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| 1 | Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival显示文摘瞄准:80 年或更多与肝细胞癌(HCC ) 识别病人的临床、预示的特征。方法:有 HCC 的 1310 个病人的一个总数在这研究被包括。80 年或更多的 91 个病人在 HCC 的诊断的时候被定义为极其老的组。>
或 = 的 234 个病人 50 年但是不到 60 年被认为是非老的组。结果:两性比率(到女性的男性) 比在非老的组在极其老的组(0.90:1 ) 是显著地更低的(3.9:1, P <
0.001 ) 。为 HBsAg 的积极的率在极其老的组和为显然在极其老的组增加的 HBsAg 和 HCVAb 否定的病人的比例是显著地更低的(P <
0.001 ) 。在下列参数没有有效差量:肿瘤,分级的孩子呸,肿瘤阶段,门静脉血栓形成或腹水的存在,和为 HCVAb 的积极的率的直径和数字。极其老的病人经常没收到外科疗法(P <
0.001 ) 并且他们是更可能的收到保守疗法(P <
0.01 ) 。基于与在二个组之间的全面病人比较的 Kaplan-Meier 方法在幸存曲线没有有效差量。然而,幸存曲线在有阶段 I/II 的极其老的病人是显著地更坏的,上演 I/II,孩子呸分级与非老的组比较的肝硬化。死亡的原因没在病人之中不同,并且大多数盒子甚至在极其老的病人死于肝相关的疾病。结论:在有好肝功能和好表演地位的病人,为 HCC 的好攻击的治疗可能改进幸存率,甚至在极其老的病人。 | Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 2 | IgG4-unrelated type 1 autoimmune pancreatitis显示文摘A 50-year-old male was referred to our hospital for the evaluation of hyperproteinemia.Fluorodeoxyglucose positron emission tomography revealed high fluorodeoxyglucose uptake in the pancreas,bilateral lacrimal glands,submandibular glands,parotid glands,bilateral pulmonary hilar lymph nodes,and kidneys.Laboratory data showed an elevation of hepatobiliary enzymes,renal dysfunction,and remarkably high immunoglobulin(Ig) G levels,without elevated serum IgG4.Abdominal computed tomography revealed swelling of the pancreatic head and bilateral kidneys.Endoscopic retrograde cholangiopancreatography showed an irregular narrowing of the main pancreatic duct in the pancreatic head and stricture of the lower common bile duct.Histological examination by endoscopic ultrasonography-guided fine-needle aspiration revealed findings of lymphoplasmacytic sclerosing pancreatitis without IgG4-positive plasma cells.Abnormal laboratory values and the swelling of several organs were improved by the treatment with steroids.The patient was diagnosed as having type 1 autoimmune pancreatitis(AIP) based on the International Consensus Diagnostic Criteria.Therefore,we encountered a case of compatible type 1 AIP without elevated levels of serum IgG4 or IgG4-positive plasma cells.This case suggests that AIP phenotypes are not always associated with IgG4. | Eriko Nakano Atsushi Kanno Atsushi Masamune Naoki Yoshida Seiji Hongo Shin Miura Tetsuya Takikawa Shin Hamada Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Keisuke Nakayama Fumiyoshi Fujishima Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，33： | 3 |
| 3 | Pancreatic duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy显示文摘The patient was a 30-year-old female who had undergone excision of the extrahepatic bile duct and Rouxen-Y hepaticojejunostomy for congenital biliary dilatation at the age of 7.Thereafter,she suffered from recurrent acute pancreatitis due to pancreaticobiliary maljunction and received subtotal stomach-preserving pancreaticoduodenectomy.She developed a pancreatic fistula and an intra-abdominal abscess after the operation.These complications were improved by percutaneous abscess drainage and antibiotic therapy.How ever,upper abdominal discomfort and the elevation of serum pancreatic enzymes persisted due to stenosis from the pancreaticojejunostomy.Because we could not accomplish dilation of the stenosis by endoscopic retrograde cholangiopancreatography,we tried an endoscopic ultrasonography(EUS) guided rendezvous technique for pancreatic duct drainage.After transgastric puncture of the pancreatic duct using an EUS-fine needle aspiration needle,the guidewire was inserted into the pancreatic duct and finally reached to the jejunum through the stenotic anastomosis.We changed the echoendoscope to an oblique-viewing endoscope,then grasped the guidewire and withdrew it through the scope.The stenosis of the pancreaticojejunostomy was dilated up to 4 mm,and a pancreatic stent was put in place.Though the pancreatic stent was removed after three months,the patient remained symptomfree.Pancreatic duct drainage using an EUS-guided rendezvous technique was useful for the treatment of a stenotic pancreaticojejunostomy after pancreaticoduodenectomy. | Tetsuya Takikawa Atsushi Kanno Atsushi Masamune Shin Hamada Eriko Nakano Shin Miura Hiroyuki Ariga Jun Unno Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Hiroshi Yoshida Yu Katayose Michiaki Unno Tooru Shimosegawa | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 4 | The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice显示文摘 | Atsushi Masamune Shin Hamada Kazuhiro Kikuta Tetsuya Takikawa Shin Miura Eriko Nakano Tooru Shimosegawa | 2013 | Scandinavian Journal of Gastroenterology2013，，5： | 2 |
| 5 | Prognostic Values of Matrix Metalloproteinase Family Expression in Human Colorectal Carcinoma显示文摘 | Toshimichi Asano Mitsuhiro Tada Shaoqiang Cheng Norihiro Takemoto Taro Kuramae Motoki Abe Osamu Takahashi Masaki Miyamoto Jun-Ichi Hamada Tetsuya Moriuchi Satoshi Kondo | 2008 | Journal of Surgical Research2008，，1： | 2 |
| 6 | A Numerical Study on the Distribution of Temperature in a Fine High Carbon Steel Wire Subjected to High-Speed Drawing显示文摘 | Takanari Hamada Tetsuya Hirouchi Masayoshi Akiyama | 2001 | Wire Journal International2001，33，5： | 1 |
| 7 | Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，： | 1 |
| 8 | Study of a simple sensor for stress history measurements of a structural member using a piezoelectric element显示文摘 | Eiji Shintaku Yukio Fujimoto Kunihiro Hamada Tetsuya Takeuchi | 2000 | Journal of Marine Science and Technology2000，，1： | 1 |
| 9 | EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins显示文摘 | Zili Lei Takako Maeda Atsushi Tamura Tetsuya Nakamura Yuji Yamazaki Hidetaka Shiratori Kenta Yashiro Sachiko Tsukita Hiroshi Hamada | 2012 | Developmental Biology2012，，2： | 1 |
| 10 | Association of abnormal diurnal blood pressure variation with the development of silent cerebral infarction in patients with late-life-onset depression显示文摘 | Tetsuhito Murata Tetsuya Takahashi Masao Omori Yuji Wada Toshihiko Hamada Haruyoshi Yoshida | 2003 | General Hospital Psychiatry2003，，4： | 1 |
| 11 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 12 | Nuclear accumulation of β-catenin without an additional somatic mutationin coding region of the APC gene in hepatoblastoma from a familial adenomatouspolyposis patient显示文摘 | Takeshi Inukai Keiji Furuuchi Kanji Sugita Kanako Uno Akishi Ooi Fumiaki Sasaki Jun-Ichi Hamada Tetsuya Moriuchi Shinpei Nakazawa | 2004 | Oncology Reports2004，，： | 1 |
| 13 | Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas显示文摘 | Motoshi Kanai Jun-Ichi Hamada Minoru Takada Toshimichi Asano Katsuhiko Murakawa Yoko Takahashi Taichi Murai Mitsuhiro Tada Masaki Miyamoto Satoshi Kondo Tetsuya Moriuchi | 2010 | Oncology Reports2010，，3： | 1 |
| 14 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 15 | Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells显示文摘 | Shin Hamada Atsushi Masamune Tetsuya Takikawa Noriaki Suzuki Kazuhiro Kikuta Morihisa Hirota Hirofumi Hamada Masayoshi Kobune Kennichi Satoh Tooru Shimosegawa | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 16 | Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae显示文摘 | Masafumi Seki Hisao Yoshida Kazuyoshi Gotoh Nobuyuki Hamada Daisuke Motooka Shota Nakamura Norihisa Yamamoto Shigeto Hamaguchi Yukihiro Akeda Hiroshi Watanabe Tetsuya Iida Kazunori Tomono | 2014 | Respiratory Medicine Case Reports2014，，： | 1 |
| 17 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 18 | Influence of co-cations on the formation of Cu + species in Cu/ZSM-5 and its effect on selective catalytic reduction of NOx with NH 3显示文摘 | Asima Sultana Tetsuya Nanba Masaaki Haneda Motoi Sasaki Hideaki Hamada | 2010 | Applied Catalysis B Environmental2010，，1： | 1 |
| 19 | miR-210 regulates the interaction between pancreatic cancer cells and stellate cells显示文摘 | Tetsuya Takikawa Atsushi Masamune Shin Hamada Eriko Nakano Naoki Yoshida Tooru Shimosegawa | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 20 | Low expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) indicates a shorter survival after resection in patients with adenocarcinoma of the lung显示文摘 | Norihiro Takemoto Mitsuhiro Tada Yasuhiro Hida Toshimichi Asano Shaoqiang Cheng Tarou Kuramae Jun-Ichi Hamada Masaki Miyamoto Satoshi Kondo Tetsuya Moriuchi | 2007 | Lung Cancer2007，，3： | 1 |
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