|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhanced anti-tumor immunity ex vivo induced by GM-CSF gene transducted dendritic cell vaccine显示文摘学习的目的是调查是否的目的树枝状的房间(DC ) 先锋,由 chemokine ligand 的注射招募了 3 (CCL3 ) ,在 granulocyte 巨噬细胞殖民地刺激以后导致提高的反肿瘤免疫在老鼠前 vivo 的因素(GM-CSF ) transfection。615 只老鼠经由尾巴静脉与 CCL3 被注射的方法。刚孤立的 B220-CD11c+ 房间与 cytokines 是有教养的。为 adenoviral (广告) 调停的基因 transduction, DC 是在感染(MOI ) 的复合的不同比率的转移 AdGM-CSF 基因决定最佳的基因 transfection 条件,并且在 transfection 以后检测 GM-CSF 的表示。GM-CSF 修改基因的 DC 的变化被词法观察,显型分析,和混合淋巴细胞反应(MLR ) 分析。DC 被装载,胃的癌症抗原由冻结并且融化的方法获得了。刺激 DC 种痘导致了 T 淋巴细胞,和 T 房间的杀死的效果到胃的癌症房间是由 MTT 的 assayed。INF- 生产与 INF- ELISA 工具包被决定。结果 B220-CD11c+ 房间数字在 CCL3 注射以后增加了。ELISA 结果证明在 GM-CSF 基因修正以后, DC 能生产 GM-CSF 的高水平。DC 是什么时候,在等于 1:100 的 MOI 转移了 AdGM-CSF 基因,在文化上层清液的 GM-CSF 水平到达了浸透[(130.00 ???????????????? ″ ? 匠牵楶楶? 僚 ??? 吗?? | Songbing He Liang Wang Kang Sun Yanyun Zhang Dechun Li | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 3 |
| 2 | Distribution and Clinical Significance of Th17Cells in the Tumor Microenvironment and Peripheral Blood of Pancreatic Cancer Patients显示文摘 | Songbing He Min Fei Yugang Wu | 2011 | International Journal of Molecular Sciences2011，12，11： | 1 |
| 3 | Clinicopathologic Significance of HIF-1 α , CXCR4, and VEGF Expression in Colon Cancer显示文摘 | Yugang Wu Min Jin Huanbai Xu Zhang Shimin Songbing He Liang Wang Yanyun Zhang Silvano Sozzani | 2010 | Clinical and Developmental Immunology2010，，： | 1 |
| 4 | Interleukin?21 promotes the development of ulcerative colitis and regulatesthe proliferation and secretion of follicular T helper cells in the colitidesmicroenvironment显示文摘 | Jing Yu Songbing He Pengfei Liu You Hu Lei Wang Xu Wang Ye Han Xinguo Zhu | 2015 | Molecular Medicine Reports2015，，2： | 1 |
| 5 | Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway显示文摘Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally.Absent in melanoma 2(AIM2),a constituent of the interferoninducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family,contributes to both cancer progression and inflammasome activation.Despite this understanding,the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain elusive.Consequently,this study endeavors to assess AIM2’s expression levels,explore its potential antitumor effects,elucidate associated cancer-related processes,and decipher the underlying signaling pathways in CRC.Our findings showed a reduced AIM2 expression in most CRC cell lines.Elevation of AIM2 levels suppressed CRC cell proliferation and migration,altered cell cycle by inhibiting G1/S transition,and induced cell apoptosis.Further research uncovered the participation of P38 mitogen-activated protein kinase(P38MAPK)in AIM2-mediated modulation of CRC cell apoptosis and proliferation.Altogether,our achievements distinctly underscored AIM2’s antitumor role in CRC.AIM2 overexpression inhibited proliferation and migration and induced apoptosis of CRC cells via activating P38MAPK signaling pathway,indicating AIM2 as a prospective and novel therapeutic target for CRC. | ZHI ZHANG XIAOSONG LI YING ZHANG HAO ZHU ZHENGUO QIAO YANG LU XIUWEI MI HUIHUA CAO GENHAI SHEN SONGBING HE | 2024 | Oncology Research2024，32，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员