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| 1 | Regulation of c-Jun/JunB heterodimers mediated by Epstein-Barr virus encoded latent membrane protein 1 on p16显示文摘Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is considered as the major oncogenic protein of EBV encoded proteins, which could transactivate many transcription factors including activator protein 1 (AP-1). Transcription factor plays its role in biological effects through binding to the target gene promoter,transactivating the transcription of target gene, regulating the target gene expression, etc. Recently, we found that LMP1 could mediate a new heterodimer form of c-Jun and JunB, which could bind to AP1 DNA sequence. In this report,we confirmed p16 as a putative target gene of c-Jun/JunB using bioinformatics. We used Tet-on-LMP1 HNE2 cell line as a cell model, which is a dual-stable LMP1 integrated HNE2 cell line and the expression of LMP1 could be regu-lated by the Tet system, and we wanted to explore whether c-Jun/JunB heterodimers mediated by LMP1 could regulate p16. Data demonstrated that c-Jun/Jun B heterodimers me-diated by LMP1 downregulated both the promoter activity and p16 expression, and accelerated the cell cycle progression. These findings established a new direct connection between the AP-I singnal pathway and the cell cycle, and provided a new model for the carcinogenesis mechanism. | SONGXin AIMidan CHENXiaoxi DENGXiyun TAOYongguang GONGJianping WUQiao | 2004 | Chinese Science Bulletin2004，49，7： | 2 |
| 2 | Design and performance of a muhiwavelength airborne polarimetric lidar for vegetation remote sensing 显示文摘 | Songxin Tan Ram M Narayanan | 2004 | Applied Optics2004，443，11： | 1 |
| 3 | Design and performance ofa multiwavelength airborne polarimetric lidar for vegetation remote sensing 显示文摘 | TAN Songxin NARAYANAN Ram M | 2004 | Applied opties2004，43，： | 1 |
| 4 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 5 | Real-time Simulation of Large-scale Dynamic River Water 显示文摘 | Songxin Shi Xiuzi Ye Zhaoxia Dong | 2007 | Simulation Modeling Practice and Theory (S1569-190X)2007，15，8： | 1 |
| 6 | Electrochemical sen- sor for melamine based on its copper complex显示文摘 | ZHU Hong ZHANG Songxin LI Meixian | 2010 | Chem Commun2010，46，13： | 1 |
| 7 | Electrochemical sen-sor for melamine based on its copper complex显示文摘 | ZHU Hong ZHANG Songxin LI Meixian | 2010 | ChemicalCommunications2010，46，13： | 1 |
| 8 | A virtual injection molding system based on numerical simulation显示文摘 | Huamin Zhou Songxin Shi Bin Ma | 2009 | International Journal of advanced manufacturing technology2009，40，34： | 1 |
| 9 | Naraynan, design and performance of a multiwavelength airborne polarimetric lidar for vegetation remote sensing显示文摘 | Songxin Tan Ram M | 2004 | Appl Opt2004，43，11： | 1 |
| 10 | Real-time Simulation of Large-scale Dynamic River Water显示文摘 | Shi Songxin Ye Xiuzi Dong Zhaoxia | 2007 | Simulation Modelling Practice & Theory2007，15，： | 1 |
| 11 | AnalysisofasaturationincidenceSVEIRSepidemicmodelwithpulseandtwotimedelays显示文摘 | SONGXinyu JIANGYu WEIHuiming | 2009 | AppliedMathematicsandComputation2009，214，2： | 1 |
| 12 | GlobalattractivityandpermanenceofadelayedSVEIRepidemicmodelwithpulsevaccinationandsaturationincidence显示文摘 | JIANGYu WEIHuiming SONGXinyu etal | 2009 | Applied MathematicsandComputation2009，213，2： | 1 |
| 13 | Real-time simulation of large-scale dynamic river water显示文摘 | Songxin SHI | | 0，，6： | 1 |
| 14 | Year-round changes in tropospheric nitrogen dioxide caused by COVID-19 in China using satellite observation显示文摘The lockdown policy deals a severe blow to the economy and greatly reduces the nitrogen oxides(NOx)emission in China when the coronavirus 2019 spreads widely in early 2020.Here we use satellite observations from Tropospheric Monitoring Instrument to study the year-round variation of the nitrogen dioxide(NO_(2))tropospheric vertical column density(TVCD)in 2020.The NO_(2)TVCD reveals a sharp drop,followed by small fluctuations and then a strong rebound when compared to 2019.By the end of 2020,the annual average NO_(2)TVCD declines by only 3.4%in Chinamainland,much less than the reduction of 24.1%in the lockdown period.On the basis of quantitative analysis,we find the rebound of NO_(2)TVCD is mainly caused by the rapid recovery of economy especially in the fourth quarter,when contribution of industry and power plant on NO_(2)TVCD continues to rise.This revenge bounce of NO_(2)indicates the emission reduction of NOx in lockdown period is basically offset by the recovery of economy,revealing the fact that China’s economic development and NOx emissions are still not decoupled.More efforts are still required to stimulate low-pollution development. | Zhenyu Luo Hailian Xu Zhining Zhang Songxin Zheng Huan Liu | 2023 | Journal of Environmental Sciences2023，，10： | 0 |
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