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| 1 | MiR-122-5p suppresses the proliferation, migration, and invasion of gastric cancer cells by targeting LYN显示文摘Gastric cancer(GC)is one of malignant tumors with high mortality and morbidity in the world.MicroRNA-122(miR-122)acts as a tumor suppressor in a variety of cancers and has been found to be dominant in gastric adenocarcinoma.However,the specific biological function of miR-122-5p in GC is not completely clear.In this study,we found that miR-122-5p was low-expressed in GC tissues and cell lines by using qRT-PCR.Overexpression of miR-122-5p inhibited the proliferation,migration,and invasion of GC cells by using CCK-8 and transwell assays.On the contrary,downregulation of miR-122-5p promoted the proliferation,migration,and invasion of GC cells.In addition,we found that the expression of LYN,an Src family tyrosine kinase,was inversely correlated with miR-122-5p expression in GC tissues by using western blot analysis,immunohistochemistry,and qRT-PCR assays.Meanwhile,luciferase assay results indicated that LYN is a direct target of miR-122-5p in GC cells.Moreover,silencing LYN expression by its siRNA inhibited the proliferation,migration,and invasion of GC cells.Importantly,overexpression of LYN restored miR-122-5p-mediated inhibition of the proliferation,migration,and invasion of GC cells.Taken together,our results indicated miR-122-5p inhibited the proliferation,migration,and invasion by targeting LYN in GC. | Lei Meng Zhangming Chen Zhe Jiang Ting Huang Jie Hu Panquan Luo Hongli Zhang Mengqi Huang Lei Huang Yu Chen Ming Lu A-man Xu Songcheng Ying | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 12 |
| 2 | microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming显示文摘成纤维细胞能由 Yamanaka 因素(OSKM ) 的申请是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed,但是位于这 reprogramming 下面的机制仍然保持糟糕理解。这里,我们报导 Sox2 直接调整内长的 microRNA-29b (miR-29b ) 表示为调停 OSKM 、调停 OSK 的 reprogramming 在 iPSC 产生和那 miR-29b 表情期间被要求。Dnmt3a 和 Dnmt3b 在 miR-29b 和那 Dnmt3a 和 Dnmt3b 表示的 vivo 目标的机械学的研究表演相反地在 reprogramming 期间与 miR-29b 表示被相关。而且, reprogramming 上的 miR-29b 的效果能被 Dnmt3a 或 Dnmt3b overexpression 堵住。进一步的实验显示发信号的 miR-29b-DNMT 显著地涉及 DNA methylation 相关的 reprogramming 事件的规定,例如 mesenchymal-to-epithelial 转变(相遇) 并且 Dlk1-Dio3 区域抄写。因此,我们的研究不仅表明 miR-29b 是 reprogramming 因素 Sox2 的一个新奇调停人而且为 Sox2 在驾驶表明调整 DNA 的轴的 miR-29b-DNMT 的 multistep 机制提供证据 methylation 相关的事件在 reprogramming 期间。 | Xudong Guo Qidong Liu Guiying Wang Songcheng Zhu Longfei Gao Wujun Hong Yafang Chen Minjuan Wu Houqi Liu Cizhong Jiang Jiuhong Kang | 2013 | Cell Research2013，23，1： | 9 |
| 3 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 4 | Development of a rapid and sensitivity magnetic chemiluminescence immunoassay for DNA methyltransferase 1 in human serum显示文摘DNA methyltransferase 1(DNMT1)is a useful biomarker for lung cancer in early clinical diagnosis.A rapid magnetic chemiluminescence immunoassay(MCLIA)for DNMT1 in human serum has been developed.Horseradish peroxidase(HRP)-second-Ab was used to labeled polyclonal antibodies of anti-DNMT1.DNMT1 in sample integrates with specific immunomagnetic beads and can constitute a supersandwiched immunoreaction.In magnetic field,nonspecific materials can be separated.After luminescent substrate luminol-H2O2-BIP was added,the relative light unit(RLU)of HRP was detected and was discovered to be directly proportional to the content of DNMT1 in sample.The correlative variables involved in the MCLIA value were optimized and the methodological evaluation was carried out.After optimization,in the range of0.5–128 ng/mL,the linear regression equation was y=0.5014 x+1.769(x was logCDNMT1,y was relative luminescence units(RLU)/RLU0),and the limit of detection was 0.01 ng/mL.The RSD of intra-and interassays were 15.8%–16.9%and 14.3%–18.1%,respectively.The recovery was from 70.0%to 106.2%.Furthermore,paralleled with purchasable enzyme-linked immunosorbent assay(ELISA)kits,MCLEIA had lower detection limit,wider linear range and shorter detection time.Therefore,the MCLEIA established in this study could be used for the sensitive detection of DNMT1 in serum sample. | Sitian He Leiliang He Beibei Liu Songcheng Yu Li'e Liu Yongmei Tian Jia Wang Lihua Ding Yilin Wang Lingbo Qu Fei Yu Yongjun Wu | 2019 | Chinese Chemical Letters2019，30，5： | 4 |
| 5 | Voltage-gated sodium channel Nav1.5 promotes proliferation, migration and invasion of oral squamous cell carcinoma显示文摘The protein voltage-gated sodium channel Nav1.5 is highly upregulated in various types of cancer and, in general, promotes cancer cell invasiveness and metastatic progression. A previous study found that Nav1.5 was highly expressed in poorly differentiated oral squamous cell carci noma (OSCC). However, whether Nav1.5 enhances invasiveness and metastasis of OSCC are still unknown. In this study, we found that Nav1.5 was highly expressed in OSCC cell lines compared with normal oral keratinocyte HOK cell line by using western blot analysis. CCK-8 assay results revealed that downregulation of Nav1.5 expression by its specific siRNA reduced proliferation of OSCC HSC-3 cells. Moreover, transwell assay results showed Nav1.5 knockdown significantly inhibited migration and invasion of HSC-3 cells. Meanwhile, qRT-PCR and western blot analysis results showed that epidermal growth factor (EGF) induced Nav1.5 expression in a time-and dosedependent manner. In addition, EGF promoted proliferation, migration and invasion of HSC-3 cells. Importantly, the Nav1.5 inhibitor tetrodotoxin significantly inhibited the proliferation of HSC-3 cells and impeded the migration and invasion of HSC-3 cells. Furthermore, it was found that siRNAmediated knockdown of Nav1.5 also lessened the proliferation of HSC-3 cells and blocked the migration and invasion of HSC-3 cells. Taken together, these results indicate that Nav1.5 is involved in the progression of OSCC and Nav1.5 promotes the proliferation, migration and invasion of OSCC cells. | Jie Zhang Weijia Mao Ybngzheng Dai Chengwei Qian Yang Dong Zhangming Chen Lei Meng Zhe Jiang Ting Huang Jie Hu Panquan Luo Heinrich Korner Yong Jiang Songcheng Ying | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 3 |
| 6 | Factors affecting thermal stability of collagen from the aspects of extraction,processing and modification显示文摘Collagen,as a thermal-sensitive protein,is the most abundant structural protein in animals.Native collagen has been widely applied in various fields due to its specific physicochemical and biological properties.The beneficial properties would disappear with the collapse of the unique triple helical structure during heating.Understanding thermal stability of collagen is of great significance for practical applications.Previous studies have shown the thermal stability would be affected by the different sources,extraction methods,solvent systems in vitro and modified methods.Accordingly,the factors affecting thermal stability of collagen are discussed in detail in this review. | Xiaoxia Zhang Songcheng Xu Lirui Shen Guoying Li | 2020 | Journal of Leather Science and Engineering2020，2，1： | 2 |
| 7 | 显示文摘 | LiuYe(刘烨) GaoXing(高兴) ZhongMing(钟鸣) HuangZhiqiang(黄志强) SongCheng(宋净) SongCaisheng(宋才生) | | 江西师范大学学报0，，： | 1 |
| 8 | A new composite impregnated diamond bit for extra-hard,compact,and nonabrasive rock formation显示文摘 | TAN Songcheng FANG Xiaohong | 2014 | International Journal of Refractory Metals and Hard Materials2014，43，3： | 1 |
| 9 | SAMHD1: a novel antiviral factor in intrinsic immunity显示文摘 | Chen Zhangming Zhang Linjie Ying Songcheng | 2012 | Future Microbiology2012，，9： | 1 |
| 10 | A competitive chemiluminescence enzyme immunoassay for rapid and sensitive determination of enrofloxacin显示文摘 | Fei Yu Yongjun Wu Songcheng Yu Huili Zhang Hongquan Zhang Lingbo Qu Peter de B. Harrington | 2012 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2012，，： | 1 |
| 11 | Study on Auger Drilling Technology for Sampling Drilling in the Lunar Stimulants显示文摘 | Duan Longchena Tan Songcheng Gao Hui | 2014 | Procedia Engineering2014，73，： | 1 |
| 12 | A new composite impregnated diamond bit for extra-hard, compact, and nonabrasive rock formation显示文摘 | Songcheng Tan Xiaohong Fang Kaihua Yang Longchen Duan | 2014 | International Journal of Refractory Metals and Hard Materials2014，，： | 1 |
| 13 | The pretreatment effects on the antioxidant activity of jujube polysaccharides显示文摘 | QU Cbenling YU Songcheng JIN Huali | 2013 | Spectrochim Acta A2013，114，： | 1 |
| 14 | Load Balancing Based on Anycast and Pseudo-Mobility in IPv6显示文摘We proposed a new Load balancing mechanism, called LBAM (Load balancing based on anycast and pseudo-mobility in IPv6), by which sessions can be distributed across a pool of servers for maximum performance. Load balancing is needed in many fields, such as Web server, FTP (File transfer protocol) server and NAT-PT (Network address translation-protocol translation) gateway, and there exist several approaches for load balancing. However, current approaches have problems such as poor scalability, inability to balance session flow,long latency time, and topological constraint on server pools. In this paper, we describe how LBAM works in principle without the above problems. We also present our simulation work using NS-2 and discuss performance comparison between LBAM and other load balancing mechanisms. The results show that LBAM has very advanced performance and scalability. Finally, the ubiquitous applications of LBAM in NGI (Next generation Internet) are presented. | FENGYanjun SONGCheng KANZhigang MAJian YERunguo | 2004 | Chinese Journal of Electronics2004，13，2： | 1 |
| 15 | Sirt6可提高年老供体来源iPS细胞基因组稳定性显示文摘文章简介诱导多能干细胞(induced Pluripotent Stem Cells,i PS Cells)在治疗衰老相关疾病中具有巨大潜力,其中i PS细胞的基因组稳定性对于其临床应用至关重要。 | Wen Chen Nana Liu Hongxia Zhang Haiping Zhang Jing Qiao Wenwen Jia Songcheng Zhu 毛志勇 康九红 | 2018 | 科学新闻2018，0，4： | 0 |
| 16 | Self-assembly of two- dimensional DNA crystals显示文摘Self-assembly of synthetic oligonucleotides into two-dimensional lattices presents a 慴ottom-up?approach to the fabrication of devices on nanometer scale. We report the design and observation of two-dimensional crystalline forms of DNAs that are composed of twenty-one plane oligonucleo-tides and one phosphate-modified oligonucleotide. These synthetic sequences are designed to self-assemble into four double-crossover (DX) DNA tiles. The 憇ticky ends?of these tiles that associate according to WatsonCrick抯 base pairing are programmed to build up specific periodic patterns upto tens of microns. The patterned crystals are visualized by the transmission electron microscopy. | SONGCheng CHENYaqing WEIShuai YOUXiaozeng XIAOShoujun | 2004 | Chinese Science Bulletin2004，49，9： | 0 |
| 17 | Cell-specific Regulation of APOBEC3F by Interferons显示文摘人的 cytidine 脱氨基酶 APOBEC3F (A3F ) 包括人的免疫不全病毒类型 1 对肝炎 B 病毒和制动火箭病毒举办宽广抗病毒的活动。然而,它在病毒的自然目标房间的规定如此的 CD4+T 淋巴细胞,巨噬细胞,和主要的肝房间一直不好学习。这里,我们证明 A3F 由在主要 hepatocytes 和多重肝房间的 -alpha 象巨噬细胞一样衬里的干扰素(IFN ) 是起来调整的。尽管 IFN-alphasignaling 小径在 T 淋巴的房间是活跃的,另外的 IFN 的正式就职刺激了基因,如此的一个说话者被检测, A3F 和 APOBEC3G (A3G ) 没被 IFN-oc 在这些房间导致。因此,除已知的刺激 IFN 的基因以外的另外的因素也调整了 IFN-alpha-induced A3F 特别在 IFN-alphastimulation 以后,在主要 hepatocytes 的 expressiondistinctly.A3F 和 A3G 表示层次比得上在在一些个人的 CD4+T 淋巴细胞的那些。在从各种各样的题目的主要 hepatocytes 的 A3F 和 A3G 表示的重要变化是在 A3F 或 A3G 规定的 observed.Individualvariations,表示可能影响肝炎 B 感染的临床的结果。 | Songcheng YING Xuzhao ZHANG Phuong Thi Nguyen SARKIS Rongzhen XU Xiaofang YU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，4： | 0 |
| 18 | Enhanced energy-storage density and temperature stability of Pb_(0.89)La_(0.06)Sr_(0.05)(Zr_(0.95)Ti_(0.05))O_(3) anti-ferroelectric thin film capacitor显示文摘As the fundamental energy storage components in electronic systems,dielectric capacitors with high power densities were demanded.In this work,the anti-ferroelectric Pb_(0.89)La_(0.06)Sr_(0.05)(Zr_(0.95)Ti_(0.05))O_(3)(PLSZT)ceramics and thin film capacitor were successfully fabricated by a solid-state reaction route and pulsed laser deposition method,respectively.The ferroelectric,dielectric,energy-storage properties,and temperature stability of anti-ferroelectric PLSZT capacitor were investigated in detail.By compared with the PLSZT ceramic(energy storage density is 1.29 J/cm^(3) with an efficiency of 78.7%under 75 kV/cm),the anti-ferroelectric PLSZT thin film capacitors exhibited the enhanced energy storage density of 52.6 J/cm^(3) with efficiency of 67.7%under an electric field as high as 2068.9 kV/cm,and the enhanced energy-storage temperature stabilities from room temperature(RT)to more than 200℃ were demonstrated,and the oxygen defects mechanism and size effect were discussed.Moreover,the fast charging(~0.05 μs)and discharging(~0.15 μs)time were certified for the anti-ferroelectric PLSZT film capacitor.These findings broaden the horizon for PLSZT anti-ferroelectrics in high energy storage properties and show promising for manufacturing pulse power capacitor. | Zhenhua Tang Songcheng Hu Dijie Yao Zeli Li Zhigang Liu Xiaobin Guo Biao Lu Jingmin Fan Xin-Gui Tang Sheng-Guo Lu Ju Gao | 2022 | Journal of Materiomics2022，8，1： | 0 |
| 19 | Adhering to Regulation on the Real Estate Market显示文摘Despite a strict policy control,housing prices in China continue to rise early this year.In addition,the recent slow-down of real estate investment may lead to lower housing stock in the future,causing higher pressure to stabilize housing prices and prevent further price increases,and making regulation more difficult.After the Spring Festival in 2019,several media reported that the real estate market began to recover,as reflected in the trend of housing prices in March.According to the changes in commercial housing prices in 70 large-and medium-sized cities,as released by the National Bureau of Statistics(NBS)of China,both new-home and second-hand home prices rose to varying degrees。 | SHENG Songcheng LIU Bin WANG Wei | 2019 | China Economic Transition2019，2，4： | 0 |
| 20 | Pd-catalyzed cascade cyclization of allenylethylene carbonates and indandiones: Synthesis of tetracyclic dihydrocyclopentaindenofuranone derivatives显示文摘A palladium-catalyzed cascade cyclization of allenylethylene carbonates with 1,3-indandiones was developed, providing biologically interesting tetracyclic dihydrocyclopentaindenofuranone derivatives having three contiguous quaternary carbon centers in moderate to high yields with excellent diastereoselectivities. In this reaction, the allene moiety was fully fused into the cyclopentene ring. | Yujie Dong Jun Liu Xing Gao Ting Pan Biming Mao Songcheng Yu Yongjun Wu Cheng Zhang Hongchao Guo | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
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