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| 1 | Prediction of permafrost distribution on the Qinghai-Tibet Plateau in the next 50 and 100 years显示文摘Intergovernmental Panel on Climate Change (IPCC) in 2001 reported that the Earth air temperature would rise by 1.4-5.8℃ and 2.5℃ on average by the year 2100. China re-gional climate model results also showed that the air temperature on the Qinghai-Tibet Plateau (QTP) would increase by 2.2-2.6℃ in the next 50 years. A numerical permafrost model was developed to predict the changes of permafrost distribution on the QTP over the next 50 and 100 years under the two climatic warming scenarios, i.e. 0.02℃/a, the lower value of IPCC’s estima-tion, and 0.052℃/a, the higher value predicted by Qin et al. Simulation results show that ( i ) in the case of 0.02℃/a air-temperature rise, permafrost area on the QTP will shrink about 8.8% in the next 50 years, and high temperature permafrost with mean annual ground temperature (MAGT) higher than ?0.11℃ may turn into seasonal frozen soils. In the next 100 years, perma-frost with MAGT higher than ?0.5℃ will disappear and the permafrost area will shrink up to 13.4%. (ii) In the case of 0.052℃/a air-temperature rise, permafrost area on the QTP will reduce about 13.5% after 50 years. More remarkable degradation will take place after 100 years, and permafrost area will reduce about 46%. Permafrost with MAGT higher than ?2℃ will turn into seasonal frozen soils and even unfrozen soils. | NAN Zhuotong LI Shuxun CHENG Guodong | 2005 | Science China Earth Sciences2005，48，6： | 40 |
| 2 | Thawing and freezing processes of active layer in Wudaoliang region of Tibetan Plateau显示文摘The interaction between permafrost and atmosphere is accomplished through transfer of heat and moisture in the overlay active layer. Thus, the research on the thermal and hydrodynamics of active layer during the thawing and freezing processes was considered a key to revealing the heat and moisture exchanges between permafrost and atmosphere. The monitoring and research on active layer were conducted because permafrost occupies about two thirds of the total area of the Tibetan Plateau. Based on the analysis of the ground temperature data and soil moisture data of monitoring near the Wudaoliang region of the Tibetan Plateau, the thawing and freezing processes of active layer were divided into four stages, i.e. summer thawing stage (ST), autumn freezing stage (AF), winter cooling stage (WC) and spring warming stage (SW). Coupled heat and water flow is much more complicated in ST and AF, and more amount of water is migrating in these two stages. Heat is transferred mainly via conductive heat flow in the | Lin Zhao Guodong Cheng Shuxun Li Xinmin Zhao Shaoling Wang | 2000 | Chinese Science Bulletin2000，45，23： | 31 |
| 3 | One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients显示文摘The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI. | Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan Zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu Zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang Jianwu Dai | 2016 | Science China(Life Sciences)2016，59，7： | 18 |
| 4 | Permafrost on the Qinghai-tibet Plateau under a Changing Climate显示文摘Permafrost on the Qinghai-Tibet Plateau (QTP) has experienced major shifts during theQuaternary. During the past 40 years, permafrost has been degrading extensively, due to climaticwarming. Simulations suggest significant degradation of permafrost both in extent and inthickness within the next 50-100 years. Freshwater wetlands on the QTP can contributesignificantly to the global budgets in the atmospheric greenhouse gases. Permafrost degradationon the QTP has caused destabilization of foundations of engineering structures, deterioration ofgrasslands and meadows, and weakening of permafrost control on water resources. | JIN Huijun CHENG Guodong LI Xin LI Shuxun Observatory and Research Station of the Qinghai-Tibet Plateau. State Key Laboratory of Frozen Soil Engineering, LIGG, CAS, Lanzhou 730000 CHINA. | 1999 | Chinese Science Bulletin1999，44，S1： | 14 |
| 5 | Optimum location of surface wells for remote pressure relief coalbed methane drainage in mining areas显示文摘Based on engineering tests in the Huainan coal mining area,we studied alternative well location to improve the performance of surface wells for remote pressure relief of coalbed methane in mining areas.The key factors,affecting location and well gas production were analyzed by simulation tests for similar material.The exploitation results indicate that wells located in various positions on panels could achieve relatively better gas production in regions with thin Cenozoic layers,low mining heights and slow rate of longwall advancement,but their periods of gas production lasted less than 230 days,as opposed to wells in regions with thick Cenozoic layers,greater mining heights and fast rates of longwall advancement.Wells near panel margins achieved relatively better gas production and lasted longer than centerline wells.The rules of development of mining fractures in strata over panels control gas production of surface wells.Mining fractures located in areas determined by lines of compaction and the effect of mining are well developed and can be maintained for long periods of time.Placing the well at the end of panels and on the updip return airway side of panels,determined by lines of compaction and the effect of mining,would result in surface wells for remote pressure relief CBM obtaining their longest gas production periods and highest cumulative gas production. | HUANG, Huazhou SANG, Shuxun FANG, Liangcai LI, Guojun XU, Hongjie REN, Bo | 2010 | Mining Science and Technology2010，20，2： | 9 |
| 6 | A novel cellulose hydrogel prepared from its ionic liquid solution显示文摘A novel cellulose hydrogel is prepared by regenerating cellulose from its ionic liquid solution. The transparency cellulose hydrogel presents a good chemical stability and an acceptable mechanical property. This non-toxic cellulose hydrogel should be biocompatible and may be useful in the future as a biomaterial. | LI Lu LIN ZhangBi YANG Xiao WAN ZhenZhen CUI ShuXun | 2009 | Chinese Science Bulletin2009，54，9： | 6 |
| 7 | Changes and spatial patterns of the differences between ground and air temperature over the Qinghai-Xizang Plateau显示文摘地面土壤和空气温度( Ts-Ta )之间的差别被从 1960~2000 在 Qinghai-Xizang (西藏)高原上使用地面的数据和 99 个车站的空气温度学习,并且它的空间分发和时间变化趋势被主要部件分析和力量诊断了光谱分析方法。结果证明价值(Ts-Ta ) 在 12 月是在 6 月和最小的最大值。开始的三装载特徵向量,它反映主要空间地异常的结构( Ts-Ta )在 Qinghai-Xizang 高原上,包含矛盾的变化模式在之间西北并且东南的区域,海水平举起的模式反应和地理,并且永久冻土的分发的模式反应。有包括有最小的价值的单调的增加或减少的趋势,基本稳定性模式和抛物线模式的模式的时间进化的四个模式。(Ts-Ta ) 有一个周期的变化大约 2 年。根据第三的空间分发装载特徵向量(Ts-Ta ) 在在冷季节,永久冻土反应区域和季节的冻结的地面的 Qinghai-Xizang 高原上,反应区域被识别。 | ZHANG Wengang LI Shuxun WU Tonghua PANG Qiangqiang | 2007 | Journal of Geographical Sciences2007，17，1： | 5 |
| 8 | The Impact of Climate Warming on Permafrost and Qinghai-Tibet Railway显示文摘Global warming is an inarguable fact. Permafrost is experiencing a change due to climate warming in Qinghai-Tibet Plateau, such as the decreasing of permafrost table, the rising of permafrost temperature, etc. On the basis of analysing the permafrost change under the climate change and engineering action, the thermal regime and spatial distribution of permafrost are predicted for air temperature rising 1℃ and 2.6℃ after 50 years in this paper. The results show that climate change results in the larger change for the thermal regime and spatial distribution of permafrost. Permafrost change will produce the great effect on the Qinghai-Tibet Railway engineering, not only resulting in the decreasing of permafrost table beneath the roadbed, but also resulting in thawing settlement due to the thawing of ground ice near permafrost table. The idea of cooling roadbed and actively protecting permafrost for the Qinghai-Tibet Railway engineering could adjust and control the permafrost thermal state, some better methods are provided to ensure the engineering stability in the areas of warm permafrost and high ice content. | Wu Qingbai Li Shuxun Liu Yongzhi | 2006 | 工程科学(英文版)2006，4，2： | 5 |
| 9 | A modified HLA-A^(*)0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses显示文摘We previously identified human phosphatidylethanolamine-binding protein 4(hPEBP4)as an antiapoptotic protein with increased expression levels in breast,ovarian and prostate cancer cells,but low expression levels in normal tissues,which makes hPEBP4 an attractive target for immunotherapy.Here,we developed hPEBP4-derived immunogenic peptides for inducing antigen-specific cytotoxic T lymphocytes(CTLs)targeting breast cancer.A panel of hPEBP4-derived peptides predicted by peptide-MHC-binding algorithms was evaluated to characterize their HLAA2.1 affinity and immunogenicity.We identified a novel immunogenic peptide,P40–48(TLFCQGLEV),that was capable of eliciting specific CTL responses in HLA-A2.1/K^(b) transgenic mice,as well as in peripheral blood lymphocytes from breast cancer patients.Furthermore,amino-acid substitutions in the P40–48 sequence improved its immunogenicity against hPEBP4,a self-antigen,thus circumventing tolerance.We designed peptide analogs by preferred auxiliary HLA-A^(*)0201 anchor residue replacement,which induced CTLs that were crossreactive to the native peptide.Several analogs were able to stably bind to HLA-A^(*)0201 and elicit specific CTL responses better than the native sequence.Importantly,adoptive transfer of CTLs induced by vaccination with two analogs more effectively inhibited tumor growth than the native peptide.These data indicate that peptide analogs with high immunogenicity represent promising candidates for peptide-mediated therapeutic cancer vaccines. | Weihong Sun Junyi Shi Jian Wu Junchu Zhang Huabiao Chen Yuanyuan Li Shuxun Liu Yanfeng Wu Zhigang Tian Xuetao Cao Nan Li | 2018 | Cellular & Molecular Immunology2018，15，8： | 4 |
| 10 | Low-Pressure Metamorphism of Granulite Facies in an Early Proterozoic Orogenic Event in Central Inner Mongolia显示文摘According to the kinds of feldspar and rock associations in the Ai-rich gneisses, the low-pressure metamorphic crust of the Early Proterozoic granulite facies in central Inner Mongolia can be divided into southern and northern belts which are composed of six rock associations. They represent the relevant rock sequences of the layered metamorphic rock series formed under specific metamorphic temperature and pressure conditions as well as tectonic environments. Mineral inclusions and reaction texture have recorded that the medium-temperature high-pressure mineral assemblages are replaced by the high-temperature low-pressure mineral assemblages, thus, giving rise to: garnet+quartz→ hypersthene+plagioclase; kyanite→sillimanite and garnet+kyanite/sillimanite+quartz→cordierite. The deformation fabrics of the rocks, the change of mineral assemblages and the PTt path of metamorphism indicate that the contempranceous high-temperature normal-slip ductile shearing is the main cause of the formation of the low-pressure metamorphic crust of granulite facies. In the orogenic event, the co-action of thrusting and extension resulted in the change of a medium-temperature high-pressure metamorphic environment into the high-temperature low-pressure metamorphic conditions. | Liu Xishan, Jin Wei and Li Shuxun Changchun University of Earth Sciences, Changchun, Jilin Sun Sheping | 1993 | Acta Geologica Sinica(English Edition)1993，67，1： | 2 |
| 11 | Civil Aircraft Assisted Space-Air-Ground Integrated Networks: Architecture Design and Coverage Analysis显示文摘In this paper, we propose a novel AIenabled space-air-ground integrated networks(SAGIN). This new integrated networks architecture consists of LEO satellites and civil aircrafts carrying aerial base stations, called 'civil aircraft assisted SAGIN(CAA-SAGIN)'. The assistance of civil aircrafts can reduce the stress of satellite networks, improve the performance of SAGIN, decrease the construction cost and save space resources. Taking the Chinese mainland as an example, this paper has analyzed the distribution of civil aircrafts, and obtained the coverage characteristics of civil aircraft assisted networks(CAAN). Taking Starlink as the benchmark, this paper has calculated the service gap of CAAN, and designed the joint coverage constellation. The simulation results prove that the number of satellites in CAASAGIN can be greatly reduced with the assistance of civil aircrafts at the same data rate. | Shuxun Li Qian Chen Zhe Li Weixiao Meng Cheng Li | 2022 | China Communications2022，19，1： | 2 |
| 12 | Production characteristics and drainage optimization of coalbed methane wells: A case study from low-permeability anthracite hosted reservoirs in southern Qinshui Basin, China显示文摘 | Huihu Liu Shuxun Sang Michael Formolo Mengxi Li Shiqi Liu Hongjie Xu Shikai An Junjun Li Xingzhen Wang | 2013 | Energy for Sustainable Development2013，，： | 2 |
| 13 | Electron theory study on mechanism of action of cobaltin Fe-Co-Cr based high-alloy steel显示文摘The valence electron structure of martensite in Fe-Co-Cr based high-alloy steel is calculated using the em-pirical electron theory of solids and molecules (EET). The results show that the incorporation of cobalt leads to a rise in nA from 0.3835 to 0.4684, which enhances the bonding forces between atoms in a-Fe matrix. Meanwhile, the incorporation of Co changes the valence electron structure of segregated structure units formed by C and other alloying elements, and increases nA for the segregated units containing C-Me sig-nificantly, resulting in changing the precipitation behavior of the secondary phases during tempering and strengtheningthe resistance to tempering. | LI Peijie, XIONG Yuhua, LIU Shuxun & ZENG DabenDepartment of Mechanical Engineering, Tsinghua University, Beijing100084, China | 2003 | Chinese Science Bulletin2003，48，2： | 1 |
| 14 | Permafrost and climatic change in China显示文摘 | JIN HUIJUN LI SHUXUN | 2000 | Global and Planetary Change2000，26，： | 1 |
| 15 | Permafrest and climatic change in China显示文摘 | Jin Huijun Li Shuxun | 2000 | Global and Planetary Change2000，26，： | 1 |
| 16 | Plasmatreatment of Ni catalyst via a corona discharge显示文摘 | LI Zhenhua TIAN Shuxun WANG Haitao | 2004 | Journal ofMolecular Catalysis A:Chemical2004，211，12： | 1 |
| 17 | Stress relief coalbed methane drainage by surface vertical wells in china 显示文摘 | Shuxun Sang Hongjie Xu Liangcai Fang Guojun Li Huazhou Huang | 2010 | International Journal of Coal Geology2010，82，34： | 1 |
| 18 | The draftgenome of a diploid cotton gossypium raimondii 显示文摘 | Kunbo Wang Zhiwen Wang Fuguang Li Wuwei Ye Junyi Wang Guoli Song Zhen Yue Lin Cong Haihong Shang Shilin Zhu Changsong Zou Qin Li Youlu Yuan Cairui Lu Hengling Wei Caiyun Gou Zequn Zheng Ye Yin Xueyan Zhang Kun Liu Bo Wang Chi Song Nan Shi Russell J Kohel Richard G Percy John Z Yu Yu-xian Zhu Jun Wang Shuxun Yu | 2012 | Nat Genet2012，，44： | 1 |
| 19 | Maskless and low-destructive nanofabrication on quartz by friction-induced selective etching显示文摘 | SONG Chenfei LI Xiaoying CUI Shuxun | 2013 | Nanoscale Research Letters2013，8，： | 1 |
| 20 | Role of iron-based catalyst and hydrogen transfer in direct coal liquefaction显示文摘 | Li Xian Hu Shuxun Jin Lijun | 2008 | Energy & Fuels2008，22，： | 1 |
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