|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1显示文摘Renal interstitial fibrosis(RIF)is the crucial pathway in chronic kidney disease(CKD)leading to the end-stage renal failure.However,the underlying mechanism of Shen Qi Wan(SQW)on RIF is not fully understood.In the current study,we investigated the role of Aquaporin 1(AQP1)in SQW on tubular epithelial-to-mesenchymal transition(EMT).A RIF mouse model induced by adenine and a TGF-β1-stimulated HK-2 cell model were etablished to explore the involvement of AQP 1 in the protective effect of SQW on EMT in vitro and in vivo.Subsequently,the molecular mechanism of SQW on EMT was explored in HK-2 cells with AQP1 knockdown.The results indicated that SQW alleviated kidney injury and renal collagen deposition in the kidneys of mice induced by adenine,increased the protein expression of E-cadherin and AQP1 expression,and decreased the expression of vimentin andα-smooth muscle actin(α-SMA).Similarly,treatmement with SQW-containing serum significantly halted EMT process in TGF-β1 stimulated HK-2 cells.The expression of snail and slug was significantly upregulated in HK-2 cells after knockdown of AQP1.AQP1 knockdown also increased the mRNA expression of vimentin andα-SMA,and decreased the expression of E-cadherin.The protein expression of vimentin increased,while the expression of E-cadherin and CK-18 significantly decreased after AQP1 knockdown in HK-2 cells.These results revealed that AQP1 knockdown promoted EMT.Furthermore,AQP1 knockdown abolished the protective effect of SQW-containing serum on EMT in HK-2 cells.In sum,SQW attentuates EMT process in RIF through upregulation of the expression of AQP1. | LIN Yiyou WEI Jiale ZHANG Yehui HUANG Junhao WANG Sichen LUO Qihan YU Hongxia JI Liting ZHOU Xiaojie LI Changyu | 2023 | Chinese Journal of Natural Medicines2023，21，5： | 1 |
| 2 | Shen-Qi-Wan Protects the Renal Peritubular Capillary Injury from Adenine-mediated Damage by Upregulating Aquaporin 1显示文摘Background:Shen-Qi-Wan(SQW),a commonly used prescription against chronic kidney disease(CKD)in Tradi-tional Chinese Medicine(TCM),has a nephroprotective action in adenine-induced kidney injury.However,the mechanism of SQW in renal injury remains unclear.Objective:This study was undertaken to measure the effect of SQW on peritubular capillary injury both in vivo and in vitro assays.Methods:The effect of SQW on the peritubular capillary injury was evaluated according to measuring hypothalamic-pituitary-adrenal(HPA)function,inflammatory cytokines,VEGF(vascular endothelial growth fac-tor),CD34(Cluster of differentiation 34),and AQP1(Aquaporin 1)levels in the kidney,cell migration,and lumen forming capacity.Results:SQW supplementation could ameliorate dysfunction of the HPA and renal function loss induced by adenine.SQW also significantly inhibited the inflammatory cytokines including MCP-1(monocyte chemotactic protein-1)and VCAM-1(vascular cell adhesion molecule-1)level.Alternatively,SQW administration showed an ameliorating effect from the toxicity and alleviated the injury of capillaries around renal tubules instigated by adenine through increasing AQP1 mRNA and protein level.SQW medicated the serum enhanced the migration and lumen formation ability of HMEC-1 cells,and significantly increased AQP1 protein level.Moreover,AQP1 knockdown efficiently inhibited the migration and lumen formation ability in HMEC-1 cells,and weakened the effect of SQW medicated serum.Conclusion:These results suggested that SQW attenuated peritubular capillary injury in adenine-induced CKD model rats through boosting angiogenesis in endothelial cell,and AQP1 may be a potential target of SQW for treating the renal injury. | Yuting Bao Yehui Zhang Yuanxiao Yang Xueming Chen Luning Lin Yunbo Fu Liting Ji Changyu Li | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，1： | 1 |
| 3 | Conodont Biostratigraphy and Age Determination of the Lower-Middle Triassic Boundary in South Guizhou Province,China显示文摘LowerMiddle 三叠纪的边界的分界是在全球 stratigraphic 研究的一个争论问题。不同类型的 LowerMiddle 三叠纪的阶层,从站台到盆外形,很好在西南中国被开发。这为 OlenekianAnisian 边界的学习是有利的并且为 Qingyan 阶段建立 stratotype。在 Guiyang 城市里在 Wangmo 县和 Qingyan 节在 Ganheqiao 节基于研究,贵州省,六个 conodont 地区被认出了,它能在另外的区域与那些被相关,在如下登上顺序:1, Neospathodus cristagalli 间隔地区;2, Neospathodus pakistanensis 间隔地区;3, Neospathodus waageni 间隔地区;4, Neospathodus homeri-N。triangularis 集合地区;5, Chiosella timorensis 间隔地区;并且 6, Neogongdolella regalis 范围地区。在 Ganheqiao 和 Qingyan 节发现的 EarlyMiddle 三叠纪的 conodont 类 Neospathodus-Chiosella-Neogongdolella 的一个进化系列把一种中间的类型命名在 Neospathodus homeri-N 的上面的部分出现在 Neospathodus homeri 和 Chiosella timorensis 之间的 Neospathodus qingyanensis。triangularis 地区,在 LowerMiddle 三叠纪的边界附近显示出 conodonts 的一种优秀进化关系。在而这条边界被定位, Chiosella timorensis 地区首先出现在 Qingyan 节的地方, LowerMiddle 三叠纪的边界在 Ziyun 形成的顶下面在 1.5 m 被定位在 Ziyun 形成的顶下面的 0.5 m,在 Chiosella timorensis 地区首先出现在 Ganheqiao 节的地方。在那里存在一将近 6-m 在在 Ganheqiao 节的 Xinyuan 形成的底部的厚玻璃的凝灰岩床,它通常在华南被认为是 LowerMiddle 三叠纪的边界的一个 lithologic 符号。基于高精确、高敏感的第二等的离子集体光谱数据的分析,这凝灰岩的锆石年龄有 239.0 牳灥的加权的吝啬的 206Pb/238U 年龄吗? | YAO Jianxin JI Zhansheng WANG Liting WANG Yanbin WU Zhenjie LIU Dunyi WU Guichun ZHANG Jianwei LI Suping | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 1 |
| 4 | Photodynamic Therapy Activities of 10-(4-Formylphenyl)-5,15-bis(pentafluorophenyl)corrole and Its Gallium Complex显示文摘10-(4-Formylphenyl )-5,15-bis(pentafluorophenyl)corrole 1 并且它的镓建筑群 1-Ga 被用来在肝癌症(BEL-7402 ) 调查他们的 photocytotoxicity,肺癌症(A549 ) 和颈的癌症(Siha, Hela ) 房间线。在所有测试肿瘤房间之中, Siha 肿瘤房间对光力学的治疗(太平洋夏季时间) 最敏感在 1 的治疗和 1-Ga。1 的太平洋夏季时间 IC 50 和向 Siha 肿瘤房间的 1-Ga 分别地到达 1.3 和 0.8 µmol/L,它比 cisplatin 的高是 10 褶层。1 并且没有搬运人蛋白质的帮助, 1-Ga 可能顺利越过肿瘤房间膜过去,并且在肿瘤的细胞质主要局部性房间。在太平洋夏季时间治疗以后,增加的细胞内部的反应的氧种类(ROS ) 水平和 mitochondrial 膜潜力显著地减少了,它将最后导致肿瘤房间的 apoptosis。 | Fan Cheng Liting Huang Huahua Wang Yunjun Liu Jaipal Kandhadi Hui Wang Liangnian Ji Haiyang Liu | 2017 | Chinese Journal of Chemistry2017，35，1： | 1 |
| 5 | Heavy atom-free triplet photosensitizer based on thermally activated delayed fluorescence material for NIR-to-blue triplet-triplet annihilation upconversion显示文摘Triplet-triplet annihilation(TTA) upconversion-based materials have potential application in the broad range of research areas, including photocatalysis and life sciences. However, near-infrared(NIR)-to-blue upconverted emission is preferred for most of the practical applications, but developing a NIR-to-blue TTA upconversion system is a challenging task in photochemistry. In this work, a thermally activated delayed fluorescence(TADF) material with intense visible-to-NIR absorption is demonstrated that shows a longer triplet state lifetime(32 μs) and high triplet state energy(E_(T)= 1.55 e V). For the first time, a heavy atomfree NIR(λ_(ex)> 650 nm) to blue(λ_(em)< 460 nm) TTA upconversion system was devised, employing the dimeric borondifluoride curcuminoid TADF material as triplet photosensitizer(PS) and a large anti-Stokes shift(0.88 e V) along with moderate upconversion yield was achieved. Our work provides the solution and guidance for the future development of purely organic heavy atom-free NIR activating TTA upconversion system for a wide array of applications. | Hui Liang Xiaoyu Liu Liting Tang Zafar Mahmood Zeduan Chen Guowei Chen Shaomin Ji Yanping Huo | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员