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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Forecasting of the daily meteoro- logical pollution using wavelets and support vector machine 显示文摘 | Stanislaw O Konrad G | 2006 | Engineering Applications of artificial intelligence2006，，10： | 1 |
| 3 | Robust threshold DSS signatures 显示文摘 | Rosario G Stanislaw J Hugo K | 2001 | Information and Computation2001，164，1： | 1 |
| 4 | Frequency response of oil impregnated pressboard and paper samples for estimating moisture in transformer insulation显示文摘 | Ekanayake C Stanislaw M G Graczkowski A | 2006 | IEEE Transactions on Power Delivery2006，21，3： | 1 |
| 5 | Forecasting of the daily meteorological pollution using wavelets and support vector machine 显示文摘 | Stanislaw O Konrad G | 2007 | Engineering Applications of Artificial Intelligence2007，20，6： | 1 |
| 6 | Denitrification rates in relation to total and extractable soil carbon显示文摘 | Stanford G Roger A Vander Pol Stanislaw Dzienia | 1975 | Soil Sci Soc Amer Proc1975，39，： | 1 |
| 7 | Robust threshold DSS signatures显示文摘 | G Rosario J Stanislaw K Hugo | 2001 | Information and Computation2001，164，1： | 1 |
| 8 | Comparing Al-SBA-15 support and Pt/Al-SBA-15 catalyst: changes in Al speciation and acidicprojperties induced by the introduction of Pt via aqueous medium显示文摘 | Soraya H J Stanislaw D G Juliette B C | 2009 | Top Catal2009，52，8： | 1 |
| 9 | Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia–reperfusion into gastric ulcers显示文摘 | Tomasz Brzozowski Peter Ch Konturek Stanislaw J Konturek Danuta Drozdowicz Slawomir Kwiecie? Robert Pajdo Wladyslaw Bielanski Eckhart G Hahn | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 10 | Early - pregnancy glucose screening for gestational diabetes mellitus 显示文摘 | NAHUM G G WILSON S B STANISLAW H | 2002 | J Repred Med2002，47，9： | 1 |
| 11 | Simulation of the opening and closing of Hsp70 chaperones by coarse-grained molecular dynamics显示文摘 | Gola(s) Ewa Maisuradze Gia G Senet Patrick Oldziej Stanislaw Czaplewski Cezary Scheraga Harold A Liwo Adam | | 0，，05： | 1 |
| 12 | The influence of the preparation procedures on the catalytic activity of Fe-BEA zeolites in SCR of NO with ammonia and N2O decomposition 显示文摘 | Pawe? B Lucjan C Jacek G Kazimierz L Barbara G Jean-Marc K Stanislaw D | 2014 | Catalysis Today2014，235，： | 1 |
| 13 | Behaviour of elements and minerals during preparation and combustion of the Pernik coal 显示文摘 | Eskenazy Greta M Vassileva Christina G | 2001 | Bulgaria Fuel Processing Technology2001，72，： | 1 |
| 14 | Use of the finite elements method for modelling the dynamic load impact on hydraulic leg 显示文摘 | Horst G Stanislaw S Krzysztof M | 2007 | Sbornik Vedecky Chpracivy Sokeskoly Banske2007，，1： | 1 |
| 15 | An integrated deci- sion-making model for condition assessment of power trans- formers using fuzzy approach and evidential reasoning显示文摘 | Liao Ruijin Zheng Hanbo STANISLAW G | 2011 | IEEE Transactions on Power Delivery2011，26，2： | 1 |
| 16 | PVA-biocatalyst with entrapped viable Bacillus subtilis ceils显示文摘 | MIROSLAWA S EDWARD G STANISLAW B | 2001 | J Mol Catal Part B: Enzym2001，11，： | 1 |
| 17 | PVA-biocatalyst with entrapped viable Bacillus subtilis cells显示文摘 | Miroslawa S Edward G Stanislaw B | 2001 | J Mol Catal Part B:Enzym2001，11，： | 1 |
| 18 | Forecasting of the Daily Meteoro- logical Pollution Using Wavelets and Support Vector Machine 显示文摘 | Stanislaw O Konrad G | 2006 | Engineering Applications of Artificial Intelligence2006，，10： | 1 |
| 19 | Early - pregnancyglucose screening for gestational diabetesmellitus 显示文摘 | Nahum G G Wilson S B Stanislaw H | 2002 | J Reprod Med2002，47，9： | 1 |
| 20 | 显示文摘 | Stanislaw G | 2000 | Appl Catal A : General2000，192，1： | 1 |
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