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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | A temporal link between the Emeishan large igneous province (SW China) and the end-Guagalupian mass extinction 显示文摘 | Zhou M F Malpas J Song X Y Robinson P T Sun M Kennedy A K Lesher C M Keays R R | 2002 | Earth arut Planetary Science Letters2002，196，： | 1 |
| 3 | The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells 显示文摘 | Song P I Abraham T A Park Y | 2001 | Ophthalmology & Visual2001，42，12： | 1 |
| 4 | The crystal structure of human eukaryotic release factor eRF1-mechanism of stop codon recognition and peptidyl-tRNA hydrolysis显示文摘 | Song H Mugnier P Das A | 2000 | Cell2000，100，3： | 1 |
| 5 | Synthesis, X-ray Crystallographic Analysis, and Antitumor Activity of N-( benzothiazole-2-yl ) -1-( fluorophenyl )-O, O-dialkyl-α-aminophospho - nares显示文摘 | JIN L H SONG B A ZHANG G P | 2006 | Bioorg Med Chem Lett2006，16，6： | 1 |
| 6 | Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus显示文摘 | Song P Onishi A Koepsell H | 2016 | Expert Opin Ther Targets2016，12，： | 1 |
| 7 | Forecasting UK house prices: A time varying coefficient approach显示文摘 | Brown J P Song H Mcgillivray A | 1997 | Economic Modelling1997，14，： | 1 |
| 8 | Identification of cry1I-type genes from Bacillus thuringiensis strains and characterization of a novel cry1I-type gene显示文摘 | Song F P Zhang J Gu A | 2003 | Applied and Environment Microbiology2003，69，9： | 1 |
| 9 | Sedimentary record of blackcarbon in the Pearl River estuary and adjacent northern South ChinaSea显示文摘 | SUN X S PENG P A SONG J Z | 2008 | Applied Geochemistry2008，23，： | 1 |
| 10 | Synthesis and antiviral activity of novel pyrazole amides contai- ning ct-aminophosphonate moiety 显示文摘 | Wu L T Song B A Bhadury P S | 2011 | Journal of Het- erocyclic Chemistry2011，45，2： | 1 |
| 11 | Claudin-6and claudin-9function as additional coreceptors for hepatitis C virus显示文摘 | Zheng A Yuan F Li Y Zhu F Hou P Li J Song X Ding M Deng H | 2007 | J Virol2007，81，12： | 1 |
| 12 | Strategies for handling UPFC constraints in steady-state power flow and voltage control显示文摘 | Jun-Yong Liu Yong-Hua Song Mehta P A | 2000 | IEEE Trans on Power Systems2000，15，2： | 1 |
| 13 | Determination of trapping pressure and temperature of petroleum inclusions using PVT simulation software: A case study of Lower Ordovician carbonates from the Lunnan low uplift, Tarim Basin显示文摘 | Liu D H Xiao X M Mi J K Li X Q Shen J G Song Z G Peng P A | 2003 | Mar Pet Geol2003，20，1： | 1 |
| 14 | Electrohydrodynamic generation and delivery of monodisperse picoliter droplets using a poly (dimethylsiloxane) microchip 显示文摘 | Kim S J Song Y A Skipper P L | 2006 | Analytical chemistry2006，78，23： | 1 |
| 15 | Characterization of microstructure and coercivity of Nd-Fe-B magnets with Ti and Al or Cu addition 显示文摘 | Yan A R Song X P Chen Z M Wang X T | 1998 | Journal of Magnetism and Magnetic Materials1998，185，： | 1 |
| 16 | Sedimentary record of black carbon in the Pearl River estuary and adjacent northern South China Sea 显示文摘 | Sun X S Peng P A Song J Z | 2008 | Applied Geochemistry2008，23，12： | 1 |
| 17 | A Chemical Kinetic Modeling Study on the Mechanism of Soot Reduction by Oxygenated Additives in Diesel Engines显示文摘 | Nag P Song K H Litzinger T A | 2001 | Int J Engine Research2001，2，3： | 1 |
| 18 | Does mycophenolate mofetil increase the risk of cytomegalovirus infection in solid organ transplant recipients? A mini-review 显示文摘 | SONG A T ABDALA E BONAZZI P R | 2006 | Braz J Infect Dis2006，10，2： | 1 |
| 19 | Cyclooxygenase-2, play- er or spectator in cyclooxygenase-2 inhibitor-induced apopto- sis in prostate cancer ceils显示文摘 | Song X Lin H P Johnson A J | 2002 | J Natl Cancer Inst2002，94，8： | 1 |
| 20 | Analytical and semi-preparative enantioseparation of organic phosphonates on a new immobilized amylose based chiral stationary phase显示文摘 | ZHANG Y P SONG B A BHADURY S P | 2008 | J Sep Sci2008，31，1617： | 1 |
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