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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 3 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 4 | Centrosome amplification drives chromosomal instability in breast tumor development显示文摘 | Wilma L L Susan L B Vivian C N | 2002 | Proc Natl Acad Sci U S A2002，99，4： | 1 |
| 5 | Vanadium induced inhibition of renal Na+,K+-ATPase in the chicken after chronic dietary exposure显示文摘 | Phillips T D Bohdan R N Susan L N | 1982 | J Toxical Environ Healthy1982，，9： | 1 |
| 6 | The effects of wording on the understanding and use of uncertainty information in a threshold forecasting decision显示文摘 | Susan L J Greenberg L N Meng U T | | 0，，8： | 1 |
| 7 | The impact of continuous subcutaneous insulin infusion and multiple daily injections of insulin on glucose variability in older adults with type 2 dia- betes显示文摘 | Susan L Johnson Laura N | 2011 | Journal of Diabetes and its Complications2011，25，4： | 1 |
| 8 | Total Hip Arthroplasty with a Collarless,Tapered,Fiber Metal Proximally Coated Femoral Stem显示文摘 | Gregg R K Harlan B L Susan C N | 2009 | J Arthroplasty2009，24，4： | 1 |
| 9 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 10 | Lighttransmission profiles in an old-growth forest canopy:Simulations of photosynthetically active radiation by using satially exlicit radiative transfer models显示文摘 | Maria J M Scott N M Susan L U | 2004 | Ecosystems2004，，7： | 1 |
| 11 | The role of testosterone therapy in poatmenopausal women:position statement of The North American Menopause Society显示文摘 | JAN L SHIFRE N SUSAN R | 2005 | Menopause2005，12，5： | 1 |
| 12 | Dynamic response of a cantilever in liquid near a solid wall 显示文摘 | TIKESWAR N ELLEN K L SUSAN C M | 2003 | Sensors and Actuators: A2003，102，3： | 1 |
| 13 | Dynamic response of a cantilever in liquid near a solid wall显示文摘 | TIKESWAR N ELLEN K L SUSAN C M | 2003 | Sensors and Actuators:A2003，102，3： | 1 |
| 14 | HIV-1infection of human macrophages directly induces Viperin which inhibits viral production显示文摘 | Najla Nasr Susan Maddocks Stuart G Turville Andrew N Harman Natalie Woolger Karla J Helbig John Wilkinson Chris R Bye Thomas K Wright Dharshini Rambukwelle Heather Donaghy Michael R Beard Anthony L Cunningham | 2012 | Blood2012，120，4： | 1 |
| 15 | 护理行业如何应对数字化未来显示文摘护理行业必须投资并引领数字健康的发展,努力与各方合作研究输出患者和公众需要的数字化工具。数字技术对全球护理行业的影响不断增加:人工智能(AI)和机器人系统的影响力与日俱增;社会对手机、网络、社交媒体高度依赖,尤其是新型冠状病毒肺炎疫情暴发后,社会越来越依赖于远程医疗及其他通过虚拟手段进行的医疗服务。 | Richard G Booth Gillian Strudwick Susan McBride Siobhán O′Connor Ana Laura Solano López 李高华(译) | 2022 | 中国医院院长2022，18，23： | 1 |
| 16 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 17 | Characteristics of adult celiac disease in the USA: results of a national survey显示文摘 | Peter H.R Green Stavros N Stavropoulos Sofia G Panagi Susan L Goldstein Donald J McMahon Habibul Absan Alfred I Neugut | 2001 | The American Journal of Gastroenterology2001，，： | 1 |
| 18 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 19 | Relationships among lifting Ability, Grip Force, and Return toWork显示文摘 | Leonard N Matheson Susan J Isernhagen Dennis L Hart | 2002 | Physical Therapy2002，82，3： | 1 |
| 20 | High and dry: variation in net photosynthesis of the intertidal seaweed Fueus gardenri显示文摘 | Susan L W N D Megan | 2005 | Ecology2005，86，9： | 1 |
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