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| 1 | Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia显示文摘AIM:To identify the distribution of hepatitis B virus (HBV) subgenotype and basal core promoter (BCP) mutations among patients with HBV-associated liver disease in Indonesia.METHODS: Patients with chronic hepatitis (CH, n=61), liver cirrhosis (LC, n=62), and hepatocellular carcinoma (HCC,n=48) were included in this study. HBV subgenotype was identified based on S or preS gene sequence, and mutations in the HBx gene including the overlapping BCP region were examined by direct sequencing.RESULTS: HBV genotype B (subgenotypes B2, B3, B4, B5 and B7) the major genotype in the samples, accounted for 75.4%, 71.0% and 75.0% of CH, LC and HCC patients, respectively, while the genotype C (subgenotypes C1, C2 and C3) was detected in 24.6%, 29.0%, and 25.0% of CH, LC, and HCC patients, respectively. Subgenotypes B3 (84.9%) and C1 (82.2%) were the main subgenotype in HBV genotype B and C, respectively. Serotype adw2 (84.9%) and adrq+ (89.4%) were the most prevalent in HBV genotype B and C, respectively. Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease. The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis.CONCLUSION: HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia. Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease. | Andi Utama Sigit Purwantomo Marlinang Diarta Siburian Rama Dhenni Rino Alvani Gani Irsan Hasan Andri Sanityoso Upik Anderiani Miskad Fardah Akil Irawan Yusuf Wenny Astuti Achwan Soewignjo Soemohardjo Syafruddin AR Lelosutan Ruswhandi Martamala Benyamin Lukito Unggul Budihusodo Laurentius Adrianus Lesmana Ali Sulaiman Susan Tai | 2009 | World Journal of Gastroenterology2009，15，32： | 4 |
| 2 | Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients显示文摘AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.METHODS:Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study.HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing.Viral load was measured by real-time polymerase chain reaction.RESULTS:Of 179 patients,108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted.The A1896 mutation was not found in HBeAg(+) patients,however,this mutation was detected in 70.7% of HBeAg(-) patients.This mutation was frequently found when HBeAg was not expressed (87.7%),compared to that found in HBeAg seroconverted patients (65.1%).The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P=0.004).The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients,however,the prevalence of this mutation did not significantly differ among the two groups (P=0.054).In HBeAg(+) patients,the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001).The A1899 mutation did not correlate with HBV DNA (P=0.609).In HBeAg(-) patients,the T1762/A1764 mutation alone was not correlated with HBV DNA (P=0.095),however,the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION:The percentage of HBeAg(-) patients is high in Indonesia,and most of the HBeAg(-) patients had been seroconverted.The A1896 mutation was most likely the major cause of HBeAg loss.The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients,but not in HBeAg(-) patients. | Andi Utama Marlinang Diarta Siburian Sigit Purwantomo Mariana Destila Bayu Intan Tri Shinta Kurniasih Susan Tai Rino Alvani Gani Laurentius Adrianus Lesmana All Sulaiman Wenny Astuti Achwan Soewignjo Soemohardjo Arnelis Nasrul Zubir Julius Syafruddin AR Lelosutan Benyamin Lukito Tantoro Harmono | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 3 | Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population显示文摘 | Hao Zhang Ling-Hong Liao Shuk-Ming Liu Kwok-Wai Lau Albert Kai-Cheong Lai Jin-Hui Zhang Qi Wang Xiao-Qian Chen Wei Wei Hua Liu Jian-Hua Cai Maria Li Lung Susan S. W. Tai Madeline Wu | 2007 | International Journal of Colorectal Disease2007，，10： | 1 |
| 4 | In vitro studies of the dry fruit of Chinesefan palm Livistona Chinensis显示文摘 | Cheung Susan Tai Joseph | 2005 | Oncology Reports2005，14，5： | 1 |
| 5 | In vitro studies of the dry fruit of Chinese fan palm Livistona Chinensis显示文摘 | Cheung Susan Tai Joseph | | 0，，： | 1 |
| 6 | Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice显示文摘 | Xiaoyan Xiao Bin Ma Baojun Dong Peng Zhao Ningwen Tai Li Chen F. Susan Wong Li Wen | 2009 | Journal of Autoimmunity2009，，2： | 1 |
| 7 | Adolescent Girls in Maine Are at Risk for Vitamin D Insufficiency显示文摘 | Susan S. Sullivan Clifford J. Rosen William A. Halteman Tai C. Chen Michael F. Holick | 2005 | Journal of the American Dietetic Association2005，，6： | 1 |
| 8 | Breast cancer risk among male BRCA1 and BRCA2 mutation carriers 显示文摘 | Tai Y -c Susan D Giovanni P | 2007 | Jrn Natl Canc Inst2007，99，23： | 1 |
| 9 | In vitro antipro-liferative and antioxidant studies on Devil's Club Oplopan ax horridus显示文摘 | Susan Cheung Stefanie Cheah | 2006 | Ethnopharmacology2006，108，2： | 1 |
| 10 | Genetic factors contribute to patient-specific warfarin dose for Han Chinese显示文摘 | Ting-Liang Wang Hong-Lei Li Wen-Ye Tjong Qian-Su Chen Guan-Sheng Wu Hai-Tao Zhu Zi-Shan Hou Shu Xu Sheng-Jun Ma Madeline Wu Susan Tai | 2008 | Clinica Chimica Acta2008，，1： | 1 |
| 11 | Development and evaluation of a reference measurement procedure for the determination of estradiol-17 β in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry 显示文摘 | Susan S Tai C Michael J Welch | 2005 | Anal Chem2005，77，： | 1 |
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