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| 1 | Direct reprogramming of induced neural progenitors: a new promising strategy for AD treatment显示文摘Alzheimer’s disease(AD)is a prominent form of dementia,characterized by aggregation of the amyloidβ-peptide(Aβ)plaques and neurofibrillary tangles,loss of synapses and neurons,and degeneration of cognitive functions.Currently,although a variety of medications can relieve some of the symptoms,there is no cure for AD.Recent breakthroughs in the stem cell field provide promising strategies for AD treatment.Stem cells including embryonic stem cells(ESCs),neural stem cells(NSCs),mesenchymal stem cells(MSCs),and induced pluripotent stem cells(iPSCs)are potentials for AD treatment.However,the limitation of cell sources,safety issues,and ethical issues restrict their applications in AD.Recently,the direct reprogramming of induced neural progenitor cells(iNPCs)has shed light on the treatment of AD.In this review,we will discuss the latest progress,challenges,and potential applications of direct reprogramming in AD treatment. | Siqiang Lai Min Zhang Dongsheng Xu Yiying Zhang Lisha Qiu Changhai Tian Jialin Charlie Zheng | 2015 | Translational Neurodegeneration2015，4，1： | 4 |
| 2 | Flow Characteristics of Grains in a Conical Silo with a Central Decompression Tube Based on Experiments and DEM Simulations显示文摘Grains are widely present in industrial productions and processing,and are stored in silos.In the silo,auxiliary structures are added to achieve efficient production.However,little effort has been devoted to the influence of the internal structure of the silo on the granular flow.In this work,a silo with a central decompression tube is studied through experimental measurements and discrete element methods.Then,the influences of the central decompression tube on the flow behavior of grains and wall pressure are analyzed.Results show that the grains are in mass flow in the silo without a central decompression tube,while the grains are in funnel flow in the silo with a central decompression tube.Moreover,regardless of whether there is a central decompression tube in the silo,the maximum pressure appears at the top of the conical silo.In the lower part of the silo,the wall pressure of the silo with a central decompression tube is lower than that of the silo without a central decompression tube.Therefore,a silo with a central decompression tube is more conducive to grain storage and discharge than a silo without a central decompression tube. | Huinan Sun Siqiang Wang Zhuoqing Zhang Chaoyong Xia Xu Chen | 2021 | Computer Modeling in Engineering & Sciences2021，，6： | 3 |
| 3 | High-temperature mechanical properties of as-extruded AZ80 magnesium alloy at different strain rates显示文摘The mechanical properties of as-extruded AZ80 magnesium alloy at temperatures of 450-525℃ and strain rates of 3.0 s^(−1)and 0.15 s^(−1)were investigated by tensile tests.Zero ductility of alloy appeared at 500℃ with a strain rate of 0.15 s^(−1),while the zero strength and zero ductility of the alloy were obtained nearly simultaneously at 525℃ with a strain rate of 3.0 s^(−1).The results indicated that the lower strain rate accelerated the arrival of zero ductility.As the temperature increased,the failure mode of the alloy developed from trans-granular fracture to cleavage fracture and then to inter-granular fracture with the feature of sugar-like grains and fusion traces.The existence of the low-melting composite ofβ-Mg_(17)Al_(12) and Al_(8)Mn_(5) particles segregated near the Mg_(17)Al_(12) phase along grain boundaries were demonstrated to be the reason for the brittle fracturing of the AZ80 alloy at high temperatures.Furthermore,microstructural evolution at temperatures approaching the solidus temperature was discussed to clarify magnesium alloy’s high temperature deformation mechanism. | Wenjun Liu Bin Jiang Hongchen Xiang Qing Ye Shengqi Xia Siqiang Chen Jiangfeng Song Yanlong Ma Mingbo Yang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 3 |
| 4 | Construction of irregular particles with superquadric equation in DEM显示文摘Non-spherical particles are widely present in industrial production,and significantly affect the macro and micro characteristics of granular materials.Although the superquadric equation can be used to construct non-spherical particles,its disadvantage is that the particle shape is geometrically symmetric and strictly convex.In this study,two composed approaches are used to describe geometrically asymmetric and concave particle shapes,including a multi-superquadric model and a poly-superquadric model.The multi-superquadric model is a combination of several superquadric elements,and can construct concave and geometrically asymmetric particle shapes.The poly-superquadric model is a combination of eight one-eighth superquadric elements,and can construct convex and geometrically asymmetric particle shapes.Both composed models are based on superquadric equations,and Newton’s iterative method is used to calculate the contact force between the elements.Furthermore,superquadric elements,multi-superquadric elements,and poly-superquadric elements are applied for the formation of complex granular beds,and the influences of particle shape on the packing fraction can be successfully captured by the proposed models. | Siqiang Wang Dzianis Marmysh Shunying Ji | 2020 | Theoretical & Applied Mechanics Letters2020，10，2： | 2 |
| 5 | Low power 3.1–10.6 GHz IR-UWB transmitter for Gbps wireless communications显示文摘This paper reviews and discusses the design of a low-power single-full-band (3.1-10.6 GHz) non- carrier impulse-radio ultra wideband (UWB) transmitter featuring 5th-order Gaussian derivative pulse shaping, integrated BPSK modulation, and 2.5 kV whole-chip ESD (electrostatic discharge) protection. The UWB transmitter design has been implemented in a commercial 0.18 μm CMOS technology with a very small die size of 0.25 mm2. The fabricated chips have demonstrated full functionality, extremely low power consumption of 0.14 pJ/p-mV, and an ultra short pulse width of 394 ps. This ESD-protected UWB transmitter has the potential to support wireless streaming to gigabit per second (Gbps). | WANG Xin LIN Lin TANG He ZHAO Hui FANG Qiang LIU Jian FAN SiQiang WANG Albert ZHAO Bin YANG LiWu ZHANG Gary | 2011 | Science China(Information Sciences)2011，54，5： | 2 |
| 6 | Flow characteristics of nonspherical granular materials simulated with multi-superquadric elements显示文摘The superquadric equation is typically used to mathematically describe nonspherical particles and construct particle shapes with different surface sharpness and aspect ratios.However,nonspherical elements constructed using the superquadric equation are strictly convex,limiting their engineering application.In this study,a multi-superquadric model based on a superquadric equation is developed.The model combines several superquadric elements that can be used to construct concave and convex particle shapes.Four tests are performed to examine the applicability of the multi-superquadric approach.The first involves a comparison of theoretical results for a single spherocylinder impacting a flat wall.The second involves the formation of a nonspherical granular bed.The third investigates the effects of the particle shape on the hopper discharge and angle of repose.The final test evaluates the mixing behaviors of granular materials within a horizontally rotating drum.These tests demonstrate the applicability of the multi-superquadric approach to nonspherical granular systems.Furthermore,the effects of particle shape on the packing density,discharge rate,angle of repose,and Lacey mixing index are discussed.Results indicate that concave particles have a lower packing density,flow rate,and mixing rate and higher angles of repose than convex particles.Interlocking of elements becomes more pronounced for concave particles and results in local cluster structures,thereby enhancing the stability of granular systems and limiting sliding or rotation between nonspherical particles. | Siqiang Wang Shunying Ji | 2021 | Particuology2021，19，1： | 2 |
| 7 | Optimization Scheme of Large Passenger Flow in Huoying Station,Line 13 of Beijing Subway System显示文摘This paper focuses on the distribution of passenger flow in Huoying Station,Line 13 of Beijing subway system.The transformation measures taken by Line 13 since operation are firstly summarized.Then the authors elaborate the facilities and equipment of this station,especially the node layout and passenger flow field.An optimization scheme is proposed to rapidly distribute the passenger flow in Huoying Station by adjusting the operation time of the escalator in the direction of Xizhimen.The authors adopt Queuing theory and Anylogic simulation software to simulate the original and the optimized schemes of Huoying Station to distribute the passenger flow.The results of the simulation indicate that the optimized scheme could effectively alleviate the traffic congestion in the hall of Huoying Station,and the pedestrian density in other places of the hall is lowered;passengers could move freely in the hall and no new congestion points would form.The rationality of the scheme is thus proved. | Jin Zhou Haochen Wang Di Sun Siqiang Xu Meng Lv Feifei Yu | 2020 | Computers, Materials & Continua2020，，6： | 2 |
| 8 | Enhanced Offset Averaging Technique for Flash ADC Design显示文摘This paper presents a new combined AC/DC-coupled output averaging technique for input amplifier design of flash analog-to-digital converters (ADC). The new offset averaging design technique takes full advantage of traditional DC-coupled resistance averaging and AC-coupled capacitance averaging techniques to minimize offset-induced ADC nonlinearities. Circuit analysis allows selection of optimum resistance and capacitance averaging factors to achieve maximum offset reduction in ADC designs. The new averaging method is verified in designing a 4 bit 1 Gs/s flash ADC that is implemented in foundry 0.13 μm CMOS technology. | Siqiang FAN He TANG Hui ZHAO Xin WANG Albert WANG Bin ZHAO Gary G ZHANG | 2011 | Tsinghua Science and Technology2011，16，3： | 2 |
| 9 | Imaging of downward-looking linear array three-dimensional SAR based on FFT-MUSIC 显示文摘 | ZHANG Siqiang ZHU Yutao KUANG Gangyao | 2015 | IEEE Geoscience and Remote Sensing Let- ters2015，12，4： | 1 |
| 10 | A RAMCloud Storage System based on HDFS: Architecture, implementation and evaluation显示文摘 | Yifeng Luo Siqiang Luo Jihong Guan Shuigeng Zhou | 2012 | The Journal of Systems & Software2012，，： | 1 |
| 11 | Whole-Chip ESD Protection Design for RF and AMS ICs显示文摘As integrated circuits (IC) technologies advance into very-deep-sub-micron (VDSM), electrostatic discharge (ESD) failure becomes one of the most devastating IC reliability problems and on-chip ESD protection design emerges as a major challenge to radio frequency (RF), analog, and mixed-signal (AMS) IC designs. This paper reviews key design aspects and recent advances in whole-chip ESD protection designs for RF/AMS IC applications in CMOS technologies. | Xin WANG Siqiang FAN Hui ZHAO Lin LIN Qiang FANG He TANG Albert WANG | 2010 | Tsinghua Science and Technology2010，15，3： | 1 |
| 12 | ESD-proteeted power amplifier design in CMOS for highly reliable RF ICs 显示文摘 | WANG Xin GUAN Xiankang FAN Siqiang | 2011 | IEEE Transactions on Industrial Electronics2011，58，7： | 1 |
| 13 | Hydrophilization of polypropylene films by using migratory additives显示文摘 | Siqiang Zhu Douglas E Hirt | 2007 | Journal of Vinyl & Additive Technology2007，，： | 1 |
| 14 | A RAMCloud storage system based on HDFS : architecture, implementation and evaluation 显示文摘 | Luo Yifeng Luo Siqiang | 2013 | Journal of Systems and Software2013，86，： | 1 |
| 15 | Halide Anchors for Single-Cluster Electronics显示文摘Due to their unique electronic structure,well-defined metal clusters at the atomic level are promising materials for single-cluster electronics.However,coupling between the electrode and the cluster remains challenging mainly due to the coverage of bulky ligands on the noble clusters.Using the scanning tunneling microscopy break junction(STM-BJ)technique,we have developed a“direct contact”approach to fabrication and investigation of the charge transport through single-cluster junctions of AgCu bimetallic metal clusterswith different halide anchors.Wefound that the electrodes could make contact directly with the surface halides of the single-cluster junctions and experience different contact resistance from different halogen atoms.Experiments and calculations reveal that the halide anchors provided efficient coupling between the cluster and the electrode,and the enhanced coupling with various halide anchors promoted electron transport and improved transmission probability.Our work offers a“direct contact”strategy for interface design between clusters of noble metals and electrodes,an essential step in progress toward single-cluster electronics. | Caiyun Wei Jingyao Ye Yuming Su Jueting Zheng Siqiang Xiao Jiawei Chen Saisai Yuan Chengyang Zhang Jie Bai Han Xu Jia Shi Jiale Huang Wenjing Hong | 2023 | CCS Chemistry2023，5，7： | 0 |
| 16 | 10 W QCW operation of a proton implanted GaAlAs diode laser array显示文摘10WQCWoperationofaprotonimplantedGaAlAsdiodelaserarrayZHANGDaoyin;HUSiqiang;MHOQingfeng(ChongqingOptoelectronicsResearchInsti... | ZHANG Daoyin HU Siqiang MHO Qingfeng (Chongqing Optoelectronics Research Institute,Yongchuan 632163,CHN) | 1995 | Semiconductor Photonics and Technology1995，1，1： | 0 |
| 17 | A kidney-brain neural circuit drives progressive kidney damage and heart failure显示文摘Chronic kidney disease(CKD)and heart failure(HF)are highly prevalent,aggravate each other,and account for substantial mortality.However,the mechanisms underlying cardiorenal interaction and the role of kidney afferent nerves and their precise central pathway remain limited.Here,we combined virus tracing techniques with optogenetic techniques to map a polysynaptic central pathway linking kidney afferent nerves to subfornical organ(SFO)and thereby to paraventricular nucleus(PVN)and rostral ventrolateral medulla that modulates sympathetic outflow.This kidney-brain neural circuit was overactivated in mouse models of CKD or HF and subsequently enhanced the sympathetic discharge to both the kidney and the heart in each model.Interruption of the pathway by kidney deafferentation,selective deletion of angiotensin II type 1a receptor(AT1a)in SFO,or optogenetic silence of the kidney-SFO or SFO-PVN projection decreased the sympathetic discharge and lessened structural damage and dysfunction of both kidney and heart in models of CKD and HF.Thus,kidney afferent nerves activate a kidney-brain neural circuit in CKD and HF that drives the sympathetic nervous system to accelerate disease progression in both organs.These results demonstrate the crucial role of kidney afferent nerves and their central connections in engaging cardiorenal interactions under both physiological and disease conditions.This suggests novel therapies for CKD or HF targeting this kidney-brain neural circuit. | Wei Cao Zhichen Yang Xiaoting Liu Siqiang Ren Huanjuan Su Bihui Yang Youhua Liu Christopher S.Wilcox Fan Fan Hou | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 18 | Extracting the phase distribution of the electron wave packet ionized by an elliptically polarized laser pulse显示文摘We use an interferometic scheme to extract the phase distribution of the electron wave packet from above-threshold ionization in elliptically polarized laser fields.In this scheme,an electron wave packet released from a circularly polarized laser pulse acts as a reference wave and interferes with the electron wave packet ionized by a time-delayed counter-rotating elliptically polarized laser field.The generated vortex-shaped interference pattern in the photoelectron momentum distribution enables us to extract the phase distribution of the electron wave packet in the elliptically polarized laser pulse with high precision.By artificially screening the ionic potential at different ranges when solving the time-dependent Schördinger equation,we find that the angle-dependent phase distribution of the electron wave packet in the elliptically polarized laser field shows an obvious angular shift as compared to the strong-field approximation,whose value is the same as the attoclock shift.We also show that the amplitude of the angle-dependent phase distribution is sensitive to the ellipticity of the laser pulse,providing an alternative way to precisely calibrate the laser ellipticity in the attoclock measurement. | Ya-Nan Qin Min Li Yudi Feng Siqiang Luo Yueming Zhou Peixiang Lu | 2021 | Frontiers of physics2021，16，3： | 0 |
| 19 | Stereodivergently asymmetric synthesis of chiral phosphorus compounds by synergistic combination of ion-pair catalyst and base显示文摘Stereodivergently constructing the designed products having adjacent multi-stereocenters via a given reaction,with excellent control of both absolute and relative configurations,presents one of the substantial hurdles in asymmetric catalysis.Herein,we report a precisely stereodivergent asymmetric protocol by synergistic combination of phosphonium-involved ion-pair catalysis and base for accessing to chiral phosphorus compounds bearing two adjacent chiral centers particularly containing an acidic protonated enantioenriched carbon atom,having broad functional group compatibility in both dynamic and thermodynamic processes under mild reaction conditions.Two keys for the success in constructing these stereoisomers with high levels of regio-,diastereo-,and enantioselectivities were contained:firstly,the precise stereo-control in providing dynamic products was enabled by bifunctional phosphonium salt catalyst with semi-enclosed cavity;secondly,the readily stereospecific transformation of adducts from dynamic to thermodynamic version was initiated by achiral base.All four stereoisomers could be readily accessed even in gram-scale in high yields with maintaining excellent stereoselectivities,illustrating the potential of this synergistic catalytic methodology in organic synthesis.Moreover,mechanistic studies including density functional theory(DFT)calculations and control experiments provide insights into the mechanism. | Hui-Lin Hu Xiaoyu Ren Jiajia He Lixiang Zhu Siqiang Fang Zhishan Su Tianli Wang | 2022 | Science China Chemistry2022，65，12： | 0 |
| 20 | Co-design of ESD protection and UWB RF front-end ICs显示文摘This paper discusses critical aspects for co-design of ultra wideband (UWB) system-on-chip (SoC) and on-chip electrostatic discharge (ESD) protection,which are beyond the considerations on data rate and bandwidth.Impulse radio UWB system architecture has been defined with critical building blocks proposed and verified,including pulse generator,transmitter,low noise amplifier (LNA) and multiplier based correlator.ESD protection is well considered for each related block.Design examples have been implemented in a commercial RFCMOS processes to demonstrate the working principles for key UWB transmitter and receiver circuit blocks.UWB-ESD co-design techniques,simulation and measurement results for these UWB RF modules are presented in detail. | WANG Xin TANG He LIN Lin LIU Jian FANG Qiang ZHAO Hui WANG Albert SHI ZiTao FAN SiQiang ZHAO Bin YANG LiWu HE Jun CHENG YuHua | 2011 | Science China(Information Sciences)2011，54，10： | 0 |
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