|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 2 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 3 | Mapping coalmine goaf using transient electromagnetic method and high density resistivity method in Ordos City, China显示文摘The research about subsurface characteristics by using transient electromagnetic method(TEM) and high density resistivity method(HDRM) were already conducted in Ordos. The objective of this research is to detect coalmine goaf areas based on rock resistivity. The data processing using wavelet transform, three point smoothing, RES2 DINV and Maxwell processing software to obtain 2D resistivity structure. The results showed that the layers with maximum resistivity values(30e33 U m on Line 1, 30e31 U m on Line 2, 32e40 U m on Line3) are founded at station 1e7, and 14e20 on Line 1,13e18 on Line 2, and 8e13 and 16e20 on Line 3 which is predicted as goaf layer, and the minimum resistivity values(20e26 U m of TEM, 45e75 U m of HDRM) at the other layers. This resistivity difference was caused by the geology and characteristics of the study area which is located close by the cleugh with rich coal, so the goaf area distinguishable with aquifer layer and coal seam. The results were also significant accidents and serious destruction of ecological environment. | Guiju Wu Guangliang Yang Hongbo Tan | 2016 | Geodesy and Geodynamics2016，7，5： | 14 |
| 4 | Detection of a half-microgal coseismic gravity change after the Ms7. 0 Lushan earthquake显示文摘Because only a small near-field coseismic gravity change signal remains after removal of noise from the accuracy of observations and the time and spatial resolution of the earth's surface gravity observation system,it is difficult to verify simulations of dislocation theory.In this study,it is shown that the GS15 gravimeter,located 99.5 km from the epicenter of the Ms7.0 Lushan earthquake on April 20,2013 at 08∶04 UTC+8,showed the influence of the earthquake from 2013-04-16 to 2013-04-26 after a time calibration,tide corrections,drift correction,period correction and relaxation correction were applied to its data.The post-seismic relaxation process of the spring in the gravimeter took approximately 430 minutes and showed a 2.5×10-8ms-2gravity change.After correcting for the relaxation process,it is shown that a coseismic gravity change of approximately+0.59±0.4×10-8ms-2was observed by the GS15 gravimeter;this agrees with the simulated gravity change of approximately 0.31×10-8ms-2.The rate of the coseismic gravity change and the coseismic vertical displacement,as measured by one-second and one-day sampling interval GPS units,is also consistent with the theoretical rate of change.Therefore,the GS15 gravimeter at the Pixian Station observed a coseismic gravity change after the Ms7.0 Lushan earthquake.This and similar measurements could be applied to test and confirm the theory used for these simulations. | Wei Jin Zhao Bin Tan Hongbo Yu Dan Shen Chongyang Li Hui | 2013 | Geodesy and Geodynamics2013，4，3： | 7 |
| 5 | A novel RHT-TBD approach for weak targets in HPRF radar显示文摘A novel approach, which can handle ambiguous data from weak targets, is proposed within the randomized Hough transform track-before-detect(RHT-TBD) framework. The main idea is that, without the pre-detection and ambiguity resolution step at each time step, the ambiguous measurements are mapped by the multiple hypothesis ranging(MHR) procedure. In this way, all the information, based on the relativity in time and pulse repetition frequency(PRF) domains, can be gathered among different PRFs and integrated over time via a batch procedure. The final step is to perform the RHT with all the extended measurements, and the ambiguous data is unfolded while the detection decision is confirmed at the end of the processing chain.Unlike classic methods, the new approach resolves the problem of range ambiguity and detects the true track for targets. Finally, its application is illustrated to analyze and compare the performance between the proposed approach and the existing approach. Simulation results exhibit the effectiveness of this approach. | Hongbo YU Guohong WANG Wei WU Shuncheng TAN | 2016 | Science China Earth Sciences2016，59，12： | 6 |
| 6 | Oxyvanite V3O5:A new intercalation-type anode for lithium-ion battery显示文摘In the present study,V3O5 microcrystals that synthesized via vacuum calcination are employed as anodes for lithium-ion batteries(LIBs)for the first time.Despite the widely observed sluggish reaction kinetics and poor cycling stability in most microsized transition metal oxides,the V3O5 microcrystals exhibit excellent rate capability(specific capacities of 144 and 125 mAh g^−1 are achieved at extremely high current densities of 20 and 50 A g^−1,respectively)and long-term cycling performance(specific capacity of 117 mAh g^−1 is sustained over 2000 cycles at 50 A g^−1).It is ascribed to the three-dimensional open-framework structure of the V3O5 microcrystals as a major factor in dictating the fast reaction kinetics(lithium diffusion coefficient:~10−9 cm^2 s^−1).In addition,significant insight into the reaction mechanism of the V3O5 microcrystals in concomitant its phase evolution are obtained from ex-situ XRD study,revealing that the V3O5 microcrystals undergo intercalation reaction with insignificant structural change in response to lithiation/delithiation. | Dong Chen Huiteng Tan Xianhong Rui Qi Zhang Yuezhan Feng Hongbo Geng Chengchao Li Shaoming Huang Yan Yu | 2019 | InfoMat2019，1，2： | 6 |
| 7 | Joint range ambiguity resolving and multiple maneuvering targets tracking in clutter via MMPHDF-DA显示文摘It is difficult to track multiple maneuvering targets of which the number is unknown and timevarying,especially when there is range ambiguity.The random finite sets(RFS)based probability hypothesis density filter(PHDF)is an effective solution to the problem of multiple targets tracking.However,when tracking multiple targets via the range ambiguous radar,the problem of range ambiguity has to be solved.In this paper,a multiple model PHDF and data association(MMPHDF-DA)based method is proposed to address multiple maneuvering targets tracking with range ambiguous radar in clutter.Firstly,by introducing the turn rate of target and the discrete pulse interval number(PIN)as components of target state vector,and modeling the incremental variable of the PIN as a three-state Markov chain,the problem of multiple maneuvering targets tracking with range ambiguity is converted into a hybrid state filtering problem.Then,by implementing a novel'track-estimate'oriented association with the filtering results of the hybrid filter,target tracks are provided at each time step.Simulation results demonstrate that the MMPHDF-DA can estimate target state as well as the PIN simultaneously,and succeeds in multiple maneuvering target tracking with range ambiguity in clutter.Simulation results also demonstrate that the MMPHDF-DA can overcome the limitation of the Chinese Remainder Theorem for range ambiguity resolving. | TAN ShunCheng WANG GuoHong WANG Na YU HongBo | 2014 | Science China(Information Sciences)2014，57，8： | 6 |
| 8 | Estimating Moho basement and faults using gravity inversion in Yushu-earthquake area,China显示文摘A gravity survey was conducted one month after the 2010 Yushu earthquake in the epicenter area.The cross-fault survey line was 500 km long,from Langqian county to Qingshuihe county,in a transition zone between Bayan Har block and Qiangtang block,in an area of high elevation,large undulating terrain,and complex geological features.An interpretation of the data was carried out together with other kinds of data,such as seismic exploration and magnetic exploration.The result shows that gravity is sensitive to fault boundary;the geologic structure of the region is complex at middle and upper depths,and the density profile reveals an eastward-pushing fault movement. | Yang Guangliang | 2012 | Geodesy and Geodynamics2012，3，2： | 4 |
| 9 | Gravity distribution characteristics and their relationship with the distribution of earthquakes and tectonic units in the Northe South seismic belt, China显示文摘The Northe South Seismic Belt(NSSB) is a Chinese tectonic boundary with a very complex structure, showing a sharp change in several geophysical field characteristics. To study these characteristics and their relationship with the distribution of earthquakes and faults in the study area, we first analyze the spatial gravity anomaly to achieve the Bouguer gravity anomaly(EGM2008 BGA) and the regional gravity survey Bouguer gravity anomaly.Next, we ascertain the Moho depth and crustal thickness of the study area using interface inversion with the control points derived from the seismic and magnetotelluric sounding profiles achieved in recent years. In this paper, we summarize the relief, trend, Moho gradient, and crustal nature, in addition to their relationship with the distribution of earthquakes and faults in the study area. The findings show that earthquakes with magnitudes greater than Ms7.0 are mainly distributed in the Moho Bouguer anomaly variation belt and faults. The results of the study are important for future research on tectonic characteristics, geological and geophysical surveys, and seismicity patterns. | Wu Guiju Tan Hongbo Zou Zhengbo Yang Guangliang Shen Chongyang | 2015 | Geodesy and Geodynamics2015，6，3： | 4 |
| 10 | Simulation of coseismic effects of the Ms7. 0 Lushan earthquake显示文摘Using plane dislocation theory and the seismic-wave inversion results from the Institute of Geophysics,China Earthquake Administration and the Institute of Geodesy and Geophysics,Chinese Academy of Sciences models,the surface coseismic deformation and gravity changes caused by the 2013 Ms7.0 Lushan earthquake are simulated.The simulations of coseismic gravity change and deformation indicate that the dislocation has dip-slip characteristics.The results also show that the coseismic deformation exhibits a symmetrical,positive-and-negative distribution,with the deformation usually being less than 10 mm in the farfield but up to 140 mm in the near-field.The gravity changes are concentrated on the fault-projection area,which is greatly affected by the vertical surface deformation.The gravity change and vertical deformation in the far field are usually less than and 5 mm,respectively,but reach and 330 mm,respectively,in the near field.The simulated results agree well with the measured results,which suggests a theoretical basis for the observed change in gravity before and after this earthquake. | Tan Hongbo Shen Chongyang Wei Jin Zhao Bin Wang Jian Xuan Songbai | 2013 | Geodesy and Geodynamics2013，4，3： | 3 |
| 11 | Orthogonal nonnegative matrix factorization based local hidden Markov model for multimode process monitoring显示文摘Traditional data driven fault detection methods assume that the process operates in a single mode so that they cannot perform well in processes with multiple operating modes. To monitor multimode processes effectively,this paper proposes a novel process monitoring scheme based on orthogonal nonnegative matrix factorization(ONMF) and hidden Markov model(HMM). The new clustering technique ONMF is employed to separate data from different process modes. The multiple HMMs for various operating modes lead to higher modeling accuracy.The proposed approach does not presume the distribution of data in each mode because the process uncertainty and dynamics can be well interpreted through the hidden Markov estimation. The HMM-based monitoring indication named negative log likelihood probability is utilized for fault detection. In order to assess the proposed monitoring strategy, a numerical example and the Tennessee Eastman process are used. The results demonstrate that this method provides efficient fault detection performance. | Fan Wang Honglin Zhu Shuai Tan Hongbo Shi | 2016 | Chinese Journal of Chemical Engineering2016，24，7： | 3 |
| 12 | Temporal gravity changes before the 2008 Yutian Ms7.3 earthquake显示文摘Based on the data of the repeated gravity observation network in Chinese mainland since 1998,we analyzed the temporal changes of regional gravity field before the 2008 Yutian Ms7.3 earthquake.The result shows some mid-to-long term(two to ten years)changes during the earthquake's preparation.Notable features are a gravity increase lasting several years and a relatively large-scaled gradient zone of gravity change,the former indicating a continuous energy accumulation and the latter a possible location of seismic rupture.These gravity changes showed a trend of increase-accelerated increase-decelerated increase,similar to that of the Tangshan Ms7.8 earthquake in 1976.The maximum accumulated gravity change related to the earthquake reached 200×10-8 ms-2. | Shen Chongyang Li Hui Sun Shaoan Yang Guangliang Xuan Songbai Tan Hongbo Liu Shaoming | 2012 | Geodesy and Geodynamics2012，3，1： | 3 |
| 13 | Research on variety characteristics of China's Mainland troposphere based on CMONOC显示文摘In this research, we processed the GPS and meteorological data from about 220 stations of Crustal Movement Observation Network of China(CMONOC) observed in 2014 and derived the Zenith Total Delay(ZTD) map in both spatial and temporal dimension. The results of ZTD have high accurate and reliable as IGS and all sites with varying locations show obvious variety characteristics of Chinese mainland. Meanwhile, the precipitable water vapor(PWV) correlation coefficients between GPS observation and upper air sounding is close to 1, and the comparison of GPS-derived PWV and observed PWV from meteorological sites indicating GPS observation data generated in CMONOC project applied to the weather forecast research is feasible. In addition, based on all stations covered the whole Chinese land area and using interpolation algorithms, we make contour plots of PWV distribution per hour. We observe obvious feature that the precipitable water in north and western area is less than south and east area all over this year. High latitudes area may be dry and low latitudes area is wet. | Hongbo Shi Rui Zhang Zhaosheng Nie Yu Li Zhengsong Chen Tan Wang | 2018 | Geodesy and Geodynamics2018，9，5： | 3 |
| 14 | LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity显示文摘Den dritic cells(DCs)play a pivotal role in priming adaptive immunity.However,the in volveme nt of DCs in con trolling excessive and deleterious T cell responses remains poorly defined.Moreover,the metabolic dependenee and regulation of DC function are unclear.Here we show that LKB1 signaling in DCs functions as a brake to restrain excessive tumor-promoting regulatory T cell(Treg)and Th17 cell responses,thereby promoting protective anti-tumor immunity and maintaining proper immune homeostasis.LKB1 deficiency results in dysregulated metabolism and mTOR activation of DCs.Loss of LKB1 also leads to aberrant DC maturation and production of cytokines and immunoregulatory molecules.Blocking mTOR signaling in LKB1-deficient DCs partially rectifies the abno rmal phe no types of DC activation and Treg expansio n,whereas unc on trolled Th17 resp on ses depend upon IL-6-STAT3 signaling.By coordi nating metabolic and immune quiesce nee of DCs,LKB1 acts as a crucial signali ng hub in DCs to enforce protective anti-tumor immunity and normal immune homeostasis. | Yanyan Wang Xingrong Du Jun Wei Lingyun Long Haiyan Tan Cliff Guy Yogesh Dhungana Chenxi Qian Geoffrey Neale Yang-Xin Fu Jiyang Yu Junmin Peng Hongbo Chi | 2019 | Cell Research2019，29，5： | 3 |
| 15 | Effect of Nano Silica on Hydration and Microstructure Characteristics of Cement High Volume Fly Ash System Under Steam Curing显示文摘The influences of nano silica (NS) on the hydration and microstructure development of steam cured cement high volume fly ash (40 wt%, CHVFA) system were investigated. The compressive strength of mortars was tested with different NS dosage from 0 to 4%. Results show that the compressive strength is dramatically improved with the increase of NS content up to 3%, and decreases with further increase of NS content (e g, at 4%). Then X?ray diffraction (XRD), differential scanning calorimetry-thermogravimetry (DSCTG), scanning electron microscope (SEM), energy disperse spectroscopy (EDS), mercury intrusion porosimeter (MIP) and nuclear magnetic resonance (NMR) were used to analyze the mechanism. The results reveal that the addition of NS accelerates the hydration of cement and fly ash, decreases the porosity and the content of calcium hydroxide (CH) and increases the polymerization degree of C-S-H thus enhancing the compressive strength of mortars. The interfacial transition zone (ITZ) of CHVFA mortars is also significantly improved by the addition ofNS, embodying in the decrease of Ca/Si ratio and CH enrichment of ITZ. | 马保国 梅军鹏 TAN Hongbo LI Hainan LIU Xiaohai JIANG Wenbin ZHANG Ting | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，3： | 3 |
| 16 | Properties and Hydration Mechanism on High-strength Anchorage Grouting Material for Highway Slope显示文摘The rheological and mechanical properties of high-strength anchorage grouting materials for highway slope were investigated to optimize the mix proportion. The experimental results showed that the optimized mix proportion of high-strength anchorage grouting material(HAGM) was C3(FA:SP:SF= 1:2:2; AG1:AG2=3:7 and 0.03% FC), which is agreement with the limitation of JCT 986-2005. Moreover, the XRD and FTIR results showed the addition of expansive components was in favor of the formation of ettringite. The intensity of AFt peak of the samples increased with the increasing of hydration time. | TANG Hua LI Xiangguo ZHANG Fachun HE Chao TAN Hongbo FANG Rui | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，6： | 2 |
| 17 | A Improved Shunt-hybrid-type Active Power Filter and Its Control Method显示文摘 | ZHOU Ke WANG Kai LIU Lu TAN Qi CHU Hongbo | 2012 | 中国电机工程学报2012，32，30： | 2 |
| 18 | Joint inversion of gravity and seismic data along a profile across the seismogenic fault of 2010 Yushu Ms7. 1 earthquake显示文摘Yushu Ms7. 1 earthquake occurred on the Ganzi-Yushu fault zone,across which we carried out a joint relative-gravity and seismic-reflection survey,and then performed a gravity inversion constrained by the seismic-reflection result. Based on the data of complete Bouguer gravity anomaly and seismic reflection,we obtained a layered interface structure in deep crust down to Moho. Our study showed that the inversion could reveal the interfaces of strata along the survey profile and the directions of regional faults in two-dimension. From the characteristics of the observed topography of the Moho basement,we tentatively confirmed that the uplift of eastern edge of Qinghai-Tibet plateau was caused by the subduction of the Indian plate. | Yang Guangliang Wang Fuyun Shen Chongyang Sun Shaoan Tan Hongbo | 2011 | Geodesy and Geodynamics2011，2，4： | 2 |
| 19 | Simulation of co-seismic gravity change and deformation of Wenchuan Ms8.0 earthquake显示文摘co 地震的严肃变化和排水量由 Wenchuan Ms8 引起了的表面。分别地, 0 地震由地球物理, CEA 和 USGS 的研究所根据一半空间脱臼理论和二差错模型 inversed 是计算的。结果显示出那 1 )脱臼由剧降组成滑倒并且权利侧面的罢工滑倒; 2 )co地震的严肃变化证明一个四象限的模式,哪个是极大地由垂直排水量的分发控制了,吗在特别近文件; 3 )严肃变化通常是不到 10 汦潯敤?楷桴? | Chongyang Shen Hui Li Hongbo Tan | 2010 | Geodesy and Geodynamics2010，1，1： | 2 |
| 20 | Experimental study on liquid/solid phase change for cold energy storage of Liquefied Natural Gas (LNG) refrigerated vehicle显示文摘 | Hongbo Tan Yanzhong Li Hanfei Tuo | 2010 | Energy2010，，35： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员