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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation显示文摘Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the pyroptotic process. Here, we also found MMP collapse and ROS generation induced by Nlrp3 inflammasome activation as previous studies reported. The elimination of ROS alleviated the cleavage of Gsdmd, suggesting that Gsdmd cleavage occurs downstream of ROS release. Consistent with this result, hydrogen peroxide treatment augmented the cleavage of Gsdmd by caspase-1. Indeed, four amino acid residues of Gsdmd were oxidized under oxidative stress in macrophages. The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death. | Yufang Wang Peiliang Shi Qin Chen Zan Huang Dayuan Zou Jingzi Zhang Xiang Gao Zhaoyu Lin | 2019 | Journal of Molecular Cell Biology2019，11，12： | 23 |
| 3 | Dispersion behavior of core-shell silica-polymer nanoparticles显示文摘Core-shell silica nanoparticles are superior in modifying surface wetting behavior, enhancing nucleation and growth in crystallization, improvingdispersion of naked nanoparticles, and thus upgrading the overall properties of organic polymers. The dispersion behavior and morphology ofmonodisperse core-shell silica particles in several polymers including polyesters are reviewed and their potential applications are discussed. | Yi Wang Yangchuan Ke Jingzi Li Shouqin Du Yanfeng Xia | 2007 | China Particuology2007，5，4： | 3 |
| 4 | Integrative taxonomy of the Plain-backed Thrush(Zoothera mollissima)complex(Aves,Turdidae)reveals cryptic species,including a new species显示文摘Background: The Plain-backed Thrush Zoothera mollissima breeds in the Himalayas and mountains of central China. It was long considered conspecific with the Long-tailed Thrush Zoothera dixoni, until these were shown to be broadly sympatric.Methods: We revise the Z. mollissima–Z. dixoni complex by integrating morphological, acoustic, genetic(two mitochondrial and two nuclear markers), ecological and distributional datasets.Results: In earlier field observations, we noted two very different song types of 'Plain-backed' Thrush segregated by breeding habitat and elevation. Further integrative analyses congruently identify three groups: an alpine breeder in the Himalayas and Sichuan, China('Alpine Thrush'); a forest breeder in the eastern Himalayas and northwest Yunnan(at least), China('Himalayan Forest Thrush'); and a forest breeder in central Sichuan('Sichuan Forest Thrush'). Alpine and Himalayan Forest Thrushes are broadly sympatric, but segregated by habitat and altitude, and the same is probably true also for Alpine and Sichuan Forest Thrushes. These three groups differ markedly in morphology and songs. In addition, DNA sequence data from three non-breeding specimens from Yunnan indicate that yet another lineage exists('Yunnan Thrush'). However, we find no consistent morphological differences from Alpine Thrush, and its breeding range is unknown. Molecular phylogenetic analyses suggest that all four groups diverged at least a few million years ago, and identify Alpine Thrush and the putative 'Yunnan Thrush' as sisters, and the two forest taxa as sisters. Cytochrome b divergences among the four Z. mollissima sensu lato(s.l.) clades are similar to those between any of them and Z. dixoni, and exceed that between the two congeneric outgroup species. We lectotypify the name Oreocincla rostrata Hodgson, 1845 with the Z. mollissima sensu stricto(s.s.) specimen long considered its type. No available name unambiguously pertains to the Himalayan Forest Thrush.Conclusions: The Plain-backed Thrush Z. mollissima s.l. comprises at least three species: Alpine Thrush Z. mollissima s.s., with a widespread alpine breeding distribution; Sichuan Forest Thrush Z. griseiceps, breeding in central Sichuan forests; and Himalayan Forest Thrush, breeding in the eastern Himalayas and northwest Yunnan(at least), which is described herein as a new species. 'Yunnan Thrush' requires further study. | Per Alstrom Pamela C.Rasmussen Chao Zhao Jingzi Xu Shashank Dalvi Tianlong Cai Yuyan Guan Ruiying Zhang Mikhail V.Kalyakin Fumin Lei Urban Olsson | 2016 | Chinese Birds2016，，1： | 2 |
| 5 | Antifibrotic effect of the Chinese herbs, Astragalus mongholicus and Angelica sinensis , in a rat model of chronic puromycin aminonucleoside nephrosis显示文摘 | Haiyan Wang Jingzi Li Ling Yu Yani Zhao Wei Ding | 2003 | Life Sciences2003，，13： | 1 |
| 6 | Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways显示文摘 | Yong Gao Yun Zhao Jingzi Pan Liu Yang Tingting Huang Xiaomin Feng Chao Li Shujing Liang Dingfu Zhou Chan Liu Fengxia Tu Cai Tao Xiang Chen | 2014 | Brain Research2014，，： | 1 |
| 7 | Antifibrotic effect of the Chinese herbs,Astragalus mongholicus and Angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis 显示文摘 | Wang Haiyan Li Jingzi Yu Ling | 2004 | Life Sci2004，74，13： | 1 |
| 8 | Suppressing the growth of rectal cancer xenografts derived from patient tumors by an adenovector expressing small hairpin RNA targeting Bcl‐XL显示文摘 | Hongbo Zhu Wei Zhou Jingzi Hu Zhongting Huang Weifeng Lao Xuefeng Huang Chao He | 2012 | J Gene Med2012，，12： | 1 |
| 9 | Orbital Apex Syndrome: A Rare Presentation of Extramedullary Hematopoiesis Case Report and Review of Literature显示文摘 | Misha Pless Joseph F. Rizzo Jingzi Shang | 2002 | Journal of Neuro - Oncology2002，，1： | 1 |
| 10 | Heavy metal pollution increases soil microbial carbon limitation:Evidence from ecological enzyme stoichiometry显示文摘Heavy metals can exist in soil for a long time and seriously affect soil quality.The coexistence of various heavy metal pollutants leads to biotoxicity and alters the activity of microorganisms.Soil microbial metabolism plays an important role in nutrient cycling and biochemical processes of soil ecosystem.However,the effects of heavy metal contamination on microbial metabolism in soil are still unclear.This study aims to reveal the responses of microbial metabolic limitation to heavy metals using extracellular enzyme stoichiometry,and further to evaluate the potential impacts of heavy metal pollution on soil nutrient cycle.The results showed that soil microbial metabolism reflected by the ecoenzymatic activities had a significant response to soil heavy metals pollution.The metabolism was limited by soil carbon(C)and phosphorus(P)under varied heavy metal levels,and the increase of heavy metal concentration significantly increased the microbial C limitation,while had no effect on microbial P limitation.Microorganisms may increase the energy investment in metabolism to resist heavy metal stress and thus induce C release.The results suggest that energy metabolism selected by microorganisms in response to long-term heavy metal stress could increase soil C release,which is not conducive to the soil C sequestration.Our study emphasizes that ecoenzymatic stoichiometry could be a promising methodology for evaluating the toxicity of heavy metal pollution and its ecological effects on nutrient cycling. | Mingzhe Xu Yongxing Cui Jingzi Beiyuan Xia Wang Chengjiao Duan Linchuan Fang | 2021 | Soil Ecology Letters2021，3，3： | 1 |
| 11 | Targeted Degradation of DNA/RNA Binding Proteins via Covalent Hydrophobic Tagging显示文摘Targeted protein degradation(TPD)holds great promise for biological inquiry and therapeutic development.However,it still remains elusive to destruct DNA/RNA binding proteins(DBPs/RBPs)previously deemed undruggable.Herein,we report ligandassisted covalent hydrophobic tagging(LACHT)as a modular strategy for TPD of these difficult-totarget proteins.Guided by a noncovalent protein ligand,LACHT leverages a reactive N-acyl-N-alkyl sulfonamide group to covalently label the protein target with a hydrophobic adamantane,which further engages the cellular quality control mechanism to induce proteolytic degradation.Using a smallmolecule ligand,we demonstrated that LACHT allowed TPD of a DBP,bromodomain-containing protein 4,in human leukemia cells with high efficiency.Mechanistic studies revealed that LACHT-mediated TPD dependent on ligand-directed irreversible tagging and the covalently labeled proteins underwent polyubiquitination before removal through both the proteasome and the lysosome.Furthermore,when an RNA ligand was employed,we showed that LACHT also enabled TPD of an RBP,Lin28a,leading to upregulation of its downstream let-7 miRNA.This study thus provides a generalizable platform to expand the TPD toolbox for biomedical applications. | Yan Wang Jingzi Zhang Jiafang Deng Chengzhi Wang Lei Fang Yan Zhang Jinbo Li | 2023 | CCS Chemistry2023，5，10： | 0 |
| 12 | Assessment on gas-polyethylene terephthalate solid interface partial discharge properties of C4F7N/CO_(2)gas mixture for eco-friendly gas insulating transformer显示文摘The eco-friendly insulating gas perfluoroisobutyronitrile(C_(4)F_(7)N)is potentially used in gas-insulated transformers(GIT)to replace sulphur hexafluoride(SF_(6)).However,evaluation of the long-term insulation reliability and gas–solid interface discharge decomposition characteristics of the gas–solid film insulation structure in GIT is indispensable.The authors simulated the gas–solid film insulation structure in GIT and explored the interface partial discharge(PD)characteristics of C4F7N/CO_(2)gas mixture with polyethylene terephthalate(PET).The effect of gas pressure,mixing ratio on gas–solid interface gas decomposition,PET degradation was investigated,and the interaction mechanism was analysed.It is found that the interface PD generated three degradation regions on a PET film.The gas–solid interface reaction in the electrode contact region and the discharge development trace was significantly higher than that of halation region.The content of gas decomposition products decreases with the increase of gas pressure and the PD intensity of SF6-PET is inferior to that of C_(4)F_(7)N/CO_(2)under the same condition.Relevant results provide reference for the development and application of C_(4)F_(7)N/CO_(2)based GIT. | Song Xiao Yifan Wang Chenhua Ren Haoran Xia Yue Zhao Jingzi Qin Xiaoxing Zhang Yi Luo Yi Li | 2024 | High Voltage2024，9，1： | 0 |
| 13 | An integrated machine learning model for accurate and robust prediction of superconducting critical temperature显示文摘Discovering new superconductors via traditional trial-and-error experimental approaches is apparently a time-consuming process,and the correlations between the critical temperature(Tc) and material features are still obscure.The rise of machine learning(ML) technology provides new opportunities to speed up inefficient exploration processes,and could potentially uncover new hints on the unclear correlations.In this work,we utilize open-source materials data,ML models,and data mining methods to explore the correlation between the chemical features and Tcvalues of superconducting materials.To further improve the prediction accuracy,a new model is created by integrating three basic algorithms,showing an enhanced accuracy with the coefficient of determination(R2) score of 95.9 % and root mean square error(RMSE) of 6.3 K.The average marginal contributions of material features towards Tcvalues are estimated to determine the importance of various features during prediction processes.The results suggest that the range thermal conductivity plays a critical role in Tcprediction among all element features.Furthermore,the integrated ML model is utilized to screen out potential twenty superconducting materials with Tcvalues beyond 50.0 K.This study provides insights towards Tcprediction to accelerate the exploration of potential high-Tcsuperconductors. | Jingzi Zhang Ke Zhang Shaomeng Xu Yi Li Chengquan Zhong Mengkun Zhao Hua-Jun Qiu Mingyang Qin X.-D.Xiang Kailong Hu Xi Lin | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 14 | Stability of potentially toxic elements in municipal sludge biochars modified by MgCl2 and phosphate显示文摘Municipal wastewater sludge can be pyrolyzed as biochars to better use nutrients and stabilize carbon compared with other typical technologies,such as landfill and incineration.However,sludge-derived biochars might contain large amounts of potentially toxic elements(PTEs),such as Zn,Cu,Cr,Ni,Pb,and As.The stability of PTEs in biochars might be improved by higher pyrolytic temperatures,which can be further improved by different modifications.Herein,PO4-modification at 300°C and Cl-modification at 700°C were carried out,respectively,to enhance the stability of PTEs.Various leaching tests have been performed to assess the stability of PTEs in biochars,including the synthetic precipitation leaching procedure(SPLP),toxicity characteristic leaching procedure(TCLP),diethylenetriamine pentaacetate(DTPA)extraction,and in vitro simple bioaccessibility extraction test(SBET).The morphological structure,elemental mapping,and mineral formation of the pristine and modified biochars were studied by scanning electron microscopy–energy-dispersive X-ray spectroscopy(SEM–EDS)and X-ray diffraction(XRD).Our results suggested that the leachability,mobility,plant-availability,and bioaccessibility of most PTEs were decreased by pyrolysis,yet the total contents of PTEs were elevated,especially at 700°C.Generally,modification by phosphates and MgCl2 enhanced the stability of PTEs in biochars.Nevertheless,it should be noted that higher bioaccessibility of PTEs was observed in biochars of P-modification than Cl-modification,which is associated with the dissolution of phosphate precipitates under acidic conditions(pH<2).Additionally,Cl-modification leads to higher plant-available Zn and Cu and bioaccessible Zn compared with the unmodified biochar produced at 700°C. | Qiqi Huang Siqi Chen Jinhao Lin Jingzi Beiyuan Jin Wang Juan Liu Yundang Wu Xiaolian Wu Fuhua Li Wenbing Yuan Chengrong Nie | 2023 | Waste Disposal and Sustainable Energy2023，5，1： | 0 |
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