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| 1 | Establishment and Characterization of a Cell Based Artificial Antigen-Presenting Cell for Expansion and Activation of CD8^+ T Cells Ex Vivo显示文摘Artificial antigen-presenting cells are expected to stimulate the expansion and acquisition of optimal therapeutic features of T cells before infusion. Here CD32 that binds to a crystallizable fragment of IgG monoclonal antibody was genetically expressed on human K562 leukemia cells to provide a ligand for T-cell receptor. CD86 and 4-1BBL,which are ligands of co-stimulating receptors of CD28 and 4-1BB,respectively,were also expressed on K562 cells. Then we accomplished the artificial antigen-presenting cells by coupling K32/CD86/4-1BBL cell with OKT3 monoclonal antibody against CD3,named K32/CD86/4-1BBL/OKT3 cells. These artificial modified cells had the abilities of inducing CD8+ T cell activation,promoting CD8+ T cell proliferation,division,and long-term growth,inhibiting CD8+ T cell apoptosis,and enhancing CD8+ T cell secretion of IFN-γ and perforin. Furthermore,antigen-specific cytotoxic T lymphocytes could be retained in the culture stimulated with K32/CD86/4-1BBL/OKT3 cells at least within 28 days. This approach was robust,simple,reproducible and economical for expansion and activation of CD8+ T cells and may have important therapeutic implications for adoptive immunotherapy. | Weijuan Gong Mingchun Ji Zhengfeng Cao Liheng Wang Yayun Qian Maozhi Hu Li Qian Xingyuan Pan | 2008 | Cellular & Molecular Immunology2008，5，1： | 5 |
| 2 | Cryptography on elliptic curves over p-adic number fields显示文摘In this paper we introduce a cryptosystem based on the quotient groups of the group of rational points of an elliptic curve defined over p-adic number field. Some additional parameters are taken in this system, which have an advantage in performing point multiplication while keeping the security of ECC over finite fields. We give a method to select generators of the cryptographic groups, and give a way to represent the elements of the quotient groups with finitely bounded storage by establishing a bijection between these elements and their approximate coordinates. The addition formula under this representation is also presented. | XU MaoZhi ZHAO ChunLai FENG Min REN ZhaoRong YE JiQing | 2008 | Science in China(Series F)2008，51，3： | 4 |
| 3 | Digital signature systems based on smart card and fingerprint feature显示文摘Two signature systems based on smart cards and fingerprint features are proposed. In one signature system, the cryptographic key is stored in the smart card and is only accessible when the signer's extracted fingerprint features match his stored template. To resist being tampered on public channel, the user's message and the signed message are encrypted by the signer's public key and the user's public key, respectively. In the other signature system, the keys are generated by combining the signer's fingerprint features, check bits, and a rememberable key, and there are no matching process and keys stored on the smart card. Additionally, there is generally more than one public key in this system, that is, there exist some pseudo public keys except a real one. | You Lin Xu Maozhi Zheng Zhiming | 2007 | Journal of Systems Engineering and Electronics2007，18，4： | 3 |
| 4 | Fighting against fall armyworm by using multiple genes pyramiding and silencing(MGPS) technology显示文摘The pest Fall Armyworm(FAW),Spodoptera frugiperda belonging to the order Lepidoptera,is one of the most devastating insect pests resulting in severe economic losses to maize,rice,wheat,cotton and soybean in South America,Africa and Asia.It consists of two morphologically indistinguishable strains:the“corn strain”feeding mainly on maize,cotton and sorghum;the“rice strain”mostly feeding on rice and various grasses(Gouin et al.,2017).Adults of FAW have strong migration ability to fly 100 km per night.In 2018 it was detected in India and then spreads to Bangladesh,Thailand,Myanmar,and China in 2019(http://gffzz7e8ce5e2b4d84f4eh5xcqkpquobvq6bo5.ffgz.tsg.suse.edu.cn/fall-armyworm/en/).It is a polyphagous lepidopteran herbivore,attacks more than 350 plant species,and causes destructive damage to many economically important crops.The FAW causes up to 30%-60% yield losses. | Maozhi Ren Muhammad Mubashar Zafar Huijuan Mo Zhaoen Yang Fuguang Li | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 5 | Speeding Up Scalar Multiplications on Hyperelliptic Curves by Making Use of Frobenius Endomorphism显示文摘 | YOU Lin XU Maozhi ZHAO Junzhong ZHENG Zhiming | 2006 | Chinese Journal of Electronics2006，15，1： | 2 |
| 6 | Immobilized MHC class I chain-related protein A synergizes with IL-15 and soluble 4-1BB ligand to expand NK cells with high cytotoxicity ex vivo显示文摘Major histocompatibility complex(MHC)class I chain-related protein A(MICA),which is a ligand for human NKG2D,is expressed by a variety of epithelial tumor cells and promotes the activation of natural killer(NK),CD81 and cd-T cells.Although ectopic expression of MICA on tumor cells elicits anti-tumor responses,soluble MICA downregulates the activities of lymphocytes.In this study,we showed that recombinant,immobilized MICA(iMICA)molecules coated on plastic wells weakly promote peripheral NK cell activation,secretion of interferon(IFN)-c and degranulation without inducing apoptosis.In addition,iMICA synergized with IL-15 and soluble 4-1BB ligand(s4-1BBL)to expand NK cells 25-to 42-fold in a 13-day culture,whereas NK cells stimulated only with IL-15 and s4-1BBL expanded 10-to 16-fold.In contrast toNKcells expanded by IL-15 and s4-1BBL stimulation,NKcells expanded long term in the presence of iMICA exhibited increased cytotoxicity against leukemia cells.These results suggest that large numbers ofNKcells with high cytotoxicity can be generated by stimulation with IL-15 and s4-1BBL in the presence of iMICA and that these cells can be used for adoptive cancer immunotherapy. | Weijuan Gong Weiming Xiao Li Qian Chunxiang Gong Maozhi Hu Xianyuan Pan Mingchun Ji | 2010 | Cellular & Molecular Immunology2010，7，6： | 2 |
| 7 | Voluntary emission reduction market in China: development, management status and future supply显示文摘The voluntary emission reduction (VER) trading mechanism has played an important role in China’s seven pilot carbon markets. From a comprehensive review of the VER trading and offsetting mechanisms since 2013, this study analyses the quality management of the Chinese Certified Emission Reduction (CCER) in the pilot carbon markets, conducts a comparative analysis of the geographical and field distributions of proposed and registered projects and emission reductions and provides the CCER supply outlook for 2020 in the aspects of on record, project registration, emission reduction registration and emission reduction issuance. Results show that the potential number of CCER projects by 2020 will be 2,864, 1,047, 818, and 286 with the corresponding emission reductions amounting to 493, 212, 133, and 49 million tCO2e, respectively. Although considerable progress has been made, China remains confronted with many challenges in developing the VER trading system. Accordingly, policy stability and continuity and guarding against market risks should be maintained to enable the system to play a substantial role in promoting ecological progress and green low-carbon development in China. | Yi Zhou Alun Gu Maozhi Deng | 2019 | Chinese Journal of Population,Resources and Environment2019，17，1： | 1 |
| 8 | Study of D^0-D^0 mixing at a giga-Z linear collider显示文摘The possibility of studying D 0-D 0 mixing at a giga-Z linear collider 'Z factory' where 10 9 hadronic Z 0 decays can be accumulated is examined.We discuss the sensitivity for the measurements of neutral D mixing parameters.These results are compared to those attainable at B factories.We find that the typical decay length of the neutral D mesons at Z factory is about 10 times larger than that at B factory.In addition,the resolution of the vertex detector of a giga-Z factory is 2-3 times better than that of B factory.The proper time resolution at Z factory is about 20-30 times better than that at B factory.Therefore the determination of the mixing parameters at a giga-Z factory is more precise. | LI HaiBo 1 & YANG MaoZhi 2 1 Institute of High Energy Physics,P.O.Box 918,Beijing 100049,China 2 School of Physics,Nankai University,Tianjin 300071,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，11： | 1 |
| 9 | Genetic variability for yield and fiber related traits in genetically modified cotton显示文摘Background:Cotton(Gossypium hirsutum L.)is grown for fiber and oil purposes in tropical and sub-tropical areas of the world.Pakistan is the 4th largest producer of cotton.It has a significant contribution in the GDP of Pakistan.Therefore,the present study was performed to assess the genetic variations and genetic diversity of yield and fiber quality traits in cotton and to analyze the associations present among them.Results:Analysis of variance exhibited significant variation for all studied traits except total number of nodes and the height to node ratio.The phenotypic coefficient of variation was higher than the genotypic coefficient of variation for all studied traits.Plant height,monopodial branches,total number of bolls,lint index,seed index,and seed cotton yield displayed high heritabilities in a broad sense with maximum genetic advanee.Correlation analysis revealed that seed cotton yield had a significant positive association with plant height,the nu mber of monopodial branches,the nu mber of sympodia I branches,ginning outturn(GOT),the number of bolls,seed per boll,seed index,uniformity index,the number of sympodial branches,reflectance,and seed index at the genotypic level while a significant positive relationship was observed with plant height,the number of sympodial branches,boll number,and GOT.Plant height,monopodial branches,GOT,boll weight,seeds per boll,and short fiber index exerted direct positive effects on seed cotton yield.The first 6 principal component analysis(PCs)out of the total fourteen PCs displayed eigenvalues(>1)and had maximum share to total variability(82.79%).The attributes that had maximum share to total divergence in eluded plant height,uniformity index,the nu mber of sympodial branches,seed per boll,GOT,seed cotton yield,and short fiber index.Conclusion:The genotype AA-802,IUB-13,FH-159,FH-458,and CIM-595 were genetically diverse for most of the yield and fiber quality traits and could be utilized for the selection of better performing genotypes for further improvement. | SAHAR Adeela ZAFAR Muhammad Mubashar RAZZAQ Abdul MANAN Abdul HAROON Muhammad SAJID Sunaina REHMAN Abdul MO Huijuan ASHRAF Muhammad REN Maozhi SHAKEEL Amir YUAN Youlu | 2021 | Journal of Cotton Research2021，4，3： | 1 |
| 10 | Clinical evalution of minimally invasive neurosurgery 显示文摘 | ZHAO Jizong ZHANG Maozhi YANG Jun | 2002 | Chin J of Neurosurg Dis Res2002，1，1： | 1 |
| 11 | Faster Pairing Compution on Genus 2 Hyperelliptic Curves 显示文摘 | TANG Chunming XU Maozhi QI Yanfeng | 2011 | Information Processinng Letters2011，111，10： | 1 |
| 12 | Research on a Reliability Calculating Model Based on Wear Data 显示文摘 | Liu Xiangkai Yuan Hongtao Gan Maozhi | 2000 | International Journal of Plant Engineerning and Management2000，，： | 1 |
| 13 | Public Perceptions of Cryosphere Change and the Selection of Adaptation Measures in the rmqi River Basin显示文摘This study focuses on the characters of public perceptions on climate and cryosphere change,which are based on a questionnaire survey in the(U|¨)r(u|¨)mqi River Basin.In comparison with scientific observation results of climate and cryosphere change,this paper analyzes the possible impact of the change on water resources and agriculture production in the area.Perceptions of most respondents on climate and cryosphere changes confirm the main objective facts.For the selection of adaptation measures addressing the shortage of water resource,the results are as follows:most people preferred to choose the measures like 'policy change' and 'basic facility construction' which are mostly implemented by the government and the policy-making department;some people showed more preference to the measures of avoiding unfavorable natural environment,such as finding job in or migrating to other places.The urgency of personal participation in the adaptation measures is still inadequate.Some adaptation measures should be implemented in line with local conditions and require the organic combination of 'resource-development' with 'water-saving'. | Maozhi Deng Hongguang Zhang Weiyi Mao Yingwei Wang | 2011 | Advances in Climate Change Research2011，2，3： | 1 |
| 14 | A Model of Hierarchical Key Assignment Scheme显示文摘A model of the hierarchical key assignment scheme is approached in this paper, which can be used with any cryptography algorithm. Besides, the optimal dynamic control property of a hierarchical key assignment scheme will be defined in this paper. Also, our scheme model will meet this property. | ZHANG Zhigang ZHAO Jing XU Maozhi | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 1 |
| 15 | Avian reovirus triggers autophagy in primary chicken fibroblast cells and Vero cells to promote virus production显示文摘 | Songshu Meng Ke Jiang Xiaorong Zhang Miao Zhang Zhizhi Zhou Maozhi Hu Rui Yang Chenli Sun Yantao Wu | 2012 | Archives of Virology2012，，4： | 1 |
| 16 | Inheritance factor on the physical properties in metallic glasses显示文摘Material genetic engineering can significantly accelerate the development of new materials.As an important topic in material science and condensed matter physics,the development of metallic glasses(MGs)with specific properties has largely been the result of trial and error since their discovery in 1960.Yet,property design based on the physical parameters of constituent elements of MGs remains a huge challenge owing to the lack of an understanding of the property inheritance from constitute elements to the resultant alloys.In this work,we report the inherent relationships of the yield strengthσ_(y),Young’s modulus E,and shear Modulus G with the valence electron density.More importantly,we reveal that the electronic density of states(EDOSs)at the Fermi surface(E_(F))is an inheritance factor for the physical properties of MGs.The physical properties of MGs are inherited from the specific element with the largest coefficient of electronic specific heat(γ_(i)),which dominates the value of the EDOS at E_(F).This work not only contributes to the understanding of property inheritances but also guides the design of novel MGs with specific properties based on material genetic engineering. | Weiming Yang Jiawei Li Hongyang Li Haishun Liu Jinyong Mo Si Lan Maozhi Li Xun-Li Wang Jürgen Eckert Juntao Huo | 2022 | Materials Futures2022，1，3： | 0 |
| 17 | Cycling Attacks against Homomorphic Cryptosystems显示文摘We study security of some homomorphic cryptosystems with similar algebraic structure. It is found out that those cryptosystems have special common properties. Based on these properties, we pose two cycling attacks and point out some parameters under which the attacks are efficient. It is verified that randomly selected parameters almost impossibly submit to such attacks. Anyhow, two effective methods are given to construct weak parameters for certain homomorphic cryptosystems, and two moduli over 1 024 bits computed by them are shown to be vulnerable to our cycling attacks. It is concluded that strong primes should be used to avert weak parameters. | WANG Lin XU Maozhi HU Zhi YUE Zhihong | 2008 | Wuhan University Journal of Natural Sciences2008，13，6： | 0 |
| 18 | Secure network coding from secure proof of retrievability显示文摘Dear editor,Compared with the traditional storing-and-forwarding routing mechanism, network coding has become a more attractive paradigm because it has been proven capable of achieving maximized throughput, enhanced robustness, and lower energy consumption for communication networks [1]. | Jinyong CHANG Bilin SHAO Yanyan JI Maozhi XU Rui XUE | 2021 | Science China(Information Sciences)2021，64，12： | 0 |
| 19 | KASDARWIN OF ABA PREFECTURE显示文摘Kasdarwin, meaning in Tibetan 'a dance performed by people wearing armor', was a kind of sacred folk performance which, before the Heshui people of olden times went out for a battle, was conducted for the soldiers to pray for victory and their relatives to pray for their safe return. Meanwhile, as one of valuable relics of China's primitive dances, it fully embodies the perfect fusion of ancient Chiang and Tubo Culture. | YU MAOZHI | 2006 | China's Tibet2006，17，3： | 0 |
| 20 | 以边缘功能化的氮化碳纳米片为非金属光催化剂实现高效饮用水获得显示文摘文章简介清洁水资源短缺是全世界面临的棘手问题,科学家通过多种途径试图寻求一种高效、节能的光催化材料,以实现有效杀菌净水。非金属光催化剂,具有成本低,酸碱耐受力高等众多优势,尤其是可以有效避免金属向水中溶出引发的二次污染,是一类非常有潜力的新型催化剂。但是目前的非金属光催化剂效率仍然不高,无法与金属基的催化剂相抗衡。 | 滕镇远 杨乃亮 Hongying Lv Sicong Wang Maozhi Hu 王谧胤 王丹 汪国秀 | 2020 | 科学新闻2020，，2： | 0 |
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