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| 1 | Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment显示文摘Salmonella:mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models,but the detailed mechanism remains unsolved.In this report,the active involvement of the host immune response in this process was confirmed by comparing the tumor-suppressive effects of Salmonella in immunocompetent and immunodeficient mice bearing melanoma allografts.Since flagella are key inducers of the host immune response during bacterial infection,flagella were genetically disrupted to analyse their involvement in Salmonella-mediated cancer therapy.The results showed that flagellum-deficient strains failed to induce significant anti-tumor effects,even when more bacteria were administered to offset the difference in invasion efficiency.Flagella mainly activate immune cells via Flagellin/Toll-like receptor 5(TLR5)signalling pathway.Indeed,we showed that exogenous activation of TLR5 signalling by recombinant Flagellin and exogenous expression of TLR5 both enhanced the therapeutic efficacy of flagellum-deficient Salmonella against melanoma.Our study highlighted the therapeutic value of the interaction between Salmonella and the host immune response through Flagellin/TLR5 signalling pathway during Salmonella-mediated cancer therapy,thereby suggesting the potential application of TLR5 agonists in the cancer immune therapy. | Jianxiang Chen Yiting Qiao Guo Chen Cunjie Chang Heng Dong Bo Tang Xiawei Cheng Xiufeng Liu Zichun Hua | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 2 | Terrain relief periods of loess landforms based on terrain profiles of the Loess Plateau in northern Shaanxi Province,China显示文摘The Loess Plateau is densely covered by numerous types of gullies which represent different soil erosion intensities.Therefore,research on topographic variation features of the loess gullies is of great significance to environmental protection and ecological management.Using a5 m digital elevation model and data from a national geographic database,this paper studies different topographical areas of the Loess Plateau,including Shenmu,Suide,Yanchuan,Ganquan,Yijun,and Chunhua,to derive representative gully terrain profile data of the sampled areas.First,the profile data are standardized in MATLAB and then decomposed using the ensemble empirical mode decomposition method.Then,a significance test is performed on the results;the test confidence is 95% to 99%.The most reliable decomposition component is then used to calculate the relief period and size of the gullies.The results showed that relief periods of the Chunhua,Shenmu,Yijun,Yuanchuan,Ganquan,and Suide gullies are 1110.14 m,1096.85 m,1002.49 m,523.48 m,498.12 m,and 270.83 m,respectively.In terms of gully size,the loess landforms are sorted as loess fragmented tableland,aeolian and dune,loess tableland,loess ridge,loess hill and loess ridge,and loess hill,in descending order.Taken together,the gully terrain features of the sample areas and the results of the study are approximately consistent with the actual terrain profiles.Thus,we conclude that ensemble empirical mode decomposition is a reliable method for the study of the relief and topography of loess gullies. | Jianjun CAO Guoan TANG Xuan FANG Jilong LI Yongjuan LIU Yiting ZHANG Ying ZHU Fayuan LI | 2019 | Frontiers of Earth Science2019，13，2： | 4 |
| 3 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 4 | PACAP in hibit the release and cytokine activity of HMGB1 and im prove the survival during lethal endotoxemia显示文摘 | YITING TANG BEN LV HAICHAO WANG | 2008 | Interna tional Immunopharmacology2008，8，： | 1 |
| 5 | OPTIMIZATION OF FERMENTATION CONDITIONS AND PURIFICATION OF CORDYCEPIN FROM Cordyceps militaris显示文摘 | Tang Jiapeng Liu Yiting Zhu Li | 2014 | Preparative Biochemistry and Biotechnology2014，，1： | 1 |
| 6 | Vasoactive intestinal peptide enhances TNF-a induced IL-6 and IL- 8 synthesis in human proximal renal tubular epithelial cells by NF-KB dependent mechanism 显示文摘 | Ling Huang Yiting Tang Jiao Qin | 2012 | Inflammation2012，35，11： | 1 |
| 7 | Potential and current oscillations during formaldehyde oxidation on platinum particles dispersed in three-dimensional pore networks of TiOx/Ti显示文摘 | Guohua Zhao Yiting Tang Rui Chen Rong Geng.Dongming Li | | 0，，： | 1 |
| 8 | Fluorofenidone Attenuates Inflammation by Inhibiting the NF-кB Pathway显示文摘 | Ling Huang Fangfang Zhang Yiting Tang Jiao Qin Yu Peng Lin Wu Fang Wang Qiongjing Yuan Zhangzhe Peng Jishi Liu Jie Meng Lijian Tao | 2014 | The American Journal of the Medical Sciences2014，，1： | 1 |
| 9 | PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia显示文摘 | Yiting Tang Ben Lv Haichao Wang Xianzhong Xiao Xiaoxia Zuo | 2008 | International Immunopharmacology2008，，12： | 1 |
| 10 | Positioning Algorithms by Information Fusion in Wireless Sensor Networks显示文摘 | Tang Liangrui Gong Yue Luo Yiting | 2014 | Wireless Personal Communications2014，74，2： | 1 |
| 11 | Direct Electrochemistry of Hemoglobin on Vertically Aligned Carbon Hybrid TiO2 Nanotubes and Its Highly Sensitive Biosensor Performance显示文摘现在的工作集中于开发一个新奇 biomaterial 平台在垂直地排列的碳混血儿 TiO2 nanotubes (C-TiO2 NT ) 上完成 hemoprotein 和更高的生物传感器性能的提高的直接电子转移(DET ) 。用一个简单帮助表面活化剂的方法,有传导性的非结晶的碳种类的 TiO2 NT 的可控制的杂交被认识到。获得的 C-TiO2 NT 有才能地被选择为蛋白质固定和生物传感器应用程序用作一个理想的“容器”。结果证明没有破坏他们的优势的管状的结构或损坏他们的优秀 biocompatibility 和 hydrophilicity,进 TiO2 NT 的 C 的适当杂交导致 TiO2 NT 的好一些的传导性。当在装载蛋白质使用了时, C-TiO2 NT 能为血红素(Hb ) 的快速、真实的固定被用作一个超级容器,与一篇大表面 electroactive Hb 报道() 3.3 楧敶挠敲敤据 ? 潴吗? | Meichuan Liu Guohua Zhao Yiting Tang Huijie Shi Nianjun Yang | 2013 | Chinese Journal of Chemistry2013，31，2： | 0 |
| 12 | Identification and characterization of the minimal promoter of Mipul: the role of GC boxes in the regulation of basal transcription显示文摘Mipu1,编码 KRAB/C2H2 锌手指蛋白质的新奇基因,首先被报导在心肌的 ischemiareperfusion 损害起来调整,工作保护房间免于氧化应力。印射基因的倡导者区域并且理解它的规定,我们识别了抄写开始地点并且表明抄写开始地点在上游的 1366-bp 碎片拥有倡导者活动。Mipu1 的 5 胁腹区域的删除构造导致一个最小的倡导者,既不一个 TATA 盒子也不一个 CAAT 盒子在被检测的鉴定。二个 GC 盒子被发现;然而,他们是为 Sp1 家庭抄写因素的特定的有约束力的地点。在这些 GC 盒子中的变化导致了 Mipu1 最小的倡导者活动的全部的损失。最后, WP631,一个 Sp1-family-specific 禁止者,以一种剂量依赖者方式被发现倡导者活动到减少,显示 GC 盒子为 Mipu1 最小的倡导者活动的活动是必要的。 | Ben Lv Yiting Tang Xiayu Li Guiliang Wang Can Yuan Ying Liu Lei Jiang Xianzhong Xiao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，4： | 0 |
| 13 | Efficacy and safety of Buyang Huanwu decoction(补阳还五汤)for diabetic peripheral neuropathy:a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the efficacy and safety of Buyang Huanwu decoction(BYHWD)in treating diabetic peripheral neuropathy(DPN).METHODS:Eight electronic databases,including China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,Chinese Biomedical Literature Database,Cochrane Library,Embase,Web of Science,and PubM ed,were searched for randomized controlled trials(RCTs)of BYHWD to treat DPN.We identified all RCTs related to BYHWD and those on the treatment of DPN with the combination of mecobalamin.RevMan software was used for the statistical analysis.RESULTS:Twenty-one RCTs with a total of 1945 patients were included.The methodological quality of the literature included was low.Meta-analysis showed that the efficacy of the treatment group was significantly better than that of the control group in the treatment of DPN with BYHWD[risk ratio(RR)=0.33,95%CI(0.27,0.40),Z=11.25,P<0.00001].The median nerve of median motor nerve conduction velocity(MNCV)[mean difference(MD)=4.16,95%CI(1.35,6.98)]and median sensory NCV(SNCV)[(MD=3.28,95%CI(2.35,4.22)]were improved in the treatment group.The MNCV in the common peroneal nerve[(MD=1.63,95%CI(0.39,2.87)]and SNCV[(MD=4.56,95%CI(3.16,5.97)]were significantly higher than those in the control group(P<0.01).Plasma viscosity[(MD=-0.15,95%CI(-0.20,-0.09),Z=5.17,P<0.01)],whole blood high shear[(MD=-0.83,95%CI(-1.56,-0.11),Z=2.26,P=0.02)]and whole blood low shear[(MD=-1.61,95%CI(-2.28,-0.94),Z=4.68,P<0.01)]decreased significantly after treatment.There was no significant difference in fasting blood glucose[(MD=-0.42,95%CI(-0.89,0.05),Z=1.76,P=0.08)]between the treatment and control groups;postprandial blood glucose[(MD=-0.62,95%CI(-1.19,0.05),Z=2.12,P=0.03)]decreased significantly.No significant difference was found in the blood lipid levels between the treatment and control groups,including triglycerides[(MD=-0.21,95%CI(-0.52,0.10),Z=1.34,P=0.18)]and cholesterol[(MD=-0.13,95%CI(-0.27,0.00),Z=1.92,P=0.06)].Of the 21 RCTs,only five reported adverse reactions,and four studies reported the length of follow-up.No serious adverse events were reported.None of the studies reported the quality of life and economic conditions.CONCLUSIONS:Our study suggests that BYHWD has a significant therapeutic effect on DPN.High-quality,largescale RCTs are needed to provide more reliable evidence. | ZHANG Meizhen HAO Xiaohui TANG Yiting CHEN Yupeng HE Puyu ZHAO Liming PANG Bing NI Qing | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 0 |
| 14 | Monitoring the in vivo siRNA release from lipid nanoparticles based on the fluorescence resonance energy transfer principle显示文摘The siRNA-loaded lipid nanoparticles have attracted much attention due to its significant gene silencing effect and successful marketization.However,the in vivo distribution and release of siRNA still cannot be effectively monitored.In this study,based on the fluorescence resonance energy transfer(FRET)principle,a fluorescence dye Cy5-modified survivin siRNA was conjugated to nanogolds(Au-DR-siRNA),which were then wrapped with lipid nanoparticles(LNPs)for monitoring the release behaviour of siRNA in vivo.The results showed that once Au-DR-siRNA was released from the LNPs and cleaved by the Dicer enzyme to produce free siRNA in cells,the fluorescence of Cy5 would change from quenched state to activated state,showing the location and time of siRNA release.Besides,the LNPs showed a significant antitumor effect by silencing the survivin gene and a CT imaging function superior to iohexol by nanogolds.Therefore,this work provided not only an effective method for monitoring the pharmacokinetic behaviour of LNP-based siRNA,but also a siRNA delivery system for treating and diagnosing tumors. | Lei Sun Jinfang Zhang Jing-e Zhou JingWang Zhehao Wang Shenggen Luo Yeying Wang Shulei Zhu Fan Yang Jie Tang Wei Lu Yiting Wang Lei Yu Zhiqiang Yan | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，1： | 0 |
| 15 | Linear and quadratic damping coefficients of a single module of a very large floating structure over variable bathymetry:Physical and numerical free-decay experiments显示文摘The linearity assumption is widely used when acquiring the hydrodynamic coefficients of a floating structure.However,the linear damping is frequently underestimated,especially for the natural frequency.To investigate the sloping seafloor effects on the damping terms of a single module of a semi-submersible Very Large Floating Structure(VLFS),this paper revisits the conventional formulation and further proposes the direct integration method for obtaining the linear and quadratic damping coefficients from free-decay tests.Numerical free-decay simulations of the single module over variable bathymetry are carried out by the CFD numerical tank.Corresponding model tests are also implemented to verify and validate against the numerical solutions.The effects of the sloping seafloor,as well as the water depth,on the hydrodynamic coefficients are investigated based on the validated CFD modeling.Both numerical and experimental results indicate that the acquisition of the linear and quadratic damping coefficients is sensitive to the data-processing and identification approaches.For the case studied in present paper,the identification errors introduced by the conventional method are 1.5%while they are 0.5%using the direct integration method.The quadratic damping coefficient for heave mode decreases about 10.4%when the sloping angle increases from 0 to 6 deg. | Yiting Wang Ziying Tang Lei Wang Xuefeng Wang | 2022 | Journal of Ocean Engineering and Science2022，7，6： | 0 |
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