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| 1 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 2 | Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant显示文摘Dear Editor,Genetic variant Delta(B.1.617.2)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which possesses a remarkable ability to transmit and spread,is currently becoming predominant worldwide.Despite its great harm to human beings,how the Delta variant with T478K,P681R and L452R mutations achieves its ultrafast spread remains elusive.Entry of SARS-CoV-2 into host cells is mediated by a rapid enzymatic hydrolysis. | Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Wei-Min Tong Jiangning Liu Chuan Qin Bo Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 3 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 4 | SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages显示文摘Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 infection.Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation.This pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal acidification.In addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects.These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future. | Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 5 | Characteristics of overpressure distribution and its implication for hydrocarbon exploration in the Qiongdongnan Basin显示文摘 | Wanzhong Shi Yuhong Xie Zhenfeng Wang Xusheng Li Chuanxin Tong | 2013 | Journal of Asian Earth Sciences2013，，： | 1 |
| 6 | Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages显示文摘Dear Editor,Alveolar macrophages(AMs)are among the first immune cells to encounter SARS-CoV-2 during an infection due to their abundant numbers and physical location in the lungs.Thus,the reaction of AMs to SARS-CoV-2 has a profound impact on the outcome of the infection.In most cases,AMs can release cytokines and prime adaptive T-and B-cell immune responses to resolve the infection. | Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Jiangning Liu Chuan Qin Wei-Min Tong Bo Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 7 | Petroleum ge- ology of Yacheng 13-1, the largest gas field in China's off shore region 显示文摘 | Xie Yuhong Wang Zhenfeng Tong Chuanxin | 2008 | Marine and Petroleum Geology2008，25，8： | 1 |
| 8 | Petroleum ge- ology of Yaeheng 13-1, the largest gas field in China's off- shore region显示文摘 | Xie Yuhong Wang Zhenfeng Tong Chuanxin | 2008 | Marine and Petroleum Geology2008，25，8： | 1 |
| 9 | Petroleum ge- ology of Yacheng 13-1, the largest gas field in China's off- shore region显示文摘 | Yuhong Xie Zhenfeng Wang Chuanxin Tong | 2008 | Marine and Petroleum Geology2008，25，： | 1 |
| 10 | Tensile Test of Rod and Tube Sample of Zirconium Alloy Material显示文摘Zirconium alloy is an important structural material for reactor fuel assemblies (including cladding,guide tube,etc.).In order to ensure the integrity of fuel assemblies during service,it is required that zirconium alloy materials have good high temperature mechanical properties. | ZHAO Yingchao YU Bintao NING Guangsheng TONG Zhenfeng | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 11 | Effect of Martensitic Microstructure Change on Fracture Behavior of 17-4PH Martensitic Stainless Steel Used in Nuclear Power Plant after Thermal Aging显示文摘For thermal aging behavior of 17-4PH martensitic stainless steel,the former results show that the mechanical properties will be significant degeneration under long-time service at high temperature(~300℃).It exhibits a sharp increase of DBTT and embrittlement,with hardness increased and plasticity worse.In the work,EBSD are used for 17-4PH martensitic stainless steel with significant thermal aging effect. | BAI Bing ZHANG Changyi TONG Zhenfeng YANG Wen | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 12 | Fatigue Mechanism of Domestic 316LN Stainless Steel in Simulation AP1000 First Loop Water Environment显示文摘316LN stainless steel is the primary coolant pipe material of AP1000 NPP which is one kind of the advanced 3rd generation NPPs.Studying fatigue failure mechanism of 316LN S.S is significant to the NPPs operation safety and material improvement.In this paper,the fatigue failure samples of 316LN S.S which test in the simula- | ZHONG Weihua TONG Zhenfeng YANG Wen | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 13 | Research on Radiation Aging Properties of Boron Polyethylene显示文摘Boron polyethylene is a shielding wall material for the reactor pit cell,which is irradiated by a large dose of radiation for a long time.In order to meet the needs of shielding wall’s subsequent use,maintenance and replacement,we must carry out research on the physical properties of the material after irradiation,so as to provide data support for it. | YU Bintao WANG Chenglong LIN Yun TONG Zhenfeng | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 14 | Creep Test of Zr Alloy Pipe显示文摘Nuclear fuel cladding is an important guarantee for the safe and stable operation of the reactor,but its working conditions are particularly harsh and need to work in a high temperature and high pressure environment for a long time.In order to ensure the safe operation of the reactor,the cladding should maintain integrity in | YU Bintao NING Guangsheng ZHAO Yingchao TONG Zhenfeng | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 15 | Multi-Layer Tree Hierarchical Architecture Based on Web Service显示文摘To solve the problem of the information share and services integration in population information system, we propose a multi-layer tree hierarchical architecture. The command (Web Service Call) is recursively multicast from top layer of tree to bottom layer of tree and statistical data are gathered from bottom layer to top layer. We implemented the architecture by using Web Services technology. In our implementation, client program is the requestor of Web Services, and all leaf nodes of the last layer are only the provider of Web Services. For those nodes of intermediate layers, every node is not only the provider of Web Services, but also the dispatcher of Web Services. We take population census as an example to describe the working flow of the architecture. | TONG Hengjian LI Deren ZHU Xinyan SHAO Zhenfeng | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 0 |
| 16 | Analysis of Microstructure of Reactor Pressure Vessel Steel due to Thermal Aging Effect by Small-angle Neutron Scattering显示文摘Reactor pressure vessels are of great importance for nuclear power safety and play an extremely important role in the safe operation of reactors and in preventing nuclear leakage.As material microstructure probe,neutrons have the advantages of high penetrability,ability to distinguish between adjacent nuclide and sensitivity to magnetism.The small-angle neutron scattering can accurately obtain the size distribution,volume fraction and composition of the defects of the nanosized copper clusters in the pressure vessel steel matrix,revealing the microstructure mechanism of the macroscopic mechanical properties.The thermal aging supervision samples from a nuclear power plant in China had been analyzed by small-angle neutron scattering. | LI Bonan WANG Zijun LIU Rongdeng HAN Songbai SUN Kai CHEN Dongfeng LIU Yuntao WANG Chenglong TONG Zhenfeng LI Tianfu | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 17 | Small Angle Scattering Study of Nano-precipitates in Stainless Steel from Nuclear Power Plant显示文摘Upon long period of service at the nulcear power plant,17-4PH stainless steel valve stems become brittle.The main structural reason for this aging effect is due to the formation of nanoprecipitates in the material.Therefore it is very necessary to carefully investigate the nano-structure change inside this material.Small angle neutron scattering(SANS)is a powerful in | LIU Yuntao ZHANG Peipei LI Tianfu WANG Zijun CHEN Dongfeng SUN Kai WANG Hongli ZHANG Li LIU Rongdeng LI Bonan TONG Zhenfeng BAI Bing | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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