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| 1 | A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic:implications and policy recommendations显示文摘The Coronavirus Disease 2019(COVID-19)epidemic emerged in Wuhan,China,spread nationwide and then onto half a dozen other countries between December 2019 and early 2020.The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people's lives.It has also triggered a wide variety of psychological problems,such as panic disorder,anxiety and depression.This study is the first nationwide largescale survey of psychological distress in the general population of China during the COVID-19 epidemic. | Jianyin Qiu Bin Shen Min Zhao Zhen Wang Bin Xie Yifeng Xu | 2020 | General Psychiatry2020，33，2： | 69 |
| 2 | Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma显示文摘AIM: To investigate the efficacy of transcatheter arterial chemoembolization (TACE) combined with radiotherapy for unresectable large hepatocellular carcinoma (HCC).METHODS: From June 1994 to June 1999, a total of 76patients with large unresectable HCC were treated with TACE followed by external-beam irradiation. 89 patients with large HCC, who underwent TACE alone during the same period,served as the control group. Clinical features, therapeutic modalities, acute effects and survival rates were analyzed and compared between TACE plus irradiation group and TACE alone group. A multivariate analysis of nine clinical variables and one treatment variable (irradiation) was performed by the Cox proportional hazards model.RESULTS: The clinical features and therapeutic modalities except irradiation between the two groups were comparable (P>0.05). The objective response rate (RR) in TACE plus irradiation group was higher than that in TACE alone group (47.4 % vs28.1%, P<0.05). The overall survival rates in TACE plus irradiation group (64.0 %, 28.6 %, and 19.3 %at 1, 3, 5 years, respectively) were significantly higher than those in TACE alone group (39.9 %, 9.5 %, and 7.2%,respectively, P=0.0001). Cox proportional hazards model analysis showed that tumor extension and Child grade were significant and were independent negative predictors of survival, while irradiation was an independent positive predictor of survival.CONCLUSION: TACE combined with radiotherapy is more effective than TACE alone, and is a promising treatment for unresectable large HCC. | WeiJianGuo Er-XinYu Lu-MingLiu JieLi ZhenChen Jun-HuaLin Zhi-QiangMeng YiFeng | 2003 | World Journal of Gastroenterology2003，9，8： | 36 |
| 3 | Recent progress of surface coating on cathode materials for high-performance lithium-ion batteries显示文摘Lithium-ion batteries (LIB) have received substantial attention in the last 10 years,as they offer great promise as power sources that can lead to the electric vehicle (EV) revolution in the next 5 years.Since the cathode serves as a key component in LIB,its properties significantly affect the performance of the whole system.Recently,the cathode surface modification based on coating technique has been widely employed to enhance the electrochemical performances by improving the material conductivity,stabilising the physical structure of materials,as well as preventing the reactions between the electrode and electrolyte.In this work,we reviewed the present of a number of promising cathode materials for Li-ion batteries.After that,we summarized the very recent research progress focusing on the surface coating strategies,mainly including the coating materials,the coating technologies,as well as the corresponding working mechanisms for cathodes.At last,the challenges faced and future guidelines for optimizing cathode materials are discussed.In this study,we propose that the structure of cathode is a crucial factor during the selection of coating materials and technologies. | Peiyuan Guan Lu Zhou Zhenlu Yu Yuandong Sun Yunjian Liu Feixiang Wu Yifeng Jiang Dewei Chu | 2020 | Journal of Energy Chemistry2020，29，4： | 28 |
| 4 | A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations显示文摘The Coronavirus Disease 2019(COVID-19)epidemic emerged in Wuhan,China,spread nationwide and then onto half a dozen other countries between December 2019 and early 2020.The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people’s lives.It has also triggered a wide variety of psychological problems,such as panic disorder,anxiety and depression.This study is the first nationwide largescale survey of psychological distress in the general population of China during the COVID-19 epidemic. | Jianyin Qiu Bin Shen Min Zhao Zhen Wang Bin Xie Yifeng Xu | 2020 | General Psychiatry2020，33，1： | 26 |
| 5 | Evidence of the Pan-Lake Stage in the Period of 40-28 ka B.P. on the Qinghai-Tibet Plateau显示文摘The Qinghai-Tibet plateau is one of major saline lake regions in China, where saline lakes are widespread and constitute an important object of researches on the palaeoclimatic change in the region. On the basis of comprehensive investigations of the evolution of the lake’s surface and sediments on the plateau, the authors have further demonstrated the existence of a pan-lake stage (river and lake flooding stage) on the Qinghai-Tibet plateau during the period of about 40+-28 ka B.P. and analyzed the palaeoclimatic characteristics of the pan-lake period and relationships between the ancient monsoons and the uplift of the plateau since the beginning of the Quaternary. | ZHENG Mianping, MENG Yifeng and Wei LejunResearch & Development Center of Saline Lake and Epithermal Deposits,Chinese Academy of Geological Sciences, Beijing 100037 | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 22 |
| 6 | Modeling of coupled deformation,water flow and gas transport in soil slopes subjected to rain infiltration显示文摘Rain infiltration into a soil slope leads to propagation of the wetting front, transport of air in pores and deformation of the soils, in which coupled processes among the solid, liquid and gas phases are typically involved. Most previous studies on the unsaturated flow and its influence on slope stability were based on the singlephase water flow model (i.e., the Richards Equation) or the waterair two-phase flow model. The effects of gas transport and soil deformation on the movement of groundwater and the evolution of slope stability were less examined with a coupled solid-water-air model. In this paper, a numerical model was established based on the principles of the continuum mechanics and the averaging approach of the mixture theory and implemented in an FEM code for analysis of the coupled deformation, water flow and gas transport in porous media. The proposed model and the computer code were validated by the Liakopoulos drainage test over a sand column, and the significant effect of the lateral air boundary condition on the draining process of water was discussed. On this basis, the coupled processes of groundwater flow, gas transport and soil deformation in a homogeneous soil slope under a long heavy rainfall were simulated with the proposed three-phase model, and the numerical results revealed the remarkable delaying effects of gas transport and soil deformation on the propagation of the wetting front and the evolution of the slope stability. The results may provide a helpful reference for hazard assessment and control of rainfall-induced landslides. | HU Ran CHEN YiFeng ZHOU ChuangBing | 2011 | Science China(Technological Sciences)2011，54，10： | 19 |
| 7 | Molecular phylogeny and biogeography of the highly specialized grade schizothoracine fishes (Teleostei:Cyprinidae) inferred from cytochrome b sequences显示文摘We recovered the phylogenetic relationships among 23 species and subspecies of the highly special-ized grade schizothoracine fishes distributing at 36 geographical sites in the Tibetan Plateau and its surrounding regions by analyzing sequences of cytochrome b genes. Furthermore, we estimated the possible divergent times among lineages based on a historical geological isolation event in the Tibetan Plateau. The molecular data revealed that the highly specialized grade schizothoracine fishes were not a monophyletic group, but were the same as genera Gymnocypris and Schizogypsis. Our results indi-cated that the molecular phylogenetic relationships apparently reflected their geographical and historical associations with drainages, namely species from the same and adjacent drainages clustered together and had close relationships. The divergence times of different lineages were well consistent with the rapid uplift phases of the Tibetan Plateau in the late Cenozoic, suggesting that the origin and evolution of schizothoracine fishes were strongly influenced by environment changes resulting from the upheaval of the Tibetan Plateau. | HE DeKui CHEN YiFeng | 2007 | Chinese Science Bulletin2007，52，6： | 19 |
| 8 | Feature extraction for latent fault detection and failure modes classification of board-level package under vibration loadings.显示文摘A feature extraction for latent fault detection and failure modes classification method of board-level package subjected to vibration loadings is presented for prognostics and health management(PHM) of electronics using adaptive spectrum kurtosis and kernel probability distance clustering. First, strain response data of electronic components is filtered by empirical mode decomposition(EMD) method based on maximum spectrum kurtosis(SK), and fault symptom vector is developed by computing and reconstructing the envelope spectrum. Second, nonlinear fault symptom data is mapped and clustered in sparse Hilbert space using Gaussian radial basis kernel probabilistic distance clustering method. Finally, the current state of board level package is estimated by computing the membership probability of its envelope spectrum. The experimental results demonstrated that the method can detect and classify the latent failure mode of board level package effectively before it happened. | TANG Wei JING Bo HUANG YiFeng SHENG ZengJin | 2015 | Science China(Technological Sciences)2015，58，11： | 16 |
| 9 | Multifunctional integration on optical fiber tips: challenges and opportunities显示文摘.The flat endface of an optical fiber tip is an emerging light-coupled microscopic platform that combines fiber optics with planar micro-and nanotechnologies.Since different materials and structures are integrated onto the endfaces,optical fiber tip devices have miniature sizes,diverse integrated functions,and low insertion losses,making them suitable for all-optical networks.In recent decades,the increasing demand for multifunctional optical fibers has created opportunities to develop various structures on fiber tips.Meanwhile,the unconventional shape of optical fibers presents challenges involving the adaptation of standard planar micro-and nanostructure preparation strategies for fiber tips.In this context,researchers are committed to exploring and optimizing fiber tip manufacturing techniques,thereby paving the way for future integrated all-fiber devices with multifunctional applications.First,we present a broad overview of current fabrication technologies,classified as“top-down,”“bottom-up,”and“material transfer”methods,for patterning optical fiber tips.Next,we review typical structures integrated on fiber tips and their known and potential applications,categorized with respect to functional structure configurations,including“optical functionalization”and“electrical integration.”Finally,we discuss the prospects for future opportunities involving multifunctional integrated fiber tips. | Yifeng Xiong Fei Xu | 2020 | Advanced Photonics2020，2，6： | 11 |
| 10 | Integrative genome-wide analysis reveals HLP1, a novel RNA-binding protein, regulates plant flowering by targeting alternative polyadenylation显示文摘 | Yong Zhang Lianfeng Gu Yifeng Hou Lulu Wang Xian Deng Runlai Hang Dong Chen Xiansheng Zhang Yi Zhang Chunyan Liu Xiaofeng Cao | 2015 | Cell Research2015，25，7： | 11 |
| 11 | Determining areas in an inclined coal seam floor prone to water-inrush by micro-seismic monitoring显示文摘当采矿在限制含水土层上面被执行时,煤缝接地板的失败深度是必须被记住的一重要考虑。决定地板失败深度是为预言地板的抵抗水的能力的必要前提。我们使用了一种高精确的微地震的监视技术克服从域大小可得到的数据的有限数量。一块煤缝接地板的失败深度,一块特别使倾向的煤缝接地板,可以被监视地板的连续、动态失败更精确地估计。监视结果在 workface 运输车道(更低的 crossheading ) 附近显示煤缝接地板的失败深度更深并且失败范围与回来航线(上面的 crossheading ) 附近的煤缝接地板相比在这里是更宽的。微地震的监视的结果证明为从煤缝接地板的水流入的危险区域可以被识别。这提供帮助在 Taoyuan 煤矿在限制含水土层上面保证使倾向的煤缝接的安全、高度有效的采矿的重要的地大小。 | Sun Jian Wang Lianguo Wang Zhansheng Hou Huaqiang Shen Yifeng | 2011 | Mining Science and Technology2011，21，2： | 11 |
| 12 | The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis显示文摘Panax notoginseng,a perennial herb of the genus Panax in the family Araliaceae,has played an important role in clinical treatment in China for thousands of years because of its extensive pharmacological effects.Here,we report a high-quality reference genome of P.notoginseng,with a genome size up to 2.66 Gb and a contig N50 of 1.12 Mb,produced with third-generation PacBio sequencing technology.This is the first chromosome-level genome assembly for the genus Panax.Through genome evolution analysis,we explored phylogenetic and whole-genome duplication events and examined their impact on saponin biosynthesis.We performed a detailed transcriptional analysis of P.notoginseng and explored genelevel mechanisms that regulate the formation of characteristic tubercles.Next,we studied the biosynthesis and regulation of saponins at temporal and spatial levels.We combined multi-omics data to identify genes that encode key enzymes in the P.notoginseng terpenoid biosynthetic pathway.Finally,we identified five glycosyltransferase genes whose products catalyzed the formation of different ginsenosides in P.notoginseng.The genetic information obtained in this study provides a resource for further exploration of the growth characteristics,cultivation,breeding,and saponin biosynthesis of P.notoginseng. | Zhouqian Jiang Lichan Tu Weifei Yang Yifeng Zhang Tianyuan Hu Baowei Ma Yun Lu Xiuming Cui Jie Gao Xiaoyi Wu Yuru Tong Jiawei Zhou Yadi Song Yuan Liu Nan Liu Luqi Huang Wei Gao | 2021 | Plant Communications2021，2，1： | 11 |
| 13 | Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer显示文摘Metformin is a widely prescribed hypoglycemic drug.Many studies have shown its anti-cancer properties.In the present study,we aimed to explore the effect of metformin on breast cancer and clarify the underlying mechanism.Our results showed that metformin induced ferroptosis in MDA-MB-231 cells through upregulating miR-324-3p expression.Overexpression of miR-324-3p inhibited cancer cell viability.miR-324-3p inhibitor promoted cell viability.Further studies showed that the effect of miR-324-3p was mediated by directly targeting glutathione peroxidase 4(GPX4).miR-324-3p bound to the 3ʹ-UTR of GPX4 and led to the downregulation of GPX4.In vivo studies showed that metformin induced ferroptosis by upregulating miR-324-3p in the xenograft model of breast cancer in mice.Our study suggested that metformin promotes ferroptosis of breast cancer by targeting the miR-324-3p/GPX4 axis.Metformin could act as a potential anti-cancer agent through the induction of ferroptosis. | Yifeng Hou Shuang Cai Shouyang Yu Hui Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 11 |
| 14 | A new classification of seepage control mechanisms in geotechnical engineering显示文摘Seepage flow through soils,rocks and geotechnical structures has a great influence on their stabilities and performances,and seepage control is a critical technological issue in engineering practices.The physical mechanisms associated with various engineering measures for seepage control are investigated from a new perspective within the framework of continuum mechanics;and an equation-based classification of seepage control mechanisms is proposed according to their roles in the mathematical models for seepage flow,including control mechanisms by coupled processes,initial states,boundary conditions and hydraulic properties.The effects of each mechanism on seepage control are illustrated with examples in hydroelectric engineering and radioactive waste disposal,and hence the reasonability of classification is demonstrated.Advice on performance assessment and optimization design of the seepage control systems in geotechnical engineering is provided,and the suggested procedure would serve as a useful guidance for cost-effective control of seepage flow in various engineering practices. | Yifeng Chen Ran Hu Chuangbing Zhou Dianqing Li Guan Rong Qinghui Jiang | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，3： | 10 |
| 15 | Effect of processing on the alkaloids in Aconitum tubers by HPLC-TOF/MS显示文摘According to the Chinese Pharmacopoeia 2015, only processed Aconitum tubers can be clinically applied, and the effect of processing is unclear. This research aimed to explore the effect of processing on cardiac efficacy of alkaloids in Aconitum tubers. First, the chemical ingredients in unprocessed and processed Aconitum tubers were identified and compared by using high performance liquid chromatography time-of-flight mass spectrometry(HPLC-TOF/MS) and multivariate pattern recognition methods. Then the representative alkaloids in Aconitum tubers, aconitine, benzoylaconine, and aconine, which belong to diester-diterpenoid alkaloids,monoester-diterpenoid alkaloids, and amine-diterpenoid alkaloids, respectively, were selected for further validation of attenuated mechanism. Subsequent pharmacological experiments with aconitine, benzoylaconine,and aconine in SD rats were used to validate the effect of processing on cardiac functions. After processing the Aconitum tubers, it was found that the contents of diester-diterpenoid alkaloids were reduced, and those of monoester-diterpenoid alkaloids and amine-diterpenoid alkaloids were increased, suggesting that diesterditerpenoid alkaloids were transformed into monoester-diterpenoid alkaloids and amine-diterpenoid alkaloids.Through further decocting the aconitine in boiling water, it was confirmed that the three alkaloids could be progressively transformed. Pharmacological experiments with aconitine, benzoylaconine, and aconine in SD rats showed that aconitine at a dose of 0.01 mg/kg and aconine at a dose of 10 mg/kg enhanced the cardiac function, while benzoylaconine at a dose of 2 mg/kg weakened the cardiac function. The effect of processing is attributed to the transformation of the most toxic diester-diterpenoid alkaloids into less toxic monoesterditerpenoid alkaloids and amine-diterpenoid alkaloids. | Min Liu Yan Cao Diya Lv Wen Zhang Zhenyu Zhu Hai Zhang Yifeng Chai | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 10 |
| 16 | The effect of Scuteilaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats显示文摘Flavonoids 被显示了改进认知功能并且推迟痴呆前进。然而,内在的机制留下逃犯。在现在的学习,我们检验了从 S 提取的黄芩 baicalensis 茎叶总数 flavonoids (SSTF ) 的效果。在脉管的痴呆(VaD ) 的空间学习和记忆上的 baicalensis Georgi 老鼠模型并且探索了它的分子的机制。VaD 老鼠被普通颈动脉动脉的永久双边的吸藏开发。在恢复以后的七天, VaD 老鼠与 SSTF 的 50 或 100 mg/kg 被对待 60 天。空间学习和记忆在莫利斯舞水迷宫(MWM ) 被评估测试。字形物 hyperphosphorylation 和相关蛋白质 kinases 或磷酸酶的层次被西方的污点分析检验。在 VaD 老鼠,在 100 mg/kg 的 SSTF 处理显著地在在 MWM 测试训练试用减少了逃跑潜伏。在探针试用, SSTF 治疗在目标象限增加了寻找的时间和旅行距离。SSTF 处理在 VaD 老鼠在外皮和马头鱼尾的怪兽禁止了字形物 phosphorylation。同时, SSTF 减少了肝糖 synthase kinase 的活动 3 并且 cyclin 依赖的 kinase 5 在 VaD 老鼠。相反, SSTF 处理在 VaD 老鼠增加了蛋白质磷酸酶 2A 子单元 B 的水平。SSTF 处理显著地在 VaD 老鼠改进了空间认知。我们的结果建议 SSTF 可以通过在击以后协调 kinases 和磷酸酶的活动减轻 tau-hyperphosphorylation-induced neurotoxicity。SSTF 可以为 VaD 被开发进有希望的新奇治疗学。 | Yanjing Cao Lizhen Liang Jian Xu Jiali Wu Yongxing Yan Ping Lin Qiang Chen Fengming Zheng Qin Wang Qian Ren Zengmei Gou Yifeng Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 17 | Spatial structure of valley economic development in the mountainous areas in Beijing显示文摘山谷经济是在被山谷开发的各种各样的人物定义的多山的区域开发的一个新模式,并且是区分为多山的区域开发的节俭的地理模式。在在山谷的不同多山的元素的分发的特殊空间联合关系是为山发展研究的新题目,并且如此的研究为研究和惯例两个都是有意义的。把简短探索基于关于多山的区域开发和追随者的长期的研究进涵义和山谷经济的空间组织进程,作者在北京多山的区域分析了山谷经济的开发的现在的状况,在北京多山的区域学习了特征和山谷经济的空间结构的变化的影响,并且最后建议了山谷经济的空间结构的合理安排山谷经济在新时代在北京多山的区域在发展和功能的转变起一个重要作用,这在这研究被考虑。第一,山谷经济没被行政边界构画出,并且它沿着主要交通线粗略地在多山的区域连接大多数村庄。因此,山谷经济能在多山的区域对发展施加积极影响,至少在象在多山的区域和农村、城市的区域的协调发展的工业结构的重新整理那样的方面。另外,在北京多山的区域的山谷经济在第二等的集中的一个空间组织阶段被发展,这被发现,它被节省资源的、生态的保护和工业优化描绘。因此,山谷经济的发展将在多山的区域对在生态的保护和经济开发之间的协作有用,并且将支持多山的区域的综合发展。在北京多山的区域的山谷经济的发展中的模式将在北京多山的区域的功能的角色的转变为决策提供基础,并且在另一方面,将在北京外面在多山的区域为研究介绍经验。 | ZHANG Yifeng JIA Dameng ZHANG Hongye TAN Jie SONG Siyu SUN Ruifeng | 2011 | Journal of Geographical Sciences2011，21，2： | 9 |
| 18 | Review of the biological and engineering aspects of algae to fuels approach显示文摘Current biofuel production relies on limited arable lands on the earth,and is impossible to meet the biofuel demands.Oil producing algae are alternative biofuel feedstock with potential to meet the world’s ambitious goal to replace fossil fuels.This review provides an overview of the biological and engineering aspects in the production and processing technologies and recent advances in research and development in the algae to fuels approach.The article covers biology,selection and genetic modification of algae species and strains,production systems design,culture media and light management,harvest and dewatering,downstream processing,and environment and economic assessment.Despite the many advances made over several decades,commercialization of algal fuels remains challenging chiefly because of the techno-economic constraints.Technological breakthroughs in all major aspects must take place before commercial production of algal fuels becomes economically viable. | Paul Chen Min Min Yifeng Chen Liang Wang Yecong Li Qin Chen Chenguang Wang Yiqin Wan Xiaoquan Wang Yanling Cheng Shaobo Deng Kevin Hennessy Xiangyang Lin Yuhuan Liu Yingkuan Wang Blanca Martinez Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 9 |
| 19 | Breeding strategy of Acrossocheilus fasciatus in the Puxi Stream of the Huangshan Mountain显示文摘Breeding strategies of Acrossocheilus fasciatus were studied from 592 specimens collected monthly during May 2007 and April 2008 in the Puxi Stream of the Huangshan Mountain.Sex ratio of the studied population was 0.90∶1(♀∶♂),not significantly different from 1∶1.Both sexes reached their first sexual maturity at age 2(the second calendar year of their birth).Fifty percent of females and males reached maturity at a total length of 69.75 mm and 69.36 mm respectively,and the minimum total length was 61.54 mm and 58.96 mm,respectively.Based on the monthly changes in gonado-somatic index and egg-development process,the breeding season of the population was from May to August,with one obvious interval(in June)occurring in the breeding activity for the females.The nonsynchronous development of oocytes observed in mature ovaries indicated that A.fasciatus is a batch spawner.Absolute fecundity of A.fasciatus ranged from 308 to 2002 eggs with a mean of 857 eggs,increased significantly with total length,and was significantly different among three age groups.Relative fecundity ranged from 38.63 to 71.70 egg/g with a mean of 53.29 egg/g,and was not significantly different among the three age groups.It was suggested that these reproductive characteristics were adaptive strategies for A.fasciatus to acclimatize to lotic water where environmental factors were unstable but predictable. | Yunzhi YAN Lili GUO Xiuying XIANG Yilong XI Yifeng CHEN | 2009 | Current Zoology2009，55，5： | 9 |
| 20 | Protective Effect of Magnesium Isoglycyrrhizinate on Ethanol-Induced Testicular Injuries in Mice显示文摘Objective:Ethanol treatment induces an increase in oxidative stress. As licorice compounds are potent antioxidants, our aim was to examine whether magnesium isoglycyrrhizinate attenuated lipid peroxidation, the major end-point of oxidative damage resulting from ethanol administration. Methods: Four groups(18 animals in each group) of male Kunming mice were used. The first group served as control and received 0.4 ml normal saline daily for 18 days orally. The second group of mice was given 56% ethanol at 16 ml/kg body weight per day for 18 days orally. The third group was given the same dose of ethanol and administrated magnesium isoglycyrrhizinate (15 mg/kg.d, i.p.) for 18 days. The fourth group was given the same dose of ethanol and administrated with magnesium isoglycyrrhizinate (45 mg/kg.d, i.p.) for 18 days. Twenty four hours after 9 days or 18 days of treatment the mice were sacrificed using 10% chloral hydrate. Sperm counts and motility in the epididymis were assessed. The lipid peroxidation and antioxidants of testicular mitochondria were also determined. The pathological changes of testicle tissue of the mice were observed by light microscopy. Results: Magnesium isoglycyrrhizinate effectively prevented the ethanol-induced seminiferous epithelium disorganization and degeneration of Sertoli cells and germ cells. Sperm counts and motility of the magnesium isoglycyrrhizinate treated groups were higher than those of the alcohol treated group, but were lower than those of the control group. The drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular malondialdehyde (MDA) and increased the activities of superoxide dismutase and glutathione peroxidase. Conclusion: Magnesium isoglycyrrhizinate is able to inhibit the ethanol-induced lipid peroxidation and has a protective effect against testicular oxidative injury. | Yuanqiao He Fuqing Zeng Qing Liu Wen Ju Houju Fu Hua Hao Lulu Lia Yifeng Xie | 2010 | The Journal of Biomedical Research2010，24，2： | 9 |
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