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| 1 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 2 | Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves implanting survival in diabetic wounds显示文摘Background:Gelatin methacryloyl(GelMA)hydrogels loaded with stem cells have proved to be an effective clinical treatment for wound healing.Advanced glycation end product(AGE),interacting with its particular receptor(AGER),gives rise to reactive oxygen species(ROS)and apoptosis.Curcumin(Cur)has excellent antioxidant activity and regulates intracellular ROS production and apoptosis.In this study,we developed a Cur-incorporated 3D-printed GelMA to insert into adiposederived stem cells(ADSCs)and applied it to diabetic wounds.Methods:GelMA hydrogels with Cur were fabricated and their in vitro effects on ADSCs were investigated.We used structural characterization,western blot,ROS and apoptosis assay to evaluate the antioxidant and anti-apoptotic activity,and assessed the wound healing effects to investigate the mechanism underlying regulation of apoptosis by Cur via the AGE/AGER/nuclear factor-κB(NF-κB)p65 pathway.Results:A 10%GelMA scaffold exhibited appropriate mechanical properties and biocompatibility for ADSCs.The circular mesh structure demonstrated printability of 10%GelMA and Cur-GelMA bioinks.The incorporation of Cur into the 10%GelMA hydrogel showed an inhibitory effect on AGEs/AGER/NF-κB p65-induced ROS generation and ADSC apoptosis.Furthermore,Cur-GelMA scaffold promoted cell survival and expedited in vivo diabetic wound healing.Conclusions:The incorporation of Cur improved the antioxidant activity of 3D-printed GelMA hydrogel and mitigated AGE/AGER/p65 axis-induced ROS and apoptosis in ADSCs.The effects of scaffolds on wound healing suggested that Cur/GelMA-ADSC hydrogel could be an effective biological material for accelerating wound healing. | Sizhan Xia Tingting Weng Ronghua Jin Min Yang Meirong Yu Wei Zhang Xingang Wang Chunmao Han | 2022 | Burns & Trauma2022，10，1： | 4 |
| 3 | Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering显示文摘 | Lie Ma Changyou Gao Zhengwei Mao Jie Zhou Jiangcong Shen Xueqing Hu Chunmao Han | | 0，，： | 1 |
| 4 | Epi demiology of chronic cutaneous wounds in China显示文摘 | Jiang Yufeng Huang Sha Fu Xiaobing Liu Hongwei Ran Xingwu Lu Shuliang Hu Dahai Li Qiang Zhang Hongwei Li Ying Wang Runxiu Xie Ting Cheng Biao Wang Ling {eng Liu Yi Ye Xiangbai Han Chunmao Chen Huade | 2011 | Wound Rep Reg2011，，19： | 1 |
| 5 | In?vitro and in?vivo biological performance of collagen-chitosan/silicone membrane bilayer dermal equivalent显示文摘 | Lie Ma Yanchao Shi Yixin Chen Haiguang Zhao Changyou Gao Chunmao Han | 2007 | Journal of Materials Science: Materials in Medicine2007，，11： | 1 |
| 6 | Preparation of a silk fibroin spongy wound dressing and its therapeutic efficiency in skin defects显示文摘 | MIN Sijia GAO Xin HAN Chunmao | 2012 | Journal of Biomaterials Science-Polymer Edition2012，23，14： | 1 |
| 7 | Thermal dehydration treatment and glutaraldehyde cross-linking to increase the biostability of collagen–chitosan porous scaffolds used as dermal equivalent显示文摘 | Lie Changyou Gao Zhengwei Mao Jiacong Shen Xueqing Hu Chunmao Han | 2003 | Journal of Biomaterials Science Polymer Edition2003，，8： | 1 |
| 8 | Applications of knitted mesh fabrication techniques to scaffolds for tissue engineering and regenerative medicine显示文摘 | Xingang Wang Chunmao Han Xinlei Hu Huafeng Sun Chuangang You Changyou Gao Yang Haiyang | 2011 | Journal of the Mechanical Behavior of Biomedical Materials2011，，7： | 1 |
| 9 | The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns显示文摘 | Lizhu Zhi Xinlei Hu Jun Xu Chaoheng Yu Huawei Shao Xuanliang Pan Hang Hu Chunmao Han | 2014 | American Journal of Emergency Medicine2014，，： | 1 |
| 10 | Thermal dehydration treatment and glutaraldehyde cross-linking to increase the biostability of collagen–chitosan porous scaffolds used as dermal equivalent显示文摘 | Lie Changyou Gao Zhengwei Mao Jiacong Shen Xueqing Hu Chunmao Han | 2003 | Journal of Biomaterials Science Polymer Edition2003，，8： | 1 |
| 11 | Progressive eschar-like wound and peripheral neurological dysfunction with severe inflammatory status:infection or unnatural immune response?显示文摘The immune system plays an essential role in maintaining health,protecting humans from pathogens and preventing the majority of tumors.Immunocompromised individuals are more likely to encounter infectious and neoplastic diseases.Excessive immune responses,which are also involved in the pathogenesis of many diseases,have drawn increasing attention in recent years.^([1])Blood and nervous system manifestations have been reported to be related to some specific viruses,and potential associations of these viruses with autoimmune diseases have come into the spotlight.Certain infections might arouse immune overreaction in susceptible individuals or even cytokine storms that are harmful to organs and tissues. | Hanghui Cen Pengqin Xu Hong Zou Jialiang Wang Xingang Wang Chunmao Han | 2023 | World Journal of Emergency Medicine2023，14，5： | 0 |
| 12 | Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization显示文摘Foreign body reactions induced by macrophages often cause delay or failure of wound healing in the application of tissue engineering scaffolds.This study explores the application of nanosilver(NAg)to reduce foreign body reactions during scaffold transplantation.An NAg hybrid collagen-chitosan scaffold(NAg-CCS)was prepared using the freeze-drying method.The NAg-CCS was implanted on the back of rats to evaluate the effects on foreign body reactions.Skin tissue samples were collected for histological and immunological evaluation at variable intervals.Miniature pigs were used to assess the effects of NAg on skin wound healing.The wounds were photographed,and tissue samples were collected for molecular biological analysis at different time points post-transplantation.NAg-CCS has a porous structure and the results showed that it could release NAg constantly for two weeks.The NAg-CCS group rarely developed a foreign body reaction,while the blank-CCS group showed granulomas or necrosis in the subcutaneous grafting experiment.Both matrix metalloproteinase-1(MMP-1)and tissue inhibitor of metalloproteinase-1(TIMP-1)were reduced significantly in the NAg-CCS group.The NAg-CCS group had higher interleukin(IL)-10 and lower IL-6 than the blank CCS group.In the wound healing study,M1 macrophage activation and inflammatory-related proteins inducible nitric oxide synthase(iNOS),IL-6,and interferon-(IFN-)were inhibited by NAg.In contrast,M2 macrophage activation and proinflammatory proteins(arginase-1),major histocompatibility complex-II(MHC-II),and found in inflammatory zone-1(FIZZ-1)were promoted,and this was responsible for suppressing the foreign body responses and accelerating wound healing.In conclusion,dermal scaffolds containing NAg suppressed the foreign body reaction by regulating macrophages and the expression of inflammatory cytokines,thereby promoting wound healing. | Chuangang YOU Zhikang ZHU Shuangshuang WANG Xingang WANG Chunmao HAN Huawei SHAO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
| 13 | Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing显示文摘Dermal substitutes provide a template for dermal regeneration and reconstruction.They constitutes an ideal clinical treatment for deep skin defects.However,rapid vascularization remains as a major hurdle to the development and application of dermal substitutes.Several bioactive factors play an important regulatory role in the process of angiogenesis and an understanding of the mechanism of achieving their effective delivery and sustained function is vital.Nanomaterials have great potential for tissue engineering.Effective delivery of bioactive factors(including growth factors,peptides and nucleic acids)by nanomaterials is of increasing research interest.This paper discusses the process of dermal substitute angiogenesis and the roles of related bioactive factors in this process.The application of nanomaterials for the delivery of bioactive factors to enhance angiogenesis and accelerate wound healing is also reviewed.We focus on new systems and approaches for delivering bioactive factors for enhancing angiogenesis in dermal substitutes. | Tingting Weng Jialiang Wang Min Yang Wei Zhang Pan Wu Chuangang You Chunmao Han Xingang Wang | 2022 | Burns & Trauma2022，10，1： | 0 |
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