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| 1 | A novel selective autophagy receptor,CCDC50,delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection显示文摘Autophagy is a con served process that delivers cytosolic substa nces to the lysosome for degradatio n,but its direct role in the regulation of antiviral inn ate immu nity remains poorly un derstood.Here,through high-throughput screeni ng,we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon(IFN)signaling pathway initiated by RIG-I-like receptors(RLRs),the sensors for RNA viruses.The expression of CCDC50 is enhanced by viral infection,and CCDC50 specifically recognizes K63-polyubiquitinated RLRs,thus delivering the activated RIG-I/MDA5 for autophagic degradation.The associatio n of CCDC50 with phagophore membrane protei n LC3 is con firmed by crystal structure analysis.In contrast to other known autophagic cargo receptors that associate with either the LIR-docking site(LDS)or the UIMdocking site(UDS)of LC3,CCDC50 can bind to both LDS and UDS,representing a new type of cargo receptor.In mouse models with RNA virus infection,CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses,resulting in enhaneed viral resistance and improved survival rates.These results reveal a new link between autophagy and antiviral innate immune resp on ses and provide additional in sights into the regulatory mecha nisms of RLR-mediated antiviral signaling. | Panpan Hou Kongxiang Yang Penghui Jia Lan Liu Yuxin Lin Zibo Li Jun Li Shuliang Chen Shuting Guo Ji'An Pan Junyu Wu Hong Peng Weijie Zeng Chunmei Li Yingfang Liu Deyin Guo | 2021 | Cell Research2021，31，1： | 5 |
| 2 | Numerical Simulation of EVA in Thermal Power Plants Based on System Dynamics显示文摘 | Liu Shuliang Liu Qianyun | 2014 | Chemical and Pharmaceutical Research2014，6，5： | 1 |
| 3 | Effects of land-use and climate change on sediment and nutrient retention in Guizhou,China显示文摘Introduction:Sediment and nutrient retention have significant impacts on agricultural productivity and water quality.Obvious changes of climate and land-use have deeply affected freshwater ecosystem services in the last several decades.Nevertheless,it is unclear what the differences are in the impact of climate and land-use changes on freshwater ecosystem services.Outcomes:The impacts of climate and land-use change on sediment and nutrient retention(two essential freshwater ecosystem services)were evaluated with the help of the Integrated Valuation of Environmental Services and Tradeoffs(InVEST)model.The results from the study area suggest a decreasing trend in sediment and nutrient retention from 1995 to 2015 when climate and land-use were changed simultaneously.A decreasing trend in sediment retention and an increasing trend in nutrient retention were presented under scenario A(climate change from 1995 to 2015 with land-use unchanged),while the sediment exported and nutrient retention exhibited a decreasing trend except sediment retained under scenario B(land-use change from 1995 to 2015 with unchanged climate).Rainfall erosivity and soil erodibility were more sensitive to the output of sediment retention,while retention efficiency produced more of an effect on nutrient retention.Discussion and Conclusion:Climate change played a dominant role in the change in sediment retention,while land-use change had a more significant effect on nutrient retention change than climate change.The results of this study provide explicitinformation for land-use managers to reduce the negative effects associated with sediment and nutrient retention. | Huiqing Han Jianqiang Yang Geng Ma Yue Liu Linan Zhang Siying Chen Shuliang Ma | 2020 | Ecosystem Health and Sustainability2020，6，1： | 1 |
| 4 | Research on Internal Control Information Disclosure of Real Estate Industry-Taking Taihe Group as an Example显示文摘After the outbreak of the Enron incident in the United States, China’s attention to internal control information disclosure has gradually increased. As a pillar industry of the national economy, real estate industry internal control system is sound, which has an important impact on social stability and healthy economic development. Therefore, this paper selects a company in the real estate industry, through the analysis of its internal control information disclosure, finds out its existing problems, and puts forward practical and feasible suggestions. | LIU Shuliang ZHOU Yue | 2019 | Management Studies2019，7，5： | 1 |
| 5 | Microglia and Astrocyte Activation by Toll-Like Receptor Ligands:Modulation by PPAR-γ, Agonists显示文摘 | Catherine Gurley Jessica Nichols Shuliang Liu | 2008 | PPAR Research2008，5，： | 1 |
| 6 | An investigation of in-cylinder tumbling motion in a four-valve spark ignition engine 显示文摘 | Li Yufeng Liu Shuliang | 2001 | Journal of Automobile Engineering2001，215，2： | 1 |
| 7 | Vulnerability analy- sis of interdependent infrastructure systems under edge attack strategies 显示文摘 | Wang Shuliang Liu Hong Chen Xueguang | 2013 | Safety Science2013，51，1： | 1 |
| 8 | Vulnerability analy- sis of interdependent infrastructure systems: A methodological framework 显示文摘 | Wang Shuliang Liu Hong Chen Xueguang | 2011 | Physica A2011，391，11： | 1 |
| 9 | Fabrication of super-hydrophobic wood surface by a sol - gelprocess 显示文摘 | WANG SHULIANG LIU CHANGYU LIU GUOCHAO | 2011 | AppliedSurfaceScience ( 1SSN0169- 4332 )2011，258，2： | 1 |
| 10 | Improvement of mechanical robustness of the superhydrophobic wood surface by coating PVA/SiO 2 composite polymer显示文摘 | Feng Liu Shuliang Wang Ming Zhang Miaolian Ma Chengyu Wang Jian Li | 2013 | Applied Surface Science2013，，： | 1 |
| 11 | Study on the Species-related Flavors and the Ways to Improve the Acceptability of Mutton显示文摘 | ZHANG Xuemei YANG Yong LIU Shuliang YE Jingsong | 2009 | 肉类研究2009，23，3： | 1 |
| 12 | Vulnerability analysis of interdependent in-frastructure systems:A methodological framework显示文摘 | Wang Shuliang Hong Liu | | 0，，11： | 1 |
| 13 | Biodegradation of3-phenoxyhenzoic acid by a novel Sphingomonas sp显示文摘 | Tang Jie Yao Kai Liu Shuliang | 2012 | FRESENIUS ENVIRONMENTAL BULLETIN2012，11，5： | 1 |
| 14 | Construction of Oryza sativa genome contigs by fingerprint strategy显示文摘We described the construction of BAC contigs of the genome of a indica variety of Oryza sativa, Guang Lu Ai 4.An entire representative (sixfold coverage of rice chromosomes) and genetically stable BAC library of rice genome constructed in this lab has been systematically analysed by restriction enzyme fragmentation and polyacrylamide gel electrophoresis. And all the images thus obtained were subject to image-processing, which consisted of preliminary location of bands, cooperative tracking of lanesby correlation of adjacent bands, a precise densitometric pass, alignment at the marker bands with the standard,optional interactive editing, and normalization of the accepted bands. The contigs were generated based on the Computer Software specially designed for genome map ping. The number of contigs with 600 kb in length on average was 464; of contigs with 1000 kb in length on average was 107; of contigs with 1500 kb in length on average was 23. Therefore, all the contigs we have obtained amounted up to 420 megabases in length. Considering the size of rice genome (430 megabased), the contigs generated in this lab have covered nearly 98% of the rice genome. We are now in the process of mapping the contigs to chromosomes. | TAO QUANZHOU YUEMIN QIAN HAIYING ZHAO SHULIANG YU LONGFANG QIU BOQIAN WU JIA ZHU DI YU XIAOHUI LIU GUOFAN HONG(National Center for Gene Research, Chinese Academy of Sciences, Shanghai 200233, China.)(Shanghai Institute of Biochemistry, Chinese Acad | 1995 | Cell Research1995，5，2： | 1 |
| 15 | Epi demiology of chronic cutaneous wounds in China显示文摘 | Jiang Yufeng Huang Sha Fu Xiaobing Liu Hongwei Ran Xingwu Lu Shuliang Hu Dahai Li Qiang Zhang Hongwei Li Ying Wang Runxiu Xie Ting Cheng Biao Wang Ling {eng Liu Yi Ye Xiangbai Han Chunmao Chen Huade | 2011 | Wound Rep Reg2011，，19： | 1 |
| 16 | Prevalence and characterization of Salmonella species isolated from pigs, ducks and chickens in Sichuan Province, China显示文摘 | Ruichao Li Jing Lai Yang Wang Shuliang Liu Yun Li Kunyao Liu Jianzhong Shen Congming Wu | 2013 | International Journal of Food Microbiology2013，，1： | 1 |
| 17 | Discovering the Association of Algae with Physicochemical Variables in Erhai Lake显示文摘Erhai Lake is the seventh largest freshwater lake in China where has been encountered with water pollution by the algae. One of important indicator of the water quality is the density of algae in the water, and the growth rate of algae is eutrophication.A novel method is proposed to discover the association of algae with physicochemical variables related to the algae growth in Erhai Lake, by integrating Maximal information coefficient(MIC) and association rules. To measure the correlation between variables, a new aspect on association rules with non-occurring domain is purposed,which decreases one item in antecedent. The correlation results present significantly in the density levels of algae,which is beneficial to control the level of physicochemical in the water for preventing the increasing number of algae. | LIU Chuanlu WANG Shuliang YUAN Hanning GENG Jing | 2020 | Chinese Journal of Electronics2020，29，2： | 1 |
| 18 | Base-free oxidative esterification of 5-hydroxymethylfurfural to furan-2,5-dimethylcarboxylate over n-doped carbon-supported Co/Fe bimetallic catalyst under batch-operation or continuous-flow conditions显示文摘Developing an efficient and easily available catalyst for the selective conversion of biomass-derived 5-hydroxymethylfurfural(HMF)into furan-2,5-dimethylcarboxylate(FDMC),a valuable biomass-based monomer,remains a high demand but formidable challenge.Herein,a facile strategy for the synthesis of N-doped carbon-supported Co/Fe bimetallic catalyst(CoFe-NC)was developed,which provided an outstanding FDMC yield of 93%in a batch reactor(base-free,80℃,2 bar O_(2),4 h).Interestingly,CoFe-NC also gave a high FDMC yield of 91%under continuous-flow conditions for 80 h(5 bar O_(2),80℃,GHSV 1320 h^(-1),LHSV 0.6 h^(-1),base-free).Notably,it is the first time that a non-noble catalyst gave such a high FDMC yield under continuous-flow conditions.The introduction of Fe could greatly improve both the electron intensity of Co-N_(x)species and basicity of the catalyst,which endowed CoFe-NC with improved O_(2)activation capacity and enhanced dehydrogenation activity for the oxidation-esterification of HMF.This work delineates the efficient strategy on the construction of N-doped carbon-supported non-noble catalyst,which might open a new avenue for developing highly efficient catalyst for FDMC production. | Weizhen Xie Binglin Chen Wenlong Jia Huai Liu Zheng Li Shuliang Yang Xing Tang Xianhai Zeng Yong Sun Xixian Ke Tianyuan Li Huayu Fang Lu Lin | 2022 | Journal of Energy Chemistry2022，，12： | 1 |
| 19 | Collecting back-reflected photons in photoacoustic microscopy显示文摘 | Zhang Hao F Wang Jing Wei Qing Liu Tan Jiao Shuliang Puliafito Carmen A | | 0，，： | 1 |
| 20 | An Investigation of In-Cylinder Tumbling Motion in a Four-Valve SI Engine显示文摘 | Li Yufeng Liu Shuliang Shi Shaoxi | 2001 | Proc Instn Mech Engrs2001，，： | 1 |
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