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| 1 | MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells显示文摘 | Xiaomin Dang Aiqun Ma Lan Yang Hao Hu Bo Zhu Dong Shang Tianjun Chen Yu Luo | 2012 | Cancer Genetics2012，，3： | 1 |
| 2 | Effects of Thirty Days Isolation on Attention Networks: A Behavioral and Event-related Potential Study显示文摘Kear Editor,Individuals in isolated,confined,and extreme environments,such as astronauts,researchers wintering over Antarctica,submarine soldiers,and participants in simulated isolation environment experiments,commonly report difficulty in focusing their attention[1,2].However,current experimental findings from studies conducted in such environments are insufficient to fully support these self-reports of reduced attention.Certain attention-demanding tasks such as simple reaction time(RT)tasks and dual tasks,including primary pursuit tracking and secondary RT,were not affected in space flight experiments[2,3]. | Jingda Feng Bin Wu Ziqing Cao Hailong Chen Tianjun Lan Haibo Qin Yusheng Shi Weifen Huang Yinghui Li | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 3 | Regulation of RNA methylation and immune infiltration patterns by m5C regulators in head and neck squamous cell carcinoma显示文摘5-Methylcytosine(m5C)methylation contributes to the development and progression of various malignant tumors.This study aimed to explore the potential role of m5C methylation regulators(m5CMRs)in head and neck squamous cell carcinoma(HNSCC).Methods:The transcription data of HNSCC samples were obtained from The Cancer Genome Atlas(TCGA)and the Gene Expression Omnibus(GEO)databases.Subsequently,the m5C patterns in HNSCC were evaluated based on 14 m5CMRs.Then,the m5Cscore was developed to quantify m5C patterns by using principal component analysis(PCA)algorithms.Two single-cell RNA sequencing datasets and various methods were employed to assess the prognostic value and sensitivity to immunotherapy.Finally,key prognostic m5CMRs were identified using univariate COX regression analysis,and their clinical significance was validated based on the Human Protein Atlas(HPA)database and by using immunohistochemistry.Results:Two distinct m5C clusters were identified.m5C cluster A is characterized by an immune-activated microenvironment and is associated with a favorable prognosis.Notable differences were observed in prognosis,immune infiltration,and immunotherapy response between the high-and low-m5Cscore groups.Patients in the high-m5Cscore group exhibited high TMB,which is correlated with poor prognosis.The m5Cscore of epithelial cells in HNSCC was higher than that in other cells.Key prognostic m5CMRs,including NSUN2,DNMT3B,ALKBH1,and Y-Box Binding Protein 1(YBX1),were associated with poor prognosis.Conclusion:Our research indicates that in head and neck squamous cell carcinoma,the m5C modification profoundly affects the TME’s diversity and complexity,influencing prognosis and the success of immunotherapy.Targeting m5C regulatory elements may be a new method for enhancing the efficacy of immunotherapy in HNSCC. | SHIDA HOU TIANJUN LAN YAOCHENG YANG PEISHENG LIANG XIN LIU JUNJIE WANG ZHIFENG CHEN RONGSHENG ZENG ZIJING HUANG | 2023 | BIOCELL2023，47，12： | 0 |
| 4 | Intratumoral CD103+CD8+T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma显示文摘Background Immune cell heterogenicity is known to determine the therapeutic response to cancer progression.Neoadjuvant chemoimmunotherapy(NACI)has shown clinical benefits in some patients with advanced head and neck squamous cell carcinoma(HNSCC),but the underlying mechanism behind this clinical response is unknown.The efficacy of NACI needs to be potentiated by identifying accurate biomarkers to predict clinical responses.Here,we attempted to identify molecules predicting NACI response in advanced HNSCC.Methods We performed combined single-cell RNA sequencing(scRNA-seq)and multiplex immunofluorescence(mIHC)staining with tumor samples derived from NACI-treated HNSCC patients to identify a new tumor-infiltrating cell(TIL)subtype,CD103+CD8+TILs,associated with clinical response,while both in vitro and in vivo assays were carried out to determine its antitumor efficiency.The regulatory mechanism of the CD103+CD8+TILs population was examined by performing cell-cell interaction analysis of the scRNA-seq data and spatial analysis of the mIHC images.Results We established intratumoral CD103+CD8+TILs density as a determinant of NACI efficacy in cancers.Our scRNA-seq results indicated that the population of CD103+CD8+TILs was dramatically increased in the responders of NACI-treated HNSCC patients,while mIHC analysis confirmed the correlation between intratumoral CD103+CD8+TILs density and NACI efficacy in HNSCC patients.Further receiver operating characteristic curve analysis defined this TIL subset as a potent marker to predict patient response to NACI.Functional assays showed that CD103+CD8+TILs were tumor-reactive T cells,while programmed cell death protein-1(PD-1)blockade enhanced CD103+CD8+TILs cytotoxicity against tumor growth in vivo.Mechanistically,targeting the triggering receptor expressed on myeloid cells 2-positive(TREM2+)macrophages might enhance the population of CD103+CD8+TILs and facilitate antitumor immunity during NACI treatment.Conclusions Our study highlights the impact of intratumoral CD103+CD8+TILs density on NACI efficacy in different cancers,while the efforts to elevate its population warrant further clinical investigation. | Siqi Ren Tianjun Lan Fan Wu Suling Chen Xue Jiang Chuying Huo Zitian Li Shule Xie Donghui Wu Ruixin Wang Yanyan Li Lin Qiu Guoxin Huang Shurui Li Xiaojuan Wang Meifeng Cen Tingting Cai Zhaoyu Lin Jinsong Li Bowen Li | 2023 | Cancer Communications2023，43，10： | 0 |
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