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| 1 | Recent developments in regenerative ophthalmology显示文摘Regenerative medicine(RM)is one of the most promising disciplines for advancements in modern medicine,and regenerative ophthalmology(RO)is one of the most active fields of regenerative medicine.This review aims to provide an overview of regenerative ophthalmology,including the range of tools and materials being used,and to describe its application in ophthalmologic subspecialties,with the exception of surgical implantation of artificial tissues or organs(e.g.,contact lens,artificial cornea,intraocular lens,artificial retina,and bionic eyes)due to space limitations.In addition,current challenges and limitations of regenerative ophthalmology are discussed and future directions are highlighted. | Ye Shen He Shen Dongyu Guo Xinghuai Sun Yuan Sun Nan Hong Xiawei Wang Chen Xie Yuan Zhao Qin He Le Jin Yingying Wen Bo Jiang Chenying Yu Miaomiao Zhu Feng Cai Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，10： | 2 |
| 2 | Linear Track Estimation Using Double Pulse Sources for Near-Field Underwater Moving Target显示文摘双脉搏来源(DPS ) 方法在这个工作为线性轨道评价被介绍。在在水下的移动的噪音鉴定的领域里指向, Doppler 将弄歪散发的噪音的频率和振幅。消除这,轨道评价是必要的。在 DPS 方法,我们首先估计通过放方法的基线在动人的目标安装的二正弦曲线脉搏来源的轴承。同时,每脉搏的射出并且记录的时间也被获得。然后,线性磁道参数将在两倍来源间距的帮助下基于几何学模式被完成。模仿的结果证实 DPS 改进以前的双来源间距方法的表演。模仿的实验用一辆动人的电池汽车被执行进一步评估它的表演。当目标离开是 4060m 时,实验结果证明那轨道方位角并且垂直偏导 DPS 的距离分别地在 0.6o 和 3.4m 下面。并且估计的速度的平均偏差在 0.25m/s 附近。 | Zhifei ChenI Hong Hou Jianhua Yang Jincai Sun Qian Wang | 2013 | Journal of Marine Science and Application2013，12，2： | 2 |
| 3 | Controlled dependent upconversion J,Yu Y, Kong X G,Zhao synthesis and morphology luminescence of NaYF4: Yb, Er nanocrystals 显示文摘 | Sun Y J ChenY Tian L JW Zhang H | 2007 | Nanotechnology2007，18，： | 1 |
| 4 | The heterolo-gous expression in Arabidopsis of a chrysanthemum Cys2/His2 zincfinger protein gene confers salinity and drought tolerance显示文摘 | GAO H S SONG A P ZHU X R CHEN F D JIANG J F CHENY SUN Y SHAN H7 GU CS LI P L CHEN S M | 2012 | Planta2012，235，： | 1 |
| 5 | The Construction of an Intrauterine Diagnosis and Treatment System and Comprehensive Lifecycle Health Service of Congenital Heart Disease:Xinhua Hospital Model显示文摘With the growing influence of slow population growth and population aging,China has established the birth policy and issued a series of documents to promote maternal and fetal health and improve the birth rate.With the increase in prevalence of birth defects,timely diagnosis and intervention in utero provide possibilities to reduce unnecessary abortions and offer better prognosis.Congenital heart disease(CHD),as one of the most common congenital birth defects,is the leading cause of mortality in patients aged<5 years,and brings a heavy burden to both the affected families and society.Fetuses with CHD are associated with an increased risk of pregnancy-related complications and premature birth,and children with CHD typically face growth and developmental problems even after the correction of malformation.Therefore,management including diagnosis,treatment,and rehabilitation throughout the fetal period into childhood and even adulthood is essential for children with CHD.Based on the rapid advances in intrauterine and perinatal medicine and an in-depth collaboration among obstetrics and pediatrics,a novel diagnosis and treatment system has been established for the management of CHD in the past 2 decades in Shanghai Xinhua Hospital.This Intrauterine Diagnosis and Treatment System and Comprehensive Lifecycle Health Service of Congenital Heart Disease model provides prenatal diagnosis,intrauterine intervention,delivery room service and neonatal therapies,and postintrauterine rehabilitation for children with CHD.We have developed a four-dimensional spatiotemporal image correlation echocardiography and a three-dimensional cardiac virtual endoscopy system for the intrauterine diagnosis of CHD,dramatically raising the diagnostic utility.Our innovative and independent newborn-intervention technique has effectively reduced the re-intervention rate in patients with pulmonary atresia with intact ventricular septum and critical pulmonary stenosis.In 2018,Xinhua Hospital independently performed the case of fetal aortic valvuloplasty in Asia through a multidepartment collaborative effort.All children treated in this system achieved biventricular circulation and a better long-term postoperative outcome.We also have conducted postoperative rehabilitation therapy to promote the development and health of children with CHD.The practice of Xinhua model has reduced unnecessary abortion of CHD fetuses,reduced the mortality rate associated with critical CHD,and improved the mid-and long-term prognosis in CHD,which is essential to promote the fertility level and children’s health.Furthermore,translational medicine platform and the birth cohort Early Life Plan was constructed to explore the origins of major developmental diseases and establish an early intervention model in CHD.This practice of assessment of the intrauterine system has been expanded to other congenital defects in Xinhua Hospital,and sequential treatment of more than 2,000 cases has been completed to date.Based on practice in intrauterine management of CHD and other diseases,the concept of Intrauterine Pediatrics was proposed as a first to emphasize early prevention and intervention of childhood diseases and promote a comprehensive lifecycle service for children.The development and evolution of this system requires further attention not only from researchers but also from the government and global medical communities. | Shiwei Jiang Jiajun Ye Hualin Wang Jian Wang Sun Cheni Yongjun Zhang Qing Du Ling Yang Lei Wang Kun Sun | 2023 | Cardiology Discovery2023，3，3： | 0 |
| 6 | Tomato LysM receptor kinase 4 mediates chitin-elicited fungal resistance in both leaves and fruit显示文摘Fungal infection is a major cause of crop and fruit losses.Recognition of chitin,a component of fungal cell walls,endows plants with enhanced fungal resistance.Here,we found that mutation of tomato LysM receptor kinase 4(SlLYK4)and chitin elicitor receptor kinase 1(SlCERK1)impaired chitin-induced immune responses in tomato leaves.Compared with the wild type,sllyk4 and slcerk1 mutant leaves were more susceptible to Botrytis cinerea(gray mold).SlLYK4 extracellular domain showed strong binding affinity to chitin,and the binding of SlLYK4 induced SlLYK4-SlCERK1 association.Remarkably,qRT–PCR analysis indicated that SlLYK4 was highly expressed in tomato fruit,andβ-GLUCURONIDASE(GUS)expression driven by the SlLYK4 promoter was observed in tomato fruit.Furthermore,SlLYK4 overexpression enhanced disease resistance not only in leaves but also in fruit.Our study suggests that chitin-mediated immunity plays a role in fruit,providing a possible way to reduce fungal infection-related fruit losses by enhancing the chitin-induced immune responses. | Yingfei Ai Qinghong Li Chenying Li Ran Wang Xun Sun Songyu Chen Xin-Zhong Cai Xingjiang Qi Yan Liang | 2023 | Horticulture Research2023，10，6： | 0 |
| 7 | A Spectrophotometric Study on the Host-Guest Complexation of β-Cyclodextrin with 3-Indolyl Acetate in Dilute Aqueous Solution by Determining Solubility of Guest Substance显示文摘3-Indolyl acetate can be soluhilized in dilute aqueous solution of beta cy clodextrin. dueto the formation of host-guest complex through hydrophobic interaction between the indolyl groupand the inside cave of the cyclodextrin molecule. The thermodynamic pararneters of thecomplexing process can be estimated utilizing the spectrophotometric data. | De Zhi SUN Jian CHENI Wei Min LU and Xiao Ming ZHENG(Institute of Catalysis. Xixi Xiaoqu. Zhejiang University. Hangzho 310028Department of Chemistry, Liaocheng Teachers College. Liaocheng, 252000 Shandong.Department of Chemistry, Zhejiang Normal Univers | 1999 | Chinese Chemical Letters1999，10，5： | 0 |
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