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| 1 | Arsenic Disulfide Induced Apoptosis and Concurrently Promoted Erythroid Differentiation in Cytokine-Dependent Myelodysplastic Syndrome-progressed Leukemia Cell Line F-36p with Complex Karyotype Including Monosomy 7显示文摘Objective:Acute myeloid leukemia progressed from myelodysplastic syndrome(MDS/AML)is generally incurable with poor prognosis for complex karyotype including monosomy 7(-7).Qinghuang Powder(青黄散,QHP),which includes Qing Dai(Indigo naturalis)and Xiong Huang(realgar)in the formula,is effective in treating MDS or MDS/AML even with the unfavorable karyotype,and its therapeutic efficacy could be enhanced by increasing the Xiong huang content in the formula,while Xiong huang contains>90%arsenic disulfide(As_2S_2).F-36p cell line was established from a MDS/AML patient with complex karyotype including-7,and was in cytokine-dependent.The present study was to investigate the effects of AS_2S_2 on F-36p cells.Methods:Cell proliferation was measured by an3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.Cell apoptosis was identified by Annexin V-staining.Cell viability was determined by a propidium iodide(PI)exclusion.Erythroid differentiation was evaluated by the expression of cell surface antigen CD235a(GpA).Results:After treatment with AS_2S_2,at concentrations of 0.5to 16μmol/L for 72 h,As_2S_2 inhibited the proliferation of F-36p cells.The 50%inhibitory concentrations(IC_(50))of As_2S_2against the proliferation of F-36p cells was 6μmol/L.The apoptotic cells significantly increased in a dose-dependent mannar(P<0.05).The cell viabilities were significantly inhibited by As_2S_2 dose-dependent in a dose-dependent manner(P<0.05).Significant increases of CD235a-positive cells were concurrently observed(P<0.05)also in a dosedependent manner.Conclusions:As_2S_2 could inhibit proliferation and viability,induce apoptosis,and concurrently promote erythroid differentiation dose-dependently in F-36p cells.AS_2S_2 can inhibit proliferation and viability,induce apoptosis,and concurrently promote erythroid differentiation in cytokine-dependent MDS-progressed human leukemia cell line F-36p with complex karyotype including-7.The data suggest that QHP and/or As_2S_2 could be a potential candidate in the treatment of MDS or MDS/AML even with unfavorable cytogenetics. | 胡晓梅 Sachiko Tanaka Kenji Onda 袁博 Hiroo Toyoda 麻柔 刘峰 Toshihiko Hirano | 2014 | Chinese Journal of Integrative Medicine2014，20，5： | 20 |
| 2 | 膨胀石墨对各种油类的吸附动力学(英文)显示文摘通过对吸附率(有效吸附系数)Ks和饱和吸附量msat的测量,描述了粘度为0.001Pa.s^0.850Pa.s的各种油类在膨胀石墨柱中的吸附动力学,发现吸附率Ks对油类粘度有很强的相关性。吸入膨胀石墨柱中的饱和吸附量msat几乎恒定在50kg/kg,该值略低于由膨胀石墨块直接浸渍在油中测得的吸附容量,这是由于所吸附的油沿膨胀石墨柱高度存在重力梯度。 | Michio INAGAKI Tomoya NAGATA Taisuke SUWA Masahiro TOYODA | 2006 | 新型炭材料2006，21，2： | 18 |
| 3 | Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B显示文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated. | Motohiro Shimizu Norihiro Furusyo Hiroaki Ikezaki Eiichi Ogawa Takeo Hayashi Takeshi Ihara Yuji Harada Kazuhiro Toyoda Masayuki Murata Jun Hayashi | 2015 | World Journal of Gastroenterology2015，21，7： | 18 |
| 4 | Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease显示文摘Adipose-derived mesenchymal stem cells(ADSCs) are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient's own subcutaneous adipose tissue, a high cell yield(i.e., reduced immune rejection response), accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, antiapoptotic effects, and control of immune cells via cellcell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry showed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein components of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease. | Saifun Nahar Yoshiki Nakashima Chika Miyagi-Shiohira Takao Kinjo Zensei Toyoda Naoya Kobayashi Issei Saitoh Masami Watanabe Hirofumi Noguchi Jiro Fujita | 2018 | World Journal of Stem Cells2018，10，11： | 11 |
| 5 | Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival显示文摘瞄准:80 年或更多与肝细胞癌(HCC ) 识别病人的临床、预示的特征。方法:有 HCC 的 1310 个病人的一个总数在这研究被包括。80 年或更多的 91 个病人在 HCC 的诊断的时候被定义为极其老的组。>
或 = 的 234 个病人 50 年但是不到 60 年被认为是非老的组。结果:两性比率(到女性的男性) 比在非老的组在极其老的组(0.90:1 ) 是显著地更低的(3.9:1, P <
0.001 ) 。为 HBsAg 的积极的率在极其老的组和为显然在极其老的组增加的 HBsAg 和 HCVAb 否定的病人的比例是显著地更低的(P <
0.001 ) 。在下列参数没有有效差量:肿瘤,分级的孩子呸,肿瘤阶段,门静脉血栓形成或腹水的存在,和为 HCVAb 的积极的率的直径和数字。极其老的病人经常没收到外科疗法(P <
0.001 ) 并且他们是更可能的收到保守疗法(P <
0.01 ) 。基于与在二个组之间的全面病人比较的 Kaplan-Meier 方法在幸存曲线没有有效差量。然而,幸存曲线在有阶段 I/II 的极其老的病人是显著地更坏的,上演 I/II,孩子呸分级与非老的组比较的肝硬化。死亡的原因没在病人之中不同,并且大多数盒子甚至在极其老的病人死于肝相关的疾病。结论:在有好肝功能和好表演地位的病人,为 HCC 的好攻击的治疗可能改进幸存率,甚至在极其老的病人。 | Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 6 | Market Disease Pathogens Detection of Imported Fruits in Shanghai显示文摘A tremendous amount of imported fresh fruits has been delivered to Shanghai markets, increasing the risk of invasion by harmful plant pathogens. Therefore, it is important to establish an effective detection and supervision system to survey the outbreak of the market diseases of the imported fruits during marketing. The samples were regularly surveyed in different markets to examine varieties, prices, localities, selling conditions, and diseases of the imported fruits from 2004 to 2008. The survey showed that 58 species of 30 different fruits were imported to Shanghai from 16 countries with more expensive price. The larger products were bananas, grapes, apples, and oranges. During the investigation, we found that the imported fruits frequently brought about the relatively serious market diseases. On the basis of morphology and the nuclear internal transcribed spacer (ITS) of ribosomal DNA (rDNA) analysis, 151 isolates of 15 fungi genera, which shown to be pathogenic after the inoculation assay, were finally identified. Among the identified fungi, Alternaria was the most frequent one with the highest detection rate (47.68%), followed by Penicillium (14.57%) and Fusarium (11.92%), respectively. Additionally, Pestalotiopsis microspora (detected in grapes Red-Globe coming from the USA) and Botrytis sp. (detected in black-plums coming from the USA) were first reported in China market. The present study summarized the selling situation of the imported fruits in Shanghai markets and constructed a library of the pathogens detected in the imported fruits during the selling period. The results obtained are useful to offer technical parameters for Chinese quarantine in order to prevent an invasion of the foreign harmful micro-organisms. | MA Teng-fei YANG Bo YU Yue WANG Yi-wen LIU Yi XU Zhen LIU Yan ZHU Pin-kuan ZHANG Wei ZHANG Zai-bao Toyoda Hideyoshi XU Ling | 2009 | Agricultural Sciences in China2009，8，9： | 5 |
| 7 | Identification of Naturally Occurring Polyamines as Root-Knot Nematode Attractants显示文摘Root-knot nematodes(RKNs;genus Meloidogyne)are a class of plant parasites that infect the roots of many plant species.It is believed that RKNs target certain signaling molecules derived from plants to locate their hosts;however,currently,no plant compound has been unambiguously identified as a universal RKN attractant.To address this question,we screened a chemical library of synthetic compounds for Meloidogyne incognita attractants.The breakdown product of aminopropylam ino-anthraquinone,1,3-diam inopropane,as well as its related compounds,putrescine and cadaverine,were found to attract M.incognita.After exam ining various polyamines,M.incognita were found to be attracted specifically by natural com pounds that possess three to five methylene groups between two terminal amino groups.Using cryo-TO F-SIM S/SEM,cadaverine was indeed detected in soybean root cortex cells and the surrounding rhizosphere,establishing a chemical gradient.In addition to cadaverine,putrescine and 1,3-diam inopropane were also detected in root exudate by HPLC-MS/MS.Furtherm ore,exogenously applied cadaverine is sufficient to enhance M.incognita infection of Arabidopsis seedlings.These results suggest that M.incognita is likely attracted by polyam ines to locate the appropriate host plants,and the naturally occurring polyamines have potential applications in agriculture in developing protection strategies for crops from RKN infection. | Morihiro Oota Allen Yi-Lun Tsai Dan Aoki Yasuyuki Matsushita Syuuto Toyoda Kazuhiko Fukushima Kentaro Saeki Kei Toda Laetitia Perfus-Barbeoch Bruno Favery Hayato Ishikawa Shinichiro Sawa | 2020 | Molecular Plant2020，13，4： | 4 |
| 8 | Involvement of leak K^+ channels in neurological disorders显示文摘TWIK-related acid-sensitive K+(TASK) channels give rise to leak K+ currents which influence the resting membrane potential and input resistance. The wide expression of TASK1 and TASK3 channels in the central nervous system suggests that these channels are critically involved in neurological disorders. It has become apparent in the past decade that TASK channels play critical roles for the development of various neurological disorders. In this review, I describe evidence for their roles in ischemia, epilepsy, learning/memory/cognition and apoptosis. | Hiroki Toyoda | 2015 | World Journal of Neurology2015，5，1： | 3 |
| 9 | Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development显示文摘AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging.RESULTS: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients. | Satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada | 2015 | World Journal of Hepatology2015，7，27： | 3 |
| 10 | Long-term effects of lamivudine treatment in Japanese chronic hepatitis B patients显示文摘AIM:To analyze the association between the emergence of tyrosine-methionine-asparatate-asparatate(YMDD) mutants(reverse transcription;rtM204I/V) and deterioration of liver function during long-term lamivudine treatment of Japanese patients with chronic hepatitis B virus(HBV) infection.METHODS:The data of 61 consecutive Japanese patients with chronic hepatitis B who underwent continuous lamivudine treatment for more than 24 mo and had a virological response were analyzed.Analysis of YMDD mutants was done by real-time polymerase chain reaction with LightCycler probe hybridization assay for up to 90 mo(mean,50.8 mo;range,24-90 mo).RESULTS:A mixed mutant-type(YMDD + tyrosine-isoleucine-asparatate-asparatate:YIDD or tyrosine-valineasparatate-asparatate:YVDD) or a mutant-type(YIDD or YVDD) were found in 57.4% of 61 patients at 1 year,78.7% of 61 patients at 2 years,79.6% of 49 patients at 3 years,70.5% of 34 patients at 4 years,68.4% of 19 patients at 5 years,57.1% of 14 patients at 6 years,and 33.3% of 6 patients at 7 years.Of the 61 patients,56(92%) had mixed mutant-or a mutant-type.Only 5(8%) had no mutants at each observation point.Virological breakthrough was found in 26(46.4%) of 56 patients with YMDD mutants,20 of whom had a hepatitis flare-up:the remaining 30(53.6%) had neither a virological breakthrough nor a flare-up.All 20 patients who developed a hepatitis flare-up had a biochemical and virological response after adefovir was added to the lamivudine treatment.CONCLUSION:Our results suggest that it is possible to continue lamivudine treatment,even after the emergence of YMDD mutants,up to the time that the patients develop a hepatitis flare-up. | Masayuki Murata Norihiro Furusyo Mami Unno Eiichi Ogawa Kazuhiro Toyoda Hiroaki Taniai Hachiro Ohnishi Jun Hayashi | 2011 | World Journal of Gastroenterology2011，17，24： | 3 |
| 11 | 牛奶中有机磷农药残留量简便分析法显示文摘鲜奶及奶制品中常含有有机磷农药残留,这主要是由于饲料在收获前用此类农药处理所致。国际乳制品联合会希望研制出一种测定牛奶中有机磷农药残留量的简便方法,但迄今未见报道。最近,有人提出一种测定糙米中有机磷农药的简便方法,即采用乙腈提取,用醋酸锌去除脂肪,抽滤后,再经二氯甲烷重复萃取,然后用配有大口径毛细管色谱柱及火焰光度检测器的气相色谱仪测定有机磷农药的含量。 | Masatake Toyoda 默涛 | 1992 | 农药译丛1992，14，2： | 3 |
| 12 | 由柏木制备纳米孔结构炭材料Ⅰ. 制备与孔结构(英文)显示文摘柏木条经过热蒸气处理,成功地制备了纳米孔炭,无需另行活化,比表面积就可达1000m2/g以上。如果在800℃~870℃炭化,柏木炭外表面积可达400m2/g以上,与同样温度在氩气中炭化得到的柏木炭相比,后者微孔面积仅为30m2/g~40m2/g。在900℃以上炭化得到的柏木炭,微孔表面积高达800m2/g以上,外表面积约为150m2/g。柏木炭的孔结构可以通过调节过热蒸气的温度得到控制。 | Eiki Ito Ikuyoshi Kouchi Sylwia Mozia Masaharu Okuda Takashi Nakano Masahiro Toyoda Michio Inagaki | 2007 | 新型炭材料2007，22，3： | 3 |
| 13 | T cell immune responses to SARS-CoV-2 and variants of concern(Alpha and Delta)in infected and vaccinated individuals显示文摘Our understanding of immune responses to SARS-CoV-2 and variants of concern(VOCs)has been primarily acquired through analysis of Spike-specific IgG responses.However,a more comprehensive understanding of the breadth and longevity of immune responses after infection and vaccination requires analysis of cellular immunity.Herein,we report on T cell immunity in infected and vaccinated individuals,identifying CD4+/CD8+T cell cytokine responses to SARS-CoV-2 and variant peptides(Alpha,B.1.1.7 and Delta,B.1.617.2). | Stanley C.Jordan Bong-Ha Shin Terry-Ann M.Gadsden Maggie Chu Anna Petrosyan Catherine N.Le Rachel Zabner Jillian Oft Isabel Pedraza Susan Cheng Ashley Vo Noriko Ammerman Jasmine Plummer Shili Ge Max Froch Anders Berg Mieko Toyoda Ruan Zhang | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 14 | Thoracoscopic en bloc total esophagectomy with radical mediastinal lymphadenectomy显示文摘 | Takashi Akaishi Iwao Kaneda Norio Higuchi Yoshiki Kuriya Jun-ichi Kuramoto Tsuneo Toyoda Akio Wakabayashi | 1996 | The Journal of Thoracic and Cardiovascular Surgery1996，，6： | 2 |
| 15 | The longitudinal quantitative assessment by transient elastography of chronic hepatitis C patients treated with pegylated interferon alpha-2b and ribavirin显示文摘 | Eiichi Ogawa Norihiro Furusyo Kazuhiro Toyoda Hiroaki Takeoka Shinji Maeda Jun Hayashi | 2009 | Antiviral Research2009，，2： | 2 |
| 16 | Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis显示文摘 | Kawasaki H Toyoda M Shinohara H | | 0，，： | 2 |
| 17 | Cronkhite-Canada syndrome: report of two cases显示文摘 | Ikuo Murata Ichiro Yoshikawa Masaaki Endo Mayumi Tai Chii Toyoda Shintaro Abe Yoshiaki Hirano Makoto Otsuki | 2000 | Journal of Gastroenterology2000，，9： | 2 |
| 18 | Sorption and recovery of heavy oils by using exfoliated graphite显示文摘 | Masahiro Toyoda | 2003 | Spill Science and Technology Bulletin2003，，： | 2 |
| 19 | Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum显示文摘Tumors of the minor papilla of the duodenum are quite rare.We successfully and safely treated an 18-mm adenoma of the minor papilla associated with pancreas divisum using endoscopic papillectomy.A 64-year-old man was admitted to our hospital for treatment of an asymptomatic mass in the minor papilla detected by upper gastrointestinal endoscopy.Endscopic analysis showed an 18-mm,whitish,sessile mass,located in the duodenum proximal to a normal-appearing major papilla.Endoscopic retrograde pancreatography did not reveal the pancreatic duct.Magnetic resonance cholangiopancreatography showed a lack of the ventral pancreatic duct.We suspected this case was associated with pancreatic divisum;therefore,we performed endoscopic papillectomy of the minor papilla tumor.Subsequently,endoscopic pancreatic stent placement in the minor papilla was done to prevent drainage disturbance.The patient has been asymptomatic without recurrence of tumor or stenosis of the Santorini orifice upon endoscopic examination for the past 2 years. | Akira Kanamori Takashi Kumada Seiki Kiriyama Yasuhiro Sone Makoto Tanikawa Yasuhiro Hisanaga Hidenori Toyoda Hiroki Kawashima Akihiro Itoh Yoshiki Hirooka Hidemi Goto | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 20 | Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy显示文摘 | Kyosuke Tanaka Hideki Toyoda Shigenori Kadowaki Ryo Kosaka Taizo Shiraishi Ichiro Imoto Hiroshi Shiku Yukihiko Adachi | 2006 | Journal of Gastroenterology2006，，4： | 2 |
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