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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 3 | Effects of inbreeding on survival and growth of Pacific white shrimp Penaeus (Litopenaeus) vannamei 显示文摘 | Dustin R Moss Steve M Arce Clete A Otoshi | 2007 | Aquaculture2007，2721，： | 1 |
| 4 | Mapping Paddy Rice Agriculture in South and Southeast Asia Using Multi-temporal MODIS Images 显示文摘 | Xiao X M Stephen B A Steve F A | 2006 | Remote Sensing of Environment2006，1，15： | 1 |
| 5 | Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice显示文摘 | Ronaldo A Ribeiro Mariana L Vale Sara M Thomazzi Adriana B.P Paschoalato Steve Poole Sergio H Ferreira Fernando Q Cunha | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 6 | Comparison of the prophylactic antiemetic ef-fect of ondansetron and droperidol on patients undergoing gynecologic laparoscopy显示文摘 | Sniadach M Steve A | 1997 | Anesth Analg1997，85，4： | 1 |
| 7 | Exploring laser-induced breakdown spectroscopy for nuclearmaterials analysis and in-situ applications 显示文摘 | Madhavi Z M Steve A Deanne J B | 2012 | Spectrochimica Acta Part B2012，74，12： | 1 |
| 8 | Comparison of the prophylactic antiemetic effect of ondansetron on patiens undergoing gynecologic laparoscopy显示文摘 | Sniadach M Steve A | 1997 | Anesth Analg1997，85，4： | 1 |
| 9 | An overview of the ON- IONS project: applying ontologies to integration of medical terminolo- gies显示文摘 | GANGEMI A PISANELLI D M STEVE G | 1999 | Data & Knowledge Engineering1999，31，2： | 1 |
| 10 | Association Between SpecificAdipose Tissue CD4+ T-Cell Populations and Insulin Resistance inObese Individuals显示文摘 | Fabbrini E Celia M Steve A | 2013 | Gastroenterology2013，145，2： | 1 |
| 11 | An Overview of the ON- IONS Project: Applying Ontologies to the Integration of Medical Terminologies显示文摘 | Gangemi A Pisanelli D M Steve G | 1999 | Data & Knowledge Engineering1999，31，2： | 1 |
| 12 | The interplay between climate change, forests, and disturbances显示文摘 | VIRGINIA H D LINDA A J STEVE M | 2000 | Science of the Total Environment2000，262，： | 1 |
| 13 | The neurally controlled animat:biological brauns acting with simulated bodues 显示文摘 | Daniel A Wagenaar Axel W Blau Steve M Potter | 2001 | Autonomous Robots2001，11，： | 1 |
| 14 | Brain aromatase in Japanese medaka (Oryzias latipes) : Molecular characterization and role in xenoestrogen-induced sex reversal 显示文摘 | kuhl a j steve m marius b | 2005 | Journal of Steroid Biochemistry and Molecular Biology2005，96，1： | 1 |
| 15 | Neurological complications of cerebral angiography:prospective analysis of 2899 procedures and review of the literatures显示文摘 | Robert A Steve M Karelter Brugge | 2003 | Radiology2003，227，： | 1 |
| 16 | Liraglutide: new GLP-I analogue for uncontrolled type 2 diabetes 显示文摘 | STEVE C M MRPHARMS AFTAB A B | 2010 | Prescriber2010，20，23： | 1 |
| 17 | Unstructured Multigridding by Volume Agglomeration:Current Status显示文摘 | Lallemand M Steve H Dervieux A | 1992 | Computerand Fluid1992，21，3： | 1 |
| 18 | Combined detrital-zircon fission track and U-Pb dating: A new approach to understanding hinter- land evolution显示文摘 | Carter A Steve J M | 1999 | Geology1999，27，3： | 1 |
| 19 | Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis显示文摘 | Steve Peigneur Annelies Van Der Haegen Carolina M?ller Etienne Waelkens Elia Diego-García Frank Marí Ryno Naudé Jan Tytgat | 2013 | Peptides2013，，： | 1 |
| 20 | Mechanical and durability properties of high volume fly ash(HVFA)concrete containing calcium carbonate(Ca CO3)nanoparticles显示文摘 | Faiz U A Shaikh Steve W M Supit | 2014 | Construction and Building Materials2014，70，： | 1 |
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