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| 1 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 2 | Evalua- tion of size exclusion chromatography (SEC)for the charac- terization of extracellular polymeric substances (EPS) in anaerobic granular sludges 显示文摘 | STEPHANE S BE RENGERE P MAUD V | 2009 | Bioresource Technology2009，100，24： | 1 |
| 3 | Photoinitiation of acrylamide polymerization by Fe2O3 nanoparticles 显示文摘 | Alexander L S Ivan V S Stephan Y K | 2007 | Journal of Photochemistry and Photobiology A: Chemistry2007，，： | 1 |
| 4 | Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart显示文摘 | Stephane H Blanche S Pieter V | 2005 | Circulation2005，112，8： | 1 |
| 5 | Performance analysis of the cyclic MUSIC method of direction estimation for cyclostationary signals显示文摘 | Stephan V S | 1994 | IEEE Transactions on Signal Processing1994，42，11： | 1 |
| 6 | The influence of additives on the crystal habit of gibbsite显示文摘 | Isabelle S Stephane V Gerard P | 1999 | Journal of Crystal Growth1999，196，1： | 1 |
| 7 | Heat shock Reponse in Ceratiti显示文摘 | STEPHANOU G ALAHIOTIS S N MANLLAS V J | 1983 | Comp Biochem Physiol1983，74，： | 1 |
| 8 | A Multieenter, randomized trial comparing calcium hydroxylapatite to two hyaluronie acids for treatment ofnasolabial folds 显示文摘 | Marion M Stephan V Begonia Martinez S | 2007 | Dermatol Surg2007，33，2： | 1 |
| 9 | ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—summary article显示文摘 | Raymond J Gibbons Jonathan Abrams Kanu Chatterjee Jennifer Daley Prakash C Deedwania John S Douglas T.Bruce Ferguson Stephan D Fihn Theodore D Fraker Julius M Gardin Robert A O’Rourke Richard C Pasternak Sankey V Williams Raymond J Gibbons Joseph S Alpert | 2003 | Journal of the American College of Cardiology2003，，1： | 1 |
| 10 | The influence of additives on the crystal habits of gibbsite 显示文摘 | ISABELLE S STEPHANE V GERARD P | 1999 | Journal of Crystal Growth1999，196，1： | 1 |
| 11 | Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival 显示文摘 | Meri V Peter O Stephan S | 2004 | Cancer Res2004，10，9： | 1 |
| 12 | Pulmonary function in children with juvenile idiopathic arthritis and effects of methotrexate therapy显示文摘 | Schmeling H Stephan V Burdach S | 2002 | Z Rheumatol2002，61，2： | 1 |
| 13 | Nanophase separation in segmented polyurethane elastomers: Effect of specific interactions on structure and properties显示文摘 | Béla Pukánszky Kristóf Bagdi Zsuzsa Tóv?lgyi József Varga Lajos Botz Stephan Hudak Tamás Dóczi Béla Pukánszky | 2008 | European Polymer Journal2008，，8： | 1 |
| 14 | FESEM and EIS study of sealed AA2024 T3 anodized in sulfuric acid electrolytes:Influence of tartaric acid显示文摘 | GRéGORY B NADINE P CATHERINE D MARTINE V STEPHANE S | 2008 | Journal of the Electrochemical Society2008，155，11： | 1 |
| 15 | Pharmaceutical care services for asthma patients:a controlled intervention study显示文摘 | Martin S Frank V Stephan M | 2001 | J Clin Pharmacol2001，41，： | 1 |
| 16 | The influence of mass imperfections on the evolution of standing waves in slowly rotating spherical bodies显示文摘 | Michael Y S Stephan V J Charlotta E C | | 0，，： | 1 |
| 17 | Multilayer capsules: A promising microencapsulation system for transplantation of pancreatic islets显示文摘 | STEPHAN S FEILEN -P-J SLOTTY -V | 2001 | Biomaterials2001，22，14： | 1 |
| 18 | The Tor and PKA signaling pathways independently target the Atgl/Atgl3 protein kinase complex to control autophagy显示文摘 | Stephan J S Yeh Y Y Ramachandran V | 2009 | Proc Natl Acad Sci U S A2009，106，17： | 1 |
| 19 | The transnational challenge: Performance and expatriate presence in the overseas affiliates of Japnese MNCs 显示文摘 | Beeehler S Pucik V Stephan J | 2004 | Advances in International Management2004，17，2： | 1 |
| 20 | Incorporation of boron and nitrogen in carbon nanomaterials and its influence on their structure and opto-electronical properties显示文摘 | ARUTYUNYAN N R ARENAL R OBRAZTSOVA E D STEPHAN O LOISEAU A POZHAROV A S GREBENYUKOV V V | | 0，，03： | 1 |
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