|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Another look at safety climate and safety behavior: Deepening the cognitive and social mediator mech- anisms显示文摘 | Carla SF Silvia AS Jose LM | 2012 | Accid Anal Prey2012，45，3： | 1 |
| 3 | Growth hormone receptors in zebrafish ( Danio rerio ): Adult and embryonic expression patterns显示文摘 | Cecilia M. Di Prinzio Pablo E. Botta Elías H. Barriga Eduardo A. Ríos Ariel E. Reyes Silvia E. Arranz | 2010 | Gene Expression Patterns2010，，4： | 1 |
| 4 | Urinary and sexual disorders after laparoscopic TME for rectal cancer in Males显示文摘 | Carlo AS Alberto S Silvia V | 2011 | J Gastrointest Surg2011，15，： | 1 |
| 5 | The case study of Madeira wine 显示文摘 | Rosa Perestrelo Silvia Petronilho Jose S Camara Com- prehensive two-dimensional gas chromatography with time-of-flight mass spectrometry combined with solid phase microextraction as a powerful tool for quantification of ethyl carbamate in fortified wines | 2010 | Journal of Chromatography A2010，1217，： | 1 |
| 6 | Molecular epidemiology and putative origin of hepatitis C virus in random volunteers from Argentina显示文摘AIM:To study the subtype prevalence and the phylogenetic relatedness of hepatitis C virus(HCV)sequences obtained from the Argentine general population,a large cohort of individuals was analyzed.METHODS:Healthy Argentinian volunteers(n=6251)from 12 provinces representing all geographical regions of the country were studied.All parents or legal guardians of individuals younger than 18 years provided informed written consent for participation.The corresponding written permission from all municipal authorities was obtained from each city or town where subjects were to be included.HCV RNA reverse transcription-polymerase chain reaction products were sequenced and phylogenetically analyzed.The 5’untranslated region(5’UTR)was used for RNA detection and initial genotype classification.The NS5B polymerase region,encompassing nt 8262-8610,was used for subtyping.RESULTS:An unexpectedly low prevalence of HCV infection in the general population(0.32%)was observed.Our data contrasted with previous studies that reported rates ranging from 1.5%to 2.5%,mainly performed in selected populations of blood donors or vulnerable groups.The latter values are in keeping with the prevalence reported by the 2007 Argentinian HCV Consensus(approximately 2%).HCV subtypes weredistributed as follows:1a(25%),1b(25%),2c(25%),3a(5%),and 2j(5%).Two isolates ascribed either to genotype 1(5%)or to genotype 3(5%)by 5’UTR phylogenetic analysis could not be subtyped.Subtype 1a sequences comprised a highly homogeneous population and clustered with United States sequences.Genotype1b sequences represented a heterogeneous population,suggesting that this genotype might have been introduced from different sources.Most subtype 2c sequences clustered close to the 2c reported from Italy and Southern France.CONCLUSION:HCV has a low prevalence of 0.32%in the studied general population of Argentina.The pattern of HCV introduction and transmission in Argentina appears to be a consequence of multiple events and different for each subtype. | Noemí del Pino José Raúl Oubia Francisco Rodríguez-Frías Juan Ignacio Esteban María Buti Teresa Otero Josep Gregori Damir García-Cehic Silvia Camos María Cubero Rosario Casillas Jaume Guàrdia Rafael Esteban Josep Quer | 2013 | World Journal of Gastroenterology2013，19，35： | 1 |
| 7 | Role of double-balloon enteroscopy in malignant small bowel tumors显示文摘AIM: To assess the double-balloon enteroscopy(DBE) role in malignant small bowel tumors(MSBT).METHODS: This is a retrospective descriptive study performed in a single center. All consecutive patients who underwent a DBE with final diagnosis of a malignant neoplasm from 2004 to 2014 in our referral center were included. Patient demographic and clinical pathological characteristics were recorded and reviewed. MSBT diagnosis was achieved either by DBE directed biopsy with multiple tissue sampling, endoscopic findings or histological analysis of surgical specimen. We have analyzed double-balloon enteroscopy impact in outcome and clinical course of these patients. RESULTS: Of 627 patients, 28(4.5%)(mean age = 60 ± 17.3 years) underwent 30 procedures(25 anterograde, 5 retrograde) and were diagnosed of a malignant tumor. Patients presented with obscure gastrointestinal bleeding(n = 19, 67.9%), occlusion syndrome(n = 7, 25%) and diarrhea(n = 1, 3.6%). They were diagnosed by DBE biopsy(n = 18, 64.3%), histological analysis of surgical specimen(n = 7, 25%) and unequivocal endoscopic findings(n = 2, 7.1%). Gastrointestinal stromal tumor(n = 8, 28.6%), adenocarcinoma(n = 7, 25%), lymphoma(n = 4, 14.3%), neuroendocrine tumor(n = 4, 14.3%), metastatic(n = 3, 10.7%) and Kaposi sarcoma(n = 1, 3.6%) were identified. DBE modified outcome in 7 cases(25%), delaying or avoiding emergency surgery(n = 3), modifying surgery approach(n = 2) and indicating emergency SB partial resection instead of elective approach(n = 2).CONCLUSION: DBE may be critical in the management of MSBT providing additional information that may be decisive in the clinical course of these patients. | Enrique Pérez-Cuadrado Robles Pilar Esteban Delgado Paloma Bebia Conesa Blanca Martínez Andrés Milivoj Franulic Guggiana Eduardo Alcaraz Mateos Mariana Fernández Caballero José Luis Rodrigo Agudo Silvia Chacón Martínez Rafael Latorre Federico Soria Juan Manuel Herrerías Gutiérrez Enrique Pérez-Cuadrado Martínez | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 1 |
| 8 | HIV-coinfection leads to a modest increase in plasma HCV-RNA load in patients with chronic HCV infection显示文摘 | Karin Neukam Silvia García-Rey Celia Cifuentes Juan Macías José A Mira María J Vázquez Manuel Parra-Sánchez José C Palomares Nicolás Merchante Federico A Di Lello Juan A Pineda | 2012 | Antiviral Research2012，，3： | 1 |
| 9 | Cardiac dysfunction in rats prone to audiogenic epileptic seizures显示文摘 | Denis D. Damasceno Silvia Q. Savergnini Enéas R.M. Gomes Silvia Guatimosim Anderson J. Ferreira Maria C. Doretto Alvair P. Almeida | 2013 | Seizure: European Journal of Epilepsy2013，，4： | 1 |
| 10 | Another look at safety climate and safety behavior: Deepening the cognitive and social mediator mecha- nisms 显示文摘 | Carla SF Silvia AS Josei M | 2012 | Accid Anal Prev2012，45，3： | 1 |
| 11 | Identification of host and viral factors involved in a dissimilar resolution of a hepatitis C virus infection显示文摘 | Maria Cubero Josep Gregori Juan I. Esteban Damir García‐Cehic Marta Bes Celia Perales Esteban Domingo Francisco Rodríguez‐Frías Silvia Sauleda Rosario Casillas Alex Sanchez Israel Ortega Rafael Esteban Jaume Guardia Josep Quer | 2014 | Liver Int2014，，6： | 1 |
| 12 | Comparison of central corneal thickness using optical low-coherence reflectometry and spectral-domain optical coherence tomography显示文摘 | Alberto López-Miguel María Encarnación Correa-Pérez Silvia Miranda-Anta Darío Iglesias-Corti?as María Bego?a Coco-Martín Miguel J. Maldonado | 2012 | Journal of Cataract & Refractive Surgery2012，，5： | 1 |
| 13 | ACE Score Identifies HBeAg-negative Inactive Carriers at a Single-point Evaluation,Regardless of HBV Genotype显示文摘Background and Aims:Hepatitis B virus(HBV)biomark-ers have been used for a better categorization of patients,even though the lack of simple algorithms and the impact of genotypes limit their application.Our aim was to assess the usefulness of noninvasive markers for the identification of HBV inactive carriers(ICs)in a single-point evaluation and to design a predictive model for their identification.Meth-ods:This retrospective-prospective study included 343 consecutive HBeAg-negative individuals.Clinical,analytical,and virological data were collected,and a liver biopsy was performed if needed.Subjects were classified at the end of follow-up as ICs,chronic hepatitis B and gray zone.A pre-dictive model was constructed,and validated by 1000-boot-strap samples.Results:After 39 months of follow-up,298 subjects were ICs,36 were chronic hepatitis B CHB,and nine were gray zone.Eighty-nine(25.9%)individuals re-quired a liver biopsy.Baseline HBV DNA hazard ratio(HR)6.0,p<0.001),HBV core-related antigen(HBcrAg)(HR 6.5,p<0.001),and elastography(HR 4.6,p<0.001)were inde-pendently associated with the IC stage.The ACE score(HBV DNA,HBcrAg,elastography),obtained by bootstrapping,yielded an area under the receiver operating characteris-tics(AUROC)of 0.925(95%CI:0.880-0.970,p<0.001)for identification of ICs.The AUROC for genotype D was 0.95,0.96 for A,0.90 for E,and 0.88 for H/F.An ACE score of<1 had a positive predictive value of 99.5%,and a score≤12 points had a diagnostic accuracy of 93.8%.Conclusions:Low baseline HBV DNA,HBcrAg,and liver stiffness were in-dependently associated with the IC phase.A score including those variables identified ICs at a single-point evaluation,and might be applied to implement less intensive follow-up strategies. | Luisa Roade Mar Riveiro-Barciela Adriana Palom Francisco Rodríguez-Frías Marta Bes Ariadna Rando María Teresa Salcedo Rosario Casillas Elena Vargas-Accarino David Tabernero Silvia Sauleda Rafael Esteban María Buti | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员