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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Daily load profiles for residential, commercial and industrial low voltage consumers 显示文摘 | JARDINI J A TAHAN C M V GOUVEA M R | 2000 | IEEE Transactions on Power Delivery2000，15，1： | 1 |
| 3 | Establishing quality performance of distribution companies based on Yardstick regulation显示文摘 | Tanure J E P dos S Tahan C M V Lima J W M | 2006 | IEEE Trans on Power Systems2006，21，3： | 1 |
| 4 | Daily load profiles for residential,commercial and industrial low voltage consumers显示文摘 | Jardini J A Tahan C M V Gouvea M R | 2000 | IEEE Transactions on Power Delivery2000，15，1： | 1 |
| 5 | Preparation and characterization of BaxSr1-xTiO3 thin films by a Sol-Gel technique显示文摘 | TAHAN D M SAFARI A KLEIN L C | 1996 | J Am Ceram Soc1996，79，6： | 1 |
| 6 | Quan- tum fluctuations, temperature, and detuning effects in solid- light systems 显示文摘 | AICHHORN M HOHENADLER M TAHAN C | 2008 | Physical Review Letters2008，100，21： | 1 |
| 7 | The role of chemokines in ex- ereise-induced ma Immunol, 2008, 96(6): 819-825 in asthma 显示文摘 | Tahan F Karaaslan C Asian A | 2008 | Ann Allergy2008，，： | 1 |
| 8 | The role of endonasal surgery in the management of frontoethmoidal osteomas 显示文摘 | SCHICK B STEIGERWALD C el RAHMAN el TAHAN A | 2001 | Rhinology2001，39，： | 1 |
| 9 | Coffee:The magical bean for liver diseases显示文摘Coffee has long been recognized as having hepatoprotective properties,however,the extent of any beneficial effect is still being elucidated.Coffee appears to reducerisk of hepatocellular carcinoma,reduce advancement of fibrotic disease in a variety of chronic liver diseases,and perhaps reduce ability of hepatitis C virus to replicate.This review aims to catalog the evidence for coffee as universally beneficial across a spectrum of chronic liver diseases,as well as spotlight opportunities for future investigation into coffee and liver disease. | Ryan D Heath Mihir Brahmbhatt Asli C Tahan Jamal A Ibdah Veysel Tahan | 2017 | World Journal of Hepatology2017，9，15： | 1 |
| 10 | Distribution Transformer Loss of Life Evaluation: A Novel Approach Based on Daily Load Profiles 显示文摘 | JARDINI J A SCHMIDT H P TAHAN C M V | 2000 | IEEE Transactions on Power Delivery2000，15，1： | 1 |
| 11 | Preparation and Characterization of BaxSr1-xTiO3 Thin Films by a Sol-gel Technique显示文摘 | TAHAN D M KLEIN L C SAFARI A | 1996 | J Am Ceram Soc1996，79，6： | 1 |
| 12 | Dissimilar friction welding of 6061- T6 aluminum and AISI 1018 steel: properties and microstructural characterization显示文摘 | Tahan E Gould J E John C L | 2010 | Materials and Design2010，31，： | 1 |
| 13 | Preparation and characterization of BaxSr1-xTiO3 thin films by a sol-gel technique显示文摘 | Tahan D M Safari A Klein L C | 1996 | J Am Ceram Soc1996，79，6： | 1 |
| 14 | Daily load profiles for residential, commercial and industrial low voltage consumers 显示文摘 | JARDINI J A TAHAN C M V GOUVEA M R | 2000 | IEEE Transactions on Power Delivery2000，15，1： | 1 |
| 15 | Distribution transformer loading evaluation based on load profiles measurements显示文摘 | JARDINI J A TAHAN C M V AHN S U | 1997 | IEEE Transactions on Power Delivery1997，12，4： | 1 |
| 16 | The role of endonasal surgery in the management of frontoethmoidal osteomas 显示文摘 | SCHICK B STEIGERWALD C EL RAHMAN EL TAHAN A | 2001 | Rhinology2001，39，： | 1 |
| 17 | Distribution Transformer Loading Evaluation Based on Load Profiles Measurements 显示文摘 | Jardini J A Tahan C M V Ahn S U Ferrari E L | 1997 | IEEE Transactions on Power Delivery1997，12，4： | 1 |
| 18 | Daily load profiles for residential, commercial and industrial low voltage consumers显示文摘 | JARDINI J A TAHAN C M V GOUVEA M R | 2000 | IEEE Trans on Power Delivery2000，15，1： | 1 |
| 19 | Quantum Phase Transitions of Light 显示文摘 | ( -REENTREE A D TAHAN C COLE J H etal | 2006 | Nat Phys2006，2856，861： | 1 |
| 20 | Establishing quality performance of distribution companies based on Yardstick regulation显示文摘 | Tanure J E P dos S Tahan C M V Lima J W M | 2006 | IEEE Trans on Power Systems2006，21，3： | 1 |
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