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| 1 | Tourette syndrome associated with attention deficit hyperactivity disorder: The impact of tics and psychopharmacological treatment options显示文摘Tourette syndrome(TS) is a neurodevelopmental disorder characterized by multiple chronic motor and vocal tics beginning in childhood. Several studies describe the association between TS and attention deficit hyperactivity disorder(ADHD). Fifty percent of children diagnosed with ADHD have comorbid tic disorder. ADHD related symptoms have been reported in 35% to 90% of children with TS. Since ADHD is the most prevalent comorbid condition with TS and those with concomitant TS and ADHD present with considerable psychosocial and behavioral impairments, it is essential for clinicians to be familiar with these diagnoses and their management. This paper highlights the association between treating ADHD with stimulants and the development of tic disorders. The two cases discussed underscore the fact that children with TS may present with ADHD symptomatology prior to the appearance of any TS related symptoms. Appropriate management of TS in a patient diagnosed with ADHD can lead to quality of life improvements and a reduction in psychosocial impairments. | Olumide O Oluwabusi Susan Parke Paul J Ambrosini | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 27 |
| 2 | 急性运动对ADHD患儿和普通儿童认知表现的影响(英文)显示文摘背景:注意力缺失过动症(attention deficit hyperactivity disorder,ADHD)是一种普通的儿童疾病,影响到大约11%的美国儿童。已有研究支持一段时间的运动有益于儿童的认知表现,数量有限的研究已证明这种影响对ADHD患儿也有效。本研究旨在探讨急性运动对ADHD患儿和普通儿童认知表现的影响。方法:让ADHD患儿和普通儿童接受为期2天、顺序平衡随机的治疗,其中一天为30 min对照状态,另一天为中等强度运动。治疗后对受试者进行认知测试。结果:运动使受试者在斯特鲁测试(Stroop Test)3种情况下的表现均有显著提高,但对伦敦塔测试(Tower of London Test)和连线测试(Trail Making Test)表现影响不大。结论:一段时间的运动能改善ADHD患儿和正常儿童的处理速度和抑制控制,但对其计划和定势转换能力没有影响。 | Aaron T.Piepmeier Chia-Hao Shih Margaret Whedon Lauren M.Williams Matthew E.Davis David A.Henning Se Yun Park Susan D.Calkins Jennifer L.Etnier | 2015 | Journal of Sport and Health Science2015，4，1： | 3 |
| 3 | Characterization of Fusobacterium nucleatum ATCC 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis显示文摘Bacterial adherence is an essential virulence factor in pathogenesis and infection. Fusobacterium nucleatum has a central role in oral bio?lm architecture by acting as a bridge between early Gram-positive and late Gram-negative colonizers that do not otherwise adhere to each other. In this study, we survey a key adherence interaction of F. nucleatum with Porphyromonas gingivalis, and present evidence that multiple fusobacterial adhesins have a role in the attachment of F. nucleatum ATCC 23726 to P. gingivalis in a highly strain-dependent manner. Interaction between these species displayed varying sensitivities to arginine,galactose and lactose. Arginine was found to hamper coaggregation by at least 62% and up to 89% with several P. gingivalis strains and galactose inhibition ranged from no inhibition up to 58% with the same P. gingivalis strains. Lactose consistently inhibited F. nucleatum interaction with these P. gingivalis strains ranging from 40% to 56% decrease in coaggregation. Among the adhesins involved are the previously described Fap2 and surprisingly, Rad D, which was described in an earlier study for its function in attachment of F. nucleatum to Gram-positive species. We also provide evidence for the presence of at least one additional adhesin that is sensitive to arginine but unlike Fap2 and Rad D, is not a member of the autotransporter family type of fusobacterial large outer membrane proteins. The strain-speci?c binding pro?le of multiple fusobacterial adhesins to P. gingivalis highlights the heterogeneity and complexity of interspecies interactions in the oral cavity. | Jane Park Bhumika Shokeen Susan K Haake Renate Lux | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 4 | Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer显示文摘 | David J. Park Jan Stoehlmacher Wu Zhang Denice Tsao-Wei Susan Groshen Heinz-Josef Lenz | 2001 | International Journal of Colorectal Disease2001，，1： | 1 |
| 5 | Cross-protection and selectable marker genes in plant transformation显示文摘 | Sung H. Park Susan C. Rose Cecilia Zapata Metinee Srivatanakul Roberta H. Smith | 1998 | In Vitro Cellular & Developmental Biology - Plant1998，，2： | 1 |
| 6 | The Sequential Action of miR156 and miR172 Regulates Developmental Timing in Arabidopsis显示文摘 | Gang Wu Mee Yeon Park Susan R. Conway Jia-Wei Wang Detlef Weigel R. Scott Poethig | 2009 | Cell2009，，4： | 1 |
| 7 | Sporadic Fundic Gland Polyps with Epithelial Dysplasia显示文摘 | Susan C. Abraham Seun Ja Park Lilian Mugartegui Stanley R. Hamilton Tsung-Teh Wu | 2002 | The American Journal of Pathology2002，，5： | 1 |
| 8 | Analysis of transcriptome data in the red flour beetle, Tribolium castaneum显示文摘 | Yoonseong Park Jamie Aikins L.J. Wang Richard W. Beeman Brenda Oppert Jeffrey C. Lord Susan J. Brown Marcé D. Lorenzen Stephen Richards George M. Weinstock Richard A. Gibbs | 2007 | Insect Biochemistry and Molecular Biology2007，，4： | 1 |
| 9 | Is tumor cell specificity distinct from tumor selectivity in vivo?A quantitative NIR molecular imaging analysis of nanoliposome targeting显示文摘The significance and ability for receptor targeted nanoliposomes(tNLs)to bind to their molecular targets in solid tumors in vivo has been questioned,particularly as the efficiency of their tumor accumulation and selectivity is not always predictive of their efficacy or molecular specificity.This study presents,for the first time,in situ near-infrared(NIR)molecular imaging-based quantitation of the in vivo specificity of tNLs for their target receptors,as opposed to tumor selectivity,which includes influences of enhanced tumor permeability and retention.Results show that neither tumor delivery nor selectivity(tumor-to-normal ratio)of cetuximab and IRDye conjugated tNLs correlate with epidermal growth factor receptor(EGFR)expression in U251,U87,and 9L tumors,and in fact underrepresent their imaging-derived molecular specificity by up to 94.2%.Conversely,their in vivo specificity,which we quantify as the concentration of tNL-reported tumor EGFR provided by NIR molecular imaging,correlates positively with EGFR expression levels in vitro and ex vivo(Pearson’s r=0.92 and 0.96,respectively).This study provides a unique opportunity to address the problematic disconnect between tNL synthesis and in vivo specificity.The findings encourage their continued adoption as platforms for precision medicine,and facilitates intelligent synthesis and patient customization in order to improve safety profiles and therapeutic outcomes. | Girgis Obaid Kimberley Samkoe Kenneth Tichauer Shazia Bano Yeonjae Park Zachary Silber Sassan Hodge Susan Callaghan Mina Guirguis Srivalleesha Mallidi Brian Pogue Tayyaba Hasan | 2021 | Nano Research2021，14，5： | 1 |
| 10 | The Effects of Audit Committee Activity and Independence on Corporate Fraud显示文摘 | Abbott L.J Young Park Susan Parker | | 0，，11： | 1 |
| 11 | Analysis of GP73 in patients with HCC as a function of anti-cancer treatment显示文摘 | Hie-Won Hann Mengjun Wang Julie Hafner Ronald E. Long Su Hee Kim Meejin Ahn Susan Park Mary Ann Comunale Timothy M. Block Anand Mehta | 2010 | Cancer Biomarkers2010，，6： | 1 |
| 12 | The effects of audit committee activity and independence on corporate fraud显示文摘 | Abbott Lawrence J Young Park Susan Parker | 2002 | Managerial Finance2002，26，11： | 1 |
| 13 | Kinetic evaluation of 313-hydroxycholest-5-en-7-one ( 7-ketocholesterol ) stability during saponification 显示文摘 | Peter W park Francesc Guardiola Susan H Park | 1996 | Journal of the American Oil Chemists'' Society1996，73，5： | 1 |
| 14 | Cancers associated with BRCA 1 and BRCA 2 mutations other than breast and ovarian显示文摘 | Jacqueline Mersch Michelle A. Jackson Minjeong Park Denise Nebgen Susan K. Peterson Claire Singletary Banu K. Arun Jennifer K. Litton | 2015 | Cancer2015，，2： | 1 |
| 15 | The Sequential Action of miR156 and miR172 Regulates Developmental Timing in Arabidopsis显示文摘 | Gang Wu Mee Yeon Park Susan R. Conway Jia-Wei Wang Detlef Weigel R. Scott Poethig | 2009 | Cell2009，，4： | 1 |
| 16 | 血管紧张素Ⅱ受体阻滞剂与胃肠道不良反应(口炎性腹泻样肠病):系统综述显示文摘背景:奥美沙坦,一种血管紧张素Ⅱ受体阻滞剂(ARB),会引起口炎性腹泻样肠病这一胃肠道不良反应。有学者提出,该肠病可能是ARB这一类药物的普遍效应,而不是奥美沙坦特异性不良反应。我们对各种ARB药物所引起的口炎性腹泻样肠病的相关文献进行了系统综述。方法:截至2018年11月21日,于PubMed和Embase数据库中检索因服用ARB引起的口炎性腹泻样肠病的病例报告、病例系列和对照研究,并对这些研究进行评估。结果:筛选出82篇病例报告或病例系列文献,以及5篇对照研究文献纳入分析,共包含248例病例。这些病例应用的ARB包括:奥美沙坦(233例;94.0%),替米沙坦(5例;2.0%),厄贝沙坦(4例;1.6%),缬沙坦(3例;1.2%),氯沙坦(2例;0.8%)和依普沙坦(1例;0.4%)。开始服用ARB至症状出现的间隔时间为2周至13年。218例病例报告了组织学结果,其中绒毛萎缩201例(92.2%),上皮内淋巴细胞增多131例(60.1%)。147例患者进行过人白细胞抗原(HLA)测试,其中105例(71.4%)为HLA-DQ2或HLA-DQ8单倍型。169例患者进行了乳糜泻相关抗体检测,其中167例(98.8%)结果呈阴性。130例接受无麸质饮食的患者中,127例(97.7%)肠病症状未获缓解。239例病例报道停用ARB的情况,其中233例(97.4%)停药后症状完全缓解。7例(2.8%)患者再次使用奥美沙坦后,出现症状复发;而其他ARB药物则未出现再次使用后的症状复发。值得注意的是,全球各地所进行的回顾性研究,其研究设计(如研究时间和对病例的定义都有差异)和研究结果不尽相同。结论:尽管口炎性腹泻样肠病临床罕见,但临床医生应该对奥美沙坦可能引起的这种不良事件保持警惕,哪怕是在用药后多年。 | Ayesha Kamal Christopher Fain Angela Park Peiqi Wang Eduardo Gonzalez-Velez Daniel A.Leffler Susan M.Hutfless | 2019 | Gastroenterology Report2019，7，3： | 0 |
| 17 | Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival显示文摘BACKGROUND Pancreatic cancer is a leading cause of cancer-related deaths.Increased activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug administration.Nevertheless,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic outcomes.We previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell death.Erlotinib has not been tested for this effect.AIM To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell death.METHODSΔψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell lines.The viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(MitoQ),aΔψm-sensitive MitoQ.The synergy between erlotinib and MitoQ was then analyzed using SynergyFinder 2.0.The preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line xenografts.RESULTS Erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive agents.MitoQ triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of MitoQ.SynergyFinder suggested that these drugs synergistically induced tumor cell lethality.Consistent with in vitro data,erlotinib and MitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each agent.CONCLUSION Our findings suggest that a combination of erlotinib and MitoQ has the potential to suppress pancreatic tumor cell viability effectively. | Pui-Yin Leung Wenjing Chen Anissa N Sari Poojitha Sitaram Pui-Kei Wu Susan Tsai Jong-In Park | 2024 | World Journal of Gastroenterology2024，30，7： | 0 |
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