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| 1 | Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients显示文摘Background:Endoscopic ultrasound-guided ethanol ablation(EUS-EA)for pancreatic cystic lesions(PCLs)has been used in recent years as a feasible treatment modality for low malignant probability PCLs or patients considered high-risk for surgery.The present study aimed to confirm the safety of EUS-EA and to find predictive factors for adverse event(AE).Methods:A retrospective review was performed from the prospectively maintained database of patients who underwent EUS-EA for PCLs from June 2006 to April 2018 at Seoul National University Hospital.The primary outcomes of the study were the rates of AEs and severe AEs by EUS-EA.The secondary outcome was the predictive factors of AEs including acute pancreatitis and abdominal pain.Results:A total of 214 patients were evaluated and the diagnoses of PCLs according to cystic fluid analysis and clinical features were as follows:serous cystic neoplasm(32.2%),mucinous cystic neoplasm(26.6%),branch duct type intraductal papillary mucinous neoplasm(BD-IPMN)(29.4%),and pseudocyst(11.7%).Three patients(1.4%)experienced severe AEs.Overall,AEs occurred in 71(33.2%)patients.BD-IPMN(OR:2.87;95%CI:1.05–7.84;P=0.040),multilocular cysts(OR:3.59;95%CI:1.09–11.85;P=0.036),suspected ethanol leakage during procedure(OR:10.68;95%CI:1.98–57.53;P=0.006),and sticky cystic fluid(OR:3.83;95%CI:1.20–12.24;P=0.024)were predictive factors for post-procedural acute pancreatitis.PCLs of uncinate process(OR:2.99;95%CI:1.22–7.35;P=0.017)and PCLs with exophytic portion(OR:3.70;95%CI:1.96–7.01;P<0.001)were predictive factors for post-procedural abdominal pain.Conclusions:EUS-EA is a safe procedure with a very low rate of severe AEs.It seems possible to predict the AEs according to the features of the procedure and PCLs. | Jin Ho Choi Sang Hyub Lee Young Hoon Choi Min Su You Bang-Sup Shin Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 6 |
| 2 | Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27显示文摘Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(STAMP2)—and fat-specific protein 27(FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA. | Sung Won Lee Jee Hyun Rho Sang Yeob Lee Won Tae Chung Yoo Jin Oh Jung Ha Kim Seung Hee Yoo Woo Young Kwon Ju Yong Bae Su Young Seo Hokeun Sun Hye Young Kim Young Hyun Yoo | 2018 | Bone Research2018，6，3： | 3 |
| 3 | Evidence from a familial case suggests maternal inheritance of primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC) is an idiopathic autoimmune liver disease characterized by chronic cholestasis and destruction of the intrahepatic bile ducts. Similar to other autoimmune diseases, the pathogenesis of PBC is considered to be a complex etiologic phenomenon involving the interaction of genetic and environmental factors. Although a number of common variants associated with PBC have been reported from genome-wide association studies, a precise genetic mechanism underlying PBC has yet to be identified. Here, we describe a family with four sisters who were diagnosed with PBC. After the diagnosis of the index patient who was in an advanced stage of PBC, one sister presented with acute hepatitis, and two sisters were subsequently diagnosed with PBC. Notably, one half-sister with a different mother exhibited no evidence of PBC following clinical investigation. Our report suggests the possibility of a maternal inheritance of PBC susceptibility. Moreover, judging from the highpenetrance of the disease observed in this family, we inferred that a pathogenic genetic variant might be the cause of PBC development. We describe a family that exhibited diverse clinical presentations of PBC that included asymptomatic stages with mildly increased liver enzyme levels and symptomatic stages with acute hepatitis or advanced liver fibrosis. Additional studies are needed to investigate the role of genetic factors in the pathogenesis of this rare autoimmune disease. | Saeam Shin In Ho Moh Young Sik Woo Sung Won Jung Jin Bae Kim Ji Won Park Ki Tae Suk Hyoung Su Kim Mineui Hong Sang Hoon Park Myung Seok Lee | 2017 | World Journal of Gastroenterology2017，23，39： | 3 |
| 4 | Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study显示文摘We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolled. The superior cerebellar peduncle, the middle cerebellar peduncle, and the inferior cerebellar peduncle were evaluated using fractional anisotropy and the apparent diffusion coefficient. The patients' functional ambulation category was 0 at the initial visit, but improved to 2 at the follow-up evaluation, and Berg's balance scale score also improved from 0 to 7. Initial diffusion tensor tractography revealed that the inferior cerebellar peduncle was not detected, that the fractional anisotropy of the superior cerebellar peduncle and middle cerebellar peduncle decreased by two standard deviations below, and that the apparent diffusion coefficient increased by two standard deviations over normal control values. However, on follow-up diffusion tensor tractography, both inferior cerebellar peduncles could be detected, and the fractional anisotropy of superior cerebellar peduncle increased to within two standard deviations of normal controls. The functional improvement in this patient appeared to correspond to changes in these cerebellar peduncles. We believe that evaluating cerebellar peduncles using diffusion tensor imaging is useful in cases when a cerebellar peduncle lesion is suspected. | Ah Young Lee Sung Ho Jang Sang Seok Yeo Ensil Lee Yun Woo Cho Su Min Son | 2013 | Neural Regeneration Research2013，8，5： | 2 |
| 5 | Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial显示文摘BACKGROUND Increasing levels of antibiotic resistance have reduced the Helicobacter pylori(H.pylori)eradication rates afforded by the standard triple therapy.Thus,2-wk firstline four-drug regimens must be considered.AIM To analyze the eradication rates of modified bismuth-containing quadruple therapy(mBCQT)and concomitant therapy(CT),the associated adverse events,and compliance.METHODS Patients infected with H.pylori were prospectively randomized to receive mBCQT or CT for 2 wk.mBCQT featured a proton pump inhibitor(PPI),bismuth,metronidazole,and tetracycline,taken twice daily.CT included a PPI,clarithromycin,metronidazole,and amoxicillin,taken twice daily.The 13C-urea breath test was performed no earlier than 4 wk after therapy concluded to confirm eradication.If either the histological or rapid urease test was positive,H.pylori infection was diagnosed.RESULTS The demographic characteristics of 68 patients who received mBCQT and 68 who received CT did not differ significantly.On intention-to-treat analysis,the eradication rate was 88.2%(60/68)in the mBCQT group and 79.4%(54/68)in the CT group(P=0.162).By per-protocol analysis,the respective eradication rates were 98.4%(60/61)and 93.1%(54/58)(P=0.199).More CT than mBCQT patients experienced adverse events[33.8%(23/68)mBCQT vs 51.5%(35/58)CT patients,respectively,P=0.037].All patients showed good compliance[85.3%(58/68)mBCQT vs 82.4%(56/68)CT patients,P=0.641].CONCLUSION The H.pylori eradication rates of the 2-wk mBCQT and CT regimens are high.Most patients show good compliance,and more CT than mBCQT patients experience adverse events. | So Jeong Kim Jun-Won Chung Hyun Sun Woo Su Young Kim Jung Ho Kim Yoon Jae Kim Kyoung Oh Kim Kwang An Kwon Dong Kyun Park | 2019 | World Journal of Gastroenterology2019，25，46： | 2 |
| 6 | Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women显示文摘 | Young Joo Jeon Yi Seul Choi HyungChul Rah Su Yeoun Kim Dong Hee Choi Sun Hee Cha Ji Eun Shin Sung Han Shim Woo Sik Lee Nam Keun Kim | 2011 | Gene2011，，2： | 1 |
| 7 | A Functional Single Nucleotide Polymorphism in Mucin 1 , at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer显示文摘 | Norihisa Saeki Akira Saito Il Ju Choi Keitaro Matsuo Sumiko Ohnami Hirohiko Totsuka Suenori Chiku Aya Kuchiba Yeon–Su Lee Kyong–Ah Yoon Myeong–Cherl Kook Sook Ryun Park Young–Woo Kim Hideo Tanaka Kazuo Tajima Hiroshi Hirose Fumihiko Tanioka Yoshihiro Mats | 2011 | Gastroenterology2011，，3： | 1 |
| 8 | Inactivating mutations of caspase-8 gene in colorectal carcinomas显示文摘 | Hong Sug Kim Jong Woo Lee Young Hwa Soung Won Sang Park Su Young Kim Jong Heun Lee Jik Young Park Youg Gu Cho Chang Jae Kim Seong Whan Jeong Suk Woo Nam Sang Ho Kim Jung Young Lee Nam Jin Yoo Sug Hyung Lee | 2003 | Gastroenterology2003，，3： | 1 |
| 9 | Risk factors of developing new symptomatic vertebral compression fractures after percutaneous vertebroplasty in osteoporotic patients显示文摘 | Wan Soo Lee Kyeong Hoon Sung Hyun Tae Jeong Youn Sang Sung Yong In Hyun Jae Young Choi Kyu Seok Lee Chul Su Ok Young Woo Choi | 2006 | European Spine Journal2006，，12： | 1 |
| 10 | Effect of Mosapride Combined with Esomeprazole Improves Esophageal Peristaltic Function in Patients with Gastroesophageal Reflux Disease: A Study Using High Resolution Manometry显示文摘 | Yu Kyung Cho Myung-Gyu Choi Eun Young Park Chul Hyun Lim Jin Su Kim Jae Myung Park In Seok Lee Sang Woo Kim Kyu Yong Choi | 2013 | Digestive Diseases and Sciences2013，，4： | 1 |
| 11 | Construction of minimum size cellulase (Cel5Z) from Pectobacterium chrysanthemi PY35 by removal of the C-terminal region显示文摘 | WOO JIN LIM SU YOUNG HONG CHANG LONG AN | 2005 | Appl Microbiol Biotechnol2005，68，： | 1 |
| 12 | Long-term prognosis of an endoscopically treated rectal neuroendocrine tumor: 10-year experience in a single institution显示文摘 | Hye Young Sung Sang Woo Kim Won Kyung Kang Su Young Kim Chan-Kwon Jung Yu Kyung Cho Jae Myung Park In Seok Lee Myung-Gyu Choi In-Sik Chung | 2012 | European Journal of Gastroenterology & Hepatology2012，，8： | 1 |
| 13 | Factors predictive of risk for complications in patients with oesophageal foreign bodies显示文摘 | Sang Hun Sung Seong Woo Jeon Hyuk Su Son Sung Kook Kim Min Kyu Jung Chang Min Cho Won Young Tak Young Oh Kweon | 2011 | Digestive and Liver Disease2011，，8： | 1 |
| 14 | Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas显示文摘 | Young Hwa Soung Jong Woo Lee Su Young Kim Si Hyung Seo Won Sang Park Suk Woo Nam Sang Yong Song Joung Ho Han Cheol Keun Park Jung Young Lee Nam Jin Yoo Sug Hyung Lee | 2005 | Virchows Archiv2005，，： | 1 |
| 15 | Efficacy of Milrinone versus Nitroglycerin in Controlling Pulmonary Arterial Hypertension Induced by Intravenous Injections of Absolute Ethanol in Anesthetized Dogs显示文摘 | Jong Sung Kim Mi Hyun Nam Young Soo Do Chul Joong Lee Chung Su Kim Woo Seok Sim Kwang Bo Park Sang Hyun Lee Jin Soo Han Byung Seop Shin Hwi Yool Kim | 2010 | Journal of Vascular and Interventional Radiology2010，，6： | 1 |
| 16 | Stand structure and natural regeneration of degraded forestland in the northern mountainous region of Vietnam 显示文摘 | Su Young Woo Hung Trieu Thai Pil Sun Park | 2011 | Landscape and Ecological Engineering2011，7，2： | 1 |
| 17 | Factors predictive of risk for complications in patients with oesophageal foreign bodies显示文摘 | Sang Hun Sung Seong Woo Jeon Hyuk Su Son Sung Kook Kim Min Kyu Jung Chang Min Cho Won Young Tak Young Oh Kweon | 2011 | Digestive and Liver Disease2011，，8： | 1 |
| 18 | Therapeutic benefit of repetitive transcranial magnetic stimulation for severe mirror movements A case report显示文摘Congenital mirror movements retard typical hand functions,but no definite therapeutic modality is available to treat such movements.We report an 8-year-old boy with severe mirror movements of both hands.His mirror movements were assessed using the Woods and Teuber grading scale and his fine motor skills were also evaluated by the Purdue Pegboard Test.A 2-week regimen of repetitive transcranial magnetic stimulation produced markedly diminished mirror movement symptoms and increased the fine motor skills of both hands.Two weeks after the completion of the regimen,mirror movement grades had improved from grade 4 to 1 in both hands and the Purdue Pegboard Test results of the right and left hands also improved from 12 to 14 or 13.These improvements were maintained for 1 month after the 2-week repetitive transcranial magnetic stimulation regimen.After 18 months,the mirror movement grade was maintained and the Purdue Pegboard test score had improved to 15 for the right hand while the left hand score was maintained at 13.This occurred without any additional repetitive transcranial magnetic stimulation or other treatment.These findings suggest that repetitive transcranial magnetic stimulation for this patient had a therapeutic and long-term effect on mirror movements. | Han Sun Kim Sung Ho Jang Zee-Ihn Lee Mi Young Lee Yun Woo Cho Migyoung Kweon Su Min Son | 2013 | Neural Regeneration Research2013，8，6： | 1 |
| 19 | Diagnostic Usefulness of Real-Time Elastography for Liver Fibrosis in Chronic Viral Hepatitis B and C显示文摘 | Young Woon Kim Jung Hyun Kwon Jeong Won Jang Min Ju Kim Byong Sun Oh Kyu Won Chung Eun Su Park Soon Woo Nam Alfred Gangl | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 20 | Effect of Mosapride Combined with Esomeprazole Improves Esophageal Peristaltic Function in Patients with Gastroesophageal Reflux Disease: A Study Using High Resolution Manometry显示文摘 | Yu Kyung Cho Myung-Gyu Choi Eun Young Park Chul Hyun Lim Jin Su Kim Jae Myung Park In Seok Lee Sang Woo Kim Kyu Yong Choi | 2013 | Digestive Diseases and Sciences2013，，4： | 1 |
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