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| 1 | Seafloor geodetic network establishment and key technologies显示文摘Seafloor geodetic network construction involves the development of geodetic station shelter, network configuration design, location selection and layout, surveying strategy, observation model establishment and optimization, data processing strategy and so on. This paper tries to present main technological problems involved in the seafloor geodetic network construction, and seek the technically feasible solutions. Basic conceptions of developing seafloor geodetic station shelters for shallow sea and deep-sea are described respectively. The overall criteria of seafloor geodetic network construction for submarine navigation and those of network design for crustal motion monitoring are both proposed. In order to enhance application performances of the seafloor geodetic network, the seafloor network configuration should prefer a symmetrical network structure. The sea surface tracking line measurements for determining the seafloor geodetic station position should also adopt an approximately symmetrical configuration, and we recommend circle tracking line observations combined with cross-shaped line(or double cross-shape line) observations for the seafloor positioning mode. As to the offset correction between the Global Navigation Satellite System antenna phase center and the acoustic transducer, it is recommended to combine the calibration through external measurements and model parameter estimation. Besides, it is suggested to correct the sound speed error with a combination of observation value correction and parameterized model correction, and to mainly use the model correction to reduce the influence of acoustic ray error on the seafloor positioning. Following the proposed basic designs, experiments are performed in shallow sea area and deep-sea area respectively. Based on the developed seafloor geodetic shelter and sufficient verification in the shallow sea experiment, a long-term seafloor geodetic station in the deep-sea area of 3000 m depth was established for the first time, and the preliminary positioning result shows that the internal precision of this station is better than 5 cm. | Yuanxi YANG Yanxiong LIU Dajun SUN Tianhe XU Shuqiang XUE Yunfeng HAN Anmin ZENG | 2020 | Science China Earth Sciences2020，63，8： | 11 |
| 2 | Novel fluorescent probes of 10-hydroxyevodiamine:autophagy and apoptosis-inducing anticancer mechanisms显示文摘Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms. | Shuqiang Chen Guoqiang Dong Shanchao Wu Na Liu Wannian Zhang Chunquan Shengn | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 9 |
| 3 | Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration显示文摘The SoxC transcription factors(Sox4,Sox11,and Sox12) play important roles in the development of the vertebrate eye and retina. However,their expression and function during retinal and optic nerve regeneration remain elusive. In this study,we investigated the expression and possible functions of the SoxC genes after retinal and optic nerve injury in adult zebrafish. We found that among the five SoxC members,Sox11b was strongly induced in BrdU-positive cells in the inner nuclear layer(INL) after retinal injury,and morpholino-mediated Sox11b-knockdown significantly reduced the number of proliferating cells in the INL at 4 days post-injury. After optic nerve lesion,both Sox11a and Sox11b were strongly expressed in retinal ganglion cells(RGCs),and knockdown of both Sox11a and Sox11b inhibited RGC axon regrowth in retinal explants. Our study thus uncovered a novel expression pattern of SoxC family genes after retinal and optic nerve injury,and suggests that they have important functions during retinal and optic nerve regeneration. | Zhaoxia Mu Shuqiang Zhang Chunjiao He Haitao Hou Dong Liu Nan Hu Hui Xu | 2017 | Neuroscience Bulletin2017，33，1： | 9 |
| 4 | A Novel Parallel Scheme for Fast Similarity Search in Large Time Series显示文摘The similarity search is one of the fundamental components in time series data mining,e.g.clustering,classification,association rules mining.Many methods have been proposed to measure the similarity between time series,including Euclidean distance,Manhattan distance,and dynamic time warping(DTW).In contrast,DTW has been suggested to allow more robust similarity measure and be able to find the optimal alignment in time series.However,due to its quadratic time and space complexity,DTW is not suitable for large time series datasets.Many improving algorithms have been proposed for DTW search in large databases,such as approximate search or exact indexed search.Unlike the previous modified algorithm,this paper presents a novel parallel scheme for fast similarity search based on DTW,which is called MRDTW(MapRedcuebased DTW).The experimental results show that our approach not only retained the original accuracy as DTW,but also greatly improved the efficiency of similarity measure in large time series. | YIN Hong YANG Shuqiang MA Shaodong LIU Fei CHEN Zhikun | 2015 | China Communications2015，12，2： | 6 |
| 5 | Dynamic blood single-cell immune responses in patients with COVID-19显示文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19. | Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 4 |
| 6 | Musk secretion in muskrats(Ondatra zibethicus L.):association with lipid and cholesterol metabolism-related pathways显示文摘Male muskrats(Ondatra zibethicus L.)secrete musk from their scent glands during musk secretion season.Musk plays an important role as a communication pheromone during the breeding season.In this study,gas chromatography–mass spectrometry(GC–MS)was used to analyze the main components of musk.The GC–MS results after methyl esterification showed that 71.55%of the musk is composed of fatty acids.The other components of muskrat musk include cholesterol(9.31%)and other organics.Transcriptome comparison between musk secretion and non-secretion seasons showed significant changes in the scent glands for 53 genes involved in fatty acid and cholesterol synthesis and metabolism regulatory pathways,which include fatty acid biosynthesis,elongation,and metabolism;steroid biosynthesis;steroid hormone biosynthesis pathways.A reverse transcription–polymerase chain reaction analysis confirmed these detected changes.Overall,our results indicated that lipid synthesis and metabolism play important roles in musk compound synthesis by providing energy for musk production,and the produced musk provides a mechanism for male muskrats to communicate with females during the breeding season. | TIANXIANG ZHANG MEISHAN ZHANG MINGHUI SHI WEIJIANG JIN SHUMIAO ZHANG MENGYUAN FAN YIMENG LI YUPING MENG XUELIN TIAN SHUQIANG LIU DEFU HU | 2021 | BIOCELL2021，45，2： | 2 |
| 7 | Analytical optimization on GNSS buoy array for underwater positioning显示文摘Global navigation satellite system(GNSS)/acoustic positioning precision is determined by the positioning geometry and the ranging precision;thus optimizing GNSS buoys array is meaningful to improve the positioning accuracy and reliability.An analytical method is proposed for optimizing the GNSS buoys array with regard to the cutoff angle constraints for underwater acoustic observations.For the practical limitation of coplanarity of GNSS buoys and the cutoff angle,an algorithm is proposed to analytically minimize the position dilution of precision(PDOP).The proposed method is validated to give complete solutions of PDOP minimization with five GNSS buoys.At last,in order to search a best configuration among the PDOP solution set,we propose a search algorithm to get the solution with the smallest geometric dilution of precision(GDOP).It indicates that within a given region,the GDOP minimization at the center of a region is equivalent to the PDOP mean minimization over the region.The relation between the positioning accuracy and the positioning geometry with five known points is illustrated in an experiment performed in South China Sea. | Ke Qi Guoqing Qu Shuqiang Xue Tianhe Xu Xiaoqing Su Yixu Liu Jun Wan | 2019 | Acta Oceanologica Sinica2019，38，7： | 2 |
| 8 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 9 | Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells显示文摘 | Liu Shuqiang Wang Dan Zhang Junwen | 2012 | Toxicology in Vitro2012，26，6： | 1 |
| 10 | Antioxidant high-conductivity copper paste for low-cost flexible printed electronics显示文摘The flexible printed electronics(e.g.,wearable devices,roll-up displays,heating circuits,radio frequency identification(RFID)tags)calls for high-conductivity and low-cost materials,particularly for copper pastes.It is still a big challenge to develop reliable copper pastes for both antioxidant and high-conductivity flexible printed films and lines.In this work,an antioxidant copper paste was achieved using copper microflakes with surface passivation by formate ions and thiols,with high conductivity of 13400 S cm^(−1)(the same order of magnitude of silver pastes,1.8-2.5×10^(4) S cm^(−1)).The universal applications of as-prepared copper paste in flexible printed electronics(e.g.,electromagnetic interference(EMI)shielding films,anti-fog films,and RFID tags)via screen printing and curing at 170℃ under ambient atmosphere were demonstrated.The as-printed electronics showed high performance in flexibility,stability,and reliability.This work shows the great potential of anti-oxidation copper pastes in low-cost flexible printed electronics for commercial usage. | Shuqing Hong Chimin Liu Shuqiang Hao Wenxing Fu Jian Peng Binghui Wu Nanfeng Zheng | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 11 | Toxic effects of citrinin on the male reproductive system in mice显示文摘 | Han Qingqing Yu Linbo Guo Yunqian Liu Shuqiang | 2010 | Experimental and Toxicologic Pathology2010，，： | 1 |
| 12 | Microsatellite and mitochondrial DNA assessment of the genetic diversity of captive Saiga antelopes(Saiga tatarica) in China显示文摘To estimate the genetic diversity of the only captive Saiga antelope(Saiga tatarica) population in China,40 umbilical cord samples were collected and mitochondrial(control region) and nuclear(microsatellite) variabilities were assessed.Both of the markers revealed low genetic variability(or high genetic homogeneity) within the population.The microsatellites yielded monitoring ranges of 2-6 alleles.The observed heterozygosities ranged from 0.28 to 0.83,and the expected heterozygosities were between 0.27 and 0.71.The Shannon information index(Shannon I) and Polymorphic Information Content(PIC) presented overall means of 0.87 and 0.43,respectively.The gene diversity was 0.49.We found only two haplotypes in the population,and the haplotype and nucleotide diversities were 39.1% and 1.13%,respectively.Founder events,bottlenecks and inbreeding have contributed to the low genetic variation observed in this population.Our findings revealed the extent of genetic diversity maintained in the present population and the urgency of implementing a protection plan,introducing animals from other populations to enhance saiga's genetic variation. | ZHAO ShaSha XU ChaoQun LIU Gang LIU ShuQiang ZHAO ChongXue CUI YaXiong HU DeFu | 2013 | Chinese Science Bulletin2013，58，17： | 1 |
| 13 | Effect of Far-Infrared Assisted Heat Pump Drying on Water Status and Moisture Sorption Isotherm of Squid (Illex illecebrosus) Fillets显示文摘 | Yun Deng Juan Wu Shuqiang Su Zhidong Liu Lang Ren Yingli Zhang | 2011 | Drying Technology2011，，13： | 1 |
| 14 | Fi broblastspecific expression of AC6 enhancesβ-adrenergic and prostacyelin signaling and blunts bleomycin-induced pulmona- ry fibrosi显示文摘 | XIAOQIU LIU FENGYING LI SHUQIANG SUN | 2010 | Am J Physiol Lung Cell Mol Physiol2010，298，6： | 1 |
| 15 | Effect of Far-Infrared Assisted Heat Pump Drying on Water Status and Moisture Sorption Isotherm of Squid (Illex illecebrosus) Fillets显示文摘 | Yun Deng Juan Wu Shuqiang Su Zhidong Liu Lang Ren Yingli Zhang | 2011 | Drying Technology2011，，13： | 1 |
| 16 | Study on the construction and operation for management system of municipal domestic wastes显示文摘In recent years, the quantity of our country’s municipal domestic wastes increase rapidly, but the waste disposal still has problems, such as the simple way of processing, wasting the resources, the serious environmental pollution and so on. By holding waste minimization as the center, the developed countries have formed perfect waste management system. Based on analyzing the status quo and problems of processing in our country, on the principle of benefit, scale, waste minimization, reclamation and hazard-free treatment, according to the recycling model of processing, the article has constructed our country’s domestic wastes management system, proposed the measures of promoting the operation of system. It has realized the transformation of waste management system from terminal disposal to source reduction, achieved the goals, including domestic wastes categorizing and reclaiming, industrialization and non-pollution processing, and finally brought sustainable development for resources, environment, economy and society. | Liu Wei Wang Shuqiang Chen Jingxin | 2006 | Ecological Economy2006，2，2： | 0 |
| 17 | Genome-wide alternative splicing variation and its potential contribution to maize immature-ear heterosis显示文摘Heterosis is a well-known phenomenon widely applied in agriculture.Recent studies have suggested that differential gene and protein expression between hybrids and their parents play important roles in heterosis.Alternative splicing(AS)is an essential posttranscriptional mechanism that can greatly affect the transcriptome and proteome diversity in plants.However,genome-wide AS divergence in hybrids compared to their parents and its potential contribution to heterosis have not been comprehensively investigated.We report the direct profiling of the AS landscape using RNA sequencing data from immature ears of the maize hybrid ZD808 and its parents NG5 and CL11.Our results revealed a large number of significant differential AS(DAS)events in ZD808 relative to its parents,which can be further classified into parental-dominant and novel DAS patterns.Parental-dominant,especially NG5-dominant,events were prevalent in the hybrid,accounting for 42%of all analyzed DAS events.Functional enrichment analysis revealed that the NG5-dominant AS events were involved mainly in regulating the expression of genes associated with carbon/nitrogen metabolism and cell division processes and contributed greatly to maize ear heterosis.Among ZD808,CL11,and NG5,32.5%of DAS contained or lacked binding sites of at least one annotated maize microRNA(miRNA)and may be involved in miRNA-mediated posttranscriptional regulation.Cis regulation was the predominant contributor to AS variation and participates in many important biological processes associated with immature ear development.This study provides a comprehensive view of genome-wide alternative splicing variation in a maize hybrid. | Xiaojiao Hu Hongwu Wang Kun Li Xiaogang Liu Zhifang Liu Yujin Wu Shuqiang Li Changling Huang | 2021 | The Crop Journal2021，9，2： | 0 |
| 18 | Characterization of intestinal microbiota and fecal cortisol,T3,and IgA in forest musk deer(Moschus berezovskii)from birth to weaning显示文摘Analysis of the intestinal microbiota and physiological parameters in mammalian infancy can reveal health status.In this study,we used a combination of molecular and immunochemical approaches to assess fecal microbiota as well as Cortisol(Cor),Triiodothyronine(T3),and immunoglobulin A(IgA)levels of young forest musk deer(FMD),from birth to one month after weaning(7 days of age–110 days of age).During development as the diet of FMD changes from consuming milk to eating plants,the richness and diversity of intestinal microbiota of young FMD increased significantly.Cor levels remained unchanged throughout early development while significantly increased after weaning,T3 and IgA initially were derived from milk during lactation,significantly decreased after weaning.Correlation network analysis showed that the community of food-oriented microbes were highly structured and that many genera were correlated.Overall,this study provides scientific insights into effective management strategies for the protection of FMD population. | Yimeng LI Tianxiang ZHANG Minghui SHI Baofeng ZHANG Xin HU Shanghua XU Jianhong DING Shuqiang LIU Defu HU Daniel RUBENSTEIN | 2021 | Integrative Zoology2021，16，3： | 0 |
| 19 | Five new genera of the subfamily Psilodercinae(Araneae: Ochyroceratidae) from Southeast Asia显示文摘Five new genera of the spider family Ochyroceratidae with remarkable palpal and epigynal characters are described: Luzonacera Li & Li, gen. nov., Qiongocera Li & Li, gen. nov., Relictocera Li & Li, gen. nov., Sinoderces Li & Li, gen. nov., and Thaiderces Li & Li, gen. nov. Six new species are described based on specimens collected in China, Philippines, Vietnam, and Thailand: Luzonacera chang Li & Li, sp. nov., Luzonacera duan Li & Li, sp. nov., Qiongocera hongjunensis Li & Li, sp. nov., Relictocera qiyi Li & Li, sp. nov., Sinoderces nawanensis Li & Li, sp. nov., and Thaiderces jian Li & Li, sp. nov. In addition, two Psiloderces species are transferred to other genera: Sinoderces exilis(Wang & Li, 2013) comb. nov. and Thaiderces vulgaris(Deeleman-Reinhold, 1995) comb. nov. All type specimens are deposited in the Institute of Zoology, Chinese Academy of Sciences(IZCAS) in Beijing. | Chang Liu Fengyuan Li Shuqiang Li Guo Zheng | 2017 | Zoological Systematics2017，42，4： | 0 |
| 20 | Roles and Molecular Mechanisms of Biomarkers in Hepatocellular Carcinoma with Microvascular Invasion: A Review显示文摘Hepatocellular carcinoma(HCC)being a leading cause of cancer-related death,has high associated mortality and recurrence rates.It has been of great necessity and urgency to find effective HCC diagnosis and treatment measures.Studies have shown that microvascular invasion(MVI)is an independent risk factor for poor prognosis after hepatectomy.The abnormal expression of biomacromolecules such as circ-RNAs,lncRNAs,STIP1,and PD-L1 in HCC patients is strongly correlated with MVI.Deregulation of several markers mentioned in this review affects the proliferation,invasion,metastasis,EMT,and anti-apoptotic processes of HCC cells through multiple complex mechanisms.Therefore,these biomarkers may have an important clinical role and serve as promising interventional targets for HCC.In this review,we provide a comprehensive overview on the functions and regulatory mechanisms of MVI-related biomarkers in HCC. | Xudong Zhao Yudan Wang Haoming Xia Shuqiang Liu Ziyue Huang Risheng He Liang Yu Nanfeng Meng Hang Wang Junqi You Jinglin Li Judy Wai Ping Yam Yi Xu Yunfu Cui | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 0 |
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