levels of reactive oxygen species(ROS)-related genes and the activity of ROS-related enzymes.The enhanced defence response status in MdSYP121-RNAi lines suggests that syntaxins are involved in the defence response to B.dothidea.More importantly,we showed that MdSYP121 forms a soluble N-ethylmaleimide-sensitive factor attachment protein receptor(SNARE)complex with MdSNAP33,and the complex may participate in regulating resistance to B.dothidea.In conclusion,by regulating the interaction of SA pathway and oxidation–reduction process,MdSYP121 can influence the pathogen infection process in apple. | Xiaowen He Yanhong Huo Xiuxia Liu Qianqian Zhou Shouqian Feng Xiang Shen Baohua Li Shujing Wu Xuesen Chen | 2018 | Horticulture Research2018，5，1： | 3 |
| 6 | Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 是世界范围的致命的肝恶意。在这研究,我们报导了那个蛋白质磷酸酶镁依赖者(PPM1D ) 1 高度在 HCC 案例(约 59%) 的多数被表示并且显著地把水平与高浆液 -fetoprotein (法新社) 联系了(P = 0.044 ) 。Kaplan- Meier 和考克斯回归数据显示 PPM1D overexpression 是 HCCspecific 全面幸存的一个独立预言者(HR, 2.799;95% CI, 1.346-5.818, P = 0.006 ) 。, Overexpressing PPM1D 支持了房间生存能力和侵略 RNA 调停干扰 PPM1D 击倒有教养的 HCC 房间的禁止的增长,侵略,和移植。另外,由小介入 RNA 的 PPM1D 抑制减少了在 vivo 的 HCC 房间的 tumorigenicity。总的来说,结果建议 PPM1D 为 HCC 是一个潜在的预示的标记和治疗学的目标。 | Zhi Xu Chunxiang Cao Haiyan Xia Shujing Shi Lingzhi Hong Xiaowei Wei Dongying Gu Jianmin Bian Zijun Liu Wenbin Huang Yixin Zhang Song He Nikki Pui-Yue Lee Jinfei Chen | 2016 | Frontiers of Medicine2016，10，1： | 3 |
| 7 | NLoS Mitigation in ToA Localization Based on Spatial Correlation Filter and Iterative Minimum Residual显示文摘To mitigate the Non-Line-of-Sight (NLoS) error which seriously affects the localization accuracy and robustness in complex indoor environment,a novel Iterative Minimum Residual (IMR) based on the consistency hypothesis of the residual and the error is proposed in this paper.It chooses the best subset of measurements to calculate the coordinates of the unknown node by comparing the residuals obtained with different subsets of beacons.To reduce the time complexity of the IMR algorithm,Spatial Correlation Filter (SCF) is also proposed,which can remove the most serious NLoS distance with low calculation cost.Combined with the proposed SCF and IMR algorithm,nodes can be localized with high accuracy and low time complexity.Experimental results with real dataset demonstrate that the proposed algorithm can identify the NLoS range effectively with about 50% time cost of employing SCF only. | Luo Haiyong Liu Shujing Liu Xiaoming | 2012 | China Communications2012，9，4： | 3 |
| 8 | Influence of Sanao Tang on urine volume and expression of aquaporin 2 in rats with respiratory function impairment induced by passive smoking and lipopolysaccharide显示文摘OBJECTIVE: To investigate the effect of Sanao Tang(SAT) on urine volume and the expression of aquaporin-2(AQP2) in rats with lung dysfunction induced by passive smoking and lipopolysaccharide.METHODS: Totally 45 healthy Specific pathogen Free Wistar Rats were randomized into 3 groups:normal control group, model group and SAT group.A rat model of respiratory dysfunction induced by exposure to cigarette smoking and lipopolysaccharide(LPS). Lavage of decoction of the Chinese medicine was performed for rats in the SAT group. Anires 2005 System was used to analyze the pulmonary function. Urine of rats was collected through metabolism cage method. Enzyme-linked immunosorbent assay(ELISA) was used to determine content of antidiuretic hormone(ADH), angiotensin Ⅱ(AngⅡ), atrial natriuretic factor(ANP), endothelin 1(ET-1), nitric oxide(NO) and prostaglandin E2(PGE2) in serum, lung and kidney. The expression of AQP2 in rat renal tissue was determined with real-time fluorescence quantitative PCR(RT-PCR).RESULTS:(a) In comparison with the normal control, It was found that enforced vital capacity(FVC),1-second forced expiratory volume/forced vital capacity%(FEV1/FVC%), 24 h urine volume content of NO and PGE2 were decreased, while AQP2 m RNA level and content of ADH, Agn Ⅱ, ANP and ET-1were increased in the model group with statistical significance(P < 0.05).(b) In comparison with the model group, It was found that FVC, FEV1, FEV1/FVC%, 24 h urine volume, content of PGE2 and NO decreased, while AQP2 m RNA level, content of ANP,ADH and AngⅡ decreased in the SAT group with statistical significance(P < 0.05).CONCLUSION: SAT might effectively regulate the urine volume in the modeled rats; ADH, Ang Ⅱ,ANP, ET-1, NO and PGE2 might play an important role in the regulation on urine volume by lungs.This might be the mechanisms underpinning the function of lung governing water passage in terms of the theory of Traditional Chinese Medicine. | Zhang Jinchao Sun Yan Zhang Shujing Gao Yushan Wang Zhenyi Liu Xiaolei Yang Jiamin Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 2 |
| 9 | Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula显示文摘Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD. | Jingang Liu Yan Sun Huimin Yuan Yuda Li Jing Feng Yushan Gao Yang Tang Shujing Zhang Hang Wang Fengjie Zheng | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，4： | 2 |
| 10 | Research on the Soil Carbon Storage of Alpine Grassland under Different Land Uses in Qinghai-Tibet Plateau显示文摘 | Tao Li Lei Ji Tao Liu Zhongqi Song Shujing Yang Youmin Gan | 2013 | Journal of Agricultural Science and Technology(A)2013，3，2： | 2 |
| 11 | Design, Synthesis, Antifungal Activities and SARs of (R)-2-Aryl-4,5-dihydrothiazole-4-carboxylic Acid Derivatives显示文摘基于自然产品 2-aryl-4,5-dihydrothiazole-4-carboxylic 酸的结构,一系列新奇(R)-2-aryl-4,5-dihydrothiazole-4-carboxylic 酸衍生物被设计并且综合。他们的结构被 1 H NMR, 13 C NMR 和 HRMS。复合 9b 的单个水晶结构被 X 光检查衍射分析决定。抗真菌的活动第一次被评估。生物鉴定结果显示展出的大多数混合物节制到好抗真菌的活动。复合 13a 的抗真菌的活动(对 Cercospora arachidicola Hori ) , 13d (对 Alternaria solani ) ,并且 16e (对 Cercospora arachidicola Hori ) 分别地,是 61.9% , 67.3% 和 61.9% 它比商业杀真菌剂 chlorothalonil 和 carbendazim 的那些高。而且,复合 13d 对测试的 7 种真菌展出了优秀抗真菌的活动(66.7% , 77.3% , 63.0% , 87.9% , 70.0% , 70.0% 和 80.0% 在 50 µg ? mL ) 。因此, 13d 能为抗真菌的代理人的发展被用作新铅结构。 | Jingbo Liu Yuxin Li Youwei Chen Xuewen Hua Yingying Wan Wei Wei Haibin Song Shujing Yu Xiao Zhang Zhengming Li | 2015 | Chinese Journal of Chemistry2015，33，11： | 2 |
| 12 | Construction of WO_(3)/Ti-doped WO_(3)bi-layer nanopore arrays with superior electrochromic and capacitive performances显示文摘Crystalline WO_(3)/Ti-doped WO_(3)bi-layer nanopore arrays were constructed by the template synthesis of a WO_(3)nanopore layer modified by a magnetron sputtering of an amorphous Ti-doped/WO_(3)layer.The obtained bi-layer nanopore array shows a remarkable electrochromic performance with large dual-band optical modulation in both visible(VIS)and near infrared(NIR)regions(optical modulation of over 70%in the wavelength range from 600 to 1600 nm)and the fast response speed(coloring for 3.4 s and bleaching for 6.6 s).In addition,the bi-layer WO_(3)/Ti-doped WO_(3)nanopore array also present superior energy-storage properties(areal capacitance of 44.0 mF cm−2 and good rate capability),better than that of titanium-free thin films.The special bifunctional characteristics of electrochromism and pseudocapacitance can be ascribed to the large specific surface area provided by the architectural design,rich ion channels in the amorphous layer as well as proper titanium doping,which bestows the bi-layer nanopore array a great potential in clean energy applications. | Yingdi Shi Shujing Liu Yong Zhang Mingjun Sun Kai Tang Jiewu Cui Xia Shu Yan Wang Jiaqin Liu Yucheng Wu | 2019 | Tungsten2019，1，3： | 2 |
| 13 | Development of potent promoters that drive the efficient expression of genes in apple protoplasts显示文摘Protoplast transient expression is a powerful strategy for gene functional characterization,especially in biochemical mechanism studies.We herein developed a highly efficient transient expression system for apple protoplasts.The abilities of the Arabidopsis thaliana and Malus domestica ubiquitin-10(AtUBQ10 and MdUBQ10)promoters to drive the expression of multiple genes were compared with that of the CaMV 35S promoter,and the results revealed that the AtUBQ10 and MdUBQ10 promoters were more efficient in apple protoplasts.With this system,we demonstrated that active AtMKK7ac could activate MAPK6/3/4 signaling cascades,which further regulated MdWRKY33 phosphorylation and stability in apple.Furthermore,the ligand-induced interaction between the immune receptor AtFLS2 and the coreceptor AtBAK1 was reconstituted in apple protoplasts.We also found that the stability of the bacterial effector AvrRpt2 was regulated by feedback involving auxin and the immune regulator RIN4.The system established herein will serve as a useful tool for the molecular and biochemical analyses of apple genes. | Xianpu Wang Lili Xu Xiuxia Liu Li Xin Shujing Wu Xuesen Chen | 2021 | Horticulture Research2021，8，1： | 2 |
| 14 | Structural long period gratings made by drilling micro-holes in photonic crystal fibers with a femtosecond infrared laser显示文摘 | Liu Shujing Jin Long Jin Wei | | 0，，06： | 1 |
| 15 | Heritability of resistance-related gene expression traits and their correlation with body size of clam Meretrix petechialis显示文摘Gene expression variation can be considered as a phenotype,and it plays an important role in both acclimation and adaption.However,genetic variation of gene expression received much less attention than traditional commercial traits in aquaculture.To estimate the genetic variation and heritability of gene transcription in clam Meretrix petechialis,five Vibrio resistance-related genes were selected for gene expression analysis in the digestive gland,and an animal linear model was used to analyze data from quantitative real-time PCR(qRT-PCR).Among the five genes,BIRC7 showed significant additive genetic variations,the heritability of this gene of 12-month-and 15-month-old clams were 0.84±0.32 and 0.91±0.34,respectively.The heritability of other four genes(Bax,NFIL3,Big-Def,and CTL9)expression were low-tomoderate but not significantly expressed.Additionally,no significant phenotypic and genetic correlations between the BIRC7 transcription trait and body size were detected.This study highlights that certain gene expression variation is heritable and provides a reference for indirect selection of M.petechialis with high Vibrio resistance. | JIANG Fengjuan YUE Xin ZHANG Shujing YU Jiajia WANG Rui LIU Baozhong WANG Hongxia | 2020 | Journal of Oceanology and Limnology2020，38，2： | 1 |
| 16 | Analysis of a nonautonomous model for migratory birds with saturation incidence rate 显示文摘 | Zhang Yan Gao Shujing Liu Yujiang | 2012 | Commun Nonlinear Sci Numer Simulat2012，17，： | 1 |
| 17 | Fast response mi- crostructured optical fiber methane sensor with multiple side-openings显示文摘 | Hoo Y L Liu Shujing Ho Hoi Lut | 2010 | IEEE Photonics Technology Letters2010，22，5： | 1 |
| 18 | Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways显示文摘 | Yong Gao Yun Zhao Jingzi Pan Liu Yang Tingting Huang Xiaomin Feng Chao Li Shujing Liang Dingfu Zhou Chan Liu Fengxia Tu Cai Tao Xiang Chen | 2014 | Brain Research2014，，： | 1 |
| 19 | Determi-nation of the Thermal Loading in Laserdiode-pumped Erbium-ytterbium-codoped Phosphate Glass Micro-chip Laser显示文摘 | Song Feng Liu Shujing Wu Zhaohui | | 0，，： | 1 |
| 20 | Seasonality and mixed vaccination strategy in an epidemic model with vertical transmission显示文摘 | Gao Shujing Liu Yujiang Juan J | 2011 | Mathematies and Computers in Simulation2011，81，： | 1 |
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