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| 1 | Ion Channels in Mesenchymal Stem Cells from Rat Bone Marrow显示文摘 | Li GR Deng XL Sun H Chung SS Tse HF Lau CP | 2006 | 中国生物学文摘2006，20，5： | 18 |
| 2 | Research on optimal immunization strategies for hepatitis B in different endemic areas in China显示文摘INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization | Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN | 2000 | World Journal of Gastroenterology2000，6，3： | 9 |
| 3 | Expression of co-stimulator 4-1BB molecule in hepatocellular carcinoma and adjacent non-tumor liver tissue,and its possible role in tumor immunity显示文摘AIM:To investigate the expression of 4-1BB molecule in hepatocellular carcinoma (HCC) and its adjacent tissues.METHODS:Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the gene expression of 4-1BB in hepatocarcinoma and its adjacent tissues,and peripheral blood mononuclear cells (PBMCs) from both HCC and health control groups.Flow cytometry was used to analyse the phenotypes of T cell subsets from the blood of HCC patients and healthy volunteers,and further to determine whether 4-1BB molecules were also expressed on the surface of CD4+ and CD8+ T cells. The localization of 4-1BB proteins on tumor infiltrating T cells was determined by direct immunofluorescence cytochemical staining and detected by confocal microscopy.RESULTS:4-1BB mRNA, which was not detectable in normal liver,was found in 19 liver tissues adjacent to tumor edge(<1.0cm).Low expression of 4-1BB mRNA was shown in 8 tumor tissues and 6 liver tissues located within 1 to 5cm away from tumor edge. In PBMCs, 4-1BB mRNA was almost not detected. Percentage of CD4^+, CD8^+ and CD3^+/CD25^+ T cells, as well as ratio of CD4 to CD8 revealed no difference between groups (P>0.05,respectively),while a significant lower percentage of CD3^+ T cell was found in HCC group as compared to healthy control group (P<0.05).However, 4-1BB molecules were almost not found on the surface of CD4+ and CD8+ T cells in HCC and healthy control group.Double-staining of 4-1BB^+/CD4^+ and 4-1BB^+/CD8^+ immunofluorescence on tumor infiltrating T cells was detected in 13 liver tissues adjacent to tumor edge (<1.0cm) by confocal microscopy.CONCLUSION: Although HCC may escape from immune attack by weak immunogenicity or downregulated expression of MHC-1 molecules on the tumor cell surface,tumor infiltrating T cells can be activated via other costimulatory signal pathways to exert a limited antitumor effect on local microenvironment. The present study also implicates that modulating 4-1BB/4-1BBL costimulatory pathway may be an effective immunotherapy strategy to augment the host response. | Wan, YL Zheng, SS Zhao, ZC Li, MW Jia, CK Zhang, H | 2004 | World Journal of Gastroenterology2004，10，2： | 6 |
| 4 | The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase显示文摘Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers.The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final geneproducts. | Chang DY Yoo SW Hong Y Kim S Kim SJ Yoon SH Cho KG Paek SH Lee YD Kim SS Suh-Kim H | 2010 | 中国神经肿瘤杂志2010，8，2： | 3 |
| 5 | 肥胖、高血压和体力运动决定儿童的血管表型显示文摘心血管病常在儿童时期引发,但是儿童血管健康和疾病的决定因素还不清楚。该研究旨在探讨儿童肥胖、高血压、体能与视网膜微血管健康以及大动脉僵硬度之间的关系。在该横断面研究中,通过标准化的程序来评估1171名小学生[年龄(7.2±0.4)岁]的视网膜中央小动脉直径(central retinal arteriolarequivalent, CRAE)和视网膜中央静脉直径(centralretinal venular equivalent, CRVE)、脉搏波传导速度(pulse wave velocity, PWV)、体质量指数(body massindex,BMI),血压和心肺耐力。 | 陈嘉睿 练桂丽 K?chli S Endes K Steiner R Engler L Infanger D Schmidt-Trucksǎss Zahner L Hanssen H | 2019 | 中华高血压杂志2019，27，4： | 3 |
| 6 | Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro显示文摘 | Ma C Lin H Leonard SS | 2003 | Oncogene2003，22，34： | 2 |
| 7 | Evaluation 0f the Knowledge,Attitude and Practice of Self-Medication a-mong Fitrst-Year Medication Students显示文摘 | Handu SS ALKhaja KA | 2006 | Medical principles and practice2006，15，4： | 1 |
| 8 | Is simultaneous surgical management of advanced craniofaeial steoradioneerosiseost-effective? 显示文摘 | Kelishadi SS St-Hilaire H Rodriguez ED | 2009 | Plast Reconstr Surg2009，123，3： | 1 |
| 9 | Volume - specific cutoffs are necessary for reproducible application of prostate - specific antigen density of the transition zone in prostate cancer detection显示文摘 | Taneja SS Tran K Lepor H | 2001 | Urology2001，58，2： | 1 |
| 10 | MicroRNA-146b inhibits glioma cell migra- tion and invasion by targeting MMPs 显示文摘 | Xia H Qi Y Ng SS | 2009 | Brain Res2009，1269，： | 1 |
| 11 | Real-time imaging of trapping and ureasedependent transmigration of Cryptococcus neoformans in mouse brain显示文摘 | Shi M Li SS Zheng C Jones GJ Kim KS Zhou H Kubes P Mody CH | 2010 | J Clin Invest2010，120，5： | 1 |
| 12 | An improved corner detection algorithm base on chain-code plane curves显示文摘 | BEUS H L TIU SS | 1987 | Pattrn Recognition1987，20，： | 1 |
| 13 | Obesity in Malaysia显示文摘 | Ismail MN Chee SS Nawawi H | 2002 | Obesity Reviews2002，3，： | 1 |
| 14 | MMPs and proteinase inhibitors in the human aqueous humor 显示文摘 | Ando H Twining SS Yue B | 1993 | Invest Ophthalmol Vis Sci1993，34，13： | 1 |
| 15 | Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: cohort study using data from the UK General Practice Research Database显示文摘 | Russmann S Kaye JA Jick SS Jick H | 2005 | Br J Clin Pharmacol2005，60，1： | 1 |
| 16 | The role of nebulised budesonide in the treatment of exacerbations of COPD显示文摘 | Gunen H Hacievliyagil SS Yetkin O | 2007 | Eur Respir2007，29，： | 1 |
| 17 | Inflammatory markers incord blood or maternal serum for early detection of neo-natal sepsis-a systemic review and meta-analysis 显示文摘 | Su H Chang SS Han CM | 2014 | JPerinatol2014，34，4： | 1 |
| 18 | Plasma glutamate-modulated interaction of A2AR and m GluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury显示文摘 | Dai SS Wang H Yang N | 2013 | J Exp Med2013，210，4： | 1 |
| 19 | A simple method for the uniform production of gastric ulceration in the rat显示文摘 | hay H Komarow SA Fels SS | 1945 | Gastroenterol1945，5，1： | 1 |
| 20 | 一般人群中发生心力衰竭的10年风险方程显示文摘目前急需能减轻心力衰竭负担的一级预防策略,但未见实用有效的风险预测工具。该研究旨在得出一个计算心力衰竭事件发生的10年风险方程。研究者根据7个社区队列,至少12年随访的个体水平数据,推导并验证了心力衰竭的种族和性别特异性10年风险方程。1985-2000年间招募年龄30~79岁在基线时无心血管病的研究对象,创建一个集合队列并随机分组以进行方程推导和内部验证。在另两个队列中也评估了该模型的性能。 | Khan SS Ning H Shah SJ Yancy CW Carnethon M Berry JD Mentz RJ O’Brien E Correa A Suthahar N de Boer RA Wilkins JT Lloyd-Jones DM 刘青 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 1 |
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