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| 1 | Manipulating the intramolecular motion of AIEgens for boosted biomedical applications显示文摘The research in the biomedical applications of aggregation? induced emission luminogens (AIEgens) has attracted increasing interest in recent years, as AIEgens have been widely accepted as promising materials for constructing new generation of phototheranostic agents [1-5]. Different from conventional organic dyes, the AIEgens often have threedimensional (3D) molecular structure and contain a number of intramolecular motion units [6-8]. In the aggregates, the 3D molecular structure results in significantly reduced intermolecular interaction such as π-π stacking as compared to planar structure. | Hanlin Ou Shuxin Dai Ruihua Liu Dan Ding | 2019 | Science China Chemistry2019，62，8： | 3 |
| 2 | The uptake and detoxification of antimony by plants: A review显示文摘 | Renwei Feng Chaoyang Wei Shuxin Tu Yongzhen Ding Ruigang Wang Junkang Guo | 2013 | Environmental and Experimental Botany2013，，： | 1 |
| 3 | Dynamic grouping of heterogeneous agents for exploration and strike missions显示文摘The ever-changing environment and complex combat missions create new demands for the formation of mission groups of unmanned combat agents.This study aims to address the problem of dynamic construction of mission groups under new requirements.Agents are heterogeneous,and a group formation method must dynamically form new groups in circumstances where missions are constantly being explored.In our method,a group formation strategy that combines heuristic rules and response threshold models is proposed to dynamically adjust the members of the mission group and adapt to the needs of new missions.The degree of matching between the mission requirements and the group’s capabilities,and the communication cost of group formation are used as indicators to evaluate the quality of the group.The response threshold method and the ant colony algorithm are selected as the comparison algorithms in the simulations.The results show that the grouping scheme obtained by the proposed method is superior to those of the comparison methods. | Chen CHEN Xiaochen WU Jie CHEN Panos M.PARDALOS Shuxin DING | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，1： | 1 |
| 4 | The zinc finger transcription factor,KLF2,protects against COVID-19 associated endothelial dysfunction显示文摘Coronavirus disease 2019(COVID-19)is regarded as an endothelial disease(endothelialitis)with its patho-mechanism being incompletely understood.Emerging evidence has demonstrated that endothelial dysfunction precipitates COVID-19 and its accompanying multi-organ injuries.Thus,pharmacotherapies targeting endothelial dysfunction have potential to ameliorate COVID-19 and its cardiovascular complications.The objective of the present study is to evaluate whether kruppel-like factor 2(KLF2),a master regulator of vascular homeostasis,represents a therapeutic target for C0VID-19-induced endothelial dysfunction.Here,we demonstrate that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules,ICAM1 and VCAM1.IL-1β and TNF-α;two cytokines elevated in cytokine release syndrome in COVID-19 patients,decreased KLF2 gene expression.Pharmacologic(atorvastatin and tannic acid)and genetic(adenoviral overexpression)approaches to augment KLF2 levels attenuated COVID-19-serum-induced increase in endothelial inflammation and monocyte adhesion.Next-generation RNA-sequencing data showed that atorvastatin treatment leads to a cardiovascular protective transcriptome associated with improved endothelial function(vasodilation,antiinflammation,antioxidant status,anti-thrombosis/-coagulation,anti-fibrosis,and reduced angiogenesis).Finally,knockdown of KLF2 partially reversed the ameliorative effect of atorvastatin on COVID-19-serum-induced endothelial inflammation and monocyte adhesion.Collectively,the present study implicates loss of KLF2 as an important molecular event in the development of COVID-19-induced vascular disease and suggests that efforts to augment KLF2 levels may be therapeutically beneficial. | Suowen Xu Yujie Liu Yu Ding Sihui Luo Xueying Zheng Xiumei Wu Zhenghong Liu Iqra Ilyas Suyu Chen Shuxin Han Peter J.Little Mukesh K.Jain Jianping Weng | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 5 | A Dual Role of Se on Cd Toxicity: Evidences from the Uptake of Cd and Some Essential Elements and the Growth Responses in Paddy Rice显示文摘 | Renwei Feng Chaoyang Wei Shuxin Tu Yongzhen Ding Zhengguo Song | 2013 | Biological Trace Element Research2013，，1： | 1 |
| 6 | Enhanced Beta2-band Oscillations Denote Auditory Hallucination in Schizophrenia Patients and a Monkey Model of Psychosis显示文摘An electroencephalographic(EEG)signature of auditory hallucinations(AHs)is important for facilitating the diagnosis and treatment of AHs in schizophrenia.We recorded EEG from 25 schizophrenia patients with recurrent AHs.During the period of AHs,EEG recordings exhibited significantly elevated beta2-band power in the temporal region,as compared to those recorded in the absence of AHs or during stimulation with verbal sounds.We further generated methamphetamine-treated rhesus monkeys exhibiting psychosis-like behaviors,including repetitive sudden searching actions in the absence of external intrusion,suggesting the occurrence of AHs.Epidural EEG beta2-band power in the temporal region of these monkeys was enhanced immediately after methamphetamine treatment and positively correlated with the frequency of sudden searching actions.Thus,the enhancement of temporal beta2-band oscillations represents a signature for AHs in both patients and a monkey model of psychosis,and this monkey model can be used for developing closed-loop neuromodulation approaches for the treatment of refractory AHs in schizophrenia. | Shuo Ma Tianzhen Chen Wenjun Jia Jie Liu Shihan Ding Puzhe Li Hong Gan Dapeng Zhang Shuxin Shao Mu-Ming Poo Min Zhao Bomin Sun Jian Jiang | 2024 | Neuroscience Bulletin2024，40，3： | 0 |
| 7 | Key technologies and applications of intelligent dispatching command for high-speed railway in China显示文摘Purpose–The intelligent Central Traffic Control(CTC)system plays a vital role in establishing an intelligent high-speed railway(HSR)system.As the core of HSR transportation command,the intelligent CTC system is a new HSR dispatching command system that integrates the widely used CTC in China with the practical service requirements of intelligent dispatching.This paper aims to propose key technologies and applications for intelligent dispatching command in HSR in China.Design/methodology/approach–This paper first briefly introduces the functions and configuration of the intelligent CTC system.Some new servers,terminals and interfaces are introduced,which are plan adjustment server/terminal,interface for automatic train operation(ATO),interface for Dynamic Monitoring System of Train Control Equipment(DMS),interface for Power Supervisory Control and Data Acquisition(PSCADA),interface for Disaster Monitoring,etc.Findings–The key technologies applied in the intelligent CTC system include automatic adjustment of train operation plans,safety control of train routes and commands,traffic information data platform,integrated simulation of traffic dispatching and ATO function.These technologies have been applied in the Beijing-Zhangjiakou HSR,which commenced operations at the end of 2019.Implementing these key intelligent functions has improved the train dispatching command capacity,ensured the safe operation of intelligent HSR,reduced the labor intensity of dispatching operators and enhanced the intelligence level of China’s dispatching system.Originality/value–This paper provides further challenges and research directions for the intelligent dispatching command of HSR.To achieve the objectives,new measures need to be conducted,including the development of advanced technologies for intelligent dispatching command,coping with new requirements with the development of China’s railway signaling system,the integration of traffic dispatching and train control and the application of AI and data-driven modeling and methods. | Shuxin Ding Tao Zhang Kai Sheng Yuanyuan Chen Zhiming Yuan | 2023 | Railway Sciences2023，2，3： | 0 |
| 8 | A train timetable rescheduling approach based on multi-train tracking optimization of high-speed railways显示文摘Purpose–This paper aims to propose a train timetable rescheduling(TTR)approach from the perspective of multi-train tracking optimization based on the mutual spatiotemporal information in the high-speed railway signaling system.Design/methodology/approach–Firstly,a single-train trajectory optimization(STTO)model is constructed based on train dynamics and operating conditions.The train kinematics parameters,including acceleration,speed and time at each position,are calculated to predict the arrival times in the train timetable.A STTO algorithm is developed to optimize a single-train time-efficient driving strategy.Then,a TTR approach based on multi-train tracking optimization(TTR-MTTO)is proposed with mutual information.The constraints of temporary speed restriction(TSR)and end of authority are decoupled to calculate the tracking trajectory of the backward tracking train.The multi-train trajectories at each position are optimized to generate a timeefficient train timetable.Findings–The numerical experiment is performed on the Beijing-Tianjin high-speed railway line and CR400AF.The STTO algorithm predicts the train’s planned arrival time to calculate the total train delay(TTD).As for the TSR scenario,the proposed TTR-MTTO can reduce TTD by 60.60%compared with the traditional TTR approach with dispatchers’experience.Moreover,TTR-MTTO can optimize a time-efficient train timetable to help dispatchers reschedule trains more reasonably.Originality/value–With the cooperative relationship and mutual information between train rescheduling and control,the proposed TTR-MTTO approach can automatically generate a time-efficient train timetable to reduce the total train delay and the work intensity of dispatchers. | Rongsheng Wang Tao Zhang Zhiming Yuan Shuxin Ding Qi Zhang | 2023 | Railway Sciences2023，2，3： | 0 |
| 9 | A multi-mode multi-skill project scheduling reformulation for reconnaissance mission planning显示文摘Dear editor,Planning multi-agents scheduling to conduct reconnaissance missions is the core of reconnaissance decision support system.A reconnaissance mission comprises several tasks and a network representing precedence relationships between them,where each task represents an area in which the agents perform information gathering. | Junqi CAI Zhihong PENG Sijian LIAO Shuxin DING | 2022 | Science China(Information Sciences)2022，65，6： | 0 |
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