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| 1 | Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy显示文摘Primary ovarian insufficiency(POI)is an ovarian dysfunction that affects more than 1%of women and is characterized by hormone imbalances that afflict women before the age of 40.The typical perimenopausal symptoms result from abnormal levels of sex hormones,especially estrogen.The most prevalent treatment is hormone replacement therapy(HRT),which can relieve symptoms and improve quality of life.However,HRT cannot restore ovarian functions,including secretion,ovulation,and fertility.Recently,as part of a developing field of regenerative medicine,stem cell therapy has been proposed for the treatment of POI.Thus,we recapitulate the literature focusing on the use of stem cells and biomaterials for POI treatment,and sum up the underlying mechanisms of action.A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. | Sichen Zhang Dashuai Zhu Xuan Mei Zhenhua Li Junlang Li Mengjie Xie Halle Jiang Williams Lutz Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 2 | An Outbreak of the SARS-CoV-2 Omicron Variant BA.1—Zhuhai City,Guangdong Province,China,January 13,2022显示文摘On January 13,2022,Zhuhai CDC received a notification that a coronavirus disease 2019(COVID-19)case was found in the fever clinic in nearby Zhongshan City.Zhuhai CDC promptly carried out large-scale population screening in three nearby counties.A total of 4 COVID-19 cases were found in Nanping County.34 cases were screened from close contacts,and 2 cases were reported from close contacts in other cities of Guangdong Province.The 20 cases were sequenced by Guangdong CDC and identified as the variant of concern(VOC)/Omicron variant BA.1.Since January 14,Zhuhai has carried out 8 rounds of nucleic acid screening for COVID-19 in the county where the cases occurred.Four large-scale nucleic acid screening tests for COVID-19 were conducted across the city,and no new community cases were reported after January 15. | Feng Ruan Xuebao Zhang Songjian Xiao Xihe Ni Xiling Yin Zhongwen Ye Guorong Chen Tingting Zhu Zeling Chen Gang Yao Long Chen Sichen Huang Huitao Huang Yi Zhou Heyan Wu Hui Huang Kejing Zhu Shanzi Huang Xiaoou Tang Min Kang Bosheng Li Wenhua Mei | 2022 | China CDC weekly2022，4，30： | 2 |
| 3 | Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1显示文摘Renal interstitial fibrosis(RIF)is the crucial pathway in chronic kidney disease(CKD)leading to the end-stage renal failure.However,the underlying mechanism of Shen Qi Wan(SQW)on RIF is not fully understood.In the current study,we investigated the role of Aquaporin 1(AQP1)in SQW on tubular epithelial-to-mesenchymal transition(EMT).A RIF mouse model induced by adenine and a TGF-β1-stimulated HK-2 cell model were etablished to explore the involvement of AQP 1 in the protective effect of SQW on EMT in vitro and in vivo.Subsequently,the molecular mechanism of SQW on EMT was explored in HK-2 cells with AQP1 knockdown.The results indicated that SQW alleviated kidney injury and renal collagen deposition in the kidneys of mice induced by adenine,increased the protein expression of E-cadherin and AQP1 expression,and decreased the expression of vimentin andα-smooth muscle actin(α-SMA).Similarly,treatmement with SQW-containing serum significantly halted EMT process in TGF-β1 stimulated HK-2 cells.The expression of snail and slug was significantly upregulated in HK-2 cells after knockdown of AQP1.AQP1 knockdown also increased the mRNA expression of vimentin andα-SMA,and decreased the expression of E-cadherin.The protein expression of vimentin increased,while the expression of E-cadherin and CK-18 significantly decreased after AQP1 knockdown in HK-2 cells.These results revealed that AQP1 knockdown promoted EMT.Furthermore,AQP1 knockdown abolished the protective effect of SQW-containing serum on EMT in HK-2 cells.In sum,SQW attentuates EMT process in RIF through upregulation of the expression of AQP1. | LIN Yiyou WEI Jiale ZHANG Yehui HUANG Junhao WANG Sichen LUO Qihan YU Hongxia JI Liting ZHOU Xiaojie LI Changyu | 2023 | Chinese Journal of Natural Medicines2023，21，5： | 1 |
| 4 | Heat treatment of electrospun Polyvinylidene fluoride fibrous membrane separators for rechargeable lithium-ion batteries显示文摘 | Yinzheng Liang Sichen Cheng Jianmeng Zhao Changhuan Zhang Shiyuan Sun Nanting Zhou Yiping Qiu Xiangwu Zhang | 2013 | Journal of Power Sources2013，，： | 1 |
| 5 | The computer-based study of muhi-component slag viscosities显示文摘 | Seetharaman S Sichen D Zhang J Y | 1999 | JOM1999，51，8： | 1 |
| 6 | A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse显示文摘Current contraceptive methods come with a number of drawbacks,including low efficacy,in the case of commercial contraceptive gels,and a reduction in the quality of sexual intercourse,in the case of condoms.Adding pharmacologically-active agents to contraceptive gels holds the potential to improve sexual experience,and hardbor safety and hygiene.In this study,we fabricated a carbomer-based contraceptive gel consisting of three agents:tenofovir,gossypol acetate,and nitroglycerin(TGN),with pH adjusted to 4.5(to be compatible with the vagina).In vitro,the gossypol component of the contraceptive gel proved to be an effective spermicide.When the concentration of gossypol acetate was 10 mg/ml,the spermicidal ability reached 100%after 30 s.In addition,tenofovir in the gel significantly inhibited lentiviral transfection efficiency in cell-containing media.In 6 pairs of rats,the gel successfully prevented all females from conceiving after successful mating.Moreover,increased sexual frequency and enhanced erection,which were promoted by the nitroglycerin in the components,were observed in male rats that had the gel applied to their penises.This novel TGN contraceptive gel yielded a higher contraceptive success rate than that of the commercial contraceptive gel(Contragel®).In addition,it has the added benefits to prevent sexually transmitted diseases and improve male libido and erectile function during sexual intercourse.Combining three FDA-approved and marketed agents together,our trifunctional TGN gel has a great potential for further translation and commercialization. | Mengjie Xie Junlang Li Sichen Zhang Dashuai Zhu Xuan Mei Zhenzhen Wang Xiao Cheng Zhenhua Li Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，6： | 1 |
| 7 | Physiological,transcriptome and gene functional analysis provide novel sights into cadmium accumulation and tolerance mechanisms in kenaf显示文摘Kenaf is considered to have great potential for remediation of heavy metals in ecosystems.However,studies on molecular mechanisms of root Cd accumulation and tolerance are still inadequate.In this study,two differently tolerant kenaf cultivars were selected as materials and the physiological and transcriptomic effects were evaluated under Cd stress.This study showed that 200μmol/L CdCl_(2) treatment triggered the reactive oxygen species(ROS)explosion and membrane lipid peroxidation.Compared with the Cd-sensitive cultivar‘Z',the Cd-tolerant cultivar‘F'was able to resist oxidative stress in cells by producing higher antioxidant enzyme activities and increasing the contents of ascorbic acid(AsA)and glutathione(GSH).The root cell wall of‘F'exhibited higher polysaccharide contents under Cd treatment,providing more Cd-binding sites.There were 3,439 differentially expressed genes(DEGs)that were co-regulated by Cd treatment in two cultivars.Phenylpropanoid biosynthesis and plant hormone signal transduction pathways were significantly enriched by functional annotation analysis.DEGs associated with pectin,cellulose,and hemi-cellulose metabolism were involved in Cd chelation of root cell wall;V-ATPases,ABCC3 and Narmp3 could participated in vacuolar compartmentalization of Cd;PDR1 was responsible for Cd effux;the organic acid transporters contributed to the absorption of Cd in soil.These genes might have played key roles in kenaf Cd tolerance and Cd accumulation.Moreover,HcZIP2 was identified to be involved in Cd uptake and transport in kenaf.Our findings provide a deeper understanding of the molecular pathways underlying Cd accumulation and detoxification mechanisms in kenaf. | Shan Cao Meng Wang Jiao Pan Dengjie Luo Samavia Mubeen Caijin Wang Jiao Yue Xia Wu Qijing Wu Hui Zhang Canni Chen Muzammal Rehman Sichen Xie Ru Li Peng Chen | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 8 | Computational methods for identifying enhancer-promoter interactions显示文摘Background:As parts of the cis-regulatory mechanism of the human genome,interactions between distal enhancers and proximal promoters play a crucial role.Enhancers,promoters,and enhancer-promoter interactions(EPIs)can be detected using many sequencing technologies and computation models.However,a systematic review that summarizes these EPI identification methods and that can help researchers apply and optimize them is still needed.Results:In this review,we first emphasize the role of EPIs in regulating gene expression and describe a generic framework for predicting enhancer-promoter interaction.Next,we review prediction methods for enhancers,promoters,loops,and enhancer-promoter interactions using different data features that have emerged since 2010,and we summarize the websites available for obtaining enhancers,promoters,and enhancer-promoter interaction datasets.Finally,we review the application of the methods for identifying EPIs in diseases such as cancer.Conclusions:The advance of computer technology has allowed traditional machine learning,and deep learning methods to be used to predict enhancer,promoter,and EPIs from genetic,genomic,and epigenomic features.In the past decade,models based on deep learning,especially transfer learning,have been proposed for directly predicting enhancer-promoter interactions from DNA sequences,and these models can reduce the parameter training time required of bioinformatics researchers.We believe this review can provide detailed research frameworks for researchers who are beginning to study enhancers,promoters,and their interactions. | Haiyan Gong Zhengyuan Chen Yuxin Tang Minghong Li Sichen Zhang Xiaotong Zhang Yang Chen | 2023 | Quantitative Biology2023，11，2： | 0 |
| 9 | Review:Phonon Engineering in Thermoelectric Materials显示文摘One of the abundantly available energies that could be found in industrial power plants, running vehicles, nuclear power stations, etc. is known as thermal energy. A physical phenomenon known as thermoelectricity converts thermal energy into electrical energy and vice versa, providing a green route for power generation and a potential solution to the world energy crisis. The thermoelectric conversion efficiency is generally characterized by the temperature-dependent dimensionless figure of merit(zT), which is generally promoted by increasing the power factor and reducing the thermal conductivity. The present work reviews heat transmission in thermoelectric materials, particularly phonon engineering to reduce the lattice thermal conductivity. The two leading strategies of point defects engineering and nanostructuring for reducing thermal conductivity have been summarized. The optimized reported zTs of various thermoelectric materials in terms of reduced thermal conductivity have been presented. | Asfandiyar Sichen Duan Jun Mao Qian Zhang | 2022 | Journal of Harbin Institute of Technology(New Series)2022，29，6： | 0 |
| 10 | Mechanical properties of thermoelectric generators显示文摘To satisfy the requirements of practical applications,thermoelectric generators should be highly efficient and mechanically robust.Recently,progress in designing high-performance thermoelectric generators has been made.However,the mechanical properties of thermoelectric generators are still unsatisfactory.In this review,studies on the mechanical properties of thermoelectric generators are summarized.The me-chanical properties of bulk thermoelectric generators will be first discussed.In this section,the mechan-ical properties of thermoelectric materials and the strategies for improving their mechanical properties are emphasized.Since the device’s failure usually occurs at the interface between the thermoelectric ma-terials and electrode,the joint strength of electrodes and thermoelectric materials will be overviewed.After that,the mechanical properties of the inorganic thin-film thermoelectric devices will be discussed.Since the figure of merit for the flexibility of thermoelectric materials depends on the film thickness,elastic modulus,and yield strength,the synthesis methods of thin-film thermoelectric materials will be reviewed.Finally,this review will be concluded with a discussion on flexible organic thermoelectric de-vices and flexible devices using bulk legs. | Xin Bao Shuaihang Hou Zhixin Wu Xiaodong Wang Li Yin Yijie Liu Huolun He Sichen Duan Baolin Wang Jun Mao Feng Cao Qian Zhang | 2023 | Journal of Materials Science & Technology2023，，17： | 0 |
| 11 | Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice显示文摘Breathing is an integrated motor behavior that is driven and controlled by a network of brainstem neurons.Zfhx4 is a zinc finger transcription factor and our results showed that it was specifically expressed in several regions of the mouse brainstem.Mice lacking Zfhx4 died shortly after birth from an apparent inability to initiate respiration.We also found that the electrical rhythm of brainstem‒spinal cord preparations was significantly depressed in Zfhx4-null mice compared to wild-type mice.Immunofluorescence staining revealed that Zfhx4 was coexpressed with Phox2b and Math1 in the brainstem and that Zfhx4 ablation greatly decreased the expression of these proteins,especially in the retrotrapezoid nucleus.Combined ChIP‒seq and mRNA expression microarray analysis identified Phox2b as the direct downstream target gene of Zfhx4,and this finding was validated by ChIP‒qPCR.Previous studies have reported that both Phox2b and Math1 play key roles in the development of the respiratory center,and Phox2b and Math1 knockout mice are neonatal lethal due to severe central apnea.On top of this,our study revealed that Zfhx4 is a critical regulator of Phox2b expression and essential for perinatal breathing. | Meiqin Zhang Sichen Du Huayuan Ou Renjie Cui Nan Jiang Yifeng Lin Runsheng Ge Duan Ma Jin Zhang | 2021 | Journal of Molecular Cell Biology2021，13，3： | 0 |
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