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| 1 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Cytogenetic and clinical characteristics of a case involving complete supplication of Xpter→Xq13 显示文摘 | Syed MJ Richard D Lisa E | 1996 | J Med genet1996，33，： | 1 |
| 4 | Cytogenetic and clinical characteristics of a case involving complete suplication of Xpter→Xq13显示文摘 | Syed MJ Richard D Lisa E | 1996 | J Med Genet1996，33，： | 1 |
| 5 | DNA ligase iii pro- motes alternative nonhomologous end-joining during chromosom- al translocation formation 显示文摘 | Simsek D Brunet E Wang SY | 2011 | PLoS Genet2011，7，10： | 1 |
| 6 | Digital PulseWidth Modulator Architectures显示文摘 | Syed A Ahmed E Maksimovic D | 2004 | IEEE 35th AnnualPower Electronics Specialists Conference2004，，6： | 1 |
| 7 | Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine- sensitive stores显示文摘 | Zhuang SY Bridges D Grigorenko E | 2005 | Neuro pharmacology2005，48，： | 1 |
| 8 | Multicenter evaluation of Bactec MGIT 960 system for second-line drug susceptibility testing of Mycobacterium tuberculosis complex显示文摘 | Lin SY Desmond E Bonato D | 2009 | J Clin Microbiol2009，47，11： | 1 |
| 9 | Effects of somatostatin prophylaxis after pylorus-preserving pancreaticoduodenecto- my:increased delayed gastric emptying and reduced plasma motilin显示文摘 | Shan Y S Sy E D Tsai M L | 2005 | World J Surg2005，29，10： | 1 |
| 10 | Cost-effectiveness of cervi- cal cancer screening with primary human papillomavirus testing in Norway显示文摘 | Burger E A Ortendahl J D Sy S | 2012 | Br J Cancer2012，106，9： | 1 |
| 11 | Intensive versus conventional glucose control in critically ill patients显示文摘 | NICE-SUGAR Study Investigators Finfer S Chittock DR Su SY Blair D Foster D Dhingra V Bellomo R Cook D Dodek P Henderson WR He bert PC Heritier S Heyland DK MeArthur C McDonald E Mitchell I Myburgh JA Norton R Potter J Robinson BG Roneo JJ | 2009 | N Engl J Med2009，360，13： | 1 |
| 12 | Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha 显示文摘 | Yong J Kong X Martins Santos ME Aleman G Chaco E Liu GE Wu SY Samols D Hakimi P Chiang CM Hanson RW | 2009 | J Biol Chem2009，284，27： | 1 |
| 13 | ROLE OF P38 MAPK, AP-1, AND NF-κB IN INTERLEUKIN-1β-INDUCED IL-8 EXPRESSION IN HUMAN VASCULAR SMOOTH MUSCLE CELLS显示文摘 | Young D Jung Fan Fan David J McConkey Marina E Jean Wenbiao Liu Niels Reinmuth Oliver Stoeltzing Syed A Ahmad Alexander A Parikh Naofumi Mukaida Lee M Ellis | 2002 | Cytokine2002，，4： | 1 |
| 14 | Increased killer immunoglobulin-like receptor expression and functional defects in natural killer cells in lung cancer显示文摘 | Al Omar SY Marshall E Middleton D | 2011 | Immunology2011，133，1： | 1 |
| 15 | Practice patterns and opinions in the management of recurrent or chronic herpes zoster ophthalmicus 显示文摘 | Sy A McLeod S D Cohen E J | 2012 | Cornea2012，31，7： | 1 |
| 16 | Biomass recalcitrance: engineering plants and enzymes for biofuels production 显示文摘 | HIMMEL M E DING SY JOHNSON D K | 2007 | Science2007，315，： | 1 |
| 17 | Increased killer immunoglobulin-like receptor expression and func-tional defects in natural killer cells in lung cancer显示文摘 | Al Omar SY Marshall E Middleton D | | 0，，01： | 1 |
| 18 | My o s i n l i g h tchain phosphorylation and pulmonary endothelial cellhyperpermeability in burns显示文摘 | Ti n s l e y JH Te a s d a l e N R Yu a n SY | 2004 | Am J Physiol Lung Cell MolPhysiol2004，286，4： | 1 |
| 19 | Digital pulse width modulator architectures显示文摘 | Syed A Ahmed E Maksimovic D | 2004 | IEEE Power Electronics Specialists Conference2004，6，4： | 1 |
| 20 | Spatial characteristics of thunderstorm rainfall fields and their relation to runoff显示文摘 | Syed K H Goodrich D C Myers D E | 2003 | Journal of Hydrology2003，271，1234： | 1 |
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