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| 1 | A comparative study between Embosphere~ and conventional transcatheter arterial chemoembolization for treatment of unresectable liver metastasis from GIST显示文摘Objective:Transcatheter arterial chemoembolization(TACE) is a standard treatment for hepatocellular carcinoma(HCC) and/or some unresectable liver metastasis tumors.Hypervascular liver metastatic lesions such as metastasis from gastrointestinal stromal tumor(GIST) are an indication for transcatheter arterial embolization(TAE).The purpose of this study was to evaluate the efficacy and safety of Embosphere~-TAE(Embo-TAE) in comparison with conventional TACE(cTACE) for the treatment of liver metastasis from GIST.Methods:A total of 45 patients who underwent TACE between Aug 2008 and Feb 2013 were enrolled.Patients with GIST who underwent TAE with Embosphere~(n=19) were compared with controls who received cTACE(n=26).The primary end points were treatment response and treatment-related adverse events.The secondary end points were progression-free survival(PFS) and overall survival(OS).Results:The treatment response of Embo-TAE group was significantly higher than that of the cTACE group(P<0.001).The PFS was significantly better in the Embosphere~-group than in the cTACE group(56.6 and 42.1 weeks,respectively;P=0.003).However,there was no statistically significant difference in liver toxicity between the two groups(P>0.05).The median OS in the Embo-TAE group was longer than that in the cTACE group(74.0 weeks,95% CI:68.2-79.8 vs.61.7 weeks,95% CI:56.2-67.2 weeks)(unadjusted P=0.045).The use of Embo-TAE significantly reduced the risk of death in patients with GIST with liver metastases according to the Cox proportional hazards regression model [hazard ratio(HR):0.149;95% CI:0.064-0.475].Conclusions:TAE with Embosphere~ showed better treatment response and delayed tumor progression compared with cTACE.There was no significant difference in treatment-related hepatic toxicities.EmboTAE thus appears to be a feasible and promising approach in the treatment of liver metastasis from GIST. | Guang Cao Xu Zhu Jian Li Lin Shen Renjie Yang Hui Chen Xiaodong Wang Song Gao Haifeng Xu Linzhong Zhu Peng Liu Jianhai Guo | 2014 | Chinese Journal of Cancer Research2014，26，1： | 18 |
| 2 | Responses of root growth of Alhagi sparsifolia Shap. (Fabaceae) to different simulated groundwater depths in the southern fringe of the Taklimakan Desert, China显示文摘Alhagi sparsifolia Shap. (Fabaceae) is a spiny, perennial herb. The species grows in the salinized, arid regions in North China. This study investigated the response characteristics of the root growth and the distribution of one-year-old A. sparsifolia seedlings to different groundwater depths in controlled plots. The ecological adaptability of the root systems of A. sparsifolia seedlings was examined using the artificial digging method. Results showed that: (1) A. sparsifolia seedlings adapted to an increase in groundwater depth mainly through increasing the penetration depth and growth rate of vertical roots. The vertical roots grew rapidly when soil moisture content reached 3%-9%, but slowly when soil moisture content was 13%-20%. The vertical roots stopped growing when soil moisture content reached 30% (the critical soil moisture point). (2) The morphological plasticity of roots is an important strategy used by A. sparsifolia seedlings to obtain water and adapt to dry soil conditions. When the groundwater table was shallow, horizontal roots quickly expanded and tillering increased in order to compete for light resources, whereas when the groundwater table was deeper, vertical roots developed quickly to exploit space in the deeper soil layers. (3) The decrease in groundwater depth was probably responsible for the root distribution in the shallow soil layers. Root biomass and surface area both decreased with soil depth. One strategy of A. sparsifolia seedlings in dealing with the increase in groundwater depth is to increase root biomass in the deep soil layers. The relationship between the root growth/distribution of A. sparsifolia and the depth of groundwater table can be used as guidance for harvesting A. sparsifolia biomass and managing water resources for forage grasses. It is also of ecological significance as it reveals how desert plants adapt to arid environments. | FanJiang ZENG Cong SONG HaiFeng GUO Bo LIU WeiCheng LUO DongWei GUI Stefan ARNDT DaLi GUO | 2013 | Journal of Arid Land2013，5，2： | 13 |
| 3 | Rb-Sr and Sm-Nd Isochron Ages of the Dongmozhazhua and Mohailaheng Pb-Zn Ore Deposits in the Yushu area, southern Qinghai and Their Geological Implications显示文摘Located on the northeast margin of the Qiangtang terrane between the Jinshajiang suture zone and Bangonghu-Nujiang suture zone, the Dongmozhazhua and Mohailaheng Pb-Zn deposits in the Yushu area of Qinghai Province are representative Pb-Zn deposits of the Pb-Zn-Cu polymetallic mineralization belt in the northern part of the Nujiang-Lancangjiang-Jinshajiang area, which are in the front belt of the Yushu thrust nappe system. The formed environments of these two deposits are different from those of sediment-hosted base metal deposits elsewhere in the world. The authors hold that they were formed during the Indian-Asian continental collision and developed within the foldthrust belt combined with thrust and strike-slip-related Cenozoic basins in the interior of the collisional zone. Studying on the metallogenic epochs of these two deposits is helpful to the understanding of ore-forming regularity of the regional Pb-Zn-Cu mineralization belt and also to the search for new deposits in this region. The age of the Dongmozhazhua deposit has been determined by the Rb-Sr isochron method for sphalerite residues, whereas the age of the Mohailaheng deposit has been determined by the Rb-Sr isochron method for sphalerite residues and the Sm-Nd isochron method for fluorite. The age of the Dongmozhazhua deposit is 35.0±0.0 Ma((87Sr/86Sr)0=0.708807) for sphalerite residues. The age of the Mohailaheng deposit is 32.2±0.4 Ma((87Sr/86Sr)0=0.708514) for sphalerite residues and 31.8±0.3 Ma((143Nd/144Nd)0=0.512362) for fluorite with an average of 32.0 Ma. Together with the regional geological setting during mineralization, a possible tectonic model for metallogeny of the Dongmozhazhua and Mohailaheng Pb-Zn deposits has been established. These two ages are close to the ages of the Pb-Zn deposits in the Lanping and Tuotuohe basins, indicating that it is possible that the narrow 1000-kilometer-long belt controlled by a thrust nappe system on the eastern and northern margins of the Tibetan plateau could be a giant Pb-Zn mineralized belt. | TIAN Shihong GONG Yingli YANG Zhusen HOU Zengqian LIU Yingchao SONG Yucai XUE Wanwen LU Haifeng WANG Fuchun ZHANG Yubao ZHU Tian YU Changjie | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 8 |
| 4 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 5 | Study of the permeability characteristics of porous media with methane hydrate by pore network model显示文摘The permeability in the methane hydrate reservoir is one of the key parameters in estimating the gas production performance and the flow behavior of gas and water during dissociation.In this paper,a three-dimensional cubic pore-network model based on invasion percolation is developed to study the effect of hydrate particle formation and growth habit on the permeability.The variation of permeability in porous media with different hydrate saturation is studied by solving the network problem.The simulation results are well consistent with the experimental data.The proposed model predicts that the permeability will reduce exponentially with the increase of hydrate saturation,which is crucial in developing a deeper understanding of the mechanism of hydrate formation and dissociation in porous media. | Haifeng Liang Yongchen Song Yu Liu Mingjun Yang Xing Huang | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 7 |
| 6 | Mammalian cell display for rapid screening scFv antibody therapy显示文摘人的抗体开始在有免疫力的基因治疗为使用正在引起注意。对癌症和传染疾病的治疗合适的有效治疗学的 monoclonal 抗体的有效产生将是极其珍贵的。抗体显示方法逐渐地被用来屏蔽人的 monoclonal 抗体。这里,我们报导一个哺乳动物的房间显示方法的构造源于一个天真的抗体全部剧目,为人,单个链的变量碎裂短暂地基于 pDisplay 向量在 293T 房间表面上被显示了。当前的 pDisplayscFv 抗体全部剧目的尺寸被估计了是 0. | Jing Zhang Xiao'ai Zhang Qiang Liu Mengyi Li Liucun Gao Xin Gao Shensi Xiang Liangliang Wu Jie Fu Haifeng Song | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 6 |
| 7 | Assessing the impacts of ecological-living-productive land changes on eco-environmental quality in Xining City on Qinghai-Tibet Plateau, China显示文摘The Ecological-living-productive land(ELPL)classification system was proposed in an effort to steer China's land pattern to an ecological-centered path,with the development model shifting from a single function into more integrated multifunction land use.The focus is coordinating the man-land contradictions and developing an intensive,efficient and sustainable land use policy in an increasingly tense relationship between humans and nature.Driven by socioeconomic change and rapid population growth,many cities are undergoing urban sprawl,which involves the consumption of cropland and ecological land and threatens the ecological balance.This paper aims to quantitatively analyze the critical effects of ELPL changes on eco-environmental quality according to land use classification based on leading function of ecology,living and production from 1990 to 2015 with a case study of Xining City.Also,four future land use scenarios were simulated for 2030 using the Future Land Use Simulation(FLUS)model that couples human and natural effects.Our results show a decrease in productive land(PL)and an increase in ecological land(EL)and living land(LL)in Xining City.Forestry ecological land(FEL)covered the top largest proportion;agriculture productive land(APL)showed the greatest reduction and urban and rural living land(U-RLL)presented a dramatic increase.The eco-environmental quality improved in 1990-2010,mainly affected by the conversion of APL to FEL and GEL.However,the encroachment of U-RLL into APL,other ecological land(OEL)and FEL was the main contributor to the decline in eco-environmental quality in 2010-2015 as well as the primary reason for the increase area of lower-quality.The Harmonious Development(HD)-Scenario,characterized by a rational allocation of LL and PL and a better eco-environment,would have implications for planning and monitoring future management of ELPL,and may represent a valuable reference for local policy-makers. | ZiYi Gao HaiFeng Zhang XiaoNan Yang ZhiYuan Song | 2019 | Research in Cold and Arid Regions2019，11，3： | 5 |
| 8 | Molybdenum isotopic composition as a tracer for low-medium temperature hydrothermal ore-forming systems:A case study on the Dajiangping pyrite deposit,western Guangdong Province,China显示文摘Little is known about the range or controls on the molybdenum isotopic composition of low-medium temperature hydrothermal ore-forming systems.We present molybdenum isotope data from 12 hydrothermal syndepositional silicalite and carbonaceous slate samples from the Dajiangping pyrite deposit in western Guangdong Province,South China.The δ 97/95Mo values from Orebody III range from ?0.02‰ to 0.29‰,with an average of 0.18‰.In contrast,the composition values from Orebody IV display a larger variation from ?0.70‰ to 0.62‰.However,the five samples from the main ore bed all show strong negative values.This indicates that the significant variation in molybdenum isotopic composition supports different hydrothermal ore-forming metallogenesis and a metallogenic environment between the two orebodies.Orebody III is likely to have been deposited from submarine exhalative hydrothermal fluids under a relatively strong reducing environment and Orebody IV may have also been influenced by hydrothermal superimposition in a more oxidized disequilibrium condition.In addition,the δ 97/95Mo values of Orebody IV are clearly negative,together with the values increasing stratigraphically upward in the ore beds,suggesting that the metallogenic environment of Orebody IV is different from the open oceanic systems.There might be dynamic fractionation in this restricted environment.Therefore,the molybdenum isotope can be used as an effective tracer for the ore-forming fluid and metallogenic environment. | SONG ShiMing HU Kai WEN HanJie ZHANG YuXu LI Kuang FAN HaiFeng | 2011 | Chinese Science Bulletin2011，56，21： | 4 |
| 9 | Identification of genes for normalization of quantitative real-time PCR data in ovarian tissues显示文摘增加的注意在最近的年里为卵巢的癌症对潜在的 biomarker 和治疗学的目标的决心被给予了。然而,量的即时 PCR 的正规化是重要的获得精确基因表示数据。我们在不同条件下面在卵巢的纸巾调查了 20 参考基因的稳定性决定为这应用最足够。学习在包含正常、非恶意、主要的卵巢的癌的 52 件卵巢的织物样品之中描绘了 20 可能的参考基因的表示。变化(ANOVA ) 的单程的分析方法被用来比较疾病前进引起的候选人基因变化。没有统计差别的基因的稳定性和适用性是进一步的采用 geNorm 和 NormFinder 软件验证。当尽管有不同卵巢的织物条件, RPL4, RPLP0, HSPCB, TPT1, RPL13A, 18S rRNA, PPIA, TBP,和 GUSB 使稳定性统计时,结果证明 20 参考基因的表示层次变化了。RPL4, RPLP0,和 HSPCB 作为最稳定的参考基因和 RPLP0 的联合被表明, RPL4 应该被推荐为更可靠的正规化策略。 | Jie Fu Lihong Bian Li Zhao Zhouhuan Dong Xin Gao Haofei Luan Yunjuan Sun Haifeng Song | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 4 |
| 10 | DID Code:A Bridge Connecting the Materials Genome Engineering Database w让h Inheritable Integrated Intelligent Manufacturing显示文摘A data identifier(DID)is an essential tag or label in all kinds of databases—particularly those related to integrated computational materials engineering(ICME),inheritable integrated intelligent manufacturing(I3M),and the Industrial Internet ofThings.With the guidance and quick acceleration of the developme nt of advanced materials,as envisioned by official documents worldwide,more investigations are required to construct relative numerical standards for material informatics.This work proposes a universal DID format consisting of a set of build chains,which aligns with the classical form of identifier in both international and national standards,such as ISO/IEC 29168-1:2000,GB/T 27766-2011,GA/T 543.2-2011,GM/T 0006-2012,GJB 7365-2011,SL 325-2014,SL 607-201&WS 363.2-2011,and QX/T 39-2005.Each build chain is made up of capital letters and numbers,with no symbols.Moreover,the total length of each build chain is not restricted,which follows the formation of the Universal Coded Character Set in the international standard of ISO/IEC 10646.Based on these rules,the proposed DID is flexible and convenient for extendi ng and sharing in and between various cloud-based platforms.Accordingly,classical two-dimensional(2D)codes,including the Hanxin Code,Lots Perception Matrix(LP)Code,Quick Response(Q.R)code,Grid Matrix(GM)code,and Data Matrix(DM)Code,can be constructed and precisely recognized and/or decoded by either smart phones or specific machines.By utilizing these 2D codes as the fingerprints of a set of data linked with cloud-based platforms,progress and updates in the composition-processing-structure-property-performance workflow process can be tracked spontaneously,paving a path to accelerate the discovery and manufacture of advanced materials and enhance research productivity,performance,and collaboration. | William Yi Wang Peixuan Li Deye Lin Bin Tang Jun Wang Quanmei Guan Qian Ye Haixing Dai Jun Gao Xiaoli Fan Hongchao Kou Haifeng Song Feng Zhou Jijun Ma Zi-Kui Liu Jinshan Li Weimin Liu | 2020 | Engineering2020，6，6： | 4 |
| 11 | Numerical studies of hydrate dissociation and gas production behavior in porous media during depressurization process显示文摘In this study,a numerical model is developed to investigate the hydrate dissociation and gas production in porous media by depressurization.A series of simulation runs are conducted to study the impacts of permeability characteristics,including permeability reduction exponent,absolute permeability,hydrate accumulation habits and hydrate saturation,sand average grain size and irreducible water saturation.The effects of the distribution of hydrate in porous media are examined by adapting conceptual models of hydrate accumulation habits into simulations to govern the evolution of permeability with hydrate decomposition,which is also compared with the conventional reservoir permeability model,i.e.Corey model.The simulations show that the hydrate dissociation rate increases with the decrease of permeability reduction exponent,hydrate saturation and the sand average grain size.Compared with the conceptual models of hydrate accumulation habits,our simulations indicate that Corey model overpredicts the gas production and the performance of hydrate coating models is superior to that of hydrate filling models in gas production,which behavior does follow by the order of capillary coating>pore coating>pore filling>capillary filling.From the analysis of t1/2,some interesting results are suggested as follows:(1) there is a 'switch' value(the'switch'absolute permeability) for laboratory-scale hydrate dissociation in porous media,the absolute permeability has almost no influence on the gas production behavior when the permeability exceeds the 'switch' value.In this study,the 'switch' value of absolute permeability can be estimated to be between 10 and 50 md.(2) An optimum value of initial effective water saturation Sw,e exists where hydrate dissociation rate reaches the maximum and the optimum value largely coincides with the value of irreducible water saturation S wr,e.For the case of Sw,Swr,e,there are different control mechanisms dominating the process of hydrate dissociation and gas production. | Xuke Ruan Mingjun Yang Yongchen Song Haifeng Liang Yanghui Li | 2012 | Journal of Natural Gas Chemistry2012，21，4： | 3 |
| 12 | CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance显示文摘 | Gaopeng Li Xiaoli Wu Wenchang Qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu Pengxu Qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan Tao Zhu | 2016 | Cell Research2016，26，6： | 3 |
| 13 | Validation for equation of state in wide regime:Copper as prototype显示文摘In this paper we introduce the wide regime equation of state(WEOS)developed in Institute of Applied Physics and Computational Mathematics(IAPCM).A semi-empirical model of the WEOS is given by a thermodynamically complete potential of the Helmholtz free energy which combines several theoretical models and has some adjustable parameters calibrated via some experimental and theoretical data.The validation methods of the equation of state in wide regime are presented using copper as a prototype.The results of the WEOS are well consistent with the available theoretical and experimental data,including ab initio cold curve under compression,isotherm,Hugoniot,off-Hugoniot and sound velocity data.It enhances our confidence in the accuracy of the WEOS,which is very important for the validation and verification of equation of state in high temperature and pressure technology. | Haifeng Liu Haifeng Song Qili Zhang Gongmu Zhang Yanhong Zhao | 2016 | Matter and Radiation at Extremes2016，1，2： | 3 |
| 14 | Behavioural study of the D-galactose induced aging model in C57BL/6J mice显示文摘 | Haifeng Wei Lin Li Qiujie Song Houxi Ai Jin Chu Wei Li | 2006 | 中国生物学文摘2006，20，3： | 2 |
| 15 | Distributed Model Predictive Control with Actuator Saturation for Markovian Jump Linear System显示文摘This paper is concerned with the distributed model predictive control(MPC) problem for a class of discrete-time Markovian jump linear systems(MJLSs) subject to actuator saturation and polytopic uncertainty in system matrices. The global system is decomposed into several subsystems which coordinate with each other. A set of distributed controllers is designed by solving a min-max optimization problem in terms of the solutions of linear matrix inequalities(LMIs). An iterative algorithm is developed to achieve the online computation. Finally,a simulation example is employed to show the effectiveness of the proposed algorithm. | Yan Song Haifeng Lou Shuai Liu | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，4： | 2 |
| 16 | Electron doping induced semiconductor to metal transitions in ZrSe2 layers via copper atomic intercalation显示文摘 | Zahir Muhammad Kejun Mu Haifeng Lv Chuanqiang Wu Zia ur Rehman Muhammad Habib Zhe Sun Xiaojun Wu Li Song | 2018 | Nano Research2018，11，9： | 2 |
| 17 | Atomically precise metal-chalcogenide semiconductor molecular nanoclusters with high dispersibility:Designed synthesis and intracluster photocarrier dynamics显示文摘A comprehensive understanding of excited-state dynamics of semiconductor quantum dots or nanomaterials at the atomic or molecular level is of scientific importance.Pure inorganic(or non-covalently protected)seimiconductor molecular nanoclusters with atomically precise structure are contributive to establish accurate correlation of excited-state dynamics with their composition/structure,however,the related studies are almost blank because of unresolved solvent dispersion issue.Herein,we designedly created the largest discrete chalcogenide seimiconductor molecular nanoclusters(denoted P2-CuMSnS,M=In or/and Ga)with great dispersibility,and revealed an interesting intracluster“core–shell”charge transfer relaxation dynamics.A systematic red shift in absorption spectra with the gradual substitution of In by Ga was experimentally and computationally investigated,and femtosecond transient absorption measurements further manifested there were three ultrafast processes in excited-state dynamics of P2 nanoclusters with the corresponding amplitudes directed by composition variation.Current results hold the great promise of the solution-processible applications of semiconductor-NC-based quantum dots and facilitate the development of atomically precise nano-chemistry. | Jiaxu Zhang Chaochao Qin Yeshuang Zhong Xiang Wang Wei Wang Dandan Hu Xiaoshuang Liu Chaozhuang Xue Rui Zhou Lei Shen Yinglin Song Dingguo Xu Zhien Lin Jun Guo Haifeng Su Dong-Sheng Li Tao Wu | 2020 | Nano Research2020，13，10： | 2 |
| 18 | Behavioural study of the d -galactose induced aging model in C57BL/6J mice显示文摘 | Haifeng Wei Lin Li Qiujie Song Houxi Ai Jin Chu Wei Li | 2004 | Behavioural Brain Research2004，，2： | 2 |
| 19 | Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration显示文摘Inflammatory responses of nucleus pulposus(NP)can induce imbalanced anabolism and catabolism of extracellular matrix,and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc(IVD)degeneration.Herein,we constructed a siSTING delivery hydrogel of aldehyde hyaluronic acid(HA-CHO)and poly(amidoamine)PAMAM/siRNA complex to intervene the abnormal STING signal for IVD degeneration treatment,where the formation of dynamic Schiff base bonds in the system(siSTING@HPgel)was able to overcome the shortcomings such as low cellular uptake,short half-life,and rapid degradation of siRNA-based strategy.PAMAM not only formed complexes with siRNA to promote siRNA transfection,but also served as dynamic crosslinker to construct hydrogel,and the injectable and self-healing hydrogel efficiently and steadily silenced STING expression in NP cells.Finally,the siSTING@HPgel significantly eased IVD inflammation and slowed IVD degeneration by prolonging STING knockdown in puncture-induced IVD degeneration rat model,revealing that STING pathway was a therapeutic target for IVD degeneration and such novel hydrogel had great potential for being applied to many other diseases for gene delivery. | Jiaxin Chen Haifeng Zhu Yutao Zhu Chenchen Zhao Shengyu Wang Yixin Zheng Ziang Xie Yang Jin Honghai Song Linjun Yang Jin Zhang Jiayong Dai Zhijun Hu Huaiyu Wang | 2022 | Bioactive Materials2022，7，3： | 2 |
| 20 | Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia显示文摘Patients with chronic kidney disease are at high risk of hyperkalemia that is associated with various lifethreatening complications.Treatments primarily rely on orally administered potassium binding agents,along with low curative effects and various side effects.Herein,direct serum potassium uptake was realized via zeolite–heparin-mimicking-polymer hybrid microbeads.The preparation process involved the synthesis of the heparin-mimicking polymer via the in situ cross-linking polymerization of acrylic acid and N-vinylpyrrolidone in polyethersulfone solution,the fabrication of microbeads via zeolite-mixing,electro-spraying and phase-inversion,and the subsequent aqueous-phase modifications based on ion-exchange and metal-leaching.An ultra-high(about 88%)amount of zeolite could be incorporated and well locked inside the polymer matrix.Potassium uptake capability was verified in water,normal saline and human serum,showing high selectivity and fast adsorption.The microbeads exhibited satisfying blood compatibility,negligible hemolysis ratio,prolonged clotting time,inhibited contact activation,and enhanced antifouling property toward serum proteins and cells.The proposed approach toward zeolite–heparin-mimicking-polymer hybrid microbeads provided a cheap,efficient and safe treatment protocol of hyperkalemia for the high-risk patients. | Zhoujun Wang Wei Sun Zhiwei Wei Jianxu Bao Xin Song Yupei Li Haifeng Ji Jue Zhang Chao He Baihai Su Weifeng Zhao Changsheng Zhao | 2021 | Bioactive Materials2021，6，2： | 2 |
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