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| 1 | Aberrant expression of enzymes regulating m^6A mRNA methylation: implication in cancer显示文摘N^6-methyladenosine(m^6 A) is an essential RNA modification that regulates key cellular processes, including stem cell renewal,cellular differentiation, and response to DNA damage. Unsurprisingly, aberrant m^6 A methylation has been implicated in the development and maintenance of diverse human cancers. Altered m^6 A levels affect RNA processing, mRNA degradation, and translation of mRNAs into proteins, thereby disrupting gene expression regulation and promoting tumorigenesis. Recent studies have reported that the abnormal expression of m^6 A regulatory enzymes affects m^6 A abundance and consequently dysregulates the expression of tumor suppressor genes and oncogenes, including MYC, SOCS2, ADAM19, and PTEN. In this review, we discuss the specific roles of m^6 A missing space 'writers', 'erasers', and 'readers' in normal physiology and how their altered expression promotes tumorigenesis. We also describe the potential of exploiting the aberrant expression of these enzymes for cancer diagnosis, prognosis, and the development of novel therapies. | Natalia Pinello Stephanie Sun Justin Jong-Leong Wong | 2018 | Cancer Biology & Medicine2018，15，4： | 15 |
| 2 | 农村受艾滋病影响的儿童和家庭需求的定性研究显示文摘目的了解艾滋病对儿童和家庭的影响,为开展干预活动提供基线资料。方法:采用专题小组讨论方法,在某艾滋病流行重点地区组织感染者/病人及受艾滋病影响的儿童的监护人进行访谈。结果受访人员都知道当地有艾滋病,且流行很严重;艾滋病防治信息的来源主要是疾控人员的宣传;都说家庭经济状况较困难;绝大多数都认为对儿童健康没影响,但在儿童营养饮食方面受到一定限制。偏见和歧视导致了对儿童心理的影响。儿童都能免费上学,在学校和老师、同学相处都很好,但有的学习成绩受到家庭一定的影响。都能得到政府的关爱和生活救助。希望有钱能让孩子们有好的生活条件,能上大学。结论:本次调查显示,艾滋病对儿童及其家庭具有明显影响,受影响的儿童和家庭的需求高。 | 计国平 LiLi Stephanie Sun 吴尊友 洪涛 朱冰 | 2007 | 健康教育与健康促进2007，2，2： | 4 |
| 3 | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization显示文摘NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity. | Yanchuan Li Jin-Young Yang Xiaoping Xie Zuliang Jie Lingyun Zhang Jianhong Shi Daniel Lin Meidi Gu Xiaofei Zhou Haiyan S. Li Stephanie S. Watowich Antrix Jain Sung Yun Jung Jun Qin Xuhong Cheng Shao-Cong Sun | 2019 | Cell Research2019，29，6： | 3 |
| 4 | Comparative Study of Three - Phase PWM Rectifiers for Wind Energy Conversion 显示文摘 | Stephanie KT Miller Jian Sun | 2006 | IEEE Applied Power Electrinics Conference and Exposition2006，，： | 1 |
| 5 | Activator Protein-1 Activation in Acute Lung Injury显示文摘 | Ren-Feng Guo Alex B. Lentsch J. Vidya Sarma Lei Sun Niels C. Riedemann Shannon D. McClintock Stephanie R. McGuire Nico Van Rooijen Peter A. Ward | 2002 | The American Journal of Pathology2002，，1： | 1 |
| 6 | 上海天文馆显示文摘上海天文馆坐落于滴水湖畔,总面积约3.8万m^(2)作为上海科技馆分馆,是全球规模最大的天文学主题博物馆。其致力于营造沉浸式体验,让游客可以与各种天文现象直接互动,并通过对比例、形态以及光线的细致处理,提升人们对于太阳和地球轨道运动之间的基本关系的认知。 | 无 V.Guy Maxwell Grace Chen Wei Wei Kuang Charles Wolf Anthony Guaraldo Jorge Arias Margarita Calero Michael Caton Christina Ciardullo Eugene Colberg Regina Jiang Jörg Kiesow Aidan Kim Stefan Knust Xinya Li Francelle Lim Xiaoyun Mao David Monnar Nikita Payusov James Rhee Yong Kyun Roh Miya Ruan Na Sun Eric Tsui Stephanie Tung Charles Wong David Yu Fred Zhang | 2022 | 建筑实践2022，，5： | 1 |
| 7 | Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing显示文摘 | Xia Wang Hui Wang Vincent Sun Han-Fang Tuan Vafa Keser Keqing Wang Huanan Ren Irma Lopez Jacques E Zaneveld Sorath Siddiqui Stephanie Bowles Ayesha Khan Jason Salvo Samuel G Jacobson Alessandro Iannaccone Feng Wang David Birch John R Heckenlively Gerald A | 2013 | Journal of Medical Genetics2013，，10： | 1 |
| 8 | Epigenetic Regulation of SOX9 by the NF‐κB Signaling Pathway in Pancreatic Cancer Stem Cells显示文摘 | Lei Sun Lesley A. Mathews Stephanie M. Cabarcas Xiaohu Zhang Acong Yang Ying Zhang Matthew R. Young Kimberly D. Klarmann Jonathan R. Keller William L. Farrar | 2013 | STEM CELLS2013，，8： | 1 |
| 9 | Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes显示文摘 | Anuradha Budhu Stephanie Roessler Xuelian Zhao Zhipeng Yu Marshonna Forgues Junfang Ji Edward Karoly Lun–Xiu Qin Qing–Hai Ye Hu–Liang Jia Jia Fan Hui–Chuan Sun Zhao–You Tang Xin Wei Wang | 2013 | Gastroenterology2013，，5： | 1 |
| 10 | 浩瀚宇宙的秘密 上海天文馆显示文摘上海天文馆由Ennead建筑设计事务所设计合伙人Thomas J.Wong设计。其方案致力于营造沉浸式体验,让游客可以与各种天文现象直接互动,并通过对比例、形态以及光线的细致处理,提升人们对于太阳和地球轨道运动这一基本关系的认知。作为上海科技馆分馆,全新的上海天文馆占地38000 m^(2),为全球规模最大的天文学主题博物馆。 | 无 V.Guy Maxwell(设计) 陈昕昉(设计) 邝薇薇(设计) Charles Wolf(设计) Anthony Guaraldo(设计) Jorge Arias(设计) Margarita Calero(设计) Michael Caton(设计) Christina Ciardullo(设计) Eugene Colberg(设计) Regina Jiang(设计) Jörg Kiesow(设计) Aidan Kim(设计) Stefan Knust(设计) 李欣亚(设计) Francelle Lim(设计) Xiaoyun Mao(设计) David Monnar(设计) Nikita Payusov(设计) James Rhee(设计) Yong Kyun Roh(设计) 阮玲丽(设计) Na Sun(设计) 徐震(设计) Stephanie Tung(设计) 黄泽修(设计) 于乐川(设计) Fred Zhang(设计) | 2021 | 室内设计与装修2021，，9： | 1 |
| 11 | Understanding Family Support for People Living with HIV/AIDS in Yunnan, China显示文摘 | Li Li Sheng Wu Zunyou Wu Stephanie Sun Haixia Cui Manhong Jia | 2006 | AIDS and Behavior2006，，5： | 1 |
| 12 | Fanconi anemia signaling network regulates the spindle assembly checkpoint显示文摘 | Nalepa Grzegorz Enzor Rikki Sun Zejin Marchal Christophe Park Su-Jung Yang Yanzhu Tedeschi Laura Kelich Stephanie Hanenberg Helmut Clapp D Wade | 2013 | Journal of Clinical Investigation2013，，9： | 1 |
| 13 | Regulation of adenosine levels during cerebra schemia显示文摘 | Stephanie CHU Wei XIONG Dali ZHANG Hanifi SOYLU Chao SUN Benedict C ALBENSI Fiona E PARKINSON | 2013 | Acta Pharmacologica Sinica2013，34，1： | 1 |
| 14 | L-3-n-Butylphthalide Improves Cognitive Impairment and Reduces Amytoid-in a Transgenic Model of Alzheimer's Disease显示文摘 | Ying Peng Jing Sun Stephanie Hon | 2010 | The Journal of Neuro science2010，30，24： | 1 |
| 15 | Disclosure of HIV Sta- tus Is a Family Matter, Field Notes From China显示文摘 | Li Li Sun Stephanie Zunyou Wu | 2007 | Journal of Family Psychology2007，21，2： | 1 |
| 16 | Characterization of Kaposi’s sarcoma-associated herpesvirus (KSHV) K1 promoter activation by Rta显示文摘 | Brian S. Bowser Stephanie Morris Moon Jung Song Ren Sun Blossom Damania | 2006 | Virology2006，，2： | 1 |
| 17 | Intermediate filament dynamics: Disassembly regulation显示文摘 | Chengjun Sun Julien Arino Stephanie Portet | 2017 | International Journal of Biomathematics2017，10，1： | 0 |
| 18 | Trends of carbon and nutrient accumulation through time in the Andong salt marsh,Hangzhou Bay,China显示文摘Salt marshes are important carbon and nutrient sinks that are threatened by climate changes and human activities.In this study,the accumulation rates of sedimentary total organic carbon(TOC),total nitrogen(TN),and total phosphorus(TP)from two cores in the Andong salt marsh,Hangzhou Bay,were investigated to determine whether TOC,TN,and TP show increasing or decreasing trends toward the present.The TOC accumulation rates at the relatively lower marsh were lower during 1990-1996(1.63-2.37 g/(cm^(2)·a))than 1997-2014(1.15-4.30 g/(cm^(2)·a)).The TN accumulation rates increased from 1990(0.14 g/(cm^(2)·a))toward 2012(0.40 g/(cm^(2)·a)),then decreased toward 2014(0.16 g/(cm^(2)·a)).The TP accumulation rates were lower during 1990-1999(0.10-0.21 mg/(cm^(2)·a)),and decreased from 2000(0.32 mg/(cm^(2)·a))toward 2014(0.15 mg/(cm^(2)·a)).The TOC accumulation rates along the relatively upper marsh during 1982-1992(1.18-3.25 g/(cm^(2)·a))were lower than during 1998-2010(2.30-4.20 g/(cm^(2)·a)),and then decreased toward 2015(2.15 g/(cm^(2)·a)).TN increased from 1982(0.18 g/(cm^(2)·a))to 2005(0.41 g/(cm^(2)·a)),then decreased toward 2015(0.22 g/(cm^(2)·a)).TP accumulation rates fluctuated within a narrow range during 1982-1997(0.21-0.41 mg/(cm^(2)·a)),increased from 1998(0.50 mg/(cm^(2)·a))to 2004(0.87 mg/(cm^(2)·a)),then decreased to 2015(0.38 mg/(cm^(2)·a)).Thus,increases in accumulation rates of TOC,TN,and TP from the 1980s to 1990s indicates that the marsh likely served as carbon and nutrient sinks,then the rates decreased during 2000-2015 due probably to the reduced sediment inputs from rivers and intensified sea level rise. | Pei Sun LOH Aimin JIN Zhanghua LOU Xuegang CHEN Shuangyan HE Chen-Tung Arthur CHEN Stephanie PARKER Jianxiong HU Hongwei YUAN Longxiu CHENG | 2023 | Journal of Oceanology and Limnology2023，41，6： | 0 |
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