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| 1 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 2 | A modified kernel method for atime-fractional inverse diffusion problem显示文摘 | Liu Songshu Feng Lixin | 2015 | Advances in Difference Equations2015，342，： | 1 |
| 3 | Participation of Gabl and Gab2 in the activation of the ERK/ MAPK pathway by epidermal growth factor 显示文摘 | Meng Songshu Chen Zhengming Munoz-antonia T | 2005 | Biochem J2005，391，： | 1 |
| 4 | Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication显示文摘 | Chunchun Meng Zhizhi Zhou Ke Jiang Shengqing Yu Lijun Jia Yantao Wu Yanqing Liu Songshu Meng Chan Ding | 2012 | Archives of Virology2012，，6： | 1 |
| 5 | Avian reovirus triggers autophagy in primary chicken fibroblast cells and Vero cells to promote virus production显示文摘 | Songshu Meng Ke Jiang Xiaorong Zhang Miao Zhang Zhizhi Zhou Maozhi Hu Rui Yang Chenli Sun Yantao Wu | 2012 | Archives of Virology2012，，4： | 1 |
| 6 | A Modified KernelMethod for Solving Cauchy Problem of Two-Dimensional Heat Conduction Equation显示文摘In this paper,a Cauchy problem of two-dimensional heat conduction equation is investigated.This is a severely iⅡ-posed problem.Based on the solution of Cauchy problem of two-dimensional heat conduction equation,we propose to solve this problem by modifying the kernel,which generates a well-posed problem.Error estimates between the exact solution and the regularized solution are given.We provide a numerical experiment to illustrate the main results. | Jingjun Zhao Songshu Liu Tao Liu | 2015 | Advances in Applied Mathematics and Mechanics2015，7，1： | 0 |
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