|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance显示文摘Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal women.Under chronic inflammatory conditions caused by estrogen deficiency,activated T cells contribute to elevated levels of proinflammatory cytokines,impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells(BMMSCs),and disturbed regulatory T cell(Treg)/Th17 cell balance.However,therapeutic strategies that re-establish immune homeostasis in this disorder have not been well developed.Here,we produced T cell-depleting nanoparticles(TDNs)that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized(OVX)mice.TDNs consist of monocyte chemotactic protein-1(MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand(FasL)as the corona.We showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in vivo.Apoptotic signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state,further attenuating the osteogenic deficiency of BMMSCs and the osteopenia phenotype.Mechanistically,we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles(ApoEVs),which promoted macrophage transformation towards the M2 phenotype.These findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders. | Xiaoshan Yang Fuxing Zhou Pingyun Yuan Geng Dou Xuemei Liu Siying Liu Xiangdong Wang Ronghua Jin Yan Dong Jun Zhou Yajie Lv Zhihong Deng Shiyu Liu Xin Chen Ying Han Yan Jin | 2021 | Bioactive Materials2021，6，10： | 4 |
| 2 | Correlation of the anisotropic hardening behavior and texture features of cold rolled Zr-4 sheet under uniaxial tension显示文摘The strongly anisotropic mechanical behaviors commonly observed in Zr-4 sheets typically lead to inferior formability.In this study,the mechanical behavior and texture evolution of a cold-rolled Zr-4 sheet under uniaxial tension in various directions were systematically investigated,and the results showed both anisotropic yielding and hardening behavior in the Zr-4 sheet.The microstructure and texture features revealed by electron backscattered diffraction(EBSD)method indicate that this anisotropic mechanical behavior is closely related to the initial texture and its evolution during plastic deformation.In conjunction with experimental observations,a visco-plastic self-consistent(VPSC)model was employed to quantitatively analyze the relationship between the mechanical anisotropy and the texture features and activation of deformation modes.It was found that the yield anisotropy is affected by the distinct activity of prismaticslip,while the different activities of basalslip and extension twinning(ETW)result in anisotropic hardening.The distinct activation of deformation modes is mainly caused by differences in the evolution of the Schmid factor(SF)and critical resolved shear stress(CRSS)with increasing strain.Additionally,the results prove that the limited twinning activation with a fraction of less than 3%plays a non-negligible role in the hardening behavior during tension along the transverse direction.The latent hardening effect caused by the interaction between prismatic slip and tensile twinning is considered to successfully capture the anisotropic hardening behavior of the Zr-4 sheet.The implementation and insights from the predictions are presented and discussed in this work. | Huan Liu Siying Deng Shuaifeng Chen Hongwu Song Shihong Zhang Ben Wang | 2022 | Journal of Materials Science & Technology2022，，24： | 0 |
| 3 | Research and Optimization of Foshou Yam and Honey Nutritional Can by Response Surface Methodology显示文摘[Objectives]This study was conducted to screen best process parameters for making Foshou yam and honey can.[Methods]The Foshou yam produced from Wuxue was used as a raw material to prepare Foshou yam and honey nutritional can by combining Foshou yam with honey through screening,pre-cooking,filling,exhausting,cooling and other technical processes.The optimum technology parameter of Foshou yam and honey nutritional can was studied through single factor tests and response surface optimization.[Results]The optimum technical parameters of Foshou yam and honey nutritional can were citric acid concentration 0.1%,amount of edible salt 0.1%,cooking time 14 min and honey concentration 26%.Under these conditions,the final sensory score was 90.20.The prepared can was not only rich in nutrition,but also had good flavor and taste.[Conclusions]This study provides reference for the development and utilization of Foshou yam and the research and development of functional food. | Siying CHEN Sui YU Xia DENG Ting HU | 2020 | Agricultural Biotechnology2020，9，6： | 0 |
| 4 | Study on Callus Induction and Tissue Culture Regeneration System of Malus toringoides显示文摘[Objectives]To study the culture of callus produced by the leaves of the ethnic medicine‘E Se’,the induction of adventitious buds and the regeneration system of tissue culture seedlings.[Methods]Multi-factor orthogonal experiment was used to design and analyze.[Results]The best medium for callus induction was MS+2.0 mg/L 6-BA+0.1 mg/L 2,4-D.By comparing the effects of cytokinin 6-BA,KT and TDZ on induction of adventitious bud differentiation,it was found that the optimum medium for adventitious bud regeneration was MS+0.5 mg/L 6-BA+0.5 mg/L KT+0.15 mg/L IBA.Finally,adding 0.2 mg/L IBA(0.1 or 0.2 mg/L)to MS medium could effectively make regenerated seedlings produce roots,and the efficiency was more than 70%.[Conclusions]It laid a foundation for the large-scale cultivation of the seedlings of the ethnic medicine‘E Se’and the promotion of their artificial cultivation. | Xiaobo QIN Bei NIU Lijuan FAN Guozhen ZHANG Dongmei HU Bingbing ZHANG Xiaodong SHI Xinyi XU Peng WU Tingwei DAI Siying QIN Xiao LI Yushan DENG Fei ZU | 2019 | Medicinal Plant2019，10，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员