|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 3 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 4 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water 显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catal Lett2006，109，： | 1 |
| 5 | Novel chemical method for synthesis of LiV3 O8 nanorods as cathode materials for lithium ion batteries 显示文摘 | Xu H Y Wang H Song Z Q | 2004 | Electrochimica Acta2004，49，2： | 1 |
| 6 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catalysis Letters2006，109，12： | 1 |
| 7 | Layered Copper Metagermanate Nanobelts: Hydrothennal Synthesis, Structure, and Magnetic Properties显示文摘 | Song R Q Xu A W Yu S H | 2007 | J Am Chem Soc2007，129，14： | 1 |
| 8 | Genetic polymorphism of Malus sieversii populations in Xinjiang, China 显示文摘 | Yan G R Long H Song W Q | 2008 | Genet Resour Crop Evol2008，，55： | 1 |
| 9 | Control of a cascade STATCOM with star configuration under unbalanced conditions显示文摘 | SONG Q LIU W H | 2009 | IEEE Trans on Power Electronics2009，24，1： | 1 |
| 10 | A new model of three-dimensional grain growth:theory and computer simulation of topology-dependency of individual grain growth rate显示文摘 | Liu G Q Yu H B Song X Y | 2001 | Materials & Design2001，22，： | 1 |
| 11 | Modified optical properties in a samarium doped titania inverse opal显示文摘 | Wang W Song H W Liu Q | | 0，，09： | 1 |
| 12 | Nitrogen transfer of fuel-N in chemical looping combustion 显示文摘 | Song T Shen L H Xiao J Chen D Q Gu H M Zhang S W | 2012 | Combustion and Flame2012，159，3： | 1 |
| 13 | Genome shuffling of hansenula anomala to improve flavour formation of soy sauce 显示文摘 | Can X H Song Q Wang C L | 2012 | World Journal of Microbiology & Biotechnology2012，28，5： | 1 |
| 14 | Chemical-looping combustion of methane with CaSO4 oxygen carder in a fixed bed reactor 显示文摘 | SONG Q XIAO R DENG Z ZHANG H SHEN L XIAO J ZHANG M | 2008 | Energy Convers Manage2008，49，11： | 1 |
| 15 | Discovery of immunerelated genes in Chinese mitten crab (Eriocheir sinensis) by expressed sequence tag analysis of haemocytes 显示文摘 | Zhao D X Song S H Wang Q | 2009 | Aquaculture2009，287，： | 1 |
| 16 | Time-dependent uniaxialpiezoresistive behavior of high-density polyethylene/shortcarbon fiber conductive composites显示文摘 | ZHENG Q ZHOU J F SONG Y H | 2004 | Journal of MaterialsResearch2004，19，9： | 1 |
| 17 | Diagnosis and management of pri- mary aortoenteric fistulas-experience learned from eighteen pa- tients显示文摘 | Song Y Liu Q Shen H | 2008 | Surgery2008，143，1： | 1 |
| 18 | Comparative analysesof the complete mitochondrial genomes of Ascarislumbricoides and Ascaris suum from humans and pigs显示文摘 | Liu G H Wu C Y Song H Q | 2012 | Gene2012，492，1： | 1 |
| 19 | Topsoil organic carbon storage of China and its loss by cultivation显示文摘 | Song G H Li L Q Pan G X | | 0，，01： | 1 |
| 20 | The Effect of Lead Time and Demand Uncertainties in(r,q)Inventory Systems显示文摘 | Song J S Zhang H Q Hou Y M Wang M Z | 2010 | Operations Research2010，58，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员