|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 2 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 3 | Nanoscopy reveals surface-metallic black phosphorus显示文摘Black phosphorus(BP)is an emerging two-dimensional material with intriguing physical properties.It is highly anisotropic and highly tunable by means of both the number of monolayers and surface doping.Here,we experimentally investigate and theoretically interpret the near-field properties of a-few-atomic-monolayer nanoflakes of BP.We discover near-field patterns of bright outside fringes and a high surface polarizability of nanofilm BP consistent with its surface-metallic,plasmonic behavior at mid-infrared frequencies o1176 cm−1.We conclude that these fringes are caused by the formation of a highly polarizable layer at the BP surface.This layer has a thickness of~1 nm and exhibits plasmonic behavior.We estimate that it contains free carriers in a concentration of n≈1.1×10^(20) cm^(−3).Surface plasmonic behavior is observed for 10–40 nm BP thicknesses but absent for a 4-nm BP thickness.This discovery opens up a new field of research and potential applications in nanoelectronics,plasmonics and optoelectronics. | Yohannes Abate Sampath Gamage Zhen Li Viktoriia Babicheva Mohammad H Javani Han Wang Stephen B Cronin Mark I Stockman | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 4 | Synthesis of polysub- stituted indoles and indulines by means of zirconcenne- stabilized benzzyne complexes 显示文摘 | JEFFREY H T STEPHEN L B | 1994 | J Am Chem Soc1994，116，11： | 1 |
| 5 | Risk factors contributing to microbiological contamination of Shallow groundwater in Kampa- la, Uganda显示文摘 | Guy H Stephen P Mike B Mail N | 2003 | Water Research2003，8，37： | 1 |
| 6 | Distribution of DNase Ⅰ and p53 in rat testis and their correlation with apoptosis 显示文摘 | Stephen H Polzar B Rauch F | 1996 | Histochem Cell Biol1996，106，4： | 1 |
| 7 | Simple Accurate Expressions for Planar Spiral Inductances显示文摘 | Sunderarajan S M Maria M H Stephen P B | 1999 | IEEE Journal of Soild-state Circuits1999，34，10： | 1 |
| 8 | Kinetics and pH dependence of Cr^6+ reduction by Fe^3+ 显示文摘 | Ignaz J B Stephen J H 1997 | 1997 | Environ Sci Technol1997，31，5： | 1 |
| 9 | Molecular character- ization of a patient' s small cell carcinoma of the ovary of the hyper- calcemic type显示文摘 | Stephens B Stephen P A Han H Y | 2012 | J Cancer2012，3，： | 1 |
| 10 | Accounting for the value of ecosystem services显示文摘 | Richard B H Stephen F | 2002 | Ecological Economics2002，41，： | 1 |
| 11 | Modified Wilkinson power dividers for millimeter-wave integrated circuits显示文摘 | STEPHEN H RAMANAN B TENTZERIS M M | 2007 | IEEE Transactions on Microwave Theory and Techniques2007，55，11： | 1 |
| 12 | Incidence and importance of antibody responses to infliximab after maintenance or episodic treatment in Crohn’s disease显示文摘 | Stephen B Hanauer Carrie L Wagner Mohan Bala Lloyd Mayer Suzanne Travers Robert H Diamond Allan Olson Warren Bao Paul Rutgeerts | 2004 | Clinical Gastroenterology and Hepatology2004，，7： | 1 |
| 13 | Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy显示文摘Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible blindness.In vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory diseases.To recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor ubiquitination.We found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human PDR.Rapid progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding disorders.In addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders. | Katherine J Wert Vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk Stephen H Tsang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 14 | Functional diversity of arbuscular mycorrhizas extends to the expression of plant genes involved in P nutrition显示文摘 | STEPHEN H B TIM C IVER J | 2002 | Journal of Experimental Botany2002，53，374： | 1 |
| 15 | Distribution of deoxyribonuclease I(Dnase I)and p53 in rat testis and their correiation with apoptosis显示文摘 | Polzar B Rauch F | 1996 | Histochem Cell Biol1996，106，4： | 1 |
| 16 | A plant DNA minipreparation: version II 显示文摘 | Stephen L D Jonathan W James B H | 1983 | Plant Molecular Biology Reporter1983，1，4： | 1 |
| 17 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 18 | Cyclic and static laboratory tests on Drammen clay 显示文摘 | Andersen K H Jacobus H P Stephen F B and Wim F R | 1980 | Journal of Geotechnical engineering Division1980，106，5： | 1 |
| 19 | Microchip capillary electrophoresis with an integrated postcolumn reactor显示文摘 | STEPHEN C J LANCE B K ROLAND H | 1994 | Anal Chem1994，66，20： | 1 |
| 20 | New managerial challenges form supply chain opportunities 显示文摘 | Ronald H B Stephen M G Askok M | 2000 | IEEE Engineering Management Review2000，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员