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| 1 | Performance-based seismic design of nonstructural building components:The next frontier of earthquake engineering显示文摘With the development and implementation of performance-based earthquake engineering,harmonization of performance levels between structural and nonstructural components becomes vital. Even if the structural components of a building achieve a continuous or immediate occupancy performance level after a seismic event,failure of architectural,mechanical or electrical components can lower the performance level of the entire building system. This reduction in performance caused by the vulnerability of nonstructural components has been observed during recent earthquakes worldwide. Moreover,nonstructural damage has limited the functionality of critical facilities,such as hospitals,following major seismic events. The investment in nonstructural components and building contents is far greater than that of structural components and framing. Therefore,it is not surprising that in many past earthquakes,losses from damage to nonstructural components have exceeded losses from structural damage. Furthermore,the failure of nonstructural components can become a safety hazard or can hamper the safe movement of occupants evacuating buildings,or of rescue workers entering buildings. In comparison to structural components and systems,there is relatively limited information on the seismic design of nonstructural components. Basic research work in this area has been sparse,and the available codes and guidelines are usually,for the most part,based on past experiences,engineering judgment and intuition,rather than on objective experimental and analytical results. Often,design engineers are forced to start almost from square one after each earthquake event: to observe what went wrong and to try to prevent repetitions. This is a consequence of the empirical nature of current seismic regulations and guidelines for nonstructural components. This review paper summarizes current knowledge on the seismic design and analysis of nonstructural building components,identifying major knowledge gaps that will need to be filled by future research. Furthermore,considering recent trends in earthquake engineering,the paper explores how performance-based seismic design might be conceived for nonstructural components,drawing on recent developments made in the field of seismic design and hinting at the specific considerations required for nonstructural components. | Andre Filiatrault Timothy Sullivan | 2014 | Earthquake Engineering and Engineering Vibration2014，13，S1： | 16 |
| 2 | Development and optimization of thermal contrast amplification lateral flow immunoassays for ultrasensitive HIV p24 protein detection显示文摘Detection of human immunodeficiency virus(HIV)p24 protein at a single pg/ml concentration in point-of-care(POC)settings is important because it can facilitate acute HIV infection diagnosis with a detection sensitivity approaching that of laboratory-based assays.However,the limit of detection(LOD)of lateral flow immunoassays(LFAs),the most prominent POC diagnostic platform,falls short of that of laboratory protein detection methods such as enzyme-linked immunosorbent assay(ELISA).Here,we report the development and optimization of a thermal contrast amplification(TCA)LFA that will allow ultrasensitive detection of 8 pg/ml p24 protein spiked into human serum at POC,approaching the LOD of a laboratory test.To achieve this aim,we pursued several innovations as follows:(a)defining a new quantitative figure of merit for LFA design based on the specific to nonspecific binding ratio(BR);(b)using different sizes and shapes of gold nanoparticles(GNPs)in the systematic optimization of TCA LFA designs;and(c)exploring new laser wavelengths and power regimes for TCA LFA designs.First,we optimized the blocking buffer for the membrane and running buffer by quantitatively measuring the BR using a TCA reader.The TCA reader interprets the thermal signal(i.e.,temperature)of GNPs within the membrane when irradiated by a laser at the plasmon resonance wavelength of the particle.This process results in higher detection and quantitation of GNPs than in traditional visual detection(i.e.,color intensity).Further,we investigated the effect of laser power(30,100,200 mW),GNP size and shape(30 and 100 nm gold spheres,150 nm gold-silica shells),and laser wavelength(532,800 nm).Applying these innovations to a new TCA LFA design,we demonstrated that 100nm spheres with a 100 mW 532 nm laser provided the best performance(i.e.,LOD=8pg/ml).This LOD is significantly better than that of the current colorimetric LFA and is in the range of the laboratory-based p24 ELISA.In summary,this TCA LFA for p24 protein shows promise for detecting acute HIV infection in POC settings. | Li Zhan Timothy Granade Yilin Liu Xierong Wei Ae Youngpairoj Vickie Sullivan Jeff Johnson John Bischof | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 3 | Factors that affect uniformity of plating of through-holes in printed circuit boards Ⅰ stagnant fluid in the through-holes显示文摘 | Sullivan Timothy Middleman Stanley | 1985 | J Electrochem Soc1985，132，5： | 1 |
| 4 | Continuing bone expansion and increasing bone loss over a two-decade period in men and women from a total community sample显示文摘 | Sullivan Timothy V Decker sauy | 1992 | American Journal of Human Biology1992，，4： | 1 |
| 5 | Bone Marrow‐Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction Following Intracoronary Delivery: Amelioration by Antithrombin Therapy显示文摘 | Birgitta M. Gleeson Kenneth Martin Mohammed T. Ali Arun H. S. Kumar M. Gopala‐Krishnan Pillai Sujith P. G. Kumar John F. O’Sullivan Derek Whelan Alessia Stocca Wisam Khider Frank P. Barry Timothy O’Brien Noel M. Caplice | 2015 | Stem Cells2015，，9： | 1 |
| 6 | Orbital Metastasis: Clinical Features, Management and Outcome显示文摘 | Alejandra A. Valenzuela Curtis W. Archibald Ben Fleming Lorraine Ong Brett O’Donnell John Crompton J Dinesh Selva Alan A. McNab Timothy J. Sullivan | 2009 | Orbit (-)2009，，2： | 1 |
| 7 | Continuing bone expansion and increasing bone loss over a two-decade period in men and women from a total community sample 显示文摘 | Garn Stanley M Sullivan Timothy V Decker Sally etal | 1992 | American Journal of Human Biology1992，，4： | 1 |
| 8 | Dose-dependent treatment of optic nerve crush by exogenous systemic mutant erythropoietin显示文摘 | Timothy A. Sullivan Eldon E. Geisert Justin P. Templeton Tonia S. Rex | 2012 | Experimental Eye Research2012，，1： | 1 |
| 9 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 10 | Monoclonal antibody to native P39 Protein from Borrelia burgdorferi 显示文摘 | Timothy J Sullivan Karim E Hechemy Hervie L Harris | 1994 | J Clin Microbiol1994，32，2： | 1 |
| 11 | Systemic adeno-associated virus- mediated gene therapy preserves retinal ganglion cells and visual function in DBA/2J glaucomatous mice 显示文摘 | Timothy A Sullivan Eldon E | 2011 | Hum Gene Ther2011，22，10： | 1 |
| 12 | A new and highly specific colorimetric test for methionine显示文摘 | Timothy E Mccarthy M X Sullivan | 1941 | Biol Chem1941，141，： | 1 |
| 13 | Capacity design considerations for RC frame-wall structures 显示文摘 | SULLIVAN TIMOTHY J | 2010 | Earthquake and Structures2010，1，4： | 1 |
| 14 | Bioinspired synthetic macroalgae: Examples from nature for antifouling applications显示文摘 | CHAPMANA J HELLIOC C Timothy Sullivan | 2014 | International Biodeterioration & Biodegradation2014，86，： | 1 |
| 15 | Splenic artery aneurysms: Methods of laparoscopic repair显示文摘 | Marjorie J. Arca Michel Gagner B.Todd Heniford Timothy M. Sullivan Edward G. Beven | 1999 | Journal of Vascular Surgery1999，，1： | 1 |
| 16 | Proximal Type I Endoleak After Endovascular Abdominal Aortic Aneurysm Repair: Predictive Factors显示文摘 | Sergio M. Sampaio Jean M. Panneton Geza I. Mozes James C. Andrews Thomas C. Bower Manju Karla Audra A. Noel Kenneth J. Cherry Timothy Sullivan Peter Gloviczki | 2004 | Annals of Vascular Surgery2004，，6： | 1 |
| 17 | A new and MgMy specific colorimetric test for methionine显示文摘 | Timothy E Mccarthy M X Sullivan | 2004 | Bio-Chem2004，141，： | 1 |
| 18 | Capacity Design of Coupled RC Walls显示文摘 | Matthew J. Fox Timothy J. Sullivan Katrin Beyer | 2014 | Journal of Earthquake Engineering2014，，5： | 1 |
| 19 | Combined External-Endonasal Approach for Complete Excision of the Lacrimal Drainage Apparatus显示文摘 | Timothy J Sullivan | | 0，，： | 1 |
| 20 | Re - examination of the role of landscape change in the acidification of lakes in the Adirondack Mountains 显示文摘 | Timothy J Sullivan Barbara McMartin Donald F Charles | 1996 | The Science of the Total Environment1996，183，： | 1 |
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