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| 1 | Marsdenia tenacissima extract induces G_0/G_1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase(MAPK) signaling pathway显示文摘Marsdenia tenacissima extract(MTE, trade name: Xiao-Ai-Ping injection) is an extract of a single Chinese plant medicine. It has been used for the treatment of cancer in China for decades, especially for esophageal cancer and other cancers in the digestive tract. In the present study, the potential mechanism for MTE's activity in esophageal cancer was explored. The effects of MTE on the proliferation of human esophageal cancer cells(KYSE150 and Eca-109) were investigated by the MTT assay, the Brd U(bromodeoxyuridine) incorporation immunofluorescence assay, and flow cytometric analysis. MTE inhibited cell proliferation through inducing G0/G1 cell cycle arrest in KYSE150 and Eca-109. Western blot analysis was employed to determine protein levels in the MTE treated cells. Compared with the control cells, the expression levels of the cell cycle regulatory proteins cyclin D1/D2/D3, cyclin E1, CDK2/4/6(CDK: cyclin dependent kinase), and p-Rb were decreased significantly in the cells treated with MTE at 40 mg·m L-1. In addition, MTE had an inhibitory effect on the MAPK(mitogen-activated protein kinase) signal transduction pathway, including ERK(extracellular signal-regulated kinase), JNK(c-Jun N-terminal kinase), and p38 MAPK. Moreover, MTE showed little additional effects on the regulation of cyclin D1/D3, CDK4/6, and p-Rb when the ERK pathway was already inhibited by the specific ERK inhibitor U0126. In conclusion, these data suggest that MTE inhibits human esophageal cancer cell proliferation through regulation of cell cycle regulatory proteins and the MAPK signaling pathways, which is probably mediated by the inhibition of ERK activation. | FAN Wei SUN Li ZHOU Jing-Qian ZHANG Cang QIN Song TANG Ying LIU Yang LIN Sen-Sen YUAN Sheng-Tao | 2015 | Chinese Journal of Natural Medicines2015，13，6： | 32 |
| 2 | Balanced solubility product and enthalpies of formation of Nb compounds in 0.09 % oriented silicon steel显示文摘Balance solubility products and enthalpy of formation for NbC0.75 , NbC0.85 , NbC0.88 , NbC and NbN in oriented silicon steels were calculated and compared qualitatively. Meanwhile, the mixing enthalpies of these five Nb compounds were calculated based on Miedema Model. The results show that the solubility products of Nb compounds in ferrite and austenite meet the following relationship, NbC0.75>NbC0.85> NbC0.88>NbC>NbN and NbN has the minimum enthalpy of formation. It indicates that NbN easily precipitate out, but it is more difficult for NbC 0.75 . | Hui Li Yun-Li Feng Dan Zhang Meng Song Da-Qiang Cang | 2013 | Rare Metals2013，32，3： | 6 |
| 3 | Theory of Dynamic Diagnosis Based on Integrated Maintenance Information显示文摘Based on the concept of an integrated maintenance information system and related information environment, this paper discusses the process of troubleshooting in modern maintenance in detail, and gives a model of dynamic diagnosis of faults, in which a reasoning program is designed through taking advantage of information fusion and time analysis. In the end, the authors present the logic process of dynamic diagnosis through a typical example, and proposes a dynamic diagnostic system based on information fusion. | WANG Xiao cheng, WU Song lin, LIU Cang yi Department of Equipment Management Engineering, Air Force University of Engineering, Shaanxi, Xi’an 710038, P.R.China | 2002 | International Journal of Plant Engineering and Management2002，7，1： | 2 |
| 4 | High production of prodigiosin by Serratia marcescen grown on ethanol显示文摘 | CANG Song SANADA M JOHDO O | 2000 | Biotechnology Letters2000，22，： | 1 |
| 5 | Performance of microbial fuel cell coupled constructed wetland system for decolorization of azo dye and bioelectricity generation 显示文摘 | FANG Z SONG H CANG N | 2013 | Bioresource Technology2013，144，： | 1 |
| 6 | High production of prodigiosin by Serratia marcescens grown on ethanol显示文摘 | Song Cang Sanada M Johdo O | 2000 | Biotech Lett2000，22，22： | 1 |
| 7 | Expression of the vitamin D receptor is increased in the hypertrophic heart 显示文摘 | Song cang Chen Denis J Glenn | 2008 | Hypertension2008，52，6： | 1 |
| 8 | Expression of the Vitamin D receptor is increased in the hypertrophic heart 显示文摘 | Song cang Chen Denis J Glenn | 2008 | Hypertension2008，52，6： | 1 |
| 9 | PSTK is a novel gene associated with early lung injury in paraquat poisoning显示文摘 | Zheng D Li C Wang S Cang Y Song Y Liu X | 2015 | Life Sci2015，123，123： | 1 |
| 10 | Effects of ultrasonic treatment during the solidification process on the structure formation of low carbon steel 显示文摘 | Kong W Cang D Q Song J H | 2011 | Materials Transactions2011，52，9： | 1 |
| 11 | Electricity production from Azo dye wastewater using a microbial fuel cell coupled constructed wetland operating under different operating conditions显示文摘 | Fang Z Song H L Cang N | 2015 | Biosensors & Bioelectronics2015，68，： | 1 |
| 12 | Deadline based scheduling for data-intensive applications in clouds显示文摘Cloud computing emerges as a new computing pattern that can provide elastic services for any users around the world. It provides good chances to solve large scale scientific problems with fewer efforts. Application deployment remains an important issue in clouds. Appropriate scheduling mechanisms can shorten the total completion time of an application and therefore improve the quality of service(QoS) for cloud users. Unlike current scheduling algorithms which mostly focus on single task allocation, we propose a deadline based scheduling approach for data-intensive applications in clouds. It does not simply consider the total completion time of an application as the sum of all its subtasks' completion time. Not only the computation capacity of virtual machine(VM) is considered, but also the communication delay and data access latencies are taken into account. Simulations show that our proposed approach has a decided advantage over the two other algorithms. | Fu Xiong Cang Yeliang Zhu Lipeng Hu Bin Deng Song Wang Dong | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，6： | 0 |
| 13 | Structure and transport mechanism of the human calcium pump SPCA1显示文摘Secretory-pathway Ca^(2+)-ATPases(SPCAs)play critical roles in maintaining Ca^(2+)homeostasis,but the exact mechanism of SPCAsmediated Ca^(2+)transport remains unclear.Here,we determined six cryo-electron microscopy(cryo-EM)structures of human SPCA1(hSPCA1)in a series of intermediate states,revealing a near-complete conformational cycle.With the aid of molecular dynamics simulations,these structures offer a clear structural basis for Ca^(2+)entry and release in hSPCA1.We found that hSPCA1 undergoes unique conformational changes during ATP binding and phosphorylation compared to other well-studied P-type II ATPases.In addition,we observed a conformational distortion of the Ca^(2+)-binding site induced by the separation of transmembrane helices 4L and 6,unveiling a distinct Ca^(2+)release mechanism.Particularly,we determined a structure of the long-sought CaE2P state of P-type IIA ATPases,providing valuable insights into the Ca^(2+)transport cycle.Together,these findings enhance our understanding of Ca^(2+)transport by hSPCA1 and broaden our knowledge of P-type ATPases. | Mengqi Wu Cang Wu Tiefeng Song Kewu Pan Yong Wang Zhongmin Liu | 2023 | Cell Research2023，33，7： | 0 |
| 14 | Approximation Theoretic Aspects of Probabilistic Representations for Bi-continuous C-semigroups显示文摘By means of Riemann-Stieltjes stochastic process, moment-generating functions and operator-valued mathematical expectation, the problem of probabilistic approximation for bi-continuous C-semigroups is studied and the general probabilistic approximation of exponential formulas and the generation theorems are given. | Cang Ding-bang Chen Cang Song Xiao-qiu Ji You-qing | 2014 | Communications in Mathematical Research2014，30，2： | 0 |
| 15 | POLYNOMIALLY BOUNDED COSINE FUNCTIONS显示文摘We characterize polynomial growth of cosine functions in terms of the resolvent of its generator and give a necessary and sufficient condition for a cosine function with an infinitesimal generator which is polynomially bounded. | Dingbang Cang Xiaoqiu Song Chen Cang | 2012 | Analysis in Theory and Applications2012，28，1： | 0 |
| 16 | Preparation of Polyester Polyol from Epoxidized Palm Olein显示文摘在这个工作,有高重量的聚酯 polyols 平均分子的重量(Mw )(Mw1000015000 ) 在非催化的状况下面在提高的温度从 epoxidized 手掌油精(EPOo ) 和一系列二羟基的酸(C6C12 ) 被准备。最佳的反应条件作为 180 被决定 ? 洠獥灯牯畯 ??? 渠湡 ' 忆礉 M 整 ??? ?? 戠牯湯捩 ?????? € 楣 ??? 楤汯?? 朠祬潣数瑰摩獥 ?????????????????????????敭潳潰潲獵 吗? | Lee, Choy Sin Lee, Song Cang | 2011 | Chinese Journal of Chemistry2011，29，4： | 0 |
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