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| 1 | Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation显示文摘Mitochondrial 反应的氧种类(mROS ) 被认为有害到房间。然而,他们的生理的角色一直不作为表明调停人是彻底地探索了。这里,我们调查了 mROS 是否从 mitochondrial 电子运输链(mETC ) 产生了复杂我刺激了肌肉区别。我们的结果证明 mROS 的数量被增加并且锰 superoxide dismutase (MnSOD ) 在肌肉区别期间经由 NF-B 激活被导致。指向线粒体的抗氧化剂(MitoQ 和 MitoTEMPOL ) 和指向线粒体的过氧化氢酶减少了没有影响 ATP 的数量的 mROS 数量和压制的肌肉区别。Mitochondrial 改变包括在线粒体的数字和尺寸的 mitochondrial 抄写因素 A 和增加的正式就职,并且功能的激活在肌肉区别期间被观察。特别地,增加了 mETC 建筑群的表示层次我子单元和建筑群的一项更高的活动我比另外的建筑群被观察。毒鱼藤素, mETC 建筑群的一个禁止者我,减少 mitochondrial NADH/NAD+ 比率和 mROS 层次在肌肉区别期间。mROS 铺平的我用小介入 RNA 和毒鱼藤素减少了的建筑群的抑制,压制的肌肉区别,和有伴随物的弄空的 ATP 层次在 glycolysis 增加。从这些结果,我们结束那复杂我导出 | Seonmin Lee Eunyoung Tak Jisun Lee MA Rashid Michael P Murphy Joohun Ha Sung Soo Kim | 2011 | Cell Research2011，21，5： | 4 |
| 2 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 3 | Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats显示文摘Objective: To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib(Iressa?) and the oriental medications Guipi Decoction(归脾汤, GPD, Guibi-tang in Korean) and Bawu Decoction(八物汤, BWD, Palmul-tang in Korean). Methods: Methylcellulose(MC, control), GPD(1,200 mg/kg), or BWD(6,000 mg/kg) was orally administered to rats either as a single dose or multiple doses prior to gefitinib administration. To examine the effects of a single dose of the herbal medicines, gefitinib(10 mg/kg) was orally administered after 5 min or 1 h of MC or the herbal medicine pretreatments. To examine the effects of the multiple doses of the herbal medicines, gefitinib(10 mg/kg) was orally administered following 7 consecutive days of the administration of MC or each herbal medicine. The plasma concentrations of gefitinib were determined with liquid chromatography-tandem mass spectrometry assay. The plasma concentration-time profiles of gefitinib were analyzed with a noncompartmental analysis. Results: Gefitinib was rapidly absorbed and showed a monoexponential decline with an elimination half-life of 3.7–4.1 h. The pharmacokinetics of gefitinib was not affected by GPD pretreatment. However, a significantly lower maximum plasma concentration(Cmax, P<0.05) and area under the curve(P<0.05), and a delayed time to reach Cmax(Tmax, P<0.01) were observed in both single-and multipledose BWD-pretreated rats compared with the control rats. Conclusions: BWD and not GPD might delay and interfere with gefitinib absorption. Further evaluations of the clinical significance of these findings are needed. | Kwon-Yeon Weon Min Gi Kim Soyoung Shin Tae Hwan Kim Sang Hoon Joo Eunsook Ma Seok Won Jeong Sun Dong Yoo Yu Seok Youn Beom Soo Shin | 2018 | Chinese Journal of Integrative Medicine2018，24，6： | 2 |
| 4 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 5 | Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease显示文摘 | Jung Mi Choi Myoung Soo Woo Hyeo-Il Ma Suk Yun Kang Young-Hee Sung Seok Woo Yong Sun Ju Chung Joong-Seok Kim Hae-won Shin Chul Hyoung Lyoo Phil Hyu Lee Jong Sam Baik Sang-Jin Kim Mee Young Park Young Ho Sohn Jin-Ho Kim Jae Woo Kim Myung Sik Lee Myoung Cho | 2008 | Neurogenetics2008，，4： | 1 |
| 6 | Plasma adiponectin as a marker of insulin receptor dysfunction:clinical utility in severe insulin resistance显示文摘 | Semple RK Cochran EK Soos MA | 2008 | Diabetes Care2008，31，5： | 1 |
| 7 | Elevated plasma adiponectin in humans with genetically defective insulin receptors显示文摘 | Semple RK Soos MA Luan J | 2006 | J Clin Endocrinol Metab2006，91，8： | 1 |
| 8 | Mutant SODI inhibits ER-Golgi transport in amyotrophic lateral sclerosis 显示文摘 | Atkin JD Farg MA Soo KY Walker AK Halloran M Turner B J Nagley P Home MK | 2014 | J Neurochem2014，129，1： | 1 |
| 9 | The role of splenectomy in patients with hepatocellular carcinoma and secondary hypersplenism显示文摘 | Jae WO Soo MA Kyung SK | 2003 | Yonsei Medical Journal2003，44，6： | 1 |
| 10 | Elevated plasma adiponectin in humans with genetically defective insulin receptors 显示文摘 | Semple RK Soos MA Luan J | 2006 | J Clin Endocrinol Metab2006，91，8： | 1 |
| 11 | Plasma adiponec-tin as a marker of insulin receptor dysfunction:clinical util-ity in severe insulin resistance 显示文摘 | Semple RK Cochran EK Soos MA | 2008 | Diabetes Care2008，31，5： | 1 |
| 12 | In vitro fungistatic activity of 36 traditional oriental medicines and their synergistic effect against Trichophyton rubrume显示文摘Objective: To investigate the fungistatic activity and synergistic effects of natural products and their constituents, including traditional oriental medicines(TOMs).Methods: Fungistatic activities of TOMs prepared by hot-water(115 ℃) or ethanol(70%; 40 ℃) extraction were determined by their minimum inhibitory concentration.To assess possible synergistic effects, minimum inhibitory concentrations of various combinations were evaluated.Results: By evaluating antifungal susceptibility of Trichophyton rubrum, which is a major causative fungus for several types of dermatophytosis, we confirmed that ethanol extracts were more active than hot-water extracts in 25 of the 36 TOMs, suggesting that the constituents with high hydrophobicity tend to contribute significantly to fungistatic activity.We selected four TOMs with high fungistatic activity, including Aucklandiae radix, Gentianae macrophyllae radix, Scutellariae radix, and Galla rhois, and their synergistic effects were investigated through the combination studies between TOMs or TOM-conventional drug terbinafine.In combinations between four TOMs, partial synergistic effects were observed in Aucklandiae radix–Galla rhois and Gentianae macrophyllae radix–Galla rhois combinations, as supported by the lowest fractional inhibitory concentration index value of 0.66 for both combinations.Furthermore, Galla rhois showed the strongest synergistic effect on growth inhibition of Trichophyton rubrumwith a fractional inhibitory concentration index value of 0.50 in combination with terbinafine.Conclusions: Our findings indicate that the combination of TOMs and TOM-terbinafine may be effective on treatment for chronic and recurrent dermatophytosis by improving fungistatic activity and led to decrease systemic toxicity in clinical practice. | Young Soo Kim Jin Yeul Ma | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，2： | 1 |
| 13 | GFR and Cardiovascular Outcomes After Acute Myocardial Infarction: Results From the Korea Acute Myocardial Infarction Registry显示文摘 | Eun Hui Bae Sang Yup Lim Kyung Hoon Cho Joon Seok Choi Chang Seong Kim Jeong Woo Park Seong Kwon Ma Myung Ho Jeong Soo Wan Kim | 2012 | American Journal of Kidney Diseases2012，，6： | 1 |
| 14 | Insulin receptor/IGF-1 receptor hybrids are widely distributed in mammalian tissues:quantification of individual receptor species by selective immunoprecipitation and immunoblotting显示文摘 | Bailyes EM Nave BT Soos MA | 1997 | Biochem J1997，3271，： | 1 |
| 15 | Severe insulinresistance due to anti-insulin antibodies: response to plasmaexchange and immunosuppressive therapy 显示文摘 | Greenfield JR Tuthill A Soos MA | 2009 | Diabet Med2009，26，1： | 1 |
| 16 | Insulin reeeptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting显示文摘 | Bailyes EM Nave BT Soos MA | 1997 | Bioehem J1997，327，： | 1 |
| 17 | Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject显示文摘 | Georgr S Johansen A Soos MA | 2003 | Endocrinology2003，144，4： | 1 |
| 18 | Severe insulin resistance due to anti-insulin antibodies: response to plasma exchange and immunosuppressive therapy显示文摘 | Greenfield JR Tuthill A Soos MA | 2009 | Diabet Med2009，26，1： | 1 |
| 19 | Development of SSR markers for studies of diversity in the genus Fagopyrmn显示文摘 | Kyung Ho Ma Nam Soo Kim Gi An Lee | 2009 | The- or Appl Genet2009，119，7： | 1 |
| 20 | Severe insulin resistance due to anti-insulin antibodies: response to plasma exchange and therapy显示文摘 | Greenfield JR Tuthill A Soos MA | 2009 | Diabet Med2009，26，1： | 1 |
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