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| 1 | Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes显示文摘AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-11β, and IFN-γ)and bacterial lipopolysaccharide (LPS) mixture(CM) in the cultured rat hepatocytes, andexamine their mechanisms action.METHODS Rat hepatocytes were incubatedwith AG, L-NAME, L-NNA, Actinomycin D (ActD)and dexamethasene in a medium containing CM(LPS plus TNF-α, IL-1β, and IFN-γ) for 24 h. NOproduction in the cultured supernatant wasmeasured with the Griese reaction. IntracellularcGMP level was detected with radioimmunoasey.RESULTS NO production was markedlyblocked by AG and L-NAME in a dose-dependentmanner under inflammatory stimuli conditiontriggered by CM in vitro. The rate of themaximum inhibitory effects of L-NAME (38.9%)was less potent than that obtained with AG(53.7%, P<0.05). There was no significantdifference between the inhibitory effects of AGand two L-arginine analogues on intracellularcGMP accumulation in rat cultured hepatocytes.Non-specific NOS expression inhibitordexamethasone ( DEX ) and iNOS mRNAtranscriptional inhibitor ActD also significantlyinhibited CM-induced NO production. AG(0.1mmol.L-1) and ActD (0.2ng@Lt) wereequipotent in decreasing NO production inducedby inflammatory stimuli in vitro, and botheffects were more potent than that induced bynon-selectivity NOS activity inhibitor L-NAME(0. 1 mmol@ L- 1) under similar stimuli conditions(P | Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 2 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 3 | Waxy allelic diversity in common millet(Panicum miliaceum L.) in China显示文摘A set of 132 accessions of common millet,Panicum miliaceum L.,from 12 provinces of China were assessed for endosperm starch type(waxy or non-waxy)using I_2-KI staining,amylose and amylopectin contents using the dual-wavelength colorimetric method,and genotype of Waxy genes conditioning amylose content by gene sequencing.Endosperm starch content varied from57.69%to 74.70%,while the amylose and amylopectin contents of the starch ranged from 0 to23.29%and from 41.99%to 70.24%,respectively.Sequencing two Wx genes,including Wx-L(intron 5-exon 7 and intron 8–9)and Wx-S(exon 9–intron 10)revealed several polymorphisms(S_0,S_(-15),L_C,L_F,L_Y).Marker M5-R11 linking to the Wx-S gene may be used to discriminate waxy common millet accessions from non-waxy ones.Among the 132 accessions,68 with the S_(-15)allele had waxy endosperm starch with the amylose content range 0–2.58%and 64 accessions with the S_0allele had non-waxy endosperm starch with amylose content range 3.94%–23.29%.Five genotypes including S_(-15)/L_F(45%of the accessions),S_0/L_F(25%),S_0/L_Y(12%),S_0/L_C(11%),and S_(-15)/L_Y(7%)were identified.Six new SNPs were detected at the Wx-L locus.These results will facilitate common millet breeding,especially of cultivars free of amylose. | Ruiyun Wang Haigang Wang Xiaohuan Liu Xu Ji Ling Chen Ping Lu Minxuan Liu Bin Teng Zhijun Qiao | 2018 | The Crop Journal2018，6，4： | 10 |
| 4 | Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells显示文摘Oxaliplatin 是在 colorectal 癌,而是它的毒性的化疗的重要的药,特别剂量相关的 neurosensory 毒性,很好没被容忍。在这研究,我们调查了 honokiol 是否能在 vitro 在结肠癌 HT-29 房间扩充 oxaliplatin 的反肿瘤效果并且 honokiol 是否能与 oxaliplatin 被使用到减少 oxaliplatin 剂量。我们使用了正常冒号房间,人的结肠的上皮的房间(HCoEpiCs ) 作为控制房间。细胞增长, apoptosis,前列腺素 E2 (PGE2 ) 和脉管的 endothelial 生长因素(VEGF ) 层次也被调查。cyclo-oxygenase 的表示层次 2 (COX-2 ) , VEGF, AKT/p-AKT,细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 1/2/p-ERK1/2,原子因素 kappa B (NF-B ) P65/p-P65,和 caspase-3 被测量。Honokiol 或 oxaliplatin 以一种集中依赖者方式,而是 honokiol 的仅仅高的集中压制了 HT-29 房间的增长将压制 HCoEpiCs 的增长。HT-29 房间面对 honokiol 对 oxaliplatin 治疗更敏感。与 honokiol 相结合的 Oxaliplatin 改进了 HT-29 房间的 apoptosis 率并且减少了 PGE2 和 VEGF 分泌物层次。COX-2 和 VEGF 蛋白质和 AKT, ERK1/2,和 NF-B P65 的 phosphorylation 的表示层次也被禁止。Caspase-3 层次是在 honokiol 处理以后的 upregulated。因此, honokiol 能在结肠癌的化疗与 oxaliplatin 在联合被使用。这联合在 oxaliplatin 剂量允许减小,并且从而减少它的不利效果。它可以也为这疾病提高 oxaliplatin 的化学疗法的效果。 | Hanju Hua Wenbin Chen Ling Shen Qinsong Sheng Lisong Teng | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 7 |
| 5 | Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation显示文摘Oral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride(CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a doubleblinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were pro?led via 16 S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index.Cetylpyridinium chloride conferred gingival bene?ts, as progression of gingival in?ammation resulting from a lack of dental hygiene was signi?cantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque α and β diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitisenriched taxa. The ?ndings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population. | Fei Teng Tao He Shi Huang Cun-Pei Bo Zhen Li Jin-Lan Chang Ji-Quan Liu Duane Charbonneau Jian Xu Rui Li Jun-Qi Ling | 2016 | International Journal of Oral Science2016，8，3： | 6 |
| 6 | Eogenetic Karst in Interbedded Carbonates and Evaporites and Its Impact on Hydrocarbon Reservoir: A New Case from Middle Triassic Leikoupo Formation in Sichuan Basin, Southwest China显示文摘Karst in interbedded carbonates and evaporites has been reported to have important and complex impacts on reservoir. It is significant for exploration and karst geology. Here, we report such a new case from Middle Triassic Leikoupo Formation of Sichuan Basin, Southwest China. Stratigraphic incompleteness and the occurrence of unconformity provide evidence for the presence of eogenetic karst. Under the impact of this eogenetic karst, residual weathered and solution-collapse breccia, solution pores and silicification and dedolomitization have been observed. Classic stratigraphic zonation of karst is not readily distinguishable, which is ascribed to the stratigraphic collapse of carbonate rocks resulting from the dissolution of evaporites by lateral subsurface fluid flow. In terms of impact on reservoir quality, karst can generally improve the initial physical property of the porous layers in theory. However, subsurface fluid flow dissolved the evarporitic beds and facilitated the collapse of overlying strata. As a consequence, the lateral continuity of the reservoirs would be destroyed, and relatively high-quality reservoirs can only be developed with little collapse of overlying strata, reflecting reservoir heterogeneities. This may be a general feature of reservoir formation under the impact of karst in interbedded carbonates and evaporites. | Hong Liu Xiucheng Tan Ling Li Xiong Ding Jian Cao Guang Yang Teng Ma | 2019 | Journal of Earth Science2019，30，5： | 5 |
| 7 | Genomic surveillance of coxsackievirus A10 reveals genetic features and recent appearance of genogroup D in Shanghai,China,2016–2020显示文摘Coxsackievirus A10(CVA10)is one of the major causative agents of hand,foot and mouth disease(HFMD).To investigate the epidemiological characteristics as well as genetic features of CVA10 currently circulating in Shanghai,China,we collected a total of 9,952 sporadic HFMD cases from January 2016 to December 2020.In the past five years,CVA10 was the fourth prevalent causatives associated with HFMD in Shanghai and the overall positive rate was 2.78%.The annual distribution experienced significant fluctuations over the past five years.In addition to entire VP1 sequencing,complete genome sequencing and recombination analysis of CVA10 isolates in Shanghai were further performed.A total of 64 near complete genomes and 11 entire VP1 sequences in this study combined with reference sequences publicly available were integrated into phylogenetic analysis.The CVA10sequences in this study mainly belonged to genogroup C and presented 91%-100%nucleotide identity with other Chinese isolates based on VP1 region.For the first time,our study reported the appearance of CVA10 genogroup D in Chinese mainland,which had led to large-scale outbreaks in Europe previously.The recombination analysis showed the recombination break point located between 5,100 nt and 6,700 nt,which suggesting intertypic recombination with CVA16 genogroup D.To conclusion,CVA10 genogroup C was the predominant genogroup in Shanghai during 2016-2020.CVA10 recombinant genogroup D was firstly reported in circulating in Chinese mainland.Continuous surveillance is needed to better understand the evolution relationships and transmission pathways of CVA10 to help to guide disease control and prevention. | Jiayu Wang Jiajing Liu Fanghao Fang Jiajin Wu Tianjiao Ji Yuying Yang Ling Liu Chongshan Li Wanju Zhang Xi Zhang Zheng Teng | 2022 | Virologica Sinica2022，37，2： | 5 |
| 8 | Numerical study on effect of tidal phase on storm surge in the South Yellow Sea显示文摘Because of the special topography and large tidal range in the South Yellow Sea,the dynamic process of tide and storm surge is very complicated.The shallow water circulation model Advanced Circulation(ADCIRC)was used to simulate the storm surge process during typhoon Winnie,Prapiroon,and Damrey,which represents three types of tracks attacking the South Yellow Sea,which are,moving northward after landing,no landing but active in offshore areas,and landing straightly to the coastline.Numerical experiments were carried out to investigate the effects of tidal phase on the tide-surge interaction as well as storm surge.The results show that the peak surge caused by Winnie and Prapiroon occurs 2-5 h before the high tide and its occurring time relative to high tide has little change with tidal phase variations.On the contrary,under the action of Damrey,the occurring time of the peak surge relative to high tide varies with tidal phase.The variation of tide-surge interaction is about 0.06-0.37 m,and the amplitude variations of interaction are smooth when tidal phase changes for Typhoon Winnie and Prapiroon.While the interaction is about 0.07-0.69 m,and great differences exists among the stations for Typhoon Damrey.It can be concluded that the tide-surge interaction of the former is dominated by the tidal phase modulation,and the time of surge peak is insensitive to the tidal phase variation.While the interaction of the latter is dominated by storm surge modulation due to the water depth varying with tide,the time of surge peak is significantly affected by tidal phase.Therefore,influence of tidal phase on storm surge is related to typhoon tracks which may provide very useful information at the design stage of coastal protection systems. | ZHANG Weisheng TENG Ling ZHANG Jinshan XIONG Mengjie YIN Chengtuan | 2019 | Journal of Oceanology and Limnology2019，37，6： | 5 |
| 9 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 10 | Preface显示文摘Wide bandgap semiconductors play more and more important roles in both scientific researches and industrial applications.The unique wide bandgap properties provide a platform for flexible functional design for crystal growth,defect engineering,interface engineering,and device construction.Meanwhile,the underlying physical | Shuyan Guo Weijun Ling Hao Teng Wei Zhang Lifeng Wang Zhiyi Wei | 2014 | Chinese Science Bulletin2014，59，12： | 4 |
| 11 | Study on Wave Dissipation of the Structure Combined by Baffle and Submerged Breakwater显示文摘This paper proposes a structure combined by baffle and submerged breakwater(abbreviated to SCBSB in the following texts). Such a combined structure is conducive to the water exchange in the harbor, and has strong capability on wave dissipation. Our paper focuses on the discussion of two typical structures, i.e., the submerged baffle and rectangular breakwater combined with the upper baffle respectively, which are named as SCBSB1 and SCBSB2 for short. The eigenfunction method corrected by experimental results is used to investigate the wave dissipation characteristics. It shows that the calculated results agree well with the experimental data and the minimum value of the wave transmission coefficient can be obtained when the distance between the front and rear structures is from 1/4 to 1/2 of the incident wave length. | JU Lie-hong zuo Qi-hua TENG Ling WANG Xing-gang | 2017 | China Ocean Engineering2017，31，6： | 4 |
| 12 | Effects of resistin-like molecule β over-expression on gastric cancer cells in vitro显示文摘AIM: To investigate the effects of resistin-like molecule β (RELMβ) over-expression on the invasion, metastasis and angiogenesis of gastric cancer cells. METHODS: Human RELMβ encoding expression vec tor was constructed and transfected into the RELMβ lowly-expressed gastric cancer cell lines SGC7901 and MKN-45. Gene expression was measured by Western blotting, reverse transcription polymerase chain reaction (PCR) and real-time quantitative PCR. Cell proliferation was measured by 2-(4,5-dimethyltriazol-2-yl)-2,5-diphenyl tetrazolium bromide colorimetry, colony formation and 5-ethynyl-20-deoxyuridine incorporation assays. The in vitro migration, invasion and metastasis of cancer cells were measured by cell adhesion assay, scratch assay and matrigel invasion assay. The angiogenic capabilities of cancer cells were measured by tube formation of endothelial cells. RESULTS: Transfection of RELMβ vector into SGC-7901 and MKN-45 cells resulted in over-expression of RELMβ, which did not infl uence the cellular proliferation. However, over-expression of RELMβ suppressed the in vitro adhesion, invasion and metastasis of cancer cells, accompanied by decreased expression of matrix metalloproteinase-2 (MMP-2) and MMP-9. Moreover, transfection of RELMβ attenuated the expression of vascular endothelial growth factor and in vitro angiogenic capabilities of cancer cells. CONCLUSION: Over-expression of RELMβ abolishes the invasion, metastasis and angiogenesis of gastric cancer cells in vitro, suggesting its potentials as a novel therapeutic target for gastric cancer. | Li-Duan Zheng Ling Tong Chun-Lei Yang Teng Qi Meng Qi Qiang-Song Tong | 2012 | World Journal of Gastroenterology2012，18，8： | 4 |
| 13 | Infrared drying kinetics and moisture diffusivity modeling of pork显示文摘This study investigated the drying kinetics of pork slice in infrared drying condition.Drying temperature,slice thickness and initial moisture content were selected as influencing factors on the drying characteristics and drying rate of pork slice.Drying curves obtained from the experimental data were fitted to semi theoretical and/or empirical thin layer drying models.The effects of drying temperature and slice thickness on the model constants were evaluated by the multiple regression method.All the models were compared according to three statistical indexes,i.e.,root mean square error,chi-square and modeling efficiency.The slice thickness,drying temperature and initial moisture content have significant influences on the effective diffusivity coefficient of pork.The results showed that the drying rate of pork slices increased with the increases of drying temperature and initial moisture content.The decreases of slice thickness also led to an increase of drying rate.The Henderson and Pabis model can best describe the drying curves of pork. | Ling Jing Teng Zhaosheng Lin Haijun Wen He | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 3 |
| 14 | Analytical method of Cr stable isotope and its application to water pollution survey显示文摘High Cr(VI) concentration is a potential serious risk to environment and ecologic system.Thus,it is essential to effectively monitor Cr contamination in water systems and scientifically evaluate its evolution trend.A new method of in-situ tracer technique by Cr isotopic analysis for quantitatively estimating Cr-contamination and its regional evolution in natural waters as well as a case application are reported in this paper.Based on documented literatures,an experimental procedure for chemical separation and purification of Cr in water samples and its analytical method for Cr isotopic measurement by thermal ionization mass spectrometry(TIMS) are established.Eleven samples collected around a chemical factory in Hubei Province were analyzed by this technique.These samples showδ53Cr values ranging from-1.7‰to 7.3‰and an elevating trend with an increasing in distance from the sampling site to pollution source.A functional correlation following Rayleigh fractionation law was established between sample'sδ53Cr value and its extent of Cr contamination.This study suggests that Cr isotopic analysis is an effective method to reveal the spatial distribution and its evolution trend of Cr contamination in the regional water system.It is thus helpful to assessing the self-purifying ability of local water system according to Cr isotopic fractionation. | GAO YongJuan 1,2,3,MA Teng 4,5,LING WenLi 1,2,LIU CunFu 4,5 & LI Li 4,5 1Faculty of Earth Science,China University of Geosciences,Wuhan 430074,China 2State Key Laboratory of Geological Processes and Mineral Resources,China University of Geosciences,Wuhan 430074,China 3 Graduate School,China University of Geosciences,Wuhan 430074,China 4 Biogeological and Environmental Geology Laboratory of Ministry of Education(China University of Geosciences) ,Wuhan 430074,China 5 Sino-Hungary Joint Laboratory of Environmental Sciences and Health,China University of Geosciences,Wuhan 430074,China | 2010 | Chinese Science Bulletin2010，55，7： | 3 |
| 15 | Improved method for prediction of milled rice moisture content based on Weibull distribution显示文摘The loss on drying method,which is regarded as the standard method of rice moisture content analysis,provides the most reliable results but is both labor intensive and time consuming.In order to improve the detection efficiency of the loss on drying method,this study investigated the drying characteristics of milled rice and developed an information fusion algorithm with which to predict milled rice moisture content based on the Weibull distribution and Levenberg-Marquardt(LM)algorithm.Application of the Weibull distribution model was investigated regarding its description of the drying kinetics of milled rice during infrared drying.An adaptive mechanism was applied to algorithm design,with the starting point of the estimation algorithm determined by calculating the drying rate at each measuring point,and the end-point distinguished using a two-level threshold algorithm.The calculated results were then compared with the measured data regarding the infrared drying of milled rice.For milled rice samples varying in moisture content from 14.44%-17.67%(dry basis),the relative error between predicted and observed values ranged 0.0037-0.0589,with a reduction in test time of 50.71%-67.87%. | Jing Ling Zhaosheng Teng Haijun Lin | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 3 |
| 16 | Structural deformation, metallogenic epoch and genetic mechanism of the Woxi Au-Sb-W deposit, Western Hunan Province, South China显示文摘The remobilization,migration,precipitation,and enrichment of ore-forming elements are closely related to structures.Therefore,detailed regional and ore-field structural analyses are critical for determining the genesis of a mineral deposit.The Jiangnan Orogenic Belt(JOB)is an important gold polymetallic metallogenic belt in South China,which is characterized by multiple periods of gold mineralization in the Paleozoic and Mesozoic.However,the genesis of these gold polymetallic deposits is still not well understood due to a lack of systematic research on the regional geology,ore-controlling structures and metallogenic mechanism.In this study,a detailed structural survey at the surface and in the subsurface tunnels was conducted on the Woxi Au-Sb-W deposit,the genesis of which is relatively controversial among the gold polymetallic deposits in the JOB due to poor structural constraints.In addition,a wolframite U-Pb dating was carried out to further constrain the relationship between structures and mineralization.Based on the results of these studies,together with those from previous studies,it is proposed that the Woxi deposit and surrounding areas likely underwent six periods of regional deformation,which are constrained in time and geodynamic setting.Furthermore,we present a systematic discussion on the roles of ore-controlling structures in the transportation,distribution,and deposition of ore-forming elements and localization of orebodies.According to the wolframite dating results,structural analyses,and previous data,we propose that the Woxi Au-Sb-W deposit was formed in two stages during the Yanshanian:a W(wolframite)-Au mineralization stage at ca.140 Ma and an Au-Sb-W(scheelite)mineralization stage at<130 Ma.These mineralizing events are interpreted to have a tight relationship with tectonic reactivation,and the ore-forming fluids were derived from deep sources,including those of magmatic or metamorphic origins.The Woxi deposit can therefore be classified as an“intracontinental reactivation-type”,and the mineralization is related to lithospheric extension caused by plate retreat,retention,and delamination following the cessation of westward subduction of the Paleo-Pacific Plate beneath the East Asian continent. | Bin LI Deru XU Daoyuan BAI Guoxiang CHI Junfeng DAI Cheng GAO Teng DENG Shaohao ZOU Wen MA Guojian WANG Yuexin LING Guangqian ZENG Yinmin LI | 2022 | Science China Earth Sciences2022，65，12： | 2 |
| 17 | Effects of Blast Wave-induced Biomechanical Changes on Lung Injury in Rats显示文摘Objective To observe the dynamic impacts of shock waves on the severity of lung injury in rats with different injury distances.Methods Simulate open-field shock waves;detect the biomechanical effects of explosion sources at distances of 40,44,and 48 cm from rats;and examine the changes in the gross anatomy of the lungs,lung wet/dry weight ratio,hemoglobin concentration,blood gas analysis,and pathology.Results Biomechanical parameters such as the overpressure peak and impulse were gradually attenuated with an increase in the injury distance.The lung tissue hemorrhage,edema,oxygenation index,and pathology changed more significantly for the 40 cm group than for the 44 and 48 cm groups.The overpressure peak and impulse were significantly higher for the 40 cm group than for the 44 and 48 cm groups(P<0.05 or P<0.01).The animal mortality was significantly higher for the 40 cm group than for the other two groups(41.2%vs.17.8%and 10.0%,P<0.05).The healing time of injured lung tissues for the 40 cm group was longer than those for the 44 and 48 cm groups.Conclusions The effects of simulated open-field shock waves on the severity of lung injuries in rats were correlated with the injury distances,the peak overpressure,and the overpressure impulse. | LIU Wei CHAI Jia Ke QIN Bin HAN Shao Fang WANG Xiao Teng JIANG Shuai BAI Hai Liang LIU Ling Ying CHANG Yang YUE Xiao Tong WU Yu Shou ZHANG Zi Hao TANG Lang | 2020 | Biomedical and Environmental Sciences2020，33，5： | 2 |
| 18 | Influence of kaolinite and montmorillonite on benzo[a]pyrene biodegradation by Paracoccus aminovorans HPD-2 and the underlying interface interaction mechanisms显示文摘Clay minerals play an important role in biogeochemical cycling.Here,kaolinite and montmorillonite,the two most abundant and widespread clay minerals with typical layered structures,were selected to investigate and compare their effects on the biodegradation of benzo[a]pyrene(BaP)by Paracoccus aminovorans HPD-2 and to investigate the underlying interface mechanisms.Overall,the BaP degradation efficiency was significantly higher 7 d after montmorillonite addition,reaching 68.9%(P<0.05),when compared with that of the control without addition of clay minerals(CK,61.4%);however,the addition of kaolinite significantly reduced the BaP degradation efficiency to 45.8%.This suggests that kaolinite inhibits BaP degradation by inhibiting the growth of strain HPD-2,or its strong hydrophobicity and readily agglomerates in the degradation system,resulting in a decrease in the bio-accessibility of BaP to strain HPD-2.Montmorillonite may buffer some unfavorable factors,and cells may be fixed on the surface of montmorillonite colloidal particles across energy barriers.Furthermore,the adsorption of BaP on montmorillonite may be weakened after swelling,reducing the effect on the bio-accessibility of BaP,thus promoting the biodegradation of BaP by strain HPD-2.The experimental results indicate that differential bacterial growth,BaP bio-accessibility,interface interaction,and the buffering effect may explain the differential effects of the different minerals on polycyclic aromatic hydrocarbon biodegradation.These observations improve our understanding of the mechanisms by which clay minerals,organic pollutants,and degrading bacteria interact during the biodegradation process and provide a theoretical basis for increasing the biodegradation of soil pollutants by native microorganisms under field conditions. | Xinhong GAN Ying TENG Jian XU Ning ZHANG Wenjie REN Ling ZHAO Peter CHRISTIE Yongming LUO | 2022 | Pedosphere2022，32，2： | 2 |
| 19 | Two new furostanol saponins from the seeds of Allium cepa L.显示文摘从瞀或蒜之类 cepa L 的种子的 n-BuOH 摘录的 Phytochemical 分析。导致了四 furostanol saponins,其二是新混合物,命名 ceparoside A (1a ) 和 ceparoside B (2a ) 的隔离。新混合物的化学结构通过 NMR 的联合被阐明, MS 光谱数据和化学分析。 | Ling Yuan Teng Fei Ji Ai Guo Wang Jian Bo Yang Ya Lun Su | 2008 | Chinese Chemical Letters2008，19，4： | 2 |
| 20 | Supercritical fluid extraction and clean-up of organ-chlorine pesticides in Chinese herbal medicine显示文摘 | Ling Y H Teng H C Cartwright C | 1999 | J Chromatogr A1999，835，： | 1 |
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